PCIDB

KNApSAcK Metabolite C00026494

Metabolite

KNApSAcK Entry

id C00026494
Name Transtorine
CAS RN 13593-94-7
Standard InChI InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
Standard InChI (Main Layer) InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)

Cluster

Phytochemical cluster
KCF-S cluster No. 3632

Link

ChEMBL

By standard InChI CHEMBL299155
By standard InChI Main Layer CHEMBL299155

KEGG

By LinkDB C01717

CTD

By CAS RN

Species

Summary

Plant class

class name count
Spermatophyta 1

Family

family name count
Ephedraceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Ephedra transitoria 288824 Ephedraceae Spermatophyta Viridiplantae

Human Protein / Gene in interaction

23 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL299155 CHEMBL1741321 (1)
1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL299155 CHEMBL1738312 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL299155 CHEMBL1614175 (1)
1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL299155 CHEMBL1741325 (1)
0 / 1
Q9HC97 G-protein coupled receptor 35 Kynurenic acid receptor CHEMBL299155 CHEMBL2038723 (1) CHEMBL2038727 (1)
CHEMBL2038732 (1) CHEMBL2038733 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL299155 CHEMBL1614458 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL299155 CHEMBL2114843 (1)
0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL299155 CHEMBL1614257 (1) CHEMBL1614410 (1)
CHEMBL1614531 (1)
1 / 3
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL299155 CHEMBL1738610 (1)
0 / 0
P06280 Alpha-galactosidase A Enzyme CHEMBL299155 CHEMBL1614217 (1)
1 / 1
P08138 Tumor necrosis factor receptor superfamily member 16 Membrane receptor CHEMBL299155 CHEMBL753644 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL299155 CHEMBL1613808 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL299155 CHEMBL1741322 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL299155 CHEMBL1613910 (1) CHEMBL1614227 (2)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL299155 CHEMBL1614038 (2)
2 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL299155 CHEMBL1613777 (1) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL299155 CHEMBL1741324 (1)
0 / 1
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL299155 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL299155 CHEMBL1614211 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL299155 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL299155 CHEMBL1613914 (3)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL299155 CHEMBL1738442 (2)
0 / 0
O00255 Menin Unclassified protein CHEMBL299155 CHEMBL1614257 (1) CHEMBL1614531 (1)
2 / 5

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#301500 Fabry disease P06280
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255

KEGG DISEASE (17)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)