Colchicum autumnale L.

• Index
• Plant Species
• Natural Activity
• Metabolite list (5)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Colchicum autumnale L.
Genus	Colchicum
Family	Colchicaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Colchicum autumnale
Linked NCBI taxonomy ID	45005
Linked level	species

Family

Family in NCBI taxonomy	Colchicaceae
ID	41218

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	Liliopsida
ID	4447

Natural Activity

List (15)

Species	Activity
Colchicum autumnale L.	Alterative
Colchicum autumnale L.	Antichemotactic
Colchicum autumnale L.	Antiinflammatory
Colchicum autumnale L.	Antimitotic
Colchicum autumnale L.	Antirheumatic
Colchicum autumnale L.	Antitumor
Colchicum autumnale L.	Aperient
Colchicum autumnale L.	Aphrodisiac
Colchicum autumnale L.	Carminative
Colchicum autumnale L.	Diaphoretic
Colchicum autumnale L.	Diuretic
Colchicum autumnale L.	Emetic
Colchicum autumnale L.	Laxative
Colchicum autumnale L.	Poison
Colchicum autumnale L.	Sedative

Metabolite list (5)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00027138	Colchamine / Demecolcine	CHEMBL433632 CHEMBL312862	D003703	19 / 10 / 6	2 / 0	No. 598	No. 4
C00027724	2-Demethylcolchicine / (-)-2-Demethylcolchicine	CHEMBL1080 CHEMBL325328		15 / 7 / 2		No. 598	No. 4
C00027741	3-Demethylcolchicine	CHEMBL1081 CHEMBL1707904	C007279	21 / 12 / 4		No. 598	No. 4
C00028077	Colchifoline	CHEMBL482108	C043920			No. 598	No. 4
C00032352	Thiocolchicine	CHEMBL273938 CHEMBL18981 CHEMBL262394	C014856	24 / 11 / 3	1 / 0	No. 598	No. 4

Human Protein / Gene in interactions

27 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q9BVA1	Tubulin beta-2B chain	Structural	C00027138 C00027724 C00027741 C00032352	1 / 0
Q9H4B7	Tubulin beta-1 chain	Structural	C00027138 C00027724 C00027741 C00032352	1 / 0
Q9BUF5	Tubulin beta-6 chain	Structural	C00027138 C00027724 C00027741 C00032352	0 / 0
Q9BQE3	Tubulin alpha-1C chain	Unclassified protein	C00027138 C00027724 C00027741 C00032352	0 / 0
Q6PEY2	Tubulin alpha-3E chain	Unclassified protein	C00027138 C00027724 C00027741 C00032352	0 / 0
Q13885	Tubulin beta-2A chain	Structural	C00027138 C00027724 C00027741 C00032352	0 / 0
P68363	Tubulin alpha-1B chain	Unclassified protein	C00027138 C00027724 C00027741 C00032352	0 / 0
Q13509	Tubulin beta-3 chain	Structural	C00027138 C00027724 C00027741 C00032352	2 / 1
P68371	Tubulin beta-4B chain	Structural	C00027138 C00027724 C00027741 C00032352	0 / 0
Q71U36	Tubulin alpha-1A chain	Structural	C00027138 C00027724 C00027741 C00032352	1 / 1
P07437	Tubulin beta chain	Structural	C00027138 C00027724 C00027741 C00032352	0 / 0
Q3ZCM7	Tubulin beta-8 chain	Structural	C00027138 C00027724 C00027741 C00032352	0 / 0
Q13748	Tubulin alpha-3C/D chain	Structural	C00027138 C00027724 C00027741 C00032352	0 / 0
P04350	Tubulin beta-4A chain	Structural	C00027138 C00027724 C00027741 C00032352	2 / 0
P68366	Tubulin alpha-4A chain	Structural	C00027138 C00027724 C00027741 C00032352	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00027138 C00027741 C00032352	0 / 0
O75496	Geminin	Unclassified protein	C00027138 C00027741 C00032352	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00027741 C00032352	2 / 0
P51843	Nuclear receptor subfamily 0 group B member 1	Nuclear hormone receptor subfamily 0 group B member 1	C00027138 C00027741	2 / 2
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00027741 C00032352	1 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00027741	0 / 0
Q06710	Paired box protein Pax-8	Unclassified protein	C00027138	1 / 2
Q02880	DNA topoisomerase 2-beta	Isomerase	C00032352	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00032352	0 / 0
Q8IUX4	DNA dC->dU-editing enzyme APOBEC-3F	Enzyme	C00032352	0 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00032352	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00032352	1 / 1

2 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00027138 C00032352
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00027138

Related Diseases

Diseases related to proteins in ChEMBL interactions