PCIDB

KNApSAcK Metabolite C00018683

Metabolite

KNApSAcK Entry

id C00018683
Name NSC 94945 / AV Toxin C / Questiomycin A / 2-Aminophenoxazone / 2-Amino-3-phenoxazone / Acrospermum viticola toxin C
CAS RN 1916-59-2
Standard InChI InChI=1S/C12H8N2O2/c13-7-5-9-12(6-10(7)15)16-11-4-2-1-3-8(11)14-9/h1-6H,13H2
Standard InChI (Main Layer) InChI=1S/C12H8N2O2/c13-7-5-9-12(6-10(7)15)16-11-4-2-1-3-8(11)14-9/h1-6H,13H2

Cluster

Phytochemical cluster
KCF-S cluster No. 1379

Link

ChEMBL

By standard InChI CHEMBL146710
By standard InChI Main Layer CHEMBL146710

KEGG

By LinkDB C02161

CTD

By CAS RN C005512

Species

Summary

Plant class

class name count

Family

family name count
Streptomycetaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Streptomyces sp. 1931 Streptomycetaceae Bacteria

Human Protein / Gene in interaction

32 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL146710 CHEMBL1738312 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL146710 CHEMBL2114784 (1)
1 / 1
P06746 DNA polymerase beta Enzyme CHEMBL146710 CHEMBL1614079 (1)
0 / 0
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme CHEMBL146710 CHEMBL1613955 (1)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL146710 CHEMBL1794585 (1)
0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL146710 CHEMBL1614166 (1)
1 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL146710 CHEMBL1794311 (1)
2 / 3
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL146710 CHEMBL1614458 (1)
0 / 0
P14902 Indoleamine 2,3-dioxygenase 1 Enzyme CHEMBL146710 CHEMBL2330523 (1) CHEMBL2330524 (1)
CHEMBL2330525 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL146710 CHEMBL1794486 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL146710 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL146710 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL146710 CHEMBL1613838 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL146710 CHEMBL1794569 (1)
1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme CHEMBL146710 CHEMBL1738315 (1)
0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme CHEMBL146710 CHEMBL1738614 (1)
3 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL146710 CHEMBL1614280 (1)
0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL146710 CHEMBL1614410 (1) CHEMBL1614531 (1)
1 / 3
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL146710 CHEMBL1963863 (1)
0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme CHEMBL146710 CHEMBL1738514 (1)
0 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL146710 CHEMBL1738588 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL146710 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL146710 CHEMBL1737991 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL146710 CHEMBL1614250 (1) CHEMBL1614421 (1)
CHEMBL1614502 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL146710 CHEMBL1738184 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL146710 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL146710 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL146710 CHEMBL1613829 (1) CHEMBL1794433 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL146710 CHEMBL2354311 (1)
1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme CHEMBL146710 CHEMBL1963966 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL146710 CHEMBL1614531 (1)
2 / 5
P01215 Glycoprotein hormones alpha chain Unclassified protein CHEMBL146710 CHEMBL2114913 (1)
0 / 3

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#114500 Colorectal cancer; crc P84022
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (20)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00213 Hypophosphatasia P05186 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)