| class name | count |
|---|---|
| Liliopsida | 3 |
| class name | count |
|---|---|
| Streptomycetaceae | 6 |
| Iridaceae | 3 |
| br08003 Category | # of metabolite |
|---|
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00002821
|
Eleutherin
/ (+)-Eleutherin |
CHEMBL594153
|
1 / 0 / 0 |
|
||
|
C00002845
|
(1S,3R)-Nanaomycin A
|
CHEMBL1212972
CHEMBL2106789 |
C008638
|
20 / 21 / 14 |
|
|
|
C00015918
|
UCF 76A
|
|
||||
|
C00018068
|
Nanaomycin C
|
C026757
|
|
|||
|
C00018203
|
Frenolicin B
|
CHEMBL474390
|
C018066
|
1 / 4 / 1 |
|
|
|
C00018204
|
Deoxyfrenolicin
|
CHEMBL444165
|
C004673
|
1 / 4 / 1 |
|
|
|
C00018752
|
U 19718
/ Kalamycin / Kalafungin / NSC 137443 / (+)-Kalafungin |
CHEMBL1988648
|
C013079
|
|
||
|
C00029282
|
(-)-Isoeleutherin
|
CHEMBL594153
|
1 / 0 / 0 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00018203 C00018204 | 4 / 1 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00002821 C00029282 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002845 | 1 / 1 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00002845 | 2 / 3 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00002845 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00002845 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002845 | 0 / 0 |
| P51684 | C-C chemokine receptor type 6 | CC chemokine receptor | C00002845 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002845 | 7 / 3 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00002845 | 1 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002845 | 0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | C00002845 | 4 / 2 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002845 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002845 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002845 | 0 / 0 |
| P07900 | Heat shock protein HSP 90-alpha | Other cytosolic protein | C00002845 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002845 | 1 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002845 | 0 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00002845 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00002845 | 2 / 1 |
| Q06710 | Paired box protein Pax-8 | Unclassified protein | C00002845 | 1 / 2 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00002845 | 1 / 1 |
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #114480 | Breast cancer |
P31749
|
| #114500 | Colorectal cancer; crc |
P31749
P84022 Q14191 |
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #218700 | Hypothyroidism, congenital, nongoitrous, 2; chng2 |
Q06710
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #176920 | Proteus syndrome |
P31749
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| KEGG | name | UniProt |
|---|---|---|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00032 | Thyroid cancer |
Q06710
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
Q06710
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|