KNApSAcK Metabolite C00018684
Metabolite
KNApSAcK Entry
| id | C00018684 |
|---|---|
| Name | BNP / NSC 64266 / Bovinocidin / Hiptagenic acid / 3-Nitro-propionic acid |
| CAS RN | 504-88-1 |
| Standard InChI | InChI=1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6) |
| Standard InChI (Main Layer) | InChI=1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 8212 |
Link
ChEMBL
| By standard InChI | CHEMBL451226 |
|---|---|
| By standard InChI Main Layer | CHEMBL451226 |
KEGG
| By LinkDB | C05669 |
|---|
CTD
| By CAS RN | C015392 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Streptomycetaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Streptomyces sp. | 1931 | Streptomycetaceae | Bacteria |
Human Protein / Gene in interaction
17 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL451226 |
CHEMBL1741321
(1)
|
1 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL451226 |
CHEMBL1614544
(1)
|
11 / 10 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL451226 |
CHEMBL1741325
(1)
|
0 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | CHEMBL451226 |
CHEMBL1614522
(1)
CHEMBL1614067
(1)
|
1 / 2 |
| P68871 | Hemoglobin subunit beta | Secreted protein | CHEMBL451226 |
CHEMBL1614204
(1)
|
4 / 4 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | CHEMBL451226 |
CHEMBL1614456
(1)
CHEMBL1613803
(1)
|
0 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL451226 |
CHEMBL2114843
(1)
|
0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL451226 |
CHEMBL1794401
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL451226 |
CHEMBL1741322
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL451226 |
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL451226 |
CHEMBL1741324
(1)
|
0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | CHEMBL451226 |
CHEMBL1794483
(1)
|
0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL451226 |
CHEMBL1737980
(1)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL451226 |
CHEMBL1738442
(1)
|
0 / 0 |
| O00255 | Menin | Unclassified protein | CHEMBL451226 |
CHEMBL1614257
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL451226 |
CHEMBL1614257
(1)
|
1 / 3 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | CHEMBL451226 |
CHEMBL2354287
(1)
|
1 / 1 |
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (22)
| OMIM | preferred title | UniProt |
|---|---|---|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #613985 | Beta-thalassemia |
P68871
|
| #603902 | Beta-thalassemia, dominant inclusion body type |
P68871
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #140700 | Heinz body anemias |
P68871
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #603903 | Sickle cell anemia |
P68871
|
KEGG DISEASE (27)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00228 | Thalassemia |
P68871
(related)
|
| H00229 | Sickle cell anemia (SCA) |
P68871
(related)
|
| H00020 | Colorectal cancer |
P68871
(marker)
|
| H00022 | Bladder cancer |
P68871
(marker)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
Diseases related to CTD interactions
14 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D003072 | C015392 | Cognition Disorders |
marker/mechanism
|
11573988
11844244 |
|
| D004195 | C015392 | Disease Models, Animal |
marker/mechanism
|
11573988
11844244 12603833 15640759 |
|
| D004409 | C015392 | Dyskinesia, Drug-Induced |
marker/mechanism
|
11844244
20448265 |
|
| D004421 | C015392 | Dystonia |
marker/mechanism
|
11844244
|
|
| D034381 | C015392 | Hearing Loss |
marker/mechanism
|
20226206
|
|
| D006816 | C015392 | Huntington Disease |
marker/mechanism
|
11844244
12603833 15217383 19476553 20305041 |
|
| D006948 | C015392 | Hyperkinesis |
marker/mechanism
|
12603833
|
|
| D008569 | C015392 | Memory Disorders |
marker/mechanism
|
16940769
|
|
| D009069 | C015392 | Movement Disorders |
marker/mechanism
|
11844244
16940769 |
|
| D009410 | C015392 | Nerve Degeneration |
marker/mechanism
|
15217383
15640759 19580850 |
|
| D009422 | C015392 | Nervous System Diseases |
marker/mechanism
|
11211235
|
|
| D019636 | C015392 | Neurodegenerative Diseases |
marker/mechanism
|
11573988
|
|
| D020258 | C015392 | Neurotoxicity Syndromes |
marker/mechanism
|
21827787
21827809 |
|
| D015431 | C015392 | Weight Loss |
marker/mechanism
|
16940769
|