KNApSAcK Metabolite C00026453
Metabolite
KNApSAcK Entry
| id | C00026453 |
|---|---|
| Name | Kynurenic acid |
| CAS RN | 492-27-3 |
| Standard InChI | InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14) |
| Standard InChI (Main Layer) | InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 3907 |
Link
ChEMBL
| By standard InChI | CHEMBL299155 |
|---|---|
| By standard InChI Main Layer | CHEMBL299155 |
KEGG
| By LinkDB | C01717 |
|---|
CTD
| By CAS RN | D007736 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| Spermatophyta | 1 |
Family
| family name | count |
|---|---|
| Ephedraceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Ephedra pachyclada ssp.sinaica | 3387 | Ephedraceae | Spermatophyta | Viridiplantae |
Human Protein / Gene in interaction
23 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL299155 |
CHEMBL1741321
(1)
|
1 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | CHEMBL299155 |
CHEMBL1738312
(1)
|
0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | CHEMBL299155 |
CHEMBL1614175
(1)
|
1 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL299155 |
CHEMBL1741325
(1)
|
0 / 1 |
| Q9HC97 | G-protein coupled receptor 35 | Kynurenic acid receptor | CHEMBL299155 |
CHEMBL2038723
(1)
CHEMBL2038727
(1)
CHEMBL2038732 (1) CHEMBL2038733 (1) |
0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL299155 |
CHEMBL1614458
(1)
|
0 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL299155 |
CHEMBL2114843
(1)
|
0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL299155 |
CHEMBL1614257
(1)
CHEMBL1614410
(1)
CHEMBL1614531 (1) |
1 / 3 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL299155 |
CHEMBL1738610
(1)
|
0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | CHEMBL299155 |
CHEMBL1614217
(1)
|
1 / 1 |
| P08138 | Tumor necrosis factor receptor superfamily member 16 | Membrane receptor | CHEMBL299155 |
CHEMBL753644
(1)
|
0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL299155 |
CHEMBL1613808
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL299155 |
CHEMBL1741322
(1)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL299155 |
CHEMBL1613910
(1)
CHEMBL1614227
(2)
|
3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL299155 |
CHEMBL1614038
(2)
|
2 / 2 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL299155 |
CHEMBL1613777
(1)
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL299155 |
CHEMBL1741324
(1)
|
0 / 1 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | CHEMBL299155 |
CHEMBL1737991
(1)
|
0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL299155 |
CHEMBL1614211
(1)
|
0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | CHEMBL299155 |
CHEMBL1794536
(1)
|
0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL299155 |
CHEMBL1613914
(3)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL299155 |
CHEMBL1738442
(2)
|
0 / 0 |
| O00255 | Menin | Unclassified protein | CHEMBL299155 |
CHEMBL1614257
(1)
CHEMBL1614531
(1)
|
2 / 5 |
CTD interaction (16)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D007736 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA] |
affects cotreatment
/ affects reaction / increases expression |
protein |
20106948
|
| D007736 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA] |
affects cotreatment
/ affects reaction / increases expression |
protein |
20106948
|
| D007736 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | Kynurenic Acid binds to and results in increased activity of AHR protein |
affects binding
/ increases activity |
protein |
20106948
|
| D007736 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA] |
affects cotreatment
/ affects reaction / increases expression |
mRNA |
20106948
|
| D007736 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA |
affects cotreatment
/ increases expression |
mRNA |
20106948
|
| D007736 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | Kynurenic Acid results in increased activity of CYP1A1 protein |
increases activity
|
protein |
20106948
|
| D007736 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | Kynurenic Acid results in increased expression of CYP1A1 mRNA |
increases expression
|
mRNA |
20106948
|
| D007736 | 2246 |
FGF1
AFGF ECGF ECGF-beta ECGFA ECGFB FGF-1 FGF-alpha FGFA GLIO703 HBGF-1 HBGF1 |
fibroblast growth factor 1 (acidic) | Kynurenic Acid results in decreased secretion of FGF1 protein |
decreases secretion
|
protein |
16392031
|
| D007736 | 2859 |
GPR35
|
G protein-coupled receptor 35 | Kynurenic Acid binds to and results in increased activity of GPR35 protein |
affects binding
/ increases activity |
protein |
20826425
|
| D007736 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA] |
affects cotreatment
/ affects reaction / increases expression |
protein |
20106948
|
| D007736 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA] |
affects cotreatment
/ affects reaction / increases expression |
protein |
20106948
|
| D007736 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | IL1B protein promotes the reaction [Kynurenic Acid results in increased expression of IL6 mRNA] |
increases expression
/ increases reaction |
protein |
20106948
|
| D007736 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | [Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA |
affects cotreatment
/ increases expression |
protein |
20106948
|
| D007736 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA] |
affects cotreatment
/ affects reaction / increases expression |
mRNA |
20106948
|
| D007736 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | IL1B protein promotes the reaction [Kynurenic Acid results in increased expression of IL6 mRNA] |
increases expression
/ increases reaction |
mRNA |
20106948
|
| D007736 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | Kynurenic Acid results in increased expression of IL6 mRNA |
increases expression
|
mRNA |
20106948
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (12)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #301500 | Fabry disease |
P06280
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
KEGG DISEASE (17)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
5 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D001172 | D007736 | Arthritis, Rheumatoid |
marker/mechanism
|
16220290
|
|
| D006948 | D007736 | Hyperkinesis |
therapeutic
|
8000442
|
|
| D006973 | D007736 | Hypertension |
marker/mechanism
|
1436509
|
|
| D009410 | D007736 | Nerve Degeneration |
therapeutic
|
17539917
|
|
| D012640 | D007736 | Seizures |
therapeutic
|
7902066
16457470 21620807 |