Ephedra pachyclada ssp.sinaica
Species
KNApSAcK Entry
| Organism name | Ephedra pachyclada ssp.sinaica |
|---|---|
| Genus | Ephedra |
| Family | Ephedraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Ephedra |
|---|---|
| Linked NCBI taxonomy ID | 3387 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Ephedraceae |
|---|---|
| ID | 3386 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Spermatophyta |
|---|---|
| ID | 58024 |
Metabolite list (2)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00026395
|
6-Methoxykynurenic acid
|
CHEMBL21358
|
No. 3907 |
|
||||
|
C00026453
|
Kynurenic acid
|
CHEMBL299155
|
D007736
|
23 / 12 / 17 | 6 / 5 | No. 3907 |
|
Human Protein / Gene in interactions
23 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00026453 | 1 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00026453 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00026453 | 1 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00026453 | 0 / 1 |
| Q9HC97 | G-protein coupled receptor 35 | Kynurenic acid receptor | C00026453 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00026453 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00026453 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00026453 | 1 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00026453 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00026453 | 1 / 1 |
| P08138 | Tumor necrosis factor receptor superfamily member 16 | Membrane receptor | C00026453 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00026453 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00026453 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00026453 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00026453 | 2 / 2 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00026453 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00026453 | 0 / 1 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00026453 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00026453 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00026453 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00026453 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00026453 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00026453 | 2 / 5 |
6 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00026453
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00026453
|
| 2246 | FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 | fibroblast growth factor 1 (acidic) |
C00026453
|
| 2859 | GPR35 | G protein-coupled receptor 35 |
C00026453
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00026453
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00026453
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (12)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #301500 | Fabry disease |
P06280
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
KEGG DISEASE (17)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|