Merendera sobolifera
Species
KNApSAcK Entry
| Organism name | Merendera sobolifera |
|---|---|
| Genus | Merendera |
| Family | Melanthiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Merendera |
|---|---|
| Linked NCBI taxonomy ID | 217491 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Colchicaceae |
|---|---|
| ID | 41218 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Liliopsida |
|---|---|
| ID | 4447 |
Metabolite list (6)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002327
|
Colcin
/ Condylon / Colchisol / Colsaloid / Colchineos / Colchicine |
CHEMBL87
CHEMBL107 CHEMBL330320 |
D003078
|
150 / 106 / 96 | 36 / 108 | No. 598 | No. 4 |
|
|
C00027135
|
Cornigerine
|
CHEMBL282984
|
C056314
|
15 / 7 / 2 | No. 598 | No. 4 |
|
|
|
C00027138
|
Colchamine
/ Demecolcine |
CHEMBL433632
CHEMBL312862 |
D003703
|
19 / 10 / 6 | 2 / 0 | No. 598 | No. 4 |
|
|
C00027724
|
2-Demethylcolchicine
/ (-)-2-Demethylcolchicine |
CHEMBL1080
CHEMBL325328 |
15 / 7 / 2 | No. 598 | No. 4 |
|
||
|
C00027741
|
3-Demethylcolchicine
|
CHEMBL1081
CHEMBL1707904 |
C007279
|
21 / 12 / 4 | No. 598 | No. 4 |
|
|
|
C00028684
|
N-Formyl-N-deacetylcolchicine
|
CHEMBL85710
|
C080994
|
1 / 0 / 0 | No. 598 | No. 4 |
|
Human Protein / Gene in interactions
151 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q9BVA1 | Tubulin beta-2B chain | Structural | C00002327 C00027135 C00027138 C00027724 C00027741 | 1 / 0 |
| Q9BUF5 | Tubulin beta-6 chain | Structural | C00002327 C00027135 C00027138 C00027724 C00027741 | 0 / 0 |
| Q9BQE3 | Tubulin alpha-1C chain | Unclassified protein | C00002327 C00027135 C00027138 C00027724 C00027741 | 0 / 0 |
| Q6PEY2 | Tubulin alpha-3E chain | Unclassified protein | C00002327 C00027135 C00027138 C00027724 C00027741 | 0 / 0 |
| Q13885 | Tubulin beta-2A chain | Structural | C00002327 C00027135 C00027138 C00027724 C00027741 | 0 / 0 |
| P68363 | Tubulin alpha-1B chain | Unclassified protein | C00002327 C00027135 C00027138 C00027724 C00027741 | 0 / 0 |
| Q9H4B7 | Tubulin beta-1 chain | Structural | C00002327 C00027135 C00027138 C00027724 C00027741 | 1 / 0 |
| Q13509 | Tubulin beta-3 chain | Structural | C00002327 C00027135 C00027138 C00027724 C00027741 | 2 / 1 |
| P68371 | Tubulin beta-4B chain | Structural | C00002327 C00027135 C00027138 C00027724 C00027741 | 0 / 0 |
| Q71U36 | Tubulin alpha-1A chain | Structural | C00002327 C00027135 C00027138 C00027724 C00027741 | 1 / 1 |
| P07437 | Tubulin beta chain | Structural | C00002327 C00027135 C00027138 C00027724 C00027741 | 0 / 0 |
| Q13748 | Tubulin alpha-3C/D chain | Structural | C00002327 C00027135 C00027138 C00027724 C00027741 | 0 / 0 |
| P04350 | Tubulin beta-4A chain | Structural | C00002327 C00027135 C00027138 C00027724 C00027741 | 2 / 0 |
| P68366 | Tubulin alpha-4A chain | Structural | C00002327 C00027135 C00027138 C00027724 C00027741 | 0 / 0 |
| Q3ZCM7 | Tubulin beta-8 chain | Structural | C00002327 C00027135 C00027138 C00027724 C00027741 | 0 / 0 |
| P51843 | Nuclear receptor subfamily 0 group B member 1 | Nuclear hormone receptor subfamily 0 group B member 1 | C00002327 C00027138 C00027741 | 2 / 2 |
| O75496 | Geminin | Unclassified protein | C00002327 C00027138 C00027741 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002327 C00027138 C00027741 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002327 C00027741 | 1 / 0 |
| Q06710 | Paired box protein Pax-8 | Unclassified protein | C00002327 C00027138 | 1 / 2 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00002327 C00027741 | 2 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002327 C00028684 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00002327 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00002327 | 3 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00002327 | 3 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00002327 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002327 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00002327 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002327 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00002327 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00002327 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00002327 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00002327 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00002327 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00002327 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00002327 | 1 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00002327 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00002327 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00002327 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002327 | 0 / 1 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00002327 | 1 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00002327 | 1 / 8 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00002327 | 2 / 3 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00002327 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00002327 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00002327 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00002327 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00002327 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00002327 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00002327 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00002327 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00002327 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00002327 | 1 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00002327 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00002327 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002327 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002327 | 11 / 10 |
| Q92793 | CREB-binding protein | Enzyme | C00002327 | 1 / 1 |
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | C00002327 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00002327 | 0 / 0 |
| P23416 | Glycine receptor subunit alpha-2 | GLR alpha | C00002327 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00002327 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00002327 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00002327 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00002327 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00002327 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00002327 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002327 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00002327 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00002327 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00002327 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00002327 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00002327 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00002327 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00002327 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00002327 | 1 / 0 |
| P03956 | Interstitial collagenase | M10A | C00002327 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00002327 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002327 | 7 / 3 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002327 | 1 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002327 | 0 / 0 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | C00002327 | 1 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002327 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002327 | 2 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002327 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00002327 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00002327 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00002327 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00002327 | 2 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00002327 | 5 / 3 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00002327 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00002327 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00002327 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00002327 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00002327 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00002327 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00002327 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00002327 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002327 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00002327 | 2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002327 | 0 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00002327 | 1 / 1 |
| O75030 | Microphthalmia-associated transcription factor | Unclassified protein | C00002327 | 4 / 4 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00002327 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002327 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00002327 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002327 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00002327 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002327 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00002327 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00002327 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00002327 | 0 / 0 |
| P23415 | Glycine receptor subunit alpha-1 | GLR alpha | C00002327 | 1 / 1 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00002327 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00002327 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00002327 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002327 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002327 | 0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00002327 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00027741 | 0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00002327 | 1 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00002327 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00002327 | 3 / 4 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00002327 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00002327 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00002327 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00002327 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00002327 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002327 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00002327 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00002327 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002327 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00002327 | 0 / 0 |
| O75751 | Solute carrier family 22 member 3 | Unclassified protein | C00002327 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00002327 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00002327 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00002327 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00002327 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00002327 | 6 / 4 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00002327 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00002327 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00002327 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00002327 | 2 / 1 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00002327 | 2 / 2 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002327 | 0 / 3 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00002327 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002327 | 1 / 1 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00002327 | 0 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00002327 | 1 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002327 | 7 / 37 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002327 | 1 / 0 |
36 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002327
C00027138
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00002327
C00027138
|
| 3552 | IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 | interleukin 1, alpha |
C00002327
|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00002327
|
| 9212 | AURKB, AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, PPP1R48, STK12, STK5, aurkb-sv1, aurkb-sv2 | aurora kinase B (EC:2.7.11.1) |
C00002327
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00002327
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00002327
|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00002327
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00002327
|
| 891 | CCNB1, CCNB | cyclin B1 |
C00002327
|
| 966 | CD59, 16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20 | CD59 molecule, complement regulatory protein |
C00002327
|
| 999 | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO | cadherin 1, type 1, E-cadherin (epithelial) |
C00002327
|
| 10659 | CELF2, BRUNOL3, CUGBP2, ETR-3, ETR3, NAPOR | CUGBP, Elav-like family member 2 |
C00002327
|
| 1437 | CSF2, GMCSF | colony stimulating factor 2 (granulocyte-macrophage) |
C00002327
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002327
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00002327
|
| 2147 | F2, PT, RPRGL2, THPH1 | coagulation factor II (thrombin) (EC:3.4.21.5) |
C00002327
|
| 3551 | IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) |
C00002327
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00002327
|
| 3558 | IL2, IL-2, TCGF, lymphokine | interleukin 2 |
C00002327
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00002327
|
| 3875 | KRT18, CYK18, K18 | keratin 18 |
C00002327
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00002327
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00002327
|
| 4137 | MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU | microtubule-associated protein tau |
C00002327
|
| 4255 | MGMT | O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) |
C00002327
|
| 4661 | MYT1, C20orf36, MTF1, MYTI, PLPB1, ZC2HC4A | myelin transcription factor 1 |
C00002327
|
| 4776 | NFATC4, NF-ATc4, NFAT3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
C00002327
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00002327
|
| 2908 | NR3C1, GCCR, GCR, GR, GRL | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
C00002327
|
| 2185 | PTK2B, CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK | protein tyrosine kinase 2 beta (EC:2.7.10.2) |
C00002327
|
| 10928 | RALBP1, RIP1, RLIP1, RLIP76 | ralA binding protein 1 |
C00002327
|
| 6898 | TAT | tyrosine aminotransferase (EC:2.6.1.5) |
C00002327
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00002327
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00002327
|
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 |
C00002327
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (106)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300018 | 46,xy sex reversal 2; srxy2 |
P51843
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #300200 | Adrenal hypoplasia, congenital; ahc |
P51843
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
O75030
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| %606641 | Body mass index; bmi |
P37231
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #614039 | Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 |
Q13509
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #128101 | Dystonia 4, torsion, autosomal dominant; dyt4 |
P04350
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600638 | Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a |
Q13509
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 P37231 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #149400 | Hyperekplexia, hereditary 1; hkpx1 |
P23415
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #218700 | Hypothyroidism, congenital, nongoitrous, 2; chng2 |
Q06710
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #612438 | Leukodystrophy, hypomyelinating, 6; hld6 |
P04350
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #611603 | Lissencephaly 3; lis3 |
Q71U36
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #613112 | Macrothrombocytopenia, autosomal dominant, tubb1-related |
Q9H4B7
|
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #614456 | Melanoma, cutaneous malignant, susceptibility to, 8; cmm8 |
O75030
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
P37231 |
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #610031 | Polymicrogyria, symmetric or asymmetric; pmgysa |
Q9BVA1
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #180849 | Rubinstein-taybi syndrome 1; rsts1 |
Q92793
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #103500 | Tietz syndrome |
O75030
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #193510 | Waardenburg syndrome, type 2a; ws2a |
O75030
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (96)
| KEGG | name | UniProt |
|---|---|---|
| H00038 | Malignant melanoma |
O75030
(related)
O75030 (marker) P04637 (related) |
| H00169 | Ocular albinism |
O75030
(related)
|
| H00759 | Waardenburg syndrome (WS) |
O75030
(related)
|
| H01187 | Tietz syndrome |
O75030
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) Q06710 (related) |
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
Q06710 (related) |
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00769 | Hyperekplexia |
P23415
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00552 | Glycerol kinase deficiency (GKD) |
P51843
(related)
|
| H00607 | 46,XY disorders of sex development (Disorders of gonadal development) |
P51843
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00838 | Congenital fibrosis of the extraocular muscles (CFEOM) |
Q13509
(related)
|
| H00268 | Lissencephaly (LIS) |
Q71U36
(related)
|
| H00504 | Rubinstein-Taybi syndrome |
Q92793
(related)
|
| H00208 | Hyperbilirubinemia |
Q92887
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
Diseases related to CTD interactions
108 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D015746 | Abdominal Pain |
C00002327
|
| D000014 | Abnormalities, Drug-Induced |
C00002327
|
| D058186 | Acute Kidney Injury |
C00002327
|
| D000505 | Alopecia |
C00002327
|
| D000544 | Alzheimer Disease |
C00002327
|
| D000647 | Amnesia |
C00002327
|
| D000686 | Amyloidosis |
C00002327
|
| D000740 | Anemia |
C00002327
|
| D000749 | Anemia, Megaloblastic |
C00002327
|
| D000783 | Aneurysm |
C00002327
|
| D001002 | Anuria |
C00002327
|
| D001039 | Aphasia, Broca |
C00002327
|
| D001145 | Arrhythmias, Cardiac |
C00002327
|
| D015210 | Arthritis, Gouty |
C00002327
|
| D015535 | Arthritis, Psoriatic |
C00002327
|
| D001259 | Ataxia |
C00002327
|
| D001528 | Behcet Syndrome |
C00002327
|
| D001768 | Blister |
C00002327
|
| D001855 | Bone Marrow Diseases |
C00002327
|
| D001927 | Brain Diseases |
C00002327
|
| D001930 | Brain Injuries |
C00002327
|
| D006528 | Carcinoma, Hepatocellular |
C00002327
|
| D002779 | Cholestasis |
C00002327
|
| D003072 | Cognition Disorders |
C00002327
|
| D003218 | Condylomata Acuminata |
C00002327
|
| D003967 | Diarrhea |
C00002327
|
| D004211 | Disseminated Intravascular Coagulation |
C00002327
|
| D004244 | Dizziness |
C00002327
|
| D004314 | Down Syndrome |
C00002327
|
| D056486 | Drug-Induced Liver Injury |
C00002327
|
| D062787 | Drug Overdose |
C00002327
|
| D004417 | Dyspnea |
C00002327
|
| D004618 | Embolism, Air |
C00002327
|
| D004760 | Enterocolitis |
C00002327
|
| D010505 | Familial Mediterranean Fever |
C00002327
|
| D005221 | Fatigue |
C00002327
|
| D005705 | Gallbladder Diseases |
C00002327
|
| D005759 | Gastroenteritis |
C00002327
|
| D005767 | Gastrointestinal Diseases |
C00002327
|
| D005902 | Glaucoma, Open-Angle |
C00002327
|
| D006073 | Gout |
C00002327
|
| D020275 | Guillain-Barre Syndrome |
C00002327
|
| D006261 | Headache |
C00002327
|
| D006470 | Hemorrhage |
C00002327
|
| D019694 | Hepatitis B, Chronic |
C00002327
|
| D006948 | Hyperkinesis |
C00002327
|
| D006955 | Hypernatremia |
C00002327
|
| D006973 | Hypertension |
C00002327
|
| D033461 | Hyperuricemia |
C00002327
|
| D007010 | Hyponatremia |
C00002327
|
| D007039 | Hypotrichosis |
C00002327
|
| D007249 | Inflammation |
C00002327
|
| D007410 | Intestinal Diseases |
C00002327
|
| D007565 | Jaundice |
C00002327
|
| D007674 | Kidney Diseases |
C00002327
|
| D007859 | Learning Disorders |
C00002327
|
| D015479 | Leukemia, Myelomonocytic, Acute |
C00002327
|
| D007970 | Leukopenia |
C00002327
|
| D008103 | Liver Cirrhosis |
C00002327
|
| D008107 | Liver Diseases |
C00002327
|
| D008108 | Liver Diseases, Alcoholic |
C00002327
|
| D017114 | Liver Failure, Acute |
C00002327
|
| D008569 | Memory Disorders |
C00002327
|
| D009101 | Multiple Myeloma |
C00002327
|
| D009102 | Multiple Organ Failure |
C00002327
|
| D018908 | Muscle Weakness |
C00002327
|
| D009133 | Muscular Atrophy |
C00002327
|
| D009135 | Muscular Diseases |
C00002327
|
| D009212 | Myoglobinuria |
C00002327
|
| D009222 | Myotonia |
C00002327
|
| D020967 | Myotonic Disorders |
C00002327
|
| D009325 | Nausea |
C00002327
|
| D009336 | Necrosis |
C00002327
|
| D009369 | Neoplasms |
C00002327
|
| D009422 | Nervous System Diseases |
C00002327
|
| D009436 | Neural Tube Defects |
C00002327
|
| D009468 | Neuromuscular Diseases |
C00002327
|
| D009846 | Oliguria |
C00002327
|
| D009896 | Optic Atrophy |
C00002327
|
| D009901 | Optic Nerve Diseases |
C00002327
|
| D010146 | Pain |
C00002327
|
| D010195 | Pancreatitis |
C00002327
|
| D010198 | Pancytopenia |
C00002327
|
| D010243 | Paralysis |
C00002327
|
| D010523 | Peripheral Nervous System Diseases |
C00002327
|
| D011115 | Polyneuropathies |
C00002327
|
| D011141 | Polyuria |
C00002327
|
| D017119 | Porphyria Cutanea Tarda |
C00002327
|
| D011565 | Psoriasis |
C00002327
|
| D011782 | Quadriplegia |
C00002327
|
| D012021 | Reflex, Abnormal |
C00002327
|
| D051437 | Renal Insufficiency |
C00002327
|
| D012131 | Respiratory Insufficiency |
C00002327
|
| D012206 | Rhabdomyolysis |
C00002327
|
| D012640 | Seizures |
C00002327
|
| D018805 | Sepsis |
C00002327
|
| D012790 | Shwartzman Phenomenon |
C00002327
|
| D012871 | Skin Diseases |
C00002327
|
| D013281 | Stomatitis, Aphthous |
C00002327
|
| D020955 | Striatonigral Degeneration |
C00002327
|
| D016463 | Sweet Syndrome |
C00002327
|
| D013616 | Tachycardia, Sinus |
C00002327
|
| D013921 | Thrombocytopenia |
C00002327
|
| C536522 | Vacuolar myopathy |
C00002327
|
| D014786 | Vision Disorders |
C00002327
|
| D014806 | Vitamin B 12 Deficiency |
C00002327
|
| D014839 | Vomiting |
C00002327
|
| D015431 | Weight Loss |
C00002327
|