KNApSAcK Metabolite C00023903
Metabolite
KNApSAcK Entry
| id | C00023903 |
|---|---|
| Name | Fusidic acid |
| CAS RN | 6990-06-3 |
| Standard InChI | InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 725 |
Link
ChEMBL
| By standard InChI | CHEMBL374975 |
|---|---|
| By standard InChI Main Layer | CHEMBL117110 CHEMBL383466 CHEMBL374975 CHEMBL1334456 CHEMBL1477084 CHEMBL1552107 CHEMBL1619349 CHEMBL1620692 CHEMBL1625992 CHEMBL2068923 |
KEGG
| By LinkDB | C06694 |
|---|
CTD
| By CAS RN | D005672 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|
List (5)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Acremonium fusidioides | 749674 | Fungi | ||
| Calcarisporium arbuscula | 240499 | Fungi | ||
| Cephalosporium acremonium | 5044 | Fungi | ||
| Gabarnaudia tholispora | ||||
| Isaria kogane |
Human Protein / Gene in interaction
10 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P02768 | Serum albumin | Secreted protein | CHEMBL374975 |
CHEMBL702885
(1)
CHEMBL1661507
(1)
CHEMBL1661527 (1) CHEMBL1661528 (1) CHEMBL1661529 (1) |
0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL1334456 |
CHEMBL1794311
(1)
|
2 / 3 |
| P39748 | Flap endonuclease 1 | Enzyme | CHEMBL1477084 |
CHEMBL1794486
(1)
|
0 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL1334456 |
CHEMBL2114843
(1)
|
0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | CHEMBL1334456 |
CHEMBL2114817
(1)
|
7 / 3 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL1334456 |
CHEMBL1794401
(1)
|
0 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | CHEMBL374975 |
CHEMBL1006005
(1)
|
1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL1477084 |
CHEMBL1738442
(1)
|
0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | CHEMBL1552107 |
CHEMBL1613933
(1)
|
0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | CHEMBL1552107 |
CHEMBL1613933
(1)
|
1 / 6 |
CTD interaction (1)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D005672 | 8647 |
ABCB11
ABC16 BRIC2 BSEP PFIC-2 PFIC2 PGY4 SPGP |
ATP-binding cassette, sub-family B (MDR/TAP), member 11 | Fusidic Acid results in decreased activity of ABCB11 protein |
decreases activity
|
protein |
20829430
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (11)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (11)
| KEGG | disease name | UniProt |
|---|---|---|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00208 | Hyperbilirubinemia |
Q92887
(related)
|
Diseases related to CTD interactions
14 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D058186 | D005672 | Acute Kidney Injury |
marker/mechanism
|
8394548
9287276 11823554 |
|
| D000756 | D005672 | Anemia, Sideroblastic |
marker/mechanism
|
12602389
15059072 |
|
| D002779 | D005672 | Cholestasis |
marker/mechanism
|
12148265
|
|
| D003424 | D005672 | Crohn Disease |
therapeutic
|
1420741
|
|
| D004697 | D005672 | Endocarditis, Bacterial |
therapeutic
|
16735427
|
|
| D006932 | D005672 | Hyperbilirubinemia |
marker/mechanism
|
3608735
7244561 |
|
| D006996 | D005672 | Hypocalcemia |
marker/mechanism
|
11823554
|
|
| D007565 | D005672 | Jaundice |
marker/mechanism
|
6867701
12148265 |
|
| D009325 | D005672 | Nausea |
marker/mechanism
|
1420741
|
|
| D010019 | D005672 | Osteomyelitis |
therapeutic
|
3608735
11823554 |
|
| D012206 | D005672 | Rhabdomyolysis |
marker/mechanism
|
18487263
20546290 |
|
| D013203 | D005672 | Staphylococcal Infections |
therapeutic
|
5560145
12148265 18199793 19188393 |
|
| D013924 | D005672 | Thrombophlebitis |
marker/mechanism
|
7244561
|
|
| D014552 | D005672 | Urinary Tract Infections |
therapeutic
|
12148265
|