Species

KNApSAcK Entry

Organism name Streptomyces sp.
Genus Streptomyces
Family Streptomycetaceae
Kingdom Bacteria

NCBI taxonomy

Entry

Linked NCBI taxonomy name Streptomyces sp.
Linked NCBI taxonomy ID 1931
Linked level species

Family

Family in NCBI taxonomy Streptomycetaceae
ID 2062

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Bacteria
ID 2

Plant class

Plant class
ID

Metabolite list (78)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00009475 External link 512 5,7,3'-Trihydroxy-8,4'-dimethoxyisoflavone
No. 3 No. 15
C00018052 External link 512 3',8-Dihydroxy-4',6,7-trimethoxyisoflavone
No. 3 No. 15
C00020154 External link 512 T-Muurolol
/ epi-alpha-Muurolol
CHEMBL486795
No. 205 No. 38
C00024753 External link 512 UCN-01
/ (+)-UCN-01
/ 7-Hydroxystaurosporine
CHEMBL339799
CHEMBL338049
CHEMBL574737
CHEMBL601799
CHEMBL1236539
C054852
81 / 19 / 20 29 / 1 No. 251
C00015627 External link 512 UCF 116C
No. 381
C00015626 External link 512 UCF 116B
No. 381
C00016323 External link 512 Cytotrienin A
/ Cytotrienin I
No. 381
C00022138 External link 512 Ingramycin
/ Albocycline
C006441
No. 611
C00038767 External link 512 Cinnabaramide C
/ (-)-Cinnabaramide C
CHEMBL221018
3 / 1 / 1 No. 616
C00038766 External link 512 Cinnabaramide B
CHEMBL387140
3 / 1 / 1 No. 616
C00038765 External link 512 Cinnabaramide A
/ (-)-Cinnabaramide A
CHEMBL384099
3 / 1 / 1 No. 616
C00016360 External link 512 Antimycin A8b
No. 846
C00016358 External link 512 Antimycin A7b
No. 846
C00016359 External link 512 Antimycin A8a
No. 846
C00016357 External link 512 Antimycin A7a
No. 846
C00016412 External link 512 Dihydromaltophilin
No. 943
C00040396 External link 512 Streptophenazine E
/ (-)-Streptophenazine E
CHEMBL522554
No. 1153
C00040397 External link 512 Streptophenazine F
/ (-)-Streptophenazine F
CHEMBL495886
No. 1153
C00040392 External link 512 Streptophenazine A
/ (-)-Streptophenazine A
CHEMBL468584
No. 1153
C00040399 External link 512 Streptophenazine H
/ (-)-Streptophenazine H
CHEMBL467740
No. 1153
C00040393 External link 512 Streptophenazine B
/ (-)-Streptophenazine B
CHEMBL467554
No. 1153
C00040398 External link 512 Streptophenazine G
/ (-)-Streptophenazine G
CHEMBL522571
No. 1153
C00040395 External link 512 Streptophenazine D
/ (-)-Streptophenazine D
CHEMBL495885
No. 1153
C00040394 External link 512 Streptophenazine C
/ (-)-Streptophenazine C
CHEMBL497540
No. 1153
C00015918 External link 512 UCF 76A
No. 1191
C00000381 External link 512 Didemethylallosamidin
No. 1357
C00000383 External link 512 Methyl-N-demethylallosamidin
No. 1357
C00000382 External link 512 Methylallosamidin
No. 1357
C00000380 External link 512 Demethylallosamidin
CHEMBL1813419
No. 1357
C00018683 External link 512 NSC 94945
/ AV Toxin C
/ Questiomycin A
/ 2-Aminophenoxazone
/ 2-Amino-3-phenoxazone
/ Acrospermum viticola toxin C
CHEMBL146710
C005512
32 / 18 / 20 No. 1379
C00015625 External link 512 UCF 116A
/ UCF 116A3
/ 11-[1-[(Cyclohexylcarbonyl)amino]cyclopropanecarboxylate] ansatrienol A
No. 1619
C00018685 External link 512 Nebularine
/ Purinosine
/ Ribosylpurine
/ Purine riboside
/ Purine-9-beta-D-ribofuranoside
/ 9-beta-D-Ribofuranosyl-9H-purine
CHEMBL1399702
CHEMBL1476759
C005248
15 / 30 / 55 No. 1761
C00046164 External link 512 MKN-004D
/ (-)-MKN-004D
CHEMBL478088
No. 1822
C00045466 External link 512 (-)-Blastmycinolactol
CHEMBL445806
No. 1822
C00046162 External link 512 MKN-004B
/ (-)-MKN-004B
CHEMBL478088
No. 1822
C00046163 External link 512 MKN-004C
/ (+)-MKN-004C
CHEMBL501148
CHEMBL478087
No. 1822
C00026918 External link 512 Maremycin A
/ (-)-Maremycin A
No. 1850
C00026919 External link 512 Maremycin B
No. 1850
C00018625 External link 512 Chlorocardicin
C045286
No. 2077
C00027055 External link 512 Isocomplestatin
CHEMBL437996
CHEMBL506605
1 / 1 / 0 No. 2099
C00041466 External link 512 cyclo(L-Pro-L-Val)
CHEMBL460243
CHEMBL454463
CHEMBL460676
CHEMBL499570
1 / 0 / 0 No. 2153
C00041282 External link 512 5-Chlorobohemamine C
/ (-)-5-Chlorobohemamine C
CHEMBL463998
No. 2179
C00041389 External link 512 Bohemamine C
/ (-)-Bohemamine C
CHEMBL513287
No. 2179
C00041388 External link 512 Bohemamine B
/ (-)-Bohemamine B
CHEMBL454967
No. 2179
C00016782 External link 512 Nitrosoxacin C
C079824
No. 2294
C00016780 External link 512 Nitrosoxacin A
C079822
No. 2294
C00016781 External link 512 Nitrosoxacin B
C079823
No. 2294
C00016416 External link 512 16-Methyloxazolomycin
No. 2319
C00017256 External link 512 Naphthopyranomycin
C074835
No. 2541
C00016104 External link 512 RK 1009
No. 2778
C00047316 External link 512 Neopyrrolomycin D
CHEMBL549677
No. 2801
C00047315 External link 512 Neopyrrolomycin C
CHEMBL553671
No. 2801
C00047314 External link 512 Neopyrrolomycin B
CHEMBL564925
No. 2801
C00017075 External link 512 Reveromycin A
CHEMBL332724
CHEMBL443981
C068098
1 / 0 / 0 No. 3078
C00015919 External link 512 UCF 76B
No. 3143
C00017913 External link 512 DC 102
/ Antibiotic DC 102
C056344
No. 3738
C00048770 External link 512 Marinopyrrole A
No. 4234
C00048771 External link 512 Marinopyrrole B
No. 4234
C00016588 External link 512 SB 212021
No. 4254
C00041264 External link 512 3-(Hydroxyacetyl)indole
CHEMBL524903
No. 4334
C00038770 External link 512 Cinnabaramide F
/ (+)-Cinnabaramide F
CHEMBL221585
3 / 1 / 1 No. 4344
C00038771 External link 512 Cinnabaramide G
/ (+)-Cinnabaramide G
CHEMBL447239
3 / 1 / 1 No. 4344
C00015155 External link 512 MF-EA 705alpha
No. 4411
C00015156 External link 512 MF-EA 705beta
No. 4411
C00046160 External link 512 MKN-003B
CHEMBL463727
No. 4592
C00046161 External link 512 MKN-003C
/ (+)-MKN-003C
CHEMBL485782
CHEMBL448881
No. 4592
C00018640 External link 512 Antibiotic X 14952B
C046082
No. 5255
C00018587 External link 512 Ascamycin
C042369
No. 5381
C00018588 External link 512 Antibiotic AT 265
/ Dealanylascamycin
C035935
No. 5381
C00038769 External link 512 Cinnabaramide E
/ (-)-Cinnabaramide E
CHEMBL374026
3 / 1 / 1 No. 5514
C00038768 External link 512 Cinnabaramide D
CHEMBL374495
3 / 1 / 1 No. 5514
C00018766 External link 512 VD 844
No. 5863
C00016589 External link 512 SB 212305
No. 6022
C00018653 External link 512 Aureothricin
CHEMBL1163542
C010684
No. 7581
C00018684 External link 512 BNP
/ NSC 64266
/ Bovinocidin
/ Hiptagenic acid
/ 3-Nitro-propionic acid
CHEMBL451226
C015392
17 / 22 / 27 0 / 14 No. 8212
C00046159 External link 512 MKN-003A
/ (+)-MKN-003A
CHEMBL468673
CHEMBL477723
No. 8231
C00017872 External link 512 Tautomycin
CHEMBL40248
CHEMBL505512
C053079
2 / 0 / 0 4 / 0 No. 8274
C00018687 External link 512 HU 1/68
/ Amidinomycin
/ Amidinomycine
/ Myxoviromycin
C016981
No. 8845

Human Protein / Gene in interactions

138 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P35030 Trypsin-3 S1A C00038765 C00038766 C00038767 C00038768 C00038769 C00038770 C00038771 0 / 0
P07477 Trypsin-1 S1A C00038765 C00038766 C00038767 C00038768 C00038769 C00038770 C00038771 1 / 1
P07478 Trypsin-2 S1A C00038765 C00038766 C00038767 C00038768 C00038769 C00038770 C00038771 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00018684 C00018685 1 / 1
O00255 Menin Unclassified protein C00018683 C00018684 2 / 5
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00018684 C00018685 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00018683 C00018684 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00018683 C00018684 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00018684 C00018685 0 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00018684 C00018685 1 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00018683 C00018685 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00018684 C00018685 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00018683 C00018684 1 / 2
O75496 Geminin Unclassified protein C00018683 C00018684 0 / 0
P68871 Hemoglobin subunit beta Secreted protein C00018684 C00018685 4 / 4
P54132 Bloom syndrome protein Enzyme C00018684 C00018685 1 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00018684 C00018685 0 / 1
P02545 Prelamin-A/C Unclassified protein C00018684 C00018685 11 / 10
Q14012 Calcium/calmodulin-dependent protein kinase type 1 Camk1 C00024753 0 / 0
P41252 Isoleucine--tRNA ligase, cytoplasmic Enzyme C00017075 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00018683 0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 C00024753 0 / 0
Q8IWQ3 Serine/threonine-protein kinase BRSK2 CAMK serine/threonine protein kinase BRSK subfamily C00024753 0 / 0
P27448 MAP/microtubule affinity-regulating kinase 3 CAMK serine/threonine protein kinase MARK subfamily C00024753 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00024753 0 / 0
P00813 Adenosine deaminase Hydrolase C00018685 1 / 1
Q05513 Protein kinase C zeta type Iota C00024753 0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim C00024753 0 / 0
P17252 Protein kinase C alpha type Alpha C00024753 0 / 0
P23443 Ribosomal protein S6 kinase beta-1 p70 C00024753 0 / 0
Q9UQB9 Aurora kinase C Aur C00024753 1 / 1
Q9HBH9 MAP kinase-interacting serine/threonine-protein kinase 2 CAMK serine/threonine protein kinase MNK subfamily C00024753 0 / 0
Q9NQU5 Serine/threonine-protein kinase PAK 6 STE serine/threonine protein kinase PAKB subfamily C00024753 0 / 0
Q16644 MAP kinase-activated protein kinase 3 CAMK serine/threonine protein kinase MAPKAPK C00024753 0 / 0
Q9H422 Homeodomain-interacting protein kinase 3 CMGC dual-specificity kinase HIPK C00024753 0 / 0
Q14680 Maternal embryonic leucine zipper kinase Melk C00024753 0 / 0
P45984 Mitogen-activated protein kinase 9 Jnk C00024753 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00018683 1 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00024753 1 / 8
P11473 Vitamin D3 receptor NR1I1 C00018683 2 / 3
Q15746 Myosin light chain kinase, smooth muscle Mlck C00024753 1 / 1
Q13188 Serine/threonine-protein kinase 3 STE serine/threonine protein kinase MST subfamily C00024753 0 / 0
P31751 RAC-beta serine/threonine-protein kinase Akt C00024753 2 / 2
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily C00024753 0 / 0
P01730 T-cell surface glycoprotein CD4 Surface antigen C00027055 1 / 0
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase C00024753 0 / 0
Q16513 Serine/threonine-protein kinase N2 Pkn C00024753 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00024753 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00018683 0 / 0
P41240 Tyrosine-protein kinase CSK Csk C00024753 0 / 0
Q8N5S9 Calcium/calmodulin-dependent protein kinase kinase 1 META serine/threonine protein kinase subfamily C00024753 0 / 0
Q9P286 Serine/threonine-protein kinase PAK 7 STE serine/threonine protein kinase PAKB subfamily C00024753 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00018684 0 / 0
P14902 Indoleamine 2,3-dioxygenase 1 Enzyme C00018683 0 / 0
Q96SB4 SRSF protein kinase 1 Srpk C00024753 0 / 0
Q92630 Dual specificity tyrosine-phosphorylation-regulated kinase 2 CMGC dual-specificity kinase DYRK2 C00024753 0 / 0
O43781 Dual specificity tyrosine-phosphorylation-regulated kinase 3 CMGC dual-specificity kinase DYRK2 C00024753 0 / 0
O96013 Serine/threonine-protein kinase PAK 4 STE serine/threonine protein kinase PAKB subfamily C00024753 0 / 0
P39748 Flap endonuclease 1 Enzyme C00018683 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00018683 2 / 0
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 C00024753 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00018683 0 / 0
P35348 Alpha-1A adrenergic receptor Adrenergic receptor C00018685 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00024753 0 / 0
Q15418 Ribosomal protein S6 kinase alpha-1 Rskb C00024753 0 / 0
O15264 Mitogen-activated protein kinase 13 p38 C00024753 0 / 0
P53779 Mitogen-activated protein kinase 10 Jnk C00024753 0 / 1
P51955 Serine/threonine-protein kinase Nek2 Nek C00024753 0 / 0
Q96RR4 Calcium/calmodulin-dependent protein kinase kinase 2 META serine/threonine protein kinase subfamily C00024753 0 / 0
Q9BUB5 MAP kinase-interacting serine/threonine-protein kinase 1 CAMK serine/threonine protein kinase MNK subfamily C00024753 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00018683 1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00018683 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00018683 3 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00018683 0 / 0
Q15257 Serine/threonine-protein phosphatase 2A activator Protein phosphatase regulatory subunit C00017872 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00018684 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00018683 0 / 0
P48730 Casein kinase I isoform delta Ck1 C00024753 1 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00024753 0 / 0
Q96GD4 Aurora kinase B Aur C00024753 0 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK C00024753 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00024753 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00018683 0 / 1
P45983 Mitogen-activated protein kinase 8 Jnk C00024753 0 / 0
P06746 DNA polymerase beta Enzyme C00018683 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00024753 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00041466 0 / 0
P53350 Serine/threonine-protein kinase PLK1 PLK serine/threonine protein kinase subfamily C00024753 0 / 0
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK C00024753 0 / 0
O75116 Rho-associated protein kinase 2 Rock C00024753 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00018685 0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt C00024753 4 / 1
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily C00024753 0 / 0
P51812 Ribosomal protein S6 kinase alpha-3 Rskb C00024753 2 / 2
Q15759 Mitogen-activated protein kinase 11 p38 C00024753 0 / 0
Q99700 Ataxin-2 Unclassified protein C00018683 1 / 1
Q9HC98 Serine/threonine-protein kinase Nek6 Nek C00024753 0 / 0
Q9H2X6 Homeodomain-interacting protein kinase 2 CMGC dual-specificity kinase HIPK C00024753 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00018683 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00018683 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00018683 4 / 3
Q16637 Survival motor neuron protein Unclassified protein C00018685 4 / 1
O96017 Serine/threonine-protein kinase Chk2 Rad53 C00024753 4 / 1
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme C00018683 0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka C00024753 0 / 0
Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A CMGC dual-specificity kinase DYRK1 C00024753 1 / 0
P53778 Mitogen-activated protein kinase 12 p38 C00024753 0 / 0
O00418 Eukaryotic elongation factor 2 kinase Atypical serine/threonine protein kinase alpha subfamily C00024753 0 / 0
Q8TD08 Mitogen-activated protein kinase 15 Mapk C00024753 0 / 0
Q86V86 Serine/threonine-protein kinase pim-3 Pim C00024753 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00018683 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00018683 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00018683 0 / 0
Q8TDX7 Serine/threonine-protein kinase Nek7 Nek C00024753 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00018683 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00018683 0 / 0
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00024753 0 / 0
Q04759 Protein kinase C theta type Delta C00024753 0 / 1
Q02156 Protein kinase C epsilon type Eta C00024753 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00024753 0 / 0
Q05655 Protein kinase C delta type Delta C00024753 0 / 0
P05129 Protein kinase C gamma type Alpha C00024753 1 / 1
P05771 Protein kinase C beta type Alpha C00024753 0 / 0
P24723 Protein kinase C eta type Eta C00024753 1 / 0
P41743 Protein kinase C iota type Iota C00024753 0 / 0
P20248 Cyclin-A2 Other cytosolic protein C00024753 0 / 0
P78396 Cyclin-A1 Other cytosolic protein C00024753 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00024753 0 / 0
P22694 cAMP-dependent protein kinase catalytic subunit beta Pka C00024753 0 / 0
P22612 cAMP-dependent protein kinase catalytic subunit gamma Pka C00024753 0 / 0
P68400 Casein kinase II subunit alpha Ck2 C00024753 0 / 0
P19784 Casein kinase II subunit alpha' Ck2 C00024753 0 / 0
P67870 Casein kinase II subunit beta REG serine/threonine protein kinase family C00024753 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00018685 7 / 37
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00017872 0 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00024753 1 / 1
P01215 Glycoprotein hormones alpha chain Unclassified protein C00018683 0 / 3
Q13148 TAR DNA-binding protein 43 Unclassified protein C00018684 1 / 1

29 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00017872 C00024753
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00017872 C00024753
4170 MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT myeloid cell leukemia sequence 1 (BCL2-related) C00017872 C00024753
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00017872 C00024753
1111 CHEK1, CHK1 checkpoint kinase 1 (EC:2.7.11.1) C00024753
573 BAG1, BAG-1, HAP, RAP46 BCL2-associated athanogene C00024753
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00024753
637 BID, FP497 BH3 interacting domain death agonist C00024753
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00024753
835 CASP2, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57 caspase 2, apoptosis-related cysteine peptidase (EC:3.4.22.55) C00024753
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00024753
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00024753
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00024753
983 CDK1, CDC2, CDC28A, P34CDC2 cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) C00024753
9131 AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 apoptosis-inducing factor, mitochondrion-associated, 1 C00024753
56616 DIABLO, DFNA64, SMAC diablo, IAP-binding mitochondrial protein C00024753
5604 MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) C00024753
5605 MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2 mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) C00024753
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00024753
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00024753
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00024753
4288 MKI67, KIA, MIB-1 marker of proliferation Ki-67 C00024753
5175 PECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM platelet/endothelial cell adhesion molecule 1 C00024753
5894 RAF1, CRAF, NS5, Raf-1, c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) C00024753
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00024753
6667 SP1 Sp1 transcription factor C00024753
412 STS, ARSC, ARSC1, ASC, ES, SSDD, XLI steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2) C00024753
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00024753
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00024753

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (68)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#615224 Advanced sleep phase syndrome, familial, 2; fasps2 P48730
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#613780 Aortic aneurysm, familial thoracic 7; aat7 Q15746
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#613985 Beta-thalassemia P68871
#603902 Beta-thalassemia, dominant inclusion body type P68871
#210900 Bloom syndrome; blm P54132
#114480 Breast cancer O96017
P31749
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#303600 Coffin-lowry syndrome; cls P51812
#114500 Colorectal cancer; crc P31749
P84022
#615109 Cowden syndrome 6; cws6 P31749
#125853 Diabetes mellitus, noninsulin-dependent; niddm P31751
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#140700 Heinz body anemias P68871
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#240900 Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh P31751
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#609265 Li-fraumeni syndrome 2; lfs2 O96017
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P00533
P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#614104 Mental retardation, autosomal dominant 7; mrd7 Q13627
#300844 Mental retardation, x-linked 19; mrx19 P51812
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#613949 Okt4 epitope deficiency P01730
#259500 Osteogenic sarcoma O96017
#167800 Pancreatitis, hereditary; pctt P07477
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#176807 Prostate cancer O96017
#176920 Proteus syndrome P31749
#275210 Restrictive dermopathy, lethal P02545
#102700 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency P00813
#603903 Sickle cell anemia P68871
#243060 Spermatogenic failure 5; spgf5 Q9UQB9
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (84)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00881 Li-Fraumeni syndrome O96017 (related)
P04637 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
H00018 Gastric cancer P00533 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04637 (related)
P68871 (marker)
H00028 Choriocarcinoma P00533 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00092 T-B-Severe combined immunodeficiencies (SCIDs) P00813 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P31751 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
P68871 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P31751 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q99700 (related)
H00213 Hypophosphatasia P05186 (related)
H00933 Hereditary pancreatitis P07477 (related)
P07478 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P51812 (related)
H00574 Coffin-Lowry syndrome (CLS) P51812 (related)
H00606 Early infantile epileptic encephalopathy P53779 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00228 Thalassemia P68871 (related)
H00229 Sickle cell anemia (SCA) P68871 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00801 Familial thoracic aortic aneurysm and dissection (TAAD) Q15746 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H01282 Spermatogenic failure Q9UQB9 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

15 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003072 Cognition Disorders C00018684
D004195 Disease Models, Animal C00018684
D004409 Dyskinesia, Drug-Induced C00018684
D004421 Dystonia C00018684
D034381 Hearing Loss C00018684
D006816 Huntington Disease C00018684
D006948 Hyperkinesis C00018684
D008569 Memory Disorders C00018684
D009069 Movement Disorders C00018684
D009410 Nerve Degeneration C00018684
D009422 Nervous System Diseases C00018684
D019636 Neurodegenerative Diseases C00018684
D020258 Neurotoxicity Syndromes C00018684
D015431 Weight Loss C00018684
D001943 Breast Neoplasms C00024753