Species

KNApSAcK Entry

Organism name Merendera robusta
Genus Merendera
Family Melanthiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Colchicum robustum
Linked NCBI taxonomy ID 481258
Linked level species

Family

Family in NCBI taxonomy Colchicaceae
ID 41218

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00027412 External link 512 Bechuanin
/ Merenderine
/ (S)-Floramultine
No. 20 No. 4
C00027138 External link 512 Colchamine
/ Demecolcine
CHEMBL433632
CHEMBL312862
D003703
19 / 10 / 6 2 / 0 No. 598 No. 4
C00027729 External link 512 2-O-Demethylcolchicine
/ (-)-2-Demethylcolchicine
CHEMBL1080
CHEMBL325328
15 / 7 / 2 No. 598 No. 4
C00028074 External link 512 Colchameine
CHEMBL327221
15 / 7 / 2 No. 598 No. 4
C00027476 External link 512 Robustamine cis-N-oxide
/ (-)-Robustamine a-N-oxide
No. 3668

Human Protein / Gene in interactions

19 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9H4B7 Tubulin beta-1 chain Structural C00027138 C00027729 C00028074 1 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00027138 C00027729 C00028074 1 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00027138 C00027729 C00028074 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00027138 C00027729 C00028074 0 / 0
Q13748 Tubulin alpha-3C/D chain Structural C00027138 C00027729 C00028074 0 / 0
P68366 Tubulin alpha-4A chain Structural C00027138 C00027729 C00028074 0 / 0
P04350 Tubulin beta-4A chain Structural C00027138 C00027729 C00028074 2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00027138 C00027729 C00028074 0 / 0
P07437 Tubulin beta chain Structural C00027138 C00027729 C00028074 0 / 0
Q13885 Tubulin beta-2A chain Structural C00027138 C00027729 C00028074 0 / 0
P68371 Tubulin beta-4B chain Structural C00027138 C00027729 C00028074 0 / 0
Q13509 Tubulin beta-3 chain Structural C00027138 C00027729 C00028074 2 / 1
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00027138 C00027729 C00028074 0 / 0
P68363 Tubulin alpha-1B chain Unclassified protein C00027138 C00027729 C00028074 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00027138 C00027729 C00028074 1 / 1
Q06710 Paired box protein Pax-8 Unclassified protein C00027138 1 / 2
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00027138 0 / 0
P51843 Nuclear receptor subfamily 0 group B member 1 Nuclear hormone receptor subfamily 0 group B member 1 C00027138 2 / 2
O75496 Geminin Unclassified protein C00027138 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00027138
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00027138

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#300018 46,xy sex reversal 2; srxy2 P51843
#300200 Adrenal hypoplasia, congenital; ahc P51843
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#218700 Hypothyroidism, congenital, nongoitrous, 2; chng2 Q06710
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1

KEGG DISEASE (6)

KEGG name UniProt
H00552 Glycerol kinase deficiency (GKD) P51843 (related)
H00607 46,XY disorders of sex development (Disorders of gonadal development) P51843 (related)
H00032 Thyroid cancer Q06710 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) Q06710 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)