KNApSAcK Metabolite C00002487
Metabolite
KNApSAcK Entry
| id | C00002487 |
|---|---|
| Name | PA 93 / U 6391 / Novo-R / Albamix / Cathocin / Inamycin / Robiocina / Albamycin / Cathomycin / Novobiocin / Sirbiocina / Stilbiocina / Cardelmycin / Spheromycin / Streptonivicin / Antibiotic PA-93 / Crystallinic acid |
| CAS RN | 303-81-1 |
| Standard InChI | InChI=1S/C31H36N2O11/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37)/t23-,25?,26+,29+/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C31H36N2O11/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 3473 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL35025 CHEMBL1237121 CHEMBL1617799 CHEMBL1619419 CHEMBL1625763 CHEMBL2221247 |
KEGG
| By LinkDB | C05080 |
|---|
CTD
| By CAS RN | D009675 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Streptomycetaceae | 2 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Streptomyces niveus | 193462 | Streptomycetaceae | Bacteria | |
| Streptomyces spheroides | 193462 | Streptomycetaceae | Bacteria |
Human Protein / Gene in interaction
14 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | CHEMBL1237121 |
CHEMBL2169429
(1)
|
1 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | CHEMBL1237121 |
CHEMBL2169431
(1)
|
0 / 0 |
| Q16543 | Hsp90 co-chaperone Cdc37 | Unclassified protein | CHEMBL1237121 |
CHEMBL1803261
(1)
|
0 / 0 |
| P02768 | Serum albumin | Secreted protein | CHEMBL1237121 |
CHEMBL702885
(1)
CHEMBL1661507
(1)
CHEMBL1661523 (1) CHEMBL1661524 (1) CHEMBL1661525 (1) CHEMBL1661526 (1) |
0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | CHEMBL1237121 |
CHEMBL663891
(1)
CHEMBL1785110
(1)
|
0 / 0 |
| Q8TCC7 | Solute carrier family 22 member 8 | Antiporter | CHEMBL1237121 |
CHEMBL1743167
(1)
|
0 / 0 |
| Q4U2R8 | Solute carrier family 22 member 6 | Antiporter | CHEMBL1237121 |
CHEMBL1743166
(1)
|
0 / 0 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | CHEMBL1237121 |
CHEMBL2169430
(1)
|
1 / 0 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | CHEMBL1237121 |
CHEMBL974473
(1)
CHEMBL1047706
(1)
CHEMBL1047707 (1) CHEMBL2075183 (1) CHEMBL2075596 (1) CHEMBL2076815 (1) |
2 / 0 |
| P08238 | Heat shock protein HSP 90-beta | Other cytosolic protein | CHEMBL1237121 |
CHEMBL1664649
(1)
CHEMBL1664650
(1)
CHEMBL1664651 (1) CHEMBL1664652 (1) CHEMBL1664660 (1) CHEMBL1664668 (1) CHEMBL1775390 (1) |
0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | CHEMBL1237121 |
CHEMBL663891
(1)
CHEMBL686753
(1)
|
0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | CHEMBL1237121 |
CHEMBL1908080
(1)
|
5 / 1 |
| P07900 | Heat shock protein HSP 90-alpha | Other cytosolic protein | CHEMBL1237121 |
CHEMBL1664661
(1)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL1237121 |
CHEMBL1738442
(1)
|
0 / 0 |
CTD interaction (3)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D009675 | 952 |
CD38
T10 |
CD38 molecule (EC:3.2.2.5) | Novobiocin results in increased expression of CD38 mRNA |
increases expression
|
mRNA |
11853877
|
| D009675 | 952 |
CD38
T10 |
CD38 molecule (EC:3.2.2.5) | Novobiocin results in increased expression of CD38 protein |
increases expression
|
protein |
11853877
|
| D009675 | 1000 |
CDH2
CD325 CDHN CDw325 NCAD |
cadherin 2, type 1, N-cadherin (neuronal) | Novobiocin results in decreased expression of CDH2 protein |
decreases expression
|
protein |
11853877
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (8)
| OMIM | preferred title | UniProt |
|---|---|---|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
|
| #606785 | Crigler-najjar syndrome, type ii |
P22309
|
| #143500 | Gilbert syndrome |
P22309
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|