| Organism name | Streptomyces sp. |
|---|---|
| Genus | Streptomyces |
| Family | Streptomycetaceae |
| Kingdom | Bacteria |
| Linked NCBI taxonomy name | Streptomyces sp. |
|---|---|
| Linked NCBI taxonomy ID | 1931 |
| Linked level | species |
| Family in NCBI taxonomy | Streptomycetaceae |
|---|---|
| ID | 2062 |
| Kingdom (Superkingdom) in NCBI taxonomy | Bacteria |
|---|---|
| ID | 2 |
| Plant class | |
|---|---|
| ID |
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
|
C00009475
|
5,7,3'-Trihydroxy-8,4'-dimethoxyisoflavone
|
No. 3 | No. 15 |
|
||||
|
C00018052
|
3',8-Dihydroxy-4',6,7-trimethoxyisoflavone
|
No. 3 | No. 15 |
|
||||
|
C00020154
|
T-Muurolol
/ epi-alpha-Muurolol |
CHEMBL486795
|
No. 205 | No. 38 |
|
|||
|
C00024753
|
UCN-01
/ (+)-UCN-01 / 7-Hydroxystaurosporine |
CHEMBL339799
CHEMBL338049 CHEMBL574737 CHEMBL601799 CHEMBL1236539 |
C054852
|
81 / 19 / 20 | 29 / 1 | No. 251 |
|
|
|
C00015627
|
UCF 116C
|
No. 381 |
|
|||||
|
C00015626
|
UCF 116B
|
No. 381 |
|
|||||
|
C00016323
|
Cytotrienin A
/ Cytotrienin I |
No. 381 |
|
|||||
|
C00022138
|
Ingramycin
/ Albocycline |
C006441
|
No. 611 |
|
||||
|
C00038767
|
Cinnabaramide C
/ (-)-Cinnabaramide C |
CHEMBL221018
|
3 / 1 / 1 | No. 616 |
|
|||
|
C00038766
|
Cinnabaramide B
|
CHEMBL387140
|
3 / 1 / 1 | No. 616 |
|
|||
|
C00038765
|
Cinnabaramide A
/ (-)-Cinnabaramide A |
CHEMBL384099
|
3 / 1 / 1 | No. 616 |
|
|||
|
C00016360
|
Antimycin A8b
|
No. 846 |
|
|||||
|
C00016358
|
Antimycin A7b
|
No. 846 |
|
|||||
|
C00016359
|
Antimycin A8a
|
No. 846 |
|
|||||
|
C00016357
|
Antimycin A7a
|
No. 846 |
|
|||||
|
C00016412
|
Dihydromaltophilin
|
No. 943 |
|
|||||
|
C00040396
|
Streptophenazine E
/ (-)-Streptophenazine E |
CHEMBL522554
|
No. 1153 |
|
||||
|
C00040397
|
Streptophenazine F
/ (-)-Streptophenazine F |
CHEMBL495886
|
No. 1153 |
|
||||
|
C00040392
|
Streptophenazine A
/ (-)-Streptophenazine A |
CHEMBL468584
|
No. 1153 |
|
||||
|
C00040399
|
Streptophenazine H
/ (-)-Streptophenazine H |
CHEMBL467740
|
No. 1153 |
|
||||
|
C00040393
|
Streptophenazine B
/ (-)-Streptophenazine B |
CHEMBL467554
|
No. 1153 |
|
||||
|
C00040398
|
Streptophenazine G
/ (-)-Streptophenazine G |
CHEMBL522571
|
No. 1153 |
|
||||
|
C00040395
|
Streptophenazine D
/ (-)-Streptophenazine D |
CHEMBL495885
|
No. 1153 |
|
||||
|
C00040394
|
Streptophenazine C
/ (-)-Streptophenazine C |
CHEMBL497540
|
No. 1153 |
|
||||
|
C00015918
|
UCF 76A
|
No. 1191 |
|
|||||
|
C00000381
|
Didemethylallosamidin
|
No. 1357 |
|
|||||
|
C00000383
|
Methyl-N-demethylallosamidin
|
No. 1357 |
|
|||||
|
C00000382
|
Methylallosamidin
|
No. 1357 |
|
|||||
|
C00000380
|
Demethylallosamidin
|
CHEMBL1813419
|
No. 1357 |
|
||||
|
C00018683
|
NSC 94945
/ AV Toxin C / Questiomycin A / 2-Aminophenoxazone / 2-Amino-3-phenoxazone / Acrospermum viticola toxin C |
CHEMBL146710
|
C005512
|
32 / 18 / 20 | No. 1379 |
|
||
|
C00015625
|
UCF 116A
/ UCF 116A3 / 11-[1-[(Cyclohexylcarbonyl)amino]cyclopropanecarboxylate] ansatrienol A |
No. 1619 |
|
|||||
|
C00018685
|
Nebularine
/ Purinosine / Ribosylpurine / Purine riboside / Purine-9-beta-D-ribofuranoside / 9-beta-D-Ribofuranosyl-9H-purine |
CHEMBL1399702
CHEMBL1476759 |
C005248
|
15 / 30 / 55 | No. 1761 |
|
||
|
C00046164
|
MKN-004D
/ (-)-MKN-004D |
CHEMBL478088
|
No. 1822 |
|
||||
|
C00045466
|
(-)-Blastmycinolactol
|
CHEMBL445806
|
No. 1822 |
|
||||
|
C00046162
|
MKN-004B
/ (-)-MKN-004B |
CHEMBL478088
|
No. 1822 |
|
||||
|
C00046163
|
MKN-004C
/ (+)-MKN-004C |
CHEMBL501148
CHEMBL478087 |
No. 1822 |
|
||||
|
C00026918
|
Maremycin A
/ (-)-Maremycin A |
No. 1850 |
|
|||||
|
C00026919
|
Maremycin B
|
No. 1850 |
|
|||||
|
C00018625
|
Chlorocardicin
|
C045286
|
No. 2077 |
|
||||
|
C00027055
|
Isocomplestatin
|
CHEMBL437996
CHEMBL506605 |
1 / 1 / 0 | No. 2099 |
|
|||
|
C00041466
|
cyclo(L-Pro-L-Val)
|
CHEMBL460243
CHEMBL454463 CHEMBL460676 CHEMBL499570 |
1 / 0 / 0 | No. 2153 |
|
|||
|
C00041282
|
5-Chlorobohemamine C
/ (-)-5-Chlorobohemamine C |
CHEMBL463998
|
No. 2179 |
|
||||
|
C00041389
|
Bohemamine C
/ (-)-Bohemamine C |
CHEMBL513287
|
No. 2179 |
|
||||
|
C00041388
|
Bohemamine B
/ (-)-Bohemamine B |
CHEMBL454967
|
No. 2179 |
|
||||
|
C00016782
|
Nitrosoxacin C
|
C079824
|
No. 2294 |
|
||||
|
C00016780
|
Nitrosoxacin A
|
C079822
|
No. 2294 |
|
||||
|
C00016781
|
Nitrosoxacin B
|
C079823
|
No. 2294 |
|
||||
|
C00016416
|
16-Methyloxazolomycin
|
No. 2319 |
|
|||||
|
C00017256
|
Naphthopyranomycin
|
C074835
|
No. 2541 |
|
||||
|
C00016104
|
RK 1009
|
No. 2778 |
|
|||||
|
C00047316
|
Neopyrrolomycin D
|
CHEMBL549677
|
No. 2801 |
|
||||
|
C00047315
|
Neopyrrolomycin C
|
CHEMBL553671
|
No. 2801 |
|
||||
|
C00047314
|
Neopyrrolomycin B
|
CHEMBL564925
|
No. 2801 |
|
||||
|
C00017075
|
Reveromycin A
|
CHEMBL332724
CHEMBL443981 |
C068098
|
1 / 0 / 0 | No. 3078 |
|
||
|
C00015919
|
UCF 76B
|
No. 3143 |
|
|||||
|
C00017913
|
DC 102
/ Antibiotic DC 102 |
C056344
|
No. 3738 |
|
||||
|
C00048770
|
Marinopyrrole A
|
No. 4234 |
|
|||||
|
C00048771
|
Marinopyrrole B
|
No. 4234 |
|
|||||
|
C00016588
|
SB 212021
|
No. 4254 |
|
|||||
|
C00041264
|
3-(Hydroxyacetyl)indole
|
CHEMBL524903
|
No. 4334 |
|
||||
|
C00038770
|
Cinnabaramide F
/ (+)-Cinnabaramide F |
CHEMBL221585
|
3 / 1 / 1 | No. 4344 |
|
|||
|
C00038771
|
Cinnabaramide G
/ (+)-Cinnabaramide G |
CHEMBL447239
|
3 / 1 / 1 | No. 4344 |
|
|||
|
C00015155
|
MF-EA 705alpha
|
No. 4411 |
|
|||||
|
C00015156
|
MF-EA 705beta
|
No. 4411 |
|
|||||
|
C00046160
|
MKN-003B
|
CHEMBL463727
|
No. 4592 |
|
||||
|
C00046161
|
MKN-003C
/ (+)-MKN-003C |
CHEMBL485782
CHEMBL448881 |
No. 4592 |
|
||||
|
C00018640
|
Antibiotic X 14952B
|
C046082
|
No. 5255 |
|
||||
|
C00018587
|
Ascamycin
|
C042369
|
No. 5381 |
|
||||
|
C00018588
|
Antibiotic AT 265
/ Dealanylascamycin |
C035935
|
No. 5381 |
|
||||
|
C00038769
|
Cinnabaramide E
/ (-)-Cinnabaramide E |
CHEMBL374026
|
3 / 1 / 1 | No. 5514 |
|
|||
|
C00038768
|
Cinnabaramide D
|
CHEMBL374495
|
3 / 1 / 1 | No. 5514 |
|
|||
|
C00018766
|
VD 844
|
No. 5863 |
|
|||||
|
C00016589
|
SB 212305
|
No. 6022 |
|
|||||
|
C00018653
|
Aureothricin
|
CHEMBL1163542
|
C010684
|
No. 7581 |
|
|||
|
C00018684
|
BNP
/ NSC 64266 / Bovinocidin / Hiptagenic acid / 3-Nitro-propionic acid |
CHEMBL451226
|
C015392
|
17 / 22 / 27 | 0 / 14 | No. 8212 |
|
|
|
C00046159
|
MKN-003A
/ (+)-MKN-003A |
CHEMBL468673
CHEMBL477723 |
No. 8231 |
|
||||
|
C00017872
|
Tautomycin
|
CHEMBL40248
CHEMBL505512 |
C053079
|
2 / 0 / 0 | 4 / 0 | No. 8274 |
|
|
|
C00018687
|
HU 1/68
/ Amidinomycin / Amidinomycine / Myxoviromycin |
C016981
|
No. 8845 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P35030 | Trypsin-3 | S1A | C00038765 C00038766 C00038767 C00038768 C00038769 C00038770 C00038771 | 0 / 0 |
| P07477 | Trypsin-1 | S1A | C00038765 C00038766 C00038767 C00038768 C00038769 C00038770 C00038771 | 1 / 1 |
| P07478 | Trypsin-2 | S1A | C00038765 C00038766 C00038767 C00038768 C00038769 C00038770 C00038771 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00018684 C00018685 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00018683 C00018684 | 2 / 5 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00018684 C00018685 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00018683 C00018684 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00018683 C00018684 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00018684 C00018685 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00018684 C00018685 | 1 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00018683 C00018685 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00018684 C00018685 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00018683 C00018684 | 1 / 2 |
| O75496 | Geminin | Unclassified protein | C00018683 C00018684 | 0 / 0 |
| P68871 | Hemoglobin subunit beta | Secreted protein | C00018684 C00018685 | 4 / 4 |
| P54132 | Bloom syndrome protein | Enzyme | C00018684 C00018685 | 1 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00018684 C00018685 | 0 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00018684 C00018685 | 11 / 10 |
| Q14012 | Calcium/calmodulin-dependent protein kinase type 1 | Camk1 | C00024753 | 0 / 0 |
| P41252 | Isoleucine--tRNA ligase, cytoplasmic | Enzyme | C00017075 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00018683 | 0 / 0 |
| O14757 | Serine/threonine-protein kinase Chk1 | Chk1 | C00024753 | 0 / 0 |
| Q8IWQ3 | Serine/threonine-protein kinase BRSK2 | CAMK serine/threonine protein kinase BRSK subfamily | C00024753 | 0 / 0 |
| P27448 | MAP/microtubule affinity-regulating kinase 3 | CAMK serine/threonine protein kinase MARK subfamily | C00024753 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00024753 | 0 / 0 |
| P00813 | Adenosine deaminase | Hydrolase | C00018685 | 1 / 1 |
| Q05513 | Protein kinase C zeta type | Iota | C00024753 | 0 / 0 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | C00024753 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00024753 | 0 / 0 |
| P23443 | Ribosomal protein S6 kinase beta-1 | p70 | C00024753 | 0 / 0 |
| Q9UQB9 | Aurora kinase C | Aur | C00024753 | 1 / 1 |
| Q9HBH9 | MAP kinase-interacting serine/threonine-protein kinase 2 | CAMK serine/threonine protein kinase MNK subfamily | C00024753 | 0 / 0 |
| Q9NQU5 | Serine/threonine-protein kinase PAK 6 | STE serine/threonine protein kinase PAKB subfamily | C00024753 | 0 / 0 |
| Q16644 | MAP kinase-activated protein kinase 3 | CAMK serine/threonine protein kinase MAPKAPK | C00024753 | 0 / 0 |
| Q9H422 | Homeodomain-interacting protein kinase 3 | CMGC dual-specificity kinase HIPK | C00024753 | 0 / 0 |
| Q14680 | Maternal embryonic leucine zipper kinase | Melk | C00024753 | 0 / 0 |
| P45984 | Mitogen-activated protein kinase 9 | Jnk | C00024753 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00018683 | 1 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00024753 | 1 / 8 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00018683 | 2 / 3 |
| Q15746 | Myosin light chain kinase, smooth muscle | Mlck | C00024753 | 1 / 1 |
| Q13188 | Serine/threonine-protein kinase 3 | STE serine/threonine protein kinase MST subfamily | C00024753 | 0 / 0 |
| P31751 | RAC-beta serine/threonine-protein kinase | Akt | C00024753 | 2 / 2 |
| O75582 | Ribosomal protein S6 kinase alpha-5 | CAMK serine/threonine protein kinase MSKB subfamily | C00024753 | 0 / 0 |
| P01730 | T-cell surface glycoprotein CD4 | Surface antigen | C00027055 | 1 / 0 |
| O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | Other serine/threonine protein kinase | C00024753 | 0 / 0 |
| Q16513 | Serine/threonine-protein kinase N2 | Pkn | C00024753 | 0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00024753 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00018683 | 0 / 0 |
| P41240 | Tyrosine-protein kinase CSK | Csk | C00024753 | 0 / 0 |
| Q8N5S9 | Calcium/calmodulin-dependent protein kinase kinase 1 | META serine/threonine protein kinase subfamily | C00024753 | 0 / 0 |
| Q9P286 | Serine/threonine-protein kinase PAK 7 | STE serine/threonine protein kinase PAKB subfamily | C00024753 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00018684 | 0 / 0 |
| P14902 | Indoleamine 2,3-dioxygenase 1 | Enzyme | C00018683 | 0 / 0 |
| Q96SB4 | SRSF protein kinase 1 | Srpk | C00024753 | 0 / 0 |
| Q92630 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | CMGC dual-specificity kinase DYRK2 | C00024753 | 0 / 0 |
| O43781 | Dual specificity tyrosine-phosphorylation-regulated kinase 3 | CMGC dual-specificity kinase DYRK2 | C00024753 | 0 / 0 |
| O96013 | Serine/threonine-protein kinase PAK 4 | STE serine/threonine protein kinase PAKB subfamily | C00024753 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00018683 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00018683 | 2 / 0 |
| O15530 | 3-phosphoinositide-dependent protein kinase 1 | Pdk1 | C00024753 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00018683 | 0 / 0 |
| P35348 | Alpha-1A adrenergic receptor | Adrenergic receptor | C00018685 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00024753 | 0 / 0 |
| Q15418 | Ribosomal protein S6 kinase alpha-1 | Rskb | C00024753 | 0 / 0 |
| O15264 | Mitogen-activated protein kinase 13 | p38 | C00024753 | 0 / 0 |
| P53779 | Mitogen-activated protein kinase 10 | Jnk | C00024753 | 0 / 1 |
| P51955 | Serine/threonine-protein kinase Nek2 | Nek | C00024753 | 0 / 0 |
| Q96RR4 | Calcium/calmodulin-dependent protein kinase kinase 2 | META serine/threonine protein kinase subfamily | C00024753 | 0 / 0 |
| Q9BUB5 | MAP kinase-interacting serine/threonine-protein kinase 1 | CAMK serine/threonine protein kinase MNK subfamily | C00024753 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00018683 | 1 / 1 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00018683 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00018683 | 3 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00018683 | 0 / 0 |
| Q15257 | Serine/threonine-protein phosphatase 2A activator | Protein phosphatase regulatory subunit | C00017872 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00018684 | 0 / 0 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00018683 | 0 / 0 |
| P48730 | Casein kinase I isoform delta | Ck1 | C00024753 | 1 / 0 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00024753 | 0 / 0 |
| Q96GD4 | Aurora kinase B | Aur | C00024753 | 0 / 0 |
| P49137 | MAP kinase-activated protein kinase 2 | CAMK serine/threonine protein kinase MAPKAPK | C00024753 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00024753 | 0 / 0 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00018683 | 0 / 1 |
| P45983 | Mitogen-activated protein kinase 8 | Jnk | C00024753 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00018683 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00024753 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00041466 | 0 / 0 |
| P53350 | Serine/threonine-protein kinase PLK1 | PLK serine/threonine protein kinase subfamily | C00024753 | 0 / 0 |
| Q8IW41 | MAP kinase-activated protein kinase 5 | CAMK serine/threonine protein kinase MAPKAPK | C00024753 | 0 / 0 |
| O75116 | Rho-associated protein kinase 2 | Rock | C00024753 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00018685 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00024753 | 4 / 1 |
| O00141 | Serine/threonine-protein kinase Sgk1 | AGC serine/threonine protein kinase SGK subfamily | C00024753 | 0 / 0 |
| P51812 | Ribosomal protein S6 kinase alpha-3 | Rskb | C00024753 | 2 / 2 |
| Q15759 | Mitogen-activated protein kinase 11 | p38 | C00024753 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00018683 | 1 / 1 |
| Q9HC98 | Serine/threonine-protein kinase Nek6 | Nek | C00024753 | 0 / 0 |
| Q9H2X6 | Homeodomain-interacting protein kinase 2 | CMGC dual-specificity kinase HIPK | C00024753 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00018683 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00018683 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00018683 | 4 / 3 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00018685 | 4 / 1 |
| O96017 | Serine/threonine-protein kinase Chk2 | Rad53 | C00024753 | 4 / 1 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00018683 | 0 / 0 |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | C00024753 | 0 / 0 |
| Q13627 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | CMGC dual-specificity kinase DYRK1 | C00024753 | 1 / 0 |
| P53778 | Mitogen-activated protein kinase 12 | p38 | C00024753 | 0 / 0 |
| O00418 | Eukaryotic elongation factor 2 kinase | Atypical serine/threonine protein kinase alpha subfamily | C00024753 | 0 / 0 |
| Q8TD08 | Mitogen-activated protein kinase 15 | Mapk | C00024753 | 0 / 0 |
| Q86V86 | Serine/threonine-protein kinase pim-3 | Pim | C00024753 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00018683 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00018683 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00018683 | 0 / 0 |
| Q8TDX7 | Serine/threonine-protein kinase Nek7 | Nek | C00024753 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00018683 | 1 / 0 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00018683 | 0 / 0 |
| Q9P1W9 | Serine/threonine-protein kinase pim-2 | Pim | C00024753 | 0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | C00024753 | 0 / 1 |
| Q02156 | Protein kinase C epsilon type | Eta | C00024753 | 0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00024753 | 0 / 0 |
| Q05655 | Protein kinase C delta type | Delta | C00024753 | 0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | C00024753 | 1 / 1 |
| P05771 | Protein kinase C beta type | Alpha | C00024753 | 0 / 0 |
| P24723 | Protein kinase C eta type | Eta | C00024753 | 1 / 0 |
| P41743 | Protein kinase C iota type | Iota | C00024753 | 0 / 0 |
| P20248 | Cyclin-A2 | Other cytosolic protein | C00024753 | 0 / 0 |
| P78396 | Cyclin-A1 | Other cytosolic protein | C00024753 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00024753 | 0 / 0 |
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | Pka | C00024753 | 0 / 0 |
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | Pka | C00024753 | 0 / 0 |
| P68400 | Casein kinase II subunit alpha | Ck2 | C00024753 | 0 / 0 |
| P19784 | Casein kinase II subunit alpha' | Ck2 | C00024753 | 0 / 0 |
| P67870 | Casein kinase II subunit beta | REG serine/threonine protein kinase family | C00024753 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00018685 | 7 / 37 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00017872 | 0 / 0 |
| Q02750 | Dual specificity mitogen-activated protein kinase kinase 1 | Ste7 | C00024753 | 1 / 1 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00018683 | 0 / 3 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00018684 | 1 / 1 |
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00017872
C00024753
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00017872
C00024753
|
| 4170 | MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT | myeloid cell leukemia sequence 1 (BCL2-related) |
C00017872
C00024753
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00017872
C00024753
|
| 1111 | CHEK1, CHK1 | checkpoint kinase 1 (EC:2.7.11.1) |
C00024753
|
| 573 | BAG1, BAG-1, HAP, RAP46 | BCL2-associated athanogene |
C00024753
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00024753
|
| 637 | BID, FP497 | BH3 interacting domain death agonist |
C00024753
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00024753
|
| 835 | CASP2, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57 | caspase 2, apoptosis-related cysteine peptidase (EC:3.4.22.55) |
C00024753
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00024753
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00024753
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00024753
|
| 983 | CDK1, CDC2, CDC28A, P34CDC2 | cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) |
C00024753
|
| 9131 | AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 | apoptosis-inducing factor, mitochondrion-associated, 1 |
C00024753
|
| 56616 | DIABLO, DFNA64, SMAC | diablo, IAP-binding mitochondrial protein |
C00024753
|
| 5604 | MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 | mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) |
C00024753
|
| 5605 | MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2 | mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) |
C00024753
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00024753
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00024753
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00024753
|
| 4288 | MKI67, KIA, MIB-1 | marker of proliferation Ki-67 |
C00024753
|
| 5175 | PECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM | platelet/endothelial cell adhesion molecule 1 |
C00024753
|
| 5894 | RAF1, CRAF, NS5, Raf-1, c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) |
C00024753
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00024753
|
| 6667 | SP1 | Sp1 transcription factor |
C00024753
|
| 412 | STS, ARSC, ARSC1, ASC, ES, SSDD, XLI | steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2) |
C00024753
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00024753
|
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis |
C00024753
|
| OMIM | preferred title | UniProt |
|---|---|---|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #615224 | Advanced sleep phase syndrome, familial, 2; fasps2 |
P48730
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #613780 | Aortic aneurysm, familial thoracic 7; aat7 |
Q15746
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #613985 | Beta-thalassemia |
P68871
|
| #603902 | Beta-thalassemia, dominant inclusion body type |
P68871
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #114480 | Breast cancer |
O96017
P31749 |
| #615279 | Cardiofaciocutaneous syndrome 3; cfc3 |
Q02750
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #303600 | Coffin-lowry syndrome; cls |
P51812
|
| #114500 | Colorectal cancer; crc |
P31749
P84022 |
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P31751
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #140700 | Heinz body anemias |
P68871
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #240900 | Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh |
P31751
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #609265 | Li-fraumeni syndrome 2; lfs2 |
O96017
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P00533
P04637 |
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #614104 | Mental retardation, autosomal dominant 7; mrd7 |
Q13627
|
| #300844 | Mental retardation, x-linked 19; mrx19 |
P51812
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #613949 | Okt4 epitope deficiency |
P01730
|
| #259500 | Osteogenic sarcoma |
O96017
|
| #167800 | Pancreatitis, hereditary; pctt |
P07477
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #176807 | Prostate cancer |
O96017
|
| #176920 | Proteus syndrome |
P31749
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #102700 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency |
P00813
|
| #603903 | Sickle cell anemia |
P68871
|
| #243060 | Spermatogenic failure 5; spgf5 |
Q9UQB9
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P24723
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00881 | Li-Fraumeni syndrome |
O96017
(related)
P04637 (related) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) |
| H00018 | Gastric cancer |
P00533
(related)
P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04637 (related) P68871 (marker) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00092 | T-B-Severe combined immunodeficiencies (SCIDs) |
P00813
(related)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P31751 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) P68871 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
P31751 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
Q99700 (related) |
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00933 | Hereditary pancreatitis |
P07477
(related)
P07478 (related) |
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P51812
(related)
|
| H00574 | Coffin-Lowry syndrome (CLS) |
P51812
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
P53779
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00228 | Thalassemia |
P68871
(related)
|
| H00229 | Sickle cell anemia (SCA) |
P68871
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q02750
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H00801 | Familial thoracic aortic aneurysm and dissection (TAAD) |
Q15746
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H01282 | Spermatogenic failure |
Q9UQB9
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D003072 | Cognition Disorders |
C00018684
|
| D004195 | Disease Models, Animal |
C00018684
|
| D004409 | Dyskinesia, Drug-Induced |
C00018684
|
| D004421 | Dystonia |
C00018684
|
| D034381 | Hearing Loss |
C00018684
|
| D006816 | Huntington Disease |
C00018684
|
| D006948 | Hyperkinesis |
C00018684
|
| D008569 | Memory Disorders |
C00018684
|
| D009069 | Movement Disorders |
C00018684
|
| D009410 | Nerve Degeneration |
C00018684
|
| D009422 | Nervous System Diseases |
C00018684
|
| D019636 | Neurodegenerative Diseases |
C00018684
|
| D020258 | Neurotoxicity Syndromes |
C00018684
|
| D015431 | Weight Loss |
C00018684
|
| D001943 | Breast Neoplasms |
C00024753
|