PCIDB

KNApSAcK Metabolite C00032352

Metabolite

KNApSAcK Entry

id C00032352
Name Thiocolchicine
CAS RN 2730-71-4
Standard InChI InChI=1S/C22H25NO5S/c1-12(24)23-16-8-6-13-10-18(26-2)21(27-3)22(28-4)20(13)14-7-9-19(29-5)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
Standard InChI (Main Layer) InChI=1S/C22H25NO5S/c1-12(24)23-16-8-6-13-10-18(26-2)21(27-3)22(28-4)20(13)14-7-9-19(29-5)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 598

Link

ChEMBL

By standard InChI CHEMBL18981
By standard InChI Main Layer CHEMBL273938 CHEMBL18981 CHEMBL262394

KEGG

By LinkDB

CTD

By CAS RN C014856

Species

Summary

Plant class

class name count
Liliopsida 1

Family

family name count
Colchicaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Colchicum autumnale L. 45005 Colchicaceae Liliopsida Viridiplantae

Human Protein / Gene in interaction

24 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein CHEMBL273938 CHEMBL2114784 (1)
1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL273938 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL273938 CHEMBL2114780 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL273938 CHEMBL1794401 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL273938 CHEMBL1738184 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL273938 CHEMBL2354311 (1)
1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme CHEMBL273938 CHEMBL1963966 (1)
0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase CHEMBL18981 CHEMBL817421 (1)
0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase CHEMBL18981 CHEMBL817421 (1)
0 / 0
Q13748 Tubulin alpha-3C/D chain Structural CHEMBL18981 CHEMBL698215 (1) CHEMBL820637 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL817774 (1) CHEMBL817775 (1)
0 / 0
P68366 Tubulin alpha-4A chain Structural CHEMBL18981 CHEMBL698215 (1) CHEMBL820637 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL817774 (1) CHEMBL817775 (1)
0 / 0
Q9H4B7 Tubulin beta-1 chain Structural CHEMBL18981 CHEMBL698215 (1) CHEMBL820637 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL817774 (1) CHEMBL817775 (1)
1 / 0
P04350 Tubulin beta-4A chain Structural CHEMBL18981 CHEMBL698215 (1) CHEMBL820637 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL817774 (1) CHEMBL817775 (1)
2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural CHEMBL18981 CHEMBL698215 (1) CHEMBL820637 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL817774 (1) CHEMBL817775 (1)
0 / 0
P07437 Tubulin beta chain Structural CHEMBL18981 CHEMBL698215 (1) CHEMBL820637 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL817774 (1) CHEMBL817775 (1)
0 / 0
Q71U36 Tubulin alpha-1A chain Structural CHEMBL18981 CHEMBL698215 (1) CHEMBL820637 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL817774 (1) CHEMBL817775 (1)
1 / 1
P68371 Tubulin beta-4B chain Structural CHEMBL18981 CHEMBL698215 (1) CHEMBL820637 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL817774 (1) CHEMBL817775 (1)
0 / 0
Q13509 Tubulin beta-3 chain Structural CHEMBL18981 CHEMBL698215 (1) CHEMBL820637 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL817774 (1) CHEMBL817775 (1)
2 / 1
P68363 Tubulin alpha-1B chain Unclassified protein CHEMBL18981 CHEMBL698215 (1) CHEMBL820637 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL817774 (1) CHEMBL817775 (1)
0 / 0
Q13885 Tubulin beta-2A chain Structural CHEMBL18981 CHEMBL698215 (1) CHEMBL820637 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL817774 (1) CHEMBL817775 (1)
0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein CHEMBL18981 CHEMBL698215 (1) CHEMBL820637 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL817774 (1) CHEMBL817775 (1)
0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein CHEMBL18981 CHEMBL698215 (1) CHEMBL820637 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL817774 (1) CHEMBL817775 (1)
0 / 0
Q9BUF5 Tubulin beta-6 chain Structural CHEMBL18981 CHEMBL698215 (1) CHEMBL820637 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL817774 (1) CHEMBL817775 (1)
0 / 0
Q9BVA1 Tubulin beta-2B chain Structural CHEMBL18981 CHEMBL698215 (1) CHEMBL820637 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL817774 (1) CHEMBL817775 (1)
1 / 0

CTD interaction (1)

compound gene gene name gene description interaction interaction type form reference
pmid
C014856 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) [pifithrin co-treated with thiocholchicine] results in increased cleavage of and results in increased activity of CASP3 protein affects cotreatment
/ increases activity
/ increases cleavage
protein 18516295

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#114500 Colorectal cancer; crc P84022
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#137800 Glioma susceptibility 1; glm1 O75874
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (3)

KEGG disease name UniProt
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)