KNApSAcK Metabolite C00023553
Metabolite
KNApSAcK Entry
| id | C00023553 |
|---|---|
| Name | FTC / Tryptoquivaline / Tryptoquivaline A / Tryptoquivaline C' |
| CAS RN | 55387-45-6 |
| Standard InChI | InChI=1S/C29H30N4O7/c1-15(2)22(39-16(3)34)23-30-19-12-8-6-10-17(19)24(35)31(23)21-14-29(40-25(21)36)18-11-7-9-13-20(18)32-26(29)33(38)28(4,5)27(32)37/h6-13,15,21-22,26,38H,14H2,1-5H3/t21-,22+,26+,29+/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C29H30N4O7/c1-15(2)22(39-16(3)34)23-30-19-12-8-6-10-17(19)24(35)31(23)21-14-29(40-25(21)36)18-11-7-9-13-20(18)32-26(29)33(38)28(4,5)27(32)37/h6-13,15,21-22,26,38H,14H2,1-5H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 597 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL1399348 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | C010522 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Aspergillaceae | 2 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Aspergillus clavatus (NRRL5890) | 5052 | Aspergillaceae | Fungi | |
| Aspergillus fumigatus | 746128 | Aspergillaceae | Fungi |
Human Protein / Gene in interaction
6 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| O75496 | Geminin | Unclassified protein | CHEMBL1399348 |
CHEMBL2114780
(1)
|
0 / 0 |
| Q9Y2T6 | G-protein coupled receptor 55 | Lysophosphatidylinositol receptor | CHEMBL1399348 |
CHEMBL1737910
(1)
|
0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | CHEMBL1399348 |
CHEMBL2114817
(1)
|
7 / 3 |
| Q9Y253 | DNA polymerase eta | Enzyme | CHEMBL1399348 |
CHEMBL1794569
(1)
|
1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL1399348 |
CHEMBL1738588
(1)
|
0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | CHEMBL1399348 |
CHEMBL2114738
(1)
|
0 / 0 |
CTD interaction (6)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C010522 | 9429 |
ABCG2
ABC15 ABCP BCRP BCRP1 BMDP CD338 CDw338 EST157481 GOUT1 MRX MXR MXR1 UAQTL1 |
ATP-binding cassette, sub-family G (WHITE), member 2 | tryptoquivaline inhibits the reaction [ABCG2 protein affects the transport of Acyclovir] |
affects transport
/ decreases reaction |
protein |
21859328
|
| C010522 | 9429 |
ABCG2
ABC15 ABCP BCRP BCRP1 BMDP CD338 CDw338 EST157481 GOUT1 MRX MXR MXR1 UAQTL1 |
ATP-binding cassette, sub-family G (WHITE), member 2 | tryptoquivaline inhibits the reaction [ABCG2 protein affects the uptake of Mitoxantrone] |
affects uptake
/ decreases reaction |
protein |
15640379
|
| C010522 | 9429 |
ABCG2
ABC15 ABCP BCRP BCRP1 BMDP CD338 CDw338 EST157481 GOUT1 MRX MXR MXR1 UAQTL1 |
ATP-binding cassette, sub-family G (WHITE), member 2 | tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of milbemycin] |
decreases reaction
/ increases export |
protein |
19428349
|
| C010522 | 9429 |
ABCG2
ABC15 ABCP BCRP BCRP1 BMDP CD338 CDw338 EST157481 GOUT1 MRX MXR MXR1 UAQTL1 |
ATP-binding cassette, sub-family G (WHITE), member 2 | tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone] |
decreases reaction
/ increases export |
protein |
19428349
|
| C010522 | 9429 |
ABCG2
ABC15 ABCP BCRP BCRP1 BMDP CD338 CDw338 EST157481 GOUT1 MRX MXR MXR1 UAQTL1 |
ATP-binding cassette, sub-family G (WHITE), member 2 | tryptoquivaline results in decreased activity of ABCG2 protein |
decreases activity
|
protein |
19505989
20457140 |
| C010522 | 9429 |
ABCG2
ABC15 ABCP BCRP BCRP1 BMDP CD338 CDw338 EST157481 GOUT1 MRX MXR MXR1 UAQTL1 |
ATP-binding cassette, sub-family G (WHITE), member 2 | [tryptoquivaline results in decreased activity of ABCG2 protein] which results in decreased export of Topotecan |
decreases activity
/ decreases export |
protein |
20457140
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (8)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|