PCIDB

KNApSAcK Metabolite C00028110

Metabolite

KNApSAcK Entry

id C00028110
Name Curacin D
CAS RN 164454-36-8
Standard InChI InChI=1S/C22H33NOS/c1-4-13-20(24-3)15-12-10-8-6-5-7-9-11-14-19-17-25-22(23-19)21-16-18(21)2/h4-6,8,10-11,14,18-21H,1,7,9,12-13,15-17H2,2-3H3/b6-5+,10-8+,14-11-/t18-,19+,20-,21+/m0/s1
Standard InChI (Main Layer) InChI=1S/C22H33NOS/c1-4-13-20(24-3)15-12-10-8-6-5-7-9-11-14-19-17-25-22(23-19)21-16-18(21)2/h4-6,8,10-11,14,18-21H,1,7,9,12-13,15-17H2,2-3H3

Cluster

Phytochemical cluster
KCF-S cluster No. 5280

Link

ChEMBL

By standard InChI CHEMBL1714537
By standard InChI Main Layer CHEMBL56309 CHEMBL1714537

KEGG

By LinkDB

CTD

By CAS RN C116945

Species

Summary

Plant class

class name count

Family

family name count

List (3)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Lyngbya majuscula 158786 Bacteria
Lyngya majuscula
Symploca hydnoides 207924 Bacteria

Human Protein / Gene in interaction

27 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL1714537 CHEMBL1738132 (1)
7 / 44
Q99700 Ataxin-2 Unclassified protein CHEMBL1714537 CHEMBL2114784 (1)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL1714537 CHEMBL1794499 (1)
2 / 0
P37840 Alpha-synuclein Unclassified protein CHEMBL1714537 CHEMBL2354282 (1)
4 / 2
P11473 Vitamin D3 receptor NR1I1 CHEMBL1714537 CHEMBL1794311 (1)
2 / 3
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL1714537 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL1714537 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL1714537 CHEMBL2114788 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL1714537 CHEMBL1794401 (1)
0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL1714537 CHEMBL1963863 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1714537 CHEMBL1738184 (1) CHEMBL2114908 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL1714537 CHEMBL2354311 (1)
1 / 0
Q13748 Tubulin alpha-3C/D chain Structural CHEMBL56309 CHEMBL622599 (1)
0 / 0
P68366 Tubulin alpha-4A chain Structural CHEMBL56309 CHEMBL622599 (1)
0 / 0
Q9H4B7 Tubulin beta-1 chain Structural CHEMBL56309 CHEMBL622599 (1)
1 / 0
P04350 Tubulin beta-4A chain Structural CHEMBL56309 CHEMBL622599 (1)
2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural CHEMBL56309 CHEMBL622599 (1)
0 / 0
P07437 Tubulin beta chain Structural CHEMBL56309 CHEMBL622599 (1)
0 / 0
Q71U36 Tubulin alpha-1A chain Structural CHEMBL56309 CHEMBL622599 (1)
1 / 1
P68371 Tubulin beta-4B chain Structural CHEMBL56309 CHEMBL622599 (1)
0 / 0
Q13509 Tubulin beta-3 chain Structural CHEMBL56309 CHEMBL622599 (1)
2 / 1
P68363 Tubulin alpha-1B chain Unclassified protein CHEMBL56309 CHEMBL622599 (1)
0 / 0
Q13885 Tubulin beta-2A chain Structural CHEMBL56309 CHEMBL622599 (1)
0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein CHEMBL56309 CHEMBL622599 (1)
0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein CHEMBL56309 CHEMBL622599 (1)
0 / 0
Q9BUF5 Tubulin beta-6 chain Structural CHEMBL56309 CHEMBL622599 (1)
0 / 0
Q9BVA1 Tubulin beta-2B chain Structural CHEMBL56309 CHEMBL622599 (1)
1 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (26)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114500 Colorectal cancer; crc P84022
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#127750 Dementia, lewy body; dlb P37840
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#133239 Esophageal cancer P04637
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#137800 Glioma susceptibility 1; glm1 O75874
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#611603 Lissencephaly 3; lis3 Q71U36
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (45)

KEGG disease name UniProt
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)