PCIDB

KNApSAcK Metabolite C00027741

Metabolite

KNApSAcK Entry

id C00027741
Name 3-Demethylcolchicine
CAS RN 7336-33-6
Standard InChI InChI=1S/C21H23NO6/c1-11(23)22-15-7-5-12-9-17(25)20(27-3)21(28-4)19(12)13-6-8-18(26-2)16(24)10-14(13)15/h6,8-10,15,25H,5,7H2,1-4H3,(H,22,23)/t15-/m0/s1
Standard InChI (Main Layer) InChI=1S/C21H23NO6/c1-11(23)22-15-7-5-12-9-17(25)20(27-3)21(28-4)19(12)13-6-8-18(26-2)16(24)10-14(13)15/h6,8-10,15,25H,5,7H2,1-4H3,(H,22,23)

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 598

Link

ChEMBL

By standard InChI CHEMBL1081
By standard InChI Main Layer CHEMBL1081 CHEMBL1707904

KEGG

By LinkDB

CTD

By CAS RN C007279

Human Protein / Gene in interaction

21 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL1707904 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL1707904 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P51843 Nuclear receptor subfamily 0 group B member 1 Nuclear hormone receptor subfamily 0 group B member 1 CHEMBL1707904 CHEMBL2354292 (1)
2 / 2
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1707904 CHEMBL1794483 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1707904 CHEMBL1738184 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL1707904 CHEMBL2354311 (1)
1 / 0
Q13748 Tubulin alpha-3C/D chain Structural CHEMBL1081 CHEMBL820637 (1)
0 / 0
P68366 Tubulin alpha-4A chain Structural CHEMBL1081 CHEMBL820637 (1)
0 / 0
Q9H4B7 Tubulin beta-1 chain Structural CHEMBL1081 CHEMBL820637 (1)
1 / 0
P04350 Tubulin beta-4A chain Structural CHEMBL1081 CHEMBL820637 (1)
2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural CHEMBL1081 CHEMBL820637 (1)
0 / 0
P07437 Tubulin beta chain Structural CHEMBL1081 CHEMBL820637 (1)
0 / 0
Q71U36 Tubulin alpha-1A chain Structural CHEMBL1081 CHEMBL820637 (1)
1 / 1
P68371 Tubulin beta-4B chain Structural CHEMBL1081 CHEMBL820637 (1)
0 / 0
Q13509 Tubulin beta-3 chain Structural CHEMBL1081 CHEMBL820637 (1)
2 / 1
P68363 Tubulin alpha-1B chain Unclassified protein CHEMBL1081 CHEMBL820637 (1)
0 / 0
Q13885 Tubulin beta-2A chain Structural CHEMBL1081 CHEMBL820637 (1)
0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein CHEMBL1081 CHEMBL820637 (1)
0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein CHEMBL1081 CHEMBL820637 (1)
0 / 0
Q9BUF5 Tubulin beta-6 chain Structural CHEMBL1081 CHEMBL820637 (1)
0 / 0
Q9BVA1 Tubulin beta-2B chain Structural CHEMBL1081 CHEMBL820637 (1)
1 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#300018 46,xy sex reversal 2; srxy2 P51843
#300200 Adrenal hypoplasia, congenital; ahc P51843
#114500 Colorectal cancer; crc P84022
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#137800 Glioma susceptibility 1; glm1 O75874
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1

KEGG DISEASE (4)

KEGG disease name UniProt
H00552 Glycerol kinase deficiency (GKD) P51843 (related)
H00607 46,XY disorders of sex development (Disorders of gonadal development) P51843 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)