PCIDB

KNApSAcK Metabolite C00027138

Metabolite

KNApSAcK Entry

id C00027138
Name Colchamine / Demecolcine
CAS RN 477-30-5
Standard InChI InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1
Standard InChI (Main Layer) InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 598

Link

ChEMBL

By standard InChI CHEMBL312862
By standard InChI Main Layer CHEMBL433632 CHEMBL312862

KEGG

By LinkDB C11250

CTD

By CAS RN D003703

Human Protein / Gene in interaction

19 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein CHEMBL433632 CHEMBL312862 CHEMBL2114843 (2) CHEMBL2114780 (2)
0 / 0
P51843 Nuclear receptor subfamily 0 group B member 1 Nuclear hormone receptor subfamily 0 group B member 1 CHEMBL312862 CHEMBL2354292 (1)
2 / 2
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL312862 CHEMBL1738184 (1)
0 / 0
Q13748 Tubulin alpha-3C/D chain Structural CHEMBL433632 CHEMBL820637 (1)
0 / 0
P68366 Tubulin alpha-4A chain Structural CHEMBL433632 CHEMBL820637 (1)
0 / 0
Q9H4B7 Tubulin beta-1 chain Structural CHEMBL433632 CHEMBL820637 (1)
1 / 0
P04350 Tubulin beta-4A chain Structural CHEMBL433632 CHEMBL820637 (1)
2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural CHEMBL433632 CHEMBL820637 (1)
0 / 0
P07437 Tubulin beta chain Structural CHEMBL433632 CHEMBL820637 (1)
0 / 0
Q71U36 Tubulin alpha-1A chain Structural CHEMBL433632 CHEMBL820637 (1)
1 / 1
P68371 Tubulin beta-4B chain Structural CHEMBL433632 CHEMBL820637 (1)
0 / 0
Q13509 Tubulin beta-3 chain Structural CHEMBL433632 CHEMBL820637 (1)
2 / 1
Q06710 Paired box protein Pax-8 Unclassified protein CHEMBL312862 CHEMBL2354301 (1)
1 / 2
P68363 Tubulin alpha-1B chain Unclassified protein CHEMBL433632 CHEMBL820637 (1)
0 / 0
Q13885 Tubulin beta-2A chain Structural CHEMBL433632 CHEMBL820637 (1)
0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein CHEMBL433632 CHEMBL820637 (1)
0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein CHEMBL433632 CHEMBL820637 (1)
0 / 0
Q9BUF5 Tubulin beta-6 chain Structural CHEMBL433632 CHEMBL820637 (1)
0 / 0
Q9BVA1 Tubulin beta-2B chain Structural CHEMBL433632 CHEMBL820637 (1)
1 / 0

CTD interaction (8)

compound gene gene name gene description interaction interaction type form reference
pmid
D003703 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Demecolcine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form] decreases reaction
/ increases activity
protein 12711602
D003703 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Demecolcine results in increased activity of ABCB1 protein mutant form increases activity
protein 12711602
D003703 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) cyclopiazonic acid inhibits the reaction [Demecolcine results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 12530016
D003703 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Demecolcine results in increased activity of CASP3 protein increases activity
protein 12530016
D003703 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) diacetylmonoxime inhibits the reaction [Demecolcine results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 12530016
D003703 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) geldanamycin inhibits the reaction [Demecolcine results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 12530016
D003703 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Lansoprazole inhibits the reaction [Demecolcine results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 12530016
D003703 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) monorden inhibits the reaction [Demecolcine results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 12530016

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#300018 46,xy sex reversal 2; srxy2 P51843
#300200 Adrenal hypoplasia, congenital; ahc P51843
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#218700 Hypothyroidism, congenital, nongoitrous, 2; chng2 Q06710
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1

KEGG DISEASE (6)

KEGG disease name UniProt
H00552 Glycerol kinase deficiency (GKD) P51843 (related)
H00607 46,XY disorders of sex development (Disorders of gonadal development) P51843 (related)
H00032 Thyroid cancer Q06710 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) Q06710 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)