PCIDB

KNApSAcK Metabolite C00024753

Metabolite

KNApSAcK Entry

id C00024753
Name UCN-01 / (+)-UCN-01 / 7-Hydroxystaurosporine
CAS RN 112953-11-4
Standard InChI InChI=1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1
Standard InChI (Main Layer) InChI=1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)

Cluster

Phytochemical cluster
KCF-S cluster No. 251

Link

ChEMBL

By standard InChI CHEMBL1236539
By standard InChI Main Layer CHEMBL339799 CHEMBL338049 CHEMBL574737 CHEMBL601799 CHEMBL1236539

KEGG

By LinkDB

CTD

By CAS RN C054852

Human Protein / Gene in interaction

81 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 CHEMBL574737 CHEMBL1060205 (1)
1 / 1
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim CHEMBL574737 CHEMBL1051298 (1)
0 / 0
Q8TDX7 Serine/threonine-protein kinase Nek7 Nek CHEMBL574737 CHEMBL1060150 (1)
0 / 0
Q15759 Mitogen-activated protein kinase 11 p38 CHEMBL574737 CHEMBL1062771 (1)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL574737 CHEMBL1052110 (1)
0 / 0
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 CHEMBL574737 CHEMBL1063720 (1)
0 / 0
P41240 Tyrosine-protein kinase CSK Csk CHEMBL574737 CHEMBL1062801 (1)
0 / 0
P45984 Mitogen-activated protein kinase 9 Jnk CHEMBL574737 CHEMBL1062756 (1)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL574737 CHEMBL339799 CHEMBL338049 CHEMBL767434 (2) CHEMBL767445 (2)
CHEMBL1061088 (1)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL574737 CHEMBL1061209 (1)
0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 CHEMBL574737 CHEMBL1062800 (1) CHEMBL1228397 (1)
CHEMBL1287592 (1)
0 / 0
Q8IWQ3 Serine/threonine-protein kinase BRSK2 CAMK serine/threonine protein kinase BRSK subfamily CHEMBL574737 CHEMBL1062893 (1)
0 / 0
P27448 MAP/microtubule affinity-regulating kinase 3 CAMK serine/threonine protein kinase MARK subfamily CHEMBL574737 CHEMBL1062760 (1)
0 / 0
Q05513 Protein kinase C zeta type Iota CHEMBL574737 CHEMBL339799 CHEMBL338049 CHEMBL767434 (2) CHEMBL767445 (2)
CHEMBL1062856 (1)
0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim CHEMBL574737 CHEMBL1051297 (1)
0 / 0
P23443 Ribosomal protein S6 kinase beta-1 p70 CHEMBL574737 CHEMBL1061106 (1)
0 / 0
Q9UQB9 Aurora kinase C Aur CHEMBL574737 CHEMBL1061992 (1)
1 / 1
Q9HBH9 MAP kinase-interacting serine/threonine-protein kinase 2 CAMK serine/threonine protein kinase MNK subfamily CHEMBL574737 CHEMBL1062764 (1)
0 / 0
Q9NQU5 Serine/threonine-protein kinase PAK 6 STE serine/threonine protein kinase PAKB subfamily CHEMBL574737 CHEMBL1051294 (1)
0 / 0
Q16644 MAP kinase-activated protein kinase 3 CAMK serine/threonine protein kinase MAPKAPK CHEMBL574737 CHEMBL1063755 (1)
0 / 0
Q9H422 Homeodomain-interacting protein kinase 3 CMGC dual-specificity kinase HIPK CHEMBL574737 CHEMBL1061963 (1)
0 / 0
Q14680 Maternal embryonic leucine zipper kinase Melk CHEMBL574737 CHEMBL1060204 (1)
0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL338049 CHEMBL677890 (1)
1 / 11
Q15746 Myosin light chain kinase, smooth muscle Mlck CHEMBL574737 CHEMBL1052120 (1)
1 / 1
Q13188 Serine/threonine-protein kinase 3 STE serine/threonine protein kinase MST subfamily CHEMBL574737 CHEMBL1060208 (1)
0 / 0
P31751 RAC-beta serine/threonine-protein kinase Akt CHEMBL574737 CHEMBL1061915 (1)
2 / 2
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily CHEMBL574737 CHEMBL1062766 (1)
0 / 0
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase CHEMBL574737 CHEMBL1063750 (1)
0 / 0
Q16513 Serine/threonine-protein kinase N2 Pkn CHEMBL574737 CHEMBL1063770 (1)
0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd CHEMBL574737 CHEMBL339799 CHEMBL338049 CHEMBL767434 (2) CHEMBL767445 (2)
CHEMBL1062020 (1)
0 / 0
Q8N5S9 Calcium/calmodulin-dependent protein kinase kinase 1 META serine/threonine protein kinase subfamily CHEMBL574737 CHEMBL1052070 (1)
0 / 0
Q9P286 Serine/threonine-protein kinase PAK 7 STE serine/threonine protein kinase PAKB subfamily CHEMBL574737 CHEMBL1051292 (1)
0 / 0
Q96SB4 SRSF protein kinase 1 Srpk CHEMBL574737 CHEMBL1052122 (1)
0 / 0
Q92630 Dual specificity tyrosine-phosphorylation-regulated kinase 2 CMGC dual-specificity kinase DYRK2 CHEMBL574737 CHEMBL1052073 (1)
0 / 0
O43781 Dual specificity tyrosine-phosphorylation-regulated kinase 3 CMGC dual-specificity kinase DYRK2 CHEMBL574737 CHEMBL1062804 (1)
0 / 0
O96013 Serine/threonine-protein kinase PAK 4 STE serine/threonine protein kinase PAKB subfamily CHEMBL574737 CHEMBL1063662 (1)
0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk CHEMBL574737 CHEMBL1062808 (1)
0 / 0
Q15418 Ribosomal protein S6 kinase alpha-1 Rskb CHEMBL574737 CHEMBL1063776 (1)
0 / 0
O15264 Mitogen-activated protein kinase 13 p38 CHEMBL574737 CHEMBL1060130 (1)
0 / 0
P53779 Mitogen-activated protein kinase 10 Jnk CHEMBL574737 CHEMBL1062816 (1)
0 / 1
P51955 Serine/threonine-protein kinase Nek2 Nek CHEMBL574737 CHEMBL1063762 (1)
0 / 0
Q96RR4 Calcium/calmodulin-dependent protein kinase kinase 2 META serine/threonine protein kinase subfamily CHEMBL574737 CHEMBL1051372 (1)
0 / 0
Q9BUB5 MAP kinase-interacting serine/threonine-protein kinase 1 CAMK serine/threonine protein kinase MNK subfamily CHEMBL574737 CHEMBL1063758 (1)
0 / 0
P48730 Casein kinase I isoform delta Ck1 CHEMBL574737 CHEMBL1052083 (1)
1 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src CHEMBL338049 CHEMBL806345 (1)
0 / 0
Q96GD4 Aurora kinase B Aur CHEMBL574737 CHEMBL1051271 (1)
0 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK CHEMBL574737 CHEMBL1060125 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL574737 CHEMBL1062010 (1)
0 / 0
P45983 Mitogen-activated protein kinase 8 Jnk CHEMBL574737 CHEMBL1061967 (1)
0 / 0
P53350 Serine/threonine-protein kinase PLK1 PLK serine/threonine protein kinase subfamily CHEMBL574737 CHEMBL1060216 (1)
0 / 0
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK CHEMBL574737 CHEMBL1061100 (1)
0 / 0
O75116 Rho-associated protein kinase 2 Rock CHEMBL574737 CHEMBL1063773 (1)
0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt CHEMBL574737 CHEMBL1061913 (1)
4 / 1
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily CHEMBL574737 CHEMBL1060220 (1)
0 / 0
P51812 Ribosomal protein S6 kinase alpha-3 Rskb CHEMBL574737 CHEMBL1063682 (1)
2 / 2
Q9HC98 Serine/threonine-protein kinase Nek6 Nek CHEMBL574737 CHEMBL1060127 (1)
0 / 0
Q9H2X6 Homeodomain-interacting protein kinase 2 CMGC dual-specificity kinase HIPK CHEMBL574737 CHEMBL1052094 (1)
0 / 0
O96017 Serine/threonine-protein kinase Chk2 Rad53 CHEMBL574737 CHEMBL1062899 (1) CHEMBL1228398 (1)
4 / 1
Q14012 Calcium/calmodulin-dependent protein kinase type 1 Camk1 CHEMBL574737 CHEMBL1062894 (1)
0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka CHEMBL574737 CHEMBL339799 CHEMBL338049 CHEMBL772605 (2) CHEMBL768001 (2)
CHEMBL1061087 (1)
0 / 0
Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A CMGC dual-specificity kinase DYRK1 CHEMBL574737 CHEMBL1052085 (1)
1 / 0
P53778 Mitogen-activated protein kinase 12 p38 CHEMBL574737 CHEMBL1052113 (1)
0 / 0
O00418 Eukaryotic elongation factor 2 kinase Atypical serine/threonine protein kinase alpha subfamily CHEMBL574737 CHEMBL1052074 (1)
0 / 0
Q8TD08 Mitogen-activated protein kinase 15 Mapk CHEMBL574737 CHEMBL1061212 (1)
0 / 0
Q86V86 Serine/threonine-protein kinase pim-3 Pim CHEMBL574737 CHEMBL1061911 (1)
0 / 0
Q04759 Protein kinase C theta type Delta CHEMBL339799 CHEMBL338049 CHEMBL574737 CHEMBL767434 (2) CHEMBL767445 (2)
0 / 1
Q02156 Protein kinase C epsilon type Eta CHEMBL339799 CHEMBL338049 CHEMBL574737 CHEMBL767434 (2) CHEMBL767445 (2)
0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd CHEMBL339799 CHEMBL338049 CHEMBL574737 CHEMBL767434 (2) CHEMBL767445 (2)
0 / 0
Q05655 Protein kinase C delta type Delta CHEMBL339799 CHEMBL338049 CHEMBL574737 CHEMBL767434 (2) CHEMBL767445 (2)
0 / 0
P05129 Protein kinase C gamma type Alpha CHEMBL339799 CHEMBL338049 CHEMBL574737 CHEMBL767434 (2) CHEMBL767445 (2)
1 / 1
P05771 Protein kinase C beta type Alpha CHEMBL339799 CHEMBL338049 CHEMBL574737 CHEMBL767434 (2) CHEMBL767445 (2)
0 / 0
P24723 Protein kinase C eta type Eta CHEMBL339799 CHEMBL338049 CHEMBL574737 CHEMBL767434 (2) CHEMBL767445 (2)
1 / 0
P41743 Protein kinase C iota type Iota CHEMBL339799 CHEMBL338049 CHEMBL574737 CHEMBL767434 (2) CHEMBL767445 (2)
0 / 0
P20248 Cyclin-A2 Other cytosolic protein CHEMBL574737 CHEMBL1052071 (1)
0 / 0
P78396 Cyclin-A1 Other cytosolic protein CHEMBL574737 CHEMBL1052071 (1)
0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL574737 CHEMBL1052071 (1)
0 / 0
P22694 cAMP-dependent protein kinase catalytic subunit beta Pka CHEMBL339799 CHEMBL338049 CHEMBL574737 CHEMBL772605 (2) CHEMBL768001 (2)
0 / 0
P22612 cAMP-dependent protein kinase catalytic subunit gamma Pka CHEMBL339799 CHEMBL338049 CHEMBL574737 CHEMBL772605 (2) CHEMBL768001 (2)
0 / 0
P68400 Casein kinase II subunit alpha Ck2 CHEMBL574737 CHEMBL1061204 (1)
0 / 0
P19784 Casein kinase II subunit alpha' Ck2 CHEMBL574737 CHEMBL1061204 (1)
0 / 0
P67870 Casein kinase II subunit beta REG serine/threonine protein kinase family CHEMBL574737 CHEMBL1061204 (1)
0 / 0

CTD interaction (46)

compound gene gene name gene description interaction interaction type form reference
pmid
C054852 9131 AIFM1
AIF
CMTX4
COWCK
COXPD6
PDCD8
apoptosis-inducing factor, mitochondrion-associated, 1 [7-hydroxystaurosporine co-treated with Sirolimus] affects the localization of AIFM1 protein affects cotreatment
/ affects localization
protein 15767555
C054852 9131 AIFM1
AIF
CMTX4
COWCK
COXPD6
PDCD8
apoptosis-inducing factor, mitochondrion-associated, 1 Boc-D-FMK inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] affects the localization of AIFM1 protein] affects cotreatment
/ affects localization
/ decreases reaction
protein 15767555
C054852 573 BAG1
BAG-1
HAP
RAP46
BCL2-associated athanogene 7-hydroxystaurosporine results in decreased expression of BAG1 protein decreases expression
protein 10887097
C054852 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 7-hydroxystaurosporine results in decreased expression of BCL2 protein decreases expression
protein 10887097
C054852 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of BCL2L1 protein affects cotreatment
/ decreases expression
protein 15767555
C054852 637 BID
FP497
BH3 interacting domain death agonist [7-hydroxystaurosporine co-treated with Sirolimus] results in increased cleavage of BID protein affects cotreatment
/ increases cleavage
protein 15767555
C054852 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 [alvocidib co-treated with 7-hydroxystaurosporine] results in decreased expression of BIRC5 protein affects cotreatment
/ decreases expression
protein 16012789
C054852 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 BIRC5 protein results in decreased susceptibility to 7-hydroxystaurosporine decreases response to substance
protein 16012789
C054852 835 CASP2
CASP-2
ICH1
NEDD-2
NEDD2
PPP1R57
caspase 2, apoptosis-related cysteine peptidase (EC:3.4.22.55) Boc-D-FMK inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP2 protein] affects cotreatment
/ decreases reaction
/ increases cleavage
protein 15767555
C054852 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) [7-hydroxystaurosporine co-treated with Sirolimus] results in increased cleavage of CASP3 protein affects cotreatment
/ increases cleavage
protein 15767555
C054852 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) [alvocidib co-treated with 7-hydroxystaurosporine] results in increased activity of CASP3 protein affects cotreatment
/ increases activity
protein 16012789
C054852 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP3 protein] affects cotreatment
/ decreases reaction
/ increases cleavage
protein 15767555
C054852 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Boc-D-FMK inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP3 protein] affects cotreatment
/ decreases reaction
/ increases cleavage
protein 15767555
C054852 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) [7-hydroxystaurosporine co-treated with Sirolimus] results in increased cleavage of CASP8 protein affects cotreatment
/ increases cleavage
protein 15767555
C054852 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) [alvocidib co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP8 protein affects cotreatment
/ increases cleavage
protein 16012789
C054852 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP8 protein] affects cotreatment
/ decreases reaction
/ increases cleavage
protein 15767555
C054852 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) [7-hydroxystaurosporine co-treated with Sirolimus] results in increased cleavage of CASP9 protein affects cotreatment
/ increases cleavage
protein 15767555
C054852 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of CCND1 protein affects cotreatment
/ decreases expression
protein 15767555
C054852 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of CDK1 mRNA affects cotreatment
/ decreases expression
mRNA 19223503
C054852 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of CDK1 protein affects cotreatment
/ decreases expression
protein 15767555
19223503
C054852 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of CDK1 protein affects cotreatment
/ decreases phosphorylation
protein 15767555
C054852 1111 CHEK1
CHK1
checkpoint kinase 1 (EC:2.7.11.1) 7-hydroxystaurosporine results in decreased activity of CHEK1 protein decreases activity
protein 16061671
C054852 56616 DIABLO
DFNA64
SMAC
diablo, IAP-binding mitochondrial protein [7-hydroxystaurosporine co-treated with Sirolimus] affects the localization of DIABLO protein affects cotreatment
/ affects localization
protein 15767555
C054852 56616 DIABLO
DFNA64
SMAC
diablo, IAP-binding mitochondrial protein Boc-D-FMK inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] affects the localization of DIABLO protein] affects cotreatment
/ affects localization
/ decreases reaction
protein 15767555
C054852 5604 MAP2K1
CFC3
MAPKK1
MEK1
MKK1
PRKMK1
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of MAP2K1 protein affects cotreatment
/ decreases expression
protein 15767555
C054852 5604 MAP2K1
CFC3
MAPKK1
MEK1
MKK1
PRKMK1
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of MAP2K1 protein affects cotreatment
/ decreases phosphorylation
protein 15767555
C054852 5605 MAP2K2
CFC4
MAPKK2
MEK2
MKK2
PRKMK2
mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of MAP2K2 protein affects cotreatment
/ decreases phosphorylation
protein 15767555
C054852 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [7-hydroxystaurosporine co-treated with 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide] results in decreased phosphorylation of MAPK1 protein affects cotreatment
/ decreases phosphorylation
protein 16319524
C054852 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of MAPK1 protein affects cotreatment
/ decreases phosphorylation
protein 15767555
C054852 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [7-hydroxystaurosporine co-treated with 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide] results in decreased phosphorylation of MAPK3 protein affects cotreatment
/ decreases phosphorylation
protein 16319524
C054852 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of MAPK3 protein affects cotreatment
/ decreases phosphorylation
protein 15767555
C054852 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) [7-hydroxystaurosporine co-treated with Sirolimus] results in increased phosphorylation of MAPK8 protein affects cotreatment
/ increases phosphorylation
protein 15767555
C054852 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased phosphorylation of MAPK8 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 15767555
C054852 4170 MCL1
BCL2L3
EAT
MCL1-ES
MCL1L
MCL1S
Mcl-1
TM
bcl2-L-3
mcl1/EAT
myeloid cell leukemia sequence 1 (BCL2-related) [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of MCL1 protein affects cotreatment
/ decreases expression
protein 15767555
C054852 4170 MCL1
BCL2L3
EAT
MCL1-ES
MCL1L
MCL1S
Mcl-1
TM
bcl2-L-3
mcl1/EAT
myeloid cell leukemia sequence 1 (BCL2-related) 7-hydroxystaurosporine results in decreased expression of MCL1 protein decreases expression
protein 10887097
C054852 4288 MKI67
KIA
MIB-1
marker of proliferation Ki-67 [7-hydroxystaurosporine co-treated with 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide] results in decreased expression of MKI67 protein affects cotreatment
/ decreases expression
protein 16319524
C054852 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) [alvocidib co-treated with 7-hydroxystaurosporine] results in increased cleavage of PARP1 protein affects cotreatment
/ increases cleavage
protein 16012789
C054852 5175 PECAM1
CD31
CD31/EndoCAM
GPIIA'
PECA1
PECAM-1
endoCAM
platelet/endothelial cell adhesion molecule 1 [7-hydroxystaurosporine co-treated with 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide] results in decreased expression of PECAM1 protein affects cotreatment
/ decreases expression
protein 16319524
C054852 5894 RAF1
CRAF
NS5
Raf-1
c-Raf
v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of RAF1 protein affects cotreatment
/ decreases expression
protein 15767555
C054852 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 7-hydroxystaurosporine results in increased expression of RB1 mRNA increases expression
mRNA 14653808
C054852 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 7-hydroxystaurosporine results in increased expression of RB1 protein increases expression
protein 14653808
C054852 6667 SP1
Sp1 transcription factor 7-hydroxystaurosporine results in increased expression of SP1 mRNA increases expression
mRNA 14653808
C054852 6667 SP1
Sp1 transcription factor 7-hydroxystaurosporine results in increased expression of SP1 protein increases expression
protein 14653808
C054852 412 STS
ARSC
ARSC1
ASC
ES
SSDD
XLI
steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2) 7-hydroxystaurosporine inhibits the reaction [Tretinoin results in increased activity of STS protein] decreases reaction
/ increases activity
protein 16178010
C054852 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 7-hydroxystaurosporine results in decreased expression of TP53 protein decreases expression
protein 11378265
C054852 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis 7-hydroxystaurosporine results in decreased expression of XIAP protein decreases expression
protein 10887097

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM preferred title UniProt
#615224 Advanced sleep phase syndrome, familial, 2; fasps2 P48730
#613780 Aortic aneurysm, familial thoracic 7; aat7 Q15746
#114480 Breast cancer O96017
P31749
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#303600 Coffin-lowry syndrome; cls P51812
#114500 Colorectal cancer; crc P31749
#615109 Cowden syndrome 6; cws6 P31749
#125853 Diabetes mellitus, noninsulin-dependent; niddm P31751
#240900 Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh P31751
#609265 Li-fraumeni syndrome 2; lfs2 O96017
#211980 Lung cancer P00533
#614104 Mental retardation, autosomal dominant 7; mrd7 Q13627
#300844 Mental retardation, x-linked 19; mrx19 P51812
#259500 Osteogenic sarcoma O96017
#176807 Prostate cancer O96017
#176920 Proteus syndrome P31749
#243060 Spermatogenic failure 5; spgf5 Q9UQB9
#605361 Spinocerebellar ataxia 14; sca14 P05129
#601367 Stroke, ischemic P24723

KEGG DISEASE (20)

KEGG disease name UniProt
H00881 Li-Fraumeni syndrome O96017 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H00027 Ovarian cancer P31751 (related)
H00420 Familial partial lipodystrophy (FPL) P31751 (related)
H00480 Non-syndromic X-linked mental retardation P51812 (related)
H00574 Coffin-Lowry syndrome (CLS) P51812 (related)
H00606 Early infantile epileptic encephalopathy P53779 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00801 Familial thoracic aortic aneurysm and dissection (TAAD) Q15746 (related)
H01282 Spermatogenic failure Q9UQB9 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001943 C054852 Breast Neoplasms therapeutic
10571245