PCIDB

KNApSAcK Metabolite C00003008

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases

Metabolite

KNApSAcK Entry

id	C00003008
Name	Ochratoxin A
CAS RN	303-47-9
Standard InChI	InChI=1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1
Standard InChI (Main Layer)	InChI=1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)

Cluster

Phytochemical cluster
KCF-S cluster	No. 5277

Link

ChEMBL

By standard InChI	CHEMBL589366
By standard InChI Main Layer	CHEMBL589366 CHEMBL592694 CHEMBL603156 CHEMBL600271

KEGG

By LinkDB	C09955

CTD

By CAS RN	C025589

Species

Summary

Plant class

class name	count

Family

family name	count
Aspergillaceae	3

List (3)

* NCBI

KNApSAcK organism	*ID	*family	*kingdom
Aspergillus ochraceus	40380	Aspergillaceae	Fungi
Aspergillus spp.	5052	Aspergillaceae	Fungi
Penicillium spp.	5073	Aspergillaceae	Fungi

Human Protein / Gene in interaction

20 ChEMBL Protein in interactions

accession	description	class description	compound	assay ID (# of activities)	# of diseases (OMIM / KEGG)
P04637	Cellular tumor antigen p53	Transcription Factor	CHEMBL589366	CHEMBL2114895 (1)	7 / 44
P04062	Glucosylceramidase	Enzyme	CHEMBL589366 CHEMBL603156	CHEMBL1613818 (2)	6 / 4
P10253	Lysosomal alpha-glucosidase	Hydrolase	CHEMBL589366 CHEMBL603156	CHEMBL1614175 (2)	1 / 1
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	CHEMBL589366	CHEMBL1794524 (1) CHEMBL1794552 (1)	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	CHEMBL589366	CHEMBL1794399 (1) CHEMBL1794561 (1)	3 / 1
P11473	Vitamin D3 receptor	NR1I1	CHEMBL589366	CHEMBL1794376 (1) CHEMBL1794339 (1)	2 / 3
P00352	Retinal dehydrogenase 1	Enzyme	CHEMBL589366	CHEMBL1614458 (1)	0 / 0
Q8TCC7	Solute carrier family 22 member 8	Antiporter	CHEMBL589366	CHEMBL2076641 (1) CHEMBL2076228 (1)	0 / 0
Q4U2R8	Solute carrier family 22 member 6	Antiporter	CHEMBL589366	CHEMBL2077047 (1)	0 / 0
P04150	Glucocorticoid receptor	NR3C1	CHEMBL589366	CHEMBL1794382 (1) CHEMBL1794456 (1)	0 / 1
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	CHEMBL589366	CHEMBL1794293 (1) CHEMBL1794510 (1)	5 / 3
P06280	Alpha-galactosidase A	Enzyme	CHEMBL589366 CHEMBL603156	CHEMBL1614217 (2) CHEMBL1614369 (1)	1 / 1
Q96RI1	Bile acid receptor	NR1H4	CHEMBL589366	CHEMBL1794415 (1) CHEMBL1794437 (1)	0 / 0
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	CHEMBL589366	CHEMBL2075327 (1) CHEMBL2075330 (1)	1 / 1
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	CHEMBL589366	CHEMBL1614038 (1)	2 / 2
P03372	Estrogen receptor	NR3A1	CHEMBL589366	CHEMBL1794364 (1) CHEMBL1794542 (1)	1 / 1
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	CHEMBL589366	CHEMBL2114853 (1)	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	CHEMBL589366	CHEMBL2114890 (1)	0 / 0
P10275	Androgen receptor	NR3C4	CHEMBL589366	CHEMBL1794321 (1) CHEMBL1794560 (1)	3 / 4
Q9NSA0	Solute carrier family 22 member 11	Transporter	CHEMBL589366	CHEMBL2077546 (1) CHEMBL2075391 (1)	0 / 0

CTD interaction (340)

compound	gene	gene name	gene description	interaction	interaction type	form	reference pmid
C025589	10351	ABCA8	ATP-binding cassette, sub-family A (ABC1), member 8	ABCA8 protein affects the transport of ochratoxin A	affects transport	protein	12379217
C025589	10351	ABCA8	ATP-binding cassette, sub-family A (ABC1), member 8	ochratoxin A inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]	decreases reaction / increases uptake	protein	12379217
C025589	10058	ABCB6 ABC ABC14 DUH3 LAN MCOPCB7 MTABC3 PRP umat	ATP-binding cassette, sub-family B (MDR/TAP), member 6	ochratoxin A results in decreased expression of ABCB6 mRNA	decreases expression	mRNA	19287073
C025589	1244	ABCC2 ABC30 CMOAT DJS MRP2 cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	ABCC2 protein affects the export of ochratoxin A	affects export	protein	15955639
C025589	1244	ABCC2 ABC30 CMOAT DJS MRP2 cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	ABCC2 protein affects the transport of ochratoxin A	affects transport	protein	19505989
C025589	1244	ABCC2 ABC30 CMOAT DJS MRP2 cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	biochanin A inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]	affects export / decreases reaction	protein	15955639
C025589	1244	ABCC2 ABC30 CMOAT DJS MRP2 cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	chrysin inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]	affects export / decreases reaction	protein	15955639
C025589	1244	ABCC2 ABC30 CMOAT DJS MRP2 cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Genistein inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]	affects export / decreases reaction	protein	15955639
C025589	1244	ABCC2 ABC30 CMOAT DJS MRP2 cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Polyphenols inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]	affects export / decreases reaction	protein	15955639
C025589	1244	ABCC2 ABC30 CMOAT DJS MRP2 cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Polyphenols metabolite inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]	affects export / decreases reaction	protein	15955639
C025589	1244	ABCC2 ABC30 CMOAT DJS MRP2 cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Quercetin inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]	affects export / decreases reaction	protein	15955639
C025589	1244	ABCC2 ABC30 CMOAT DJS MRP2 cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	resveratrol inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]	affects export / decreases reaction	protein	15955639
C025589	30	ACAA1 ACAA PTHIO THIO	acetyl-CoA acyltransferase 1 (EC:2.3.1.16)	ochratoxin A results in decreased expression of ACAA1 mRNA	decreases expression	mRNA	19287073
C025589	100380740			ochratoxin A results in decreased expression of ADFP mRNA	decreases expression	mRNA	19287073
C025589	196	AHR bHLHe76	aryl hydrocarbon receptor	ochratoxin A results in increased expression of AHR mRNA	increases expression	mRNA	21834667
C025589	204	AK2 ADK2 AK_2	adenylate kinase 2 (EC:2.7.4.3)	ochratoxin A results in increased expression of AK2 mRNA	increases expression	mRNA	22124623
C025589	1645	AKR1C1 2-ALPHA-HSD 20-ALPHA-HSD C9 DD1 DD1/DD2 DDH DDH1 H-37 HAKRC HBAB MBAB	aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112)	ochratoxin A results in decreased expression of AKR1C1 mRNA	decreases expression	mRNA	19287073
C025589	1646	AKR1C2 AKR1C-pseudo BABP DD DD2 DDH2 HAKRD HBAB MCDR2 SRXY8	aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357)	ochratoxin A results in decreased expression of AKR1C2 mRNA	decreases expression	mRNA	19287073
C025589	8644	AKR1C3 DD3 DDX HA1753 HAKRB HAKRe HSD17B5 PGFS hluPGFS	aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357)	ochratoxin A results in decreased expression of AKR1C3 mRNA	decreases expression	mRNA	19287073
C025589	213	ALB PRO0883 PRO0903 PRO1341	albumin	ALB protein results in decreased transport of ochratoxin A	decreases transport	protein	22037670
C025589	79868	ALG13 CDG1S CXorf45 GLT28D1 MDS031 TDRD13 YGL047W	ALG13, UDP-N-acetylglucosaminyltransferase subunit (EC:3.4.19.12 2.4.1.141)	ochratoxin A results in decreased expression of ALG13 mRNA	decreases expression	mRNA	19287073
C025589	8639	AOC3 HPAO SSAO VAP-1 VAP1	amine oxidase, copper containing 3 (EC:1.4.3.21)	ochratoxin A results in increased expression of AOC3 mRNA	increases expression	mRNA	22124623
C025589	317	APAF1 APAF-1 CED4	apoptotic peptidase activating factor 1	ochratoxin A results in decreased expression of APAF1 mRNA	decreases expression	mRNA	17316727
C025589	8542	APOL1 APO-L APOL APOL-I FSGS4	apolipoprotein L, 1	ochratoxin A results in decreased expression of APOL1 mRNA	decreases expression	mRNA	19287073
C025589	10565	ARFGEF1 ARFGEP1 BIG1 P200	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	ochratoxin A results in decreased expression of ARFGEF1 mRNA	decreases expression	mRNA	22124623
C025589	10123	ARL4C ARL7 LAK	ADP-ribosylation factor-like 4C	ochratoxin A results in decreased expression of ARL4C mRNA	decreases expression	mRNA	22124623
C025589	26225	ARL5A ARFLP5 ARL5	ADP-ribosylation factor-like 5A	ochratoxin A results in decreased expression of ARL5A mRNA	decreases expression	mRNA	22124623
C025589	488	ATP2A2 ATP2B DAR DD SERCA2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (EC:3.6.3.8)	ochratoxin A results in decreased expression of ATP2A2 mRNA	decreases expression	mRNA	19287073
C025589	506	ATP5B ATPMB ATPSB	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (EC:3.6.3.14)	ochratoxin A results in increased expression of ATP5B mRNA	increases expression	mRNA	17316727
C025589	513	ATP5D	ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit (EC:3.6.1.14)	ochratoxin A results in increased expression of ATP5D mRNA	increases expression	mRNA	17316727
C025589	522	ATP5J ATP5 ATP5A ATPM CF6 F6	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 (EC:3.6.1.14)	ochratoxin A results in increased expression of ATP5J mRNA	increases expression	mRNA	17316727
C025589	10677	AVIL ADVIL DOC6 p92	advillin	ochratoxin A results in increased expression of AVIL mRNA	increases expression	mRNA	22124623
C025589	10678	B3GNT2 B3GN-T2 B3GNT B3GNT-2 B3GNT1 BETA3GNT BGNT2 BGnT-2	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (EC:2.4.1.149)	ochratoxin A results in decreased expression of B3GNT2 mRNA	decreases expression	mRNA	22124623
C025589	11285	B4GALT7 EDSP1 XGALT1 XGPT1	xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (EC:2.4.1.133)	ochratoxin A results in decreased expression of B4GALT7 mRNA	decreases expression	mRNA	19287073
C025589	397543			ochratoxin A results in decreased expression of BAK protein	decreases expression	protein	19367635
C025589	581	BAX BCL2L4	BCL2-associated X protein	BAX protein results in increased susceptibility to ochratoxin A	increases response to substance	protein	20549612
C025589	581	BAX BCL2L4	BCL2-associated X protein	ochratoxin A affects the localization of BAX protein	affects localization	protein	20549612
C025589	581	BAX BCL2L4	BCL2-associated X protein	ochratoxin A results in decreased expression of BAX protein	decreases expression	protein	19367635
C025589	581	BAX BCL2L4	BCL2-associated X protein	ochratoxin A results in increased expression of BAX protein	increases expression	protein	20549612
C025589	27113	BBC3 JFY-1 JFY1 PUMA	BCL2 binding component 3	ochratoxin A results in decreased expression of BBC3 protein	decreases expression	protein	19367635
C025589	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	BCL2 protein results in decreased susceptibility to ochratoxin A	decreases response to substance	protein	20549612
C025589	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	ochratoxin A results in decreased expression of BCL2 protein	decreases expression	protein	20549612
C025589	598	BCL2L1 BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS	BCL2-like 1	BCL2L1 protein results in decreased susceptibility to ochratoxin A	decreases response to substance	protein	20549612
C025589	598	BCL2L1 BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS	BCL2-like 1	ochratoxin A results in decreased expression of BCL2L1 protein	decreases expression	protein	15056805
C025589	10904	BLCAP BC10	bladder cancer associated protein	ochratoxin A results in decreased expression of BLCAP mRNA	decreases expression	mRNA	22124623
C025589	716061			ochratoxin A results in decreased expression of C2ORF3 mRNA	decreases expression	mRNA	19287073
C025589	735	C9	complement component 9	ochratoxin A results in increased expression of C9 mRNA	increases expression	mRNA	22124623
C025589	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	ochratoxin A results in decreased expression of CASP3 mRNA	decreases expression	mRNA	17316727
C025589	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	ochratoxin A results in increased activity of CASP3 protein	increases activity	protein	15056805
C025589	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	ochratoxin A results in increased cleavage of and results in increased activity of CASP3 protein	increases activity / increases cleavage	protein	19367635 20549612
C025589	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	ochratoxin A results in increased cleavage of CASP3 protein	increases cleavage	protein	20060447
C025589	840	CASP7 CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3	caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)	ochratoxin A results in decreased expression of CASP7 mRNA	decreases expression	mRNA	17316727
C025589	841	CASP8 ALPS2B CAP4 Casp-8 FLICE MACH MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	ochratoxin A results in decreased expression of CASP8 mRNA	decreases expression	mRNA	17316727
C025589	842	CASP9 APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	ochratoxin A results in decreased expression of CASP9 mRNA	decreases expression	mRNA	17316727
C025589	842	CASP9 APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	ochratoxin A results in increased activity of CASP9 protein	increases activity	protein	15056805
C025589	842	CASP9 APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	ochratoxin A results in increased cleavage of and results in increased activity of CASP9 protein	increases activity / increases cleavage	protein	19367635
C025589	842	CASP9 APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	ochratoxin A results in increased cleavage of CASP9 protein	increases cleavage	protein	20549612
C025589	847	CAT	catalase (EC:1.11.1.6)	ochratoxin A results in increased expression of CAT mRNA	increases expression	mRNA	17316727
C025589	6358	CCL14 CC-1 CC-3 CKB1 HCC-1 HCC-1(1-74) HCC-1/HCC-3 HCC-3 MCIF NCC-2 NCC2 SCYA14 SCYL2 SY14	chemokine (C-C motif) ligand 14	ochratoxin A results in decreased expression of CCL14 mRNA	decreases expression	mRNA	19287073
C025589	891	CCNB1 CCNB	cyclin B1	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]	affects binding / decreases reaction	protein	22230261
C025589	891	CCNB1 CCNB	cyclin B1	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of CCNB1 protein]	decreases expression / decreases reaction	protein	22230261
C025589	891	CCNB1 CCNB	cyclin B1	MAPK14 protein promotes the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]	affects binding / decreases reaction / increases reaction	protein	22230261
C025589	891	CCNB1 CCNB	cyclin B1	MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CCNB1 protein]	decreases expression / increases reaction	protein	22230261
C025589	891	CCNB1 CCNB	cyclin B1	MAPK1 protein promotes the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]	affects binding / decreases reaction / increases reaction	protein	22230261
C025589	891	CCNB1 CCNB	cyclin B1	MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CCNB1 protein]	decreases expression / increases reaction	protein	22230261
C025589	891	CCNB1 CCNB	cyclin B1	ochratoxin A inhibits the reaction [CCNB1 protein binds to CDK1 protein]	affects binding / decreases reaction	protein	20060447
C025589	891	CCNB1 CCNB	cyclin B1	ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]	affects binding / decreases reaction	protein	22230261
C025589	891	CCNB1 CCNB	cyclin B1	ochratoxin A results in decreased expression of CCNB1 mRNA	decreases expression	mRNA	20060447
C025589	891	CCNB1 CCNB	cyclin B1	ochratoxin A results in decreased expression of CCNB1 protein	decreases expression	protein	20060447 22230261
C025589	891	CCNB1 CCNB	cyclin B1	SB 203580 inhibits the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]	affects binding / decreases reaction	protein	22230261
C025589	891	CCNB1 CCNB	cyclin B1	SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CCNB1 protein]	decreases expression / decreases reaction	protein	22230261
C025589	900	CCNG1 CCNG	cyclin G1	ochratoxin A results in decreased expression of CCNG1 mRNA	decreases expression	mRNA	19287073
C025589	100133941	CD24 CD24A	CD24 molecule	ochratoxin A results in decreased expression of CD24 mRNA	decreases expression	mRNA	19287073
C025589	10421	CD2BP2 FWP010 LIN1 PPP1R59 Snu40 U5-52K	CD2 (cytoplasmic tail) binding protein 2	ochratoxin A results in decreased expression of CD2BP2 mRNA	decreases expression	mRNA	19287073 22124623
C025589	995	CDC25C CDC25 PPP1R60	cell division cycle 25C (EC:3.1.3.48)	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of CDC25C protein]	decreases expression / decreases reaction	protein	22230261
C025589	995	CDC25C CDC25 PPP1R60	cell division cycle 25C (EC:3.1.3.48)	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of CDC25C protein modified form]	decreases expression / decreases reaction	protein	22230261
C025589	995	CDC25C CDC25 PPP1R60	cell division cycle 25C (EC:3.1.3.48)	MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDC25C protein]	decreases expression / increases reaction	protein	22230261
C025589	995	CDC25C CDC25 PPP1R60	cell division cycle 25C (EC:3.1.3.48)	MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDC25C protein modified form]	decreases expression / increases reaction	protein	22230261
C025589	995	CDC25C CDC25 PPP1R60	cell division cycle 25C (EC:3.1.3.48)	MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDC25C protein]	decreases expression / increases reaction	protein	22230261
C025589	995	CDC25C CDC25 PPP1R60	cell division cycle 25C (EC:3.1.3.48)	MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDC25C protein modified form]	decreases expression / increases reaction	protein	22230261
C025589	995	CDC25C CDC25 PPP1R60	cell division cycle 25C (EC:3.1.3.48)	ochratoxin A results in decreased expression of CDC25C mRNA	decreases expression	mRNA	20060447
C025589	995	CDC25C CDC25 PPP1R60	cell division cycle 25C (EC:3.1.3.48)	ochratoxin A results in decreased expression of CDC25C protein	decreases expression	protein	20060447 22230261
C025589	995	CDC25C CDC25 PPP1R60	cell division cycle 25C (EC:3.1.3.48)	ochratoxin A results in decreased expression of CDC25C protein modified form	decreases expression	protein	22230261
C025589	995	CDC25C CDC25 PPP1R60	cell division cycle 25C (EC:3.1.3.48)	SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDC25C protein]	decreases expression / decreases reaction	protein	22230261
C025589	995	CDC25C CDC25 PPP1R60	cell division cycle 25C (EC:3.1.3.48)	SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDC25C protein modified form]	decreases expression / decreases reaction	protein	22230261
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]	affects binding / decreases reaction	protein	22230261
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein]	decreases expression / decreases reaction	protein	22230261
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]	decreases expression / decreases reaction	protein	22230261
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	MAPK14 protein promotes the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]	affects binding / decreases reaction / increases reaction	protein	22230261
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein]	decreases expression / increases reaction	protein	22230261
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]	decreases expression / increases reaction	protein	22230261
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	MAPK1 protein promotes the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]	affects binding / decreases reaction / increases reaction	protein	22230261
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein]	decreases expression / increases reaction	protein	22230261
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]	decreases expression / increases reaction	protein	22230261
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	ochratoxin A inhibits the reaction [CCNB1 protein binds to CDK1 protein]	affects binding / decreases reaction	protein	20060447
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]	affects binding / decreases reaction	protein	22230261
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	ochratoxin A results in decreased expression of CDK1 mRNA	decreases expression	mRNA	20060447
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	ochratoxin A results in decreased expression of CDK1 protein	decreases expression	protein	20060447 22230261
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	ochratoxin A results in decreased expression of CDK1 protein modified form	decreases expression	protein	22230261
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	SB 203580 inhibits the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]	affects binding / decreases reaction	protein	22230261
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein]	decreases expression / decreases reaction	protein	22230261
C025589	983	CDK1 CDC2 CDC28A P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]	decreases expression / decreases reaction	protein	22230261
C025589	1026	CDKN1A CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	ochratoxin A results in decreased expression of CDKN1A mRNA	decreases expression	mRNA	17316727
C025589	1026	CDKN1A CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	ochratoxin A results in decreased expression of CDKN1A protein	decreases expression	protein	19367635
C025589	1050	CEBPA C/EBP-alpha CEBP	CCAAT/enhancer binding protein (C/EBP), alpha	ochratoxin A results in decreased expression of CEBPA	decreases expression		20590410
C025589	1051	CEBPB C/EBP-beta CRP2 IL6DBP LAP LIP NF-IL6 TCF5	CCAAT/enhancer binding protein (C/EBP), beta	ochratoxin A results in decreased expression of CEBPB mRNA	decreases expression	mRNA	19287073
C025589	1153	CIRBP CIRP	cold inducible RNA binding protein	ochratoxin A results in decreased expression of CIRBP mRNA	decreases expression	mRNA	22124623
C025589	51397	COMMD10 PTD002	COMM domain containing 10	ochratoxin A results in decreased expression of COMMD10 mRNA	decreases expression	mRNA	19287073
C025589	51122	COMMD2	COMM domain containing 2	ochratoxin A results in decreased expression of COMMD2 mRNA	decreases expression	mRNA	22124623
C025589	10229	COQ7 CAT5 CLK-1 CLK1	coenzyme Q7 homolog, ubiquinone (yeast)	ochratoxin A results in decreased expression of COQ7 mRNA	decreases expression	mRNA	19287073
C025589	1329	COX5B COXVB	cytochrome c oxidase subunit Vb (EC:1.9.3.1)	ochratoxin A results in increased expression of COX5B mRNA	increases expression	mRNA	17316727
C025589	9167	COX7A2L COX7AR COX7RP EB1 SIG81	cytochrome c oxidase subunit VIIa polypeptide 2 like	ochratoxin A results in increased expression of COX7A2L mRNA	increases expression	mRNA	17316727
C025589	1351	COX8A COX COX8 COX8-2 COX8L VIII VIII-L	cytochrome c oxidase subunit VIIIA (ubiquitous) (EC:1.9.3.1)	ochratoxin A results in increased expression of COX8A mRNA	increases expression	mRNA	17316727
C025589	57325	CSRP2BP ATAC2 CRP2BP KAT14 PRO1194 dJ717M23.1	CSRP2 binding protein	ochratoxin A results in decreased expression of CSRP2BP mRNA	decreases expression	mRNA	22124623
C025589	1495	CTNNA1 CAP102	catenin (cadherin-associated protein), alpha 1, 102kDa	ochratoxin A results in increased expression of CTNNA1 mRNA	increases expression	mRNA	22124623
C025589	9820	CUL7 KIAA0076 dJ20C7.5	cullin 7	ochratoxin A results in decreased expression of CUL7 mRNA	decreases expression	mRNA	19287073
C025589	1727	CYB5R3 B5R DIA1	cytochrome b5 reductase 3 (EC:1.6.2.2)	ochratoxin A results in decreased expression of CYB5R3 mRNA	decreases expression	mRNA	19287073
C025589	1535	CYBA p22-PHOX	cytochrome b-245, alpha polypeptide	ochratoxin A results in increased expression of CYBA mRNA	increases expression	mRNA	17316727
C025589	54205	CYCS CYC HCS THC4	cytochrome c, somatic	ochratoxin A affects the localization of CYCS protein	affects localization	protein	20549612
C025589	1588	CYP19A1 ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM	cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)	ochratoxin A results in increased expression of CYP19A1 protein	increases expression	protein	23296098
C025589	1543	CYP1A1 AHH AHRR CP11 CYP1 P1-450 P450-C P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	CYP1A1 protein results in increased susceptibility to ochratoxin A	increases response to substance	protein	8542584 21781659
C025589	1543	CYP1A1 AHH AHRR CP11 CYP1 P1-450 P450-C P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	ochratoxin A results in increased expression of CYP1A1 mRNA	increases expression	mRNA	17316727 21834667
C025589	1544	CYP1A2 CP12 P3-450 P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	CYP1A2 protein results in increased susceptibility to ochratoxin A	increases response to substance	protein	8542584 11189750 21781659
C025589	1544	CYP1A2 CP12 P3-450 P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	ochratoxin A results in increased expression of CYP1A2 mRNA	increases expression	mRNA	21834667
C025589	1555	CYP2B6 CPB6 CYP2B CYP2B7 CYP2B7P CYPIIB6 EFVM IIB1 P450	cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1)	ochratoxin A results in increased expression of CYP2B6 mRNA	increases expression	mRNA	21834667
C025589	1559	CYP2C9 CPC9 CYP2C CYP2C10 CYPIIC9 P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	CYP2C9 protein results in increased susceptibility to ochratoxin A	increases response to substance	protein	8542584 21781659
C025589	1559	CYP2C9 CPC9 CYP2C CYP2C10 CYPIIC9 P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	ochratoxin A results in increased expression of CYP2C9 mRNA	increases expression	mRNA	21834667
C025589	1571	CYP2E1 CPE1 CYP2E P450-J P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	CYP2E1 protein results in increased susceptibility to ochratoxin A	increases response to substance	protein	11189750
C025589	1576	CYP3A4 CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	CYP3A4 protein results in increased susceptibility to ochratoxin A	increases response to substance	protein	8542584 21781659
C025589	1576	CYP3A4 CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	ochratoxin A results in increased expression of CYP3A4 mRNA	increases expression	mRNA	21834667
C025589	1577	CYP3A5 CP35 CYPIIIA5 P450PCN3 PCN3	cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1)	CYP3A5 protein results in increased susceptibility to ochratoxin A	increases response to substance	protein	11189750
C025589	1577	CYP3A5 CP35 CYPIIIA5 P450PCN3 PCN3	cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1)	ochratoxin A results in increased expression of CYP3A5 mRNA	increases expression	mRNA	21834667
C025589	84259	DCUN1D5	DCN1, defective in cullin neddylation 1, domain containing 5	ochratoxin A results in increased expression of DCUN1D5 mRNA	increases expression	mRNA	22124623
C025589	1717	DHCR7 SLOS	7-dehydrocholesterol reductase (EC:1.3.1.21)	ochratoxin A results in decreased expression of DHCR7 mRNA	decreases expression	mRNA	19287073
C025589	56616	DIABLO DFNA64 SMAC	diablo, IAP-binding mitochondrial protein	ochratoxin A results in decreased expression of DIABLO mRNA	decreases expression	mRNA	17316727
C025589	11083	DIDO1 BYE1 C20orf158 DATF-1 DATF1 DIDO2 DIDO3 DIO-1 DIO1 dJ885L7.8	death inducer-obliterator 1	ochratoxin A results in decreased expression of DIDO1 mRNA	decreases expression	mRNA	19287073
C025589	129563	DIS3L2 FAM6A PRLMNS hDIS3L2	DIS3 mitotic control homolog (S. cerevisiae)-like 2	ochratoxin A results in increased expression of DIS3L2 mRNA	increases expression	mRNA	22124623
C025589	8847	DLEU2 1B4 BCMSUN DLB2 LEU2 LINC00022 MIR15AHG NCRNA00022 RFP2OS TRIM13OS	deleted in lymphocytic leukemia 2 (non-protein coding)	ochratoxin A results in decreased expression of DLEU2 mRNA	decreases expression	mRNA	19287073
C025589	1798	DPAGT1 ALG7 CDG-Ij CDG1J CMSTA2 D11S366 DGPT DPAGT DPAGT2 G1PT GPT UAGT UGAT	dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) (EC:2.7.8.15)	ochratoxin A results in decreased expression of DPAGT1 mRNA	decreases expression	mRNA	19287073
C025589	23333	DPY19L1	dpy-19-like 1 (C. elegans)	ochratoxin A results in increased expression of DPY19L1 mRNA	increases expression	mRNA	22124623
C025589	1632	ECI1 DCI	enoyl-CoA delta isomerase 1 (EC:5.3.3.8)	ochratoxin A results in decreased expression of ECI1 mRNA	decreases expression	mRNA	19287073
C025589	30844	EHD4 PAST4	EH-domain containing 4	ochratoxin A results in decreased expression of EHD4 mRNA	decreases expression	mRNA	22124623
C025589	27436	EML4 C2orf2 ELP120 EMAP-4 EMAPL4 ROPP120	echinoderm microtubule associated protein like 4	ochratoxin A results in decreased expression of EML4 mRNA	decreases expression	mRNA	19287073
C025589	2029	ENSA ARPP-19e	endosulfine alpha	ochratoxin A results in decreased expression of ENSA mRNA	decreases expression	mRNA	22124623
C025589	2034	EPAS1 ECYT4 HIF2A HLF MOP2 PASD2 bHLHe73	endothelial PAS domain protein 1	EPAS1 protein inhibits the reaction [ochratoxin A results in decreased expression of VEGFA protein]	decreases expression / decreases reaction	protein	21554934
C025589	2034	EPAS1 ECYT4 HIF2A HLF MOP2 PASD2 bHLHe73	endothelial PAS domain protein 1	ochratoxin A results in decreased expression of EPAS1 protein	decreases expression	protein	21554934
C025589	2066	ERBB4 ALS19 HER4 p180erbB4	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 (EC:2.7.10.1)	ochratoxin A results in decreased expression of ERBB4 mRNA	decreases expression	mRNA	22124623
C025589	2152	F3 CD142 TF TFA	coagulation factor III (thromboplastin, tissue factor)	ochratoxin A inhibits the reaction [IL1B protein results in increased expression of F3 protein]	decreases reaction / increases expression	protein	18289624
C025589	2152	F3 CD142 TF TFA	coagulation factor III (thromboplastin, tissue factor)	ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]	decreases reaction / increases activity	protein	18289624
C025589	2152	F3 CD142 TF TFA	coagulation factor III (thromboplastin, tissue factor)	ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased expression of F3 mRNA]	decreases reaction / increases expression	mRNA	18289624
C025589	2152	F3 CD142 TF TFA	coagulation factor III (thromboplastin, tissue factor)	ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]	decreases reaction / increases expression	protein	18289624
C025589	2152	F3 CD142 TF TFA	coagulation factor III (thromboplastin, tissue factor)	ochratoxin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of F3 protein]	decreases reaction / increases expression	protein	18289624
C025589	2152	F3 CD142 TF TFA	coagulation factor III (thromboplastin, tissue factor)	ochratoxin A inhibits the reaction [TNF protein results in increased expression of F3 protein]	decreases reaction / increases expression	protein	18289624
C025589	2153	F5 FVL PCCF RPRGL1 THPH2	coagulation factor V (proaccelerin, labile factor)	ochratoxin A results in decreased expression of F5 mRNA	decreases expression	mRNA	19287073
C025589	2167	FABP4 A-FABP AFABP ALBP aP2	fatty acid binding protein 4, adipocyte	ochratoxin A results in decreased expression of FABP4	decreases expression		20590410
C025589	8772	FADD MORT1	Fas (TNFRSF6)-associated via death domain	ochratoxin A results in decreased expression of FADD mRNA	decreases expression	mRNA	17316727
C025589	3992	FADS1 D5D FADS6 FADSD5 LLCDL1 TU12	fatty acid desaturase 1 (EC:1.14.19.-)	ochratoxin A results in decreased expression of FADS1 mRNA	decreases expression	mRNA	19287073
C025589	81889	FAHD1 C16orf36 YISKL	fumarylacetoacetate hydrolase domain containing 1 (EC:3.7.1.5)	ochratoxin A results in decreased expression of FAHD1 mRNA	decreases expression	mRNA	22124623
C025589	151354	FAM84A NSE1 PP11517	family with sequence similarity 84, member A	ochratoxin A results in decreased expression of FAM84A mRNA	decreases expression	mRNA	22124623
C025589	355	FAS ALPS1A APO-1 APT1 CD95 FAS1 FASTM TNFRSF6	Fas cell surface death receptor	ochratoxin A results in decreased expression of FAS mRNA	decreases expression	mRNA	17316727
C025589	8817	FGF18 FGF-18 ZFGF5	fibroblast growth factor 18	ochratoxin A results in increased expression of FGF18 mRNA	increases expression	mRNA	22124623
C025589	2353	FOS AP-1 C-FOS p55	FBJ murine osteosarcoma viral oncogene homolog	ochratoxin A results in increased expression of FOS mRNA	increases expression	mRNA	17316727
C025589	2487	FRZB FRE FRITZ FRP-3 FRZB-1 FRZB-PEN FRZB1 FZRB OS1 SFRP3 SRFP3 hFIZ	frizzled-related protein	ochratoxin A results in increased expression of FRZB mRNA	increases expression	mRNA	22124623
C025589	2528	FUT6 FCT3A FT1A Fuc-TVI FucT-VI	fucosyltransferase 6 (alpha (1,3) fucosyltransferase) (EC:2.4.1.65)	ochratoxin A results in decreased expression of FUT6 mRNA	decreases expression	mRNA	19287073
C025589	35646			ochratoxin A results in decreased expression of GADD45 mRNA	decreases expression	mRNA	17316727
C025589	2697	GJA1 AVSD3 CMDR CX43 DFNB38 GJAL HLHS1 HSS ODDD	gap junction protein, alpha 1, 43kDa	ochratoxin A results in increased phosphorylation of GJA1 protein	increases phosphorylation	protein	11711124
C025589	2814	GP5 CD42d GPV	glycoprotein V (platelet)	ochratoxin A results in increased expression of GP5 mRNA	increases expression	mRNA	22124623
C025589	2876	GPX1 GPXD GSHPX1	glutathione peroxidase 1 (EC:1.11.1.9)	ochratoxin A results in increased expression of GPX1 mRNA	increases expression	mRNA	17316727
C025589	2878	GPX3 GPx-P GSHPx-3 GSHPx-P	glutathione peroxidase 3 (plasma) (EC:1.11.1.9)	ochratoxin A results in increased expression of GPX3 mRNA	increases expression	mRNA	17316727
C025589	9446	GSTO1 GSTO_1-1 GSTTLp28 P28 SPG-R	glutathione S-transferase omega 1 (EC:2.5.1.18 1.8.5.1 1.20.4.2)	ochratoxin A results in decreased expression of GSTO1 mRNA	decreases expression	mRNA	19287073
C025589	9446	GSTO1 GSTO_1-1 GSTTLp28 P28 SPG-R	glutathione S-transferase omega 1 (EC:2.5.1.18 1.8.5.1 1.20.4.2)	ochratoxin A results in decreased expression of GSTO1 protein	decreases expression	protein	19287073
C025589	404672	GTF2H5 C6orf175 TFB5 TFIIH TGF2H5 TTD TTD-A TTDA bA120J8.2	general transcription factor IIH, polypeptide 5	ochratoxin A results in increased expression of GTF2H5 mRNA	increases expression	mRNA	22124623
C025589	3014	H2AFX H2A.X H2A/X H2AX	H2A histone family, member X	ochratoxin A results in decreased expression of H2AFX mRNA	decreases expression	mRNA	19287073
C025589	10767	HBS1L EF-1a ERFS HBS1 HSPC276	HBS1-like (S. cerevisiae)	ochratoxin A results in increased expression of HBS1L mRNA	increases expression	mRNA	22124623
C025589	3010	HIST1H1T H1FT H1t dJ221C16.2	histone cluster 1, H1t	ochratoxin A results in increased expression of HIST1H1T mRNA	increases expression	mRNA	22124623
C025589	3148	HMGB2 HMG2	high mobility group box 2	ochratoxin A results in decreased expression of HMGB2 mRNA	decreases expression	mRNA	22124623
C025589	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	ochratoxin A results in decreased expression of HMOX1 mRNA	decreases expression	mRNA	17316727
C025589	3303	HSPA1A HSP70-1 HSP70-1A HSP70I HSP72 HSPA1	heat shock 70kDa protein 1A	ochratoxin A results in decreased expression of HSPA1A mRNA	decreases expression	mRNA	17316727 19051279 19367635
C025589	3303	HSPA1A HSP70-1 HSP70-1A HSP70I HSP72 HSPA1	heat shock 70kDa protein 1A	ochratoxin A results in decreased expression of HSPA1A protein	decreases expression	protein	19051279 19367635
C025589	3309	HSPA5 BIP GRP78 MIF2	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	ochratoxin A results in decreased expression of HSPA5 mRNA	decreases expression	mRNA	19051279
C025589	3313	HSPA9 CSA GRP-75 GRP75 HSPA9B MOT MOT2 MTHSP75 PBP74	heat shock 70kDa protein 9 (mortalin)	ochratoxin A results in decreased expression of HSPA9 mRNA	decreases expression	mRNA	19051279
C025589	3315	HSPB1 CMT2F HMN2B HS.76067 HSP27 HSP28 Hsp25 SRP27	heat shock 27kDa protein 1	ochratoxin A results in decreased expression of HSPB1 mRNA	decreases expression	mRNA	19051279 19367635
C025589	3315	HSPB1 CMT2F HMN2B HS.76067 HSP27 HSP28 Hsp25 SRP27	heat shock 27kDa protein 1	ochratoxin A results in decreased expression of HSPB1 protein	decreases expression	protein	19051279 19367635
C025589	3420	IDH3B H-IDHB RP46	isocitrate dehydrogenase 3 (NAD+) beta (EC:1.1.1.41)	ochratoxin A results in decreased expression of IDH3B mRNA	decreases expression	mRNA	19287073
C025589	3421	IDH3G H-IDHG	isocitrate dehydrogenase 3 (NAD+) gamma (EC:1.1.1.41)	ochratoxin A results in decreased expression of IDH3G mRNA	decreases expression	mRNA	19287073
C025589	3481	IGF2 C11orf43 IGF-II PP9974	insulin-like growth factor 2 (somatomedin A)	ochratoxin A results in decreased expression of IGF2 mRNA	decreases expression	mRNA	19287073
C025589	3484	IGFBP1 AFBP IBP1 IGF-BP25 PP12 hIGFBP-1	insulin-like growth factor binding protein 1	ochratoxin A results in decreased expression of IGFBP1 mRNA	decreases expression	mRNA	19287073
C025589	3484	IGFBP1 AFBP IBP1 IGF-BP25 PP12 hIGFBP-1	insulin-like growth factor binding protein 1	ochratoxin A results in decreased expression of IGFBP1 protein	decreases expression	protein	19287073
C025589	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	ochratoxin A inhibits the reaction [IL1B protein results in increased expression of F3 protein]	decreases reaction / increases expression	protein	18289624
C025589	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	ochratoxin A inhibits the reaction [IL1B protein results in increased expression of IL8 protein]	decreases reaction / increases expression	protein	18308354
C025589	7850	IL1R2 CD121b CDw121b IL-1R-2 IL-1RT-2 IL-1RT2 IL1R2c IL1RB	interleukin 1 receptor, type II	ochratoxin A results in increased expression of IL1R2 mRNA	increases expression	mRNA	22124623
C025589	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	ochratoxin A inhibits the reaction [IL1B protein results in increased expression of IL8 protein]	decreases reaction / increases expression	protein	18308354
C025589	23210	JMJD6 PSR PTDSR PTDSR1	jumonji domain containing 6 (EC:1.14.11.-)	ochratoxin A results in increased expression of JMJD6 mRNA	increases expression	mRNA	22124623
C025589	3725	JUN AP-1 AP1 c-Jun	jun proto-oncogene	ochratoxin A results in decreased expression of JUN mRNA	decreases expression	mRNA	17316727
C025589	3726	JUNB AP-1	jun B proto-oncogene	ochratoxin A results in increased expression of JUNB mRNA	increases expression	mRNA	17316727
C025589	23189	KANK1 ANKRD15 CPSQ2 KANK	KN motif and ankyrin repeat domains 1	ochratoxin A results in increased expression of KANK1 mRNA	increases expression	mRNA	22124623
C025589	3758	KCNJ1 KIR1.1 ROMK ROMK1	potassium inwardly-rectifying channel, subfamily J, member 1	ochratoxin A results in decreased expression of KCNJ1 mRNA	decreases expression	mRNA	22124623
C025589	3772	KCNJ15 IRKK KIR1.3 KIR4.2	potassium inwardly-rectifying channel, subfamily J, member 15	ochratoxin A results in decreased expression of KCNJ15 mRNA	decreases expression	mRNA	22124623
C025589	23588	KLHDC2 HCLP-1 HCLP1 LCP	kelch domain containing 2	ochratoxin A results in decreased expression of KLHDC2 mRNA	decreases expression	mRNA	22124623
C025589	3866	KRT15 CK15 K15 K1CO	keratin 15	ochratoxin A results in increased expression of KRT15 mRNA	increases expression	mRNA	22124623
C025589	4023	LPL HDLCQ11 LIPD	lipoprotein lipase (EC:3.1.1.34)	ochratoxin A results in decreased expression of LPL	decreases expression		20590410
C025589	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in increased phosphorylation of MAPK1 protein]	decreases reaction / increases phosphorylation	protein	22230261
C025589	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	MAPK1 protein promotes the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]	affects binding / decreases reaction / increases reaction	protein	22230261
C025589	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CCNB1 protein]	decreases expression / increases reaction	protein	22230261
C025589	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDC25C protein]	decreases expression / increases reaction	protein	22230261
C025589	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDC25C protein modified form]	decreases expression / increases reaction	protein	22230261
C025589	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein]	decreases expression / increases reaction	protein	22230261
C025589	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]	decreases expression / increases reaction	protein	22230261
C025589	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	MAPK1 protein results in increased susceptibility to ochratoxin A	increases response to substance	protein	22230261
C025589	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	ochratoxin A results in increased phosphorylation of and results in increased activity of MAPK1 protein	increases activity / increases phosphorylation	protein	11711124
C025589	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	ochratoxin A results in increased phosphorylation of MAPK1 protein	increases phosphorylation	protein	22230261
C025589	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]	affects binding / decreases reaction / increases reaction	protein	22230261
C025589	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CCNB1 protein]	decreases expression / increases reaction	protein	22230261
C025589	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDC25C protein]	decreases expression / increases reaction	protein	22230261
C025589	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDC25C protein modified form]	decreases expression / increases reaction	protein	22230261
C025589	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein]	decreases expression / increases reaction	protein	22230261
C025589	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]	decreases expression / increases reaction	protein	22230261
C025589	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein results in increased susceptibility to ochratoxin A	increases response to substance	protein	22230261
C025589	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in increased phosphorylation of MAPK3 protein]	decreases reaction / increases phosphorylation	protein	22230261
C025589	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	ochratoxin A results in increased phosphorylation of and results in increased activity of MAPK3 protein	increases activity / increases phosphorylation	protein	11711124
C025589	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	ochratoxin A results in increased phosphorylation of MAPK3 protein	increases phosphorylation	protein	22230261
C025589	22919	MAPRE1 EB1	microtubule-associated protein, RP/EB family, member 1	ochratoxin A results in decreased expression of MAPRE1 mRNA	decreases expression	mRNA	19287073
C025589	4155	MBP	myelin basic protein	ochratoxin A results in increased expression of MBP mRNA	increases expression	mRNA	22124623
C025589	9412	MED21 SRB7 SURB7 hSrb7	mediator complex subunit 21	ochratoxin A results in decreased expression of MED21 mRNA	decreases expression	mRNA	22124623
C025589	9526	MPDU1 CDGIF HBEBP2BPA Lec35 My008 PP3958 PQLC5 SL15	mannose-P-dolichol utilization defect 1	ochratoxin A results in decreased expression of MPDU1 mRNA	decreases expression	mRNA	19287073
C025589	23164	MPRIP M-RIP MRIP RHOIP3 RIP3 p116Rip	myosin phosphatase Rho interacting protein	ochratoxin A results in decreased expression of MPRIP mRNA	decreases expression	mRNA	22124623
C025589	4489	MT1A MT1 MT1S MTC	metallothionein 1A	[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT1A mRNA	affects cotreatment / increases expression	mRNA	19720134
C025589	4490	MT1B MT1 MT1Q MTP	metallothionein 1B	[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT1B mRNA	affects cotreatment / increases expression	mRNA	19720134
C025589	4502	MT2A MT2	metallothionein 2A	[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT2A mRNA	affects cotreatment / increases expression	mRNA	19720134
C025589	4502	MT2A MT2	metallothionein 2A	ochratoxin A results in increased expression of MT2A mRNA	increases expression	mRNA	19720134
C025589	4502	MT2A MT2	metallothionein 2A	Zinc deficiency inhibits the reaction [ochratoxin A results in increased expression of MT2A mRNA]	decreases reaction / increases expression	mRNA	19720134
C025589	4609	MYC MRTL MYCC bHLHe39 c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	ochratoxin A results in decreased expression of MYC mRNA	decreases expression	mRNA	17316727
C025589	79829	NAA40 NAT11 PATT1	N(alpha)-acetyltransferase 40, NatD catalytic subunit (EC:2.3.1.-)	ochratoxin A results in decreased expression of NAA40 mRNA	decreases expression	mRNA	19287073
C025589	4668	NAGA D22S674 GALB	N-acetylgalactosaminidase, alpha- (EC:3.2.1.49)	ochratoxin A results in decreased expression of NAGA mRNA	decreases expression	mRNA	19287073
C025589	55577	NAGK GNK HSA242910	N-acetylglucosamine kinase (EC:2.7.1.59)	ochratoxin A results in decreased expression of NAGK mRNA	decreases expression	mRNA	22124623
C025589	4694	NDUFA1 CI-MWFE MWFE ZNF183	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa (EC:1.6.99.3)	ochratoxin A results in increased expression of NDUFA1 mRNA	increases expression	mRNA	17316727
C025589	4705	NDUFA10 CI-42KD CI-42k	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa (EC:1.6.5.3 1.6.99.3)	ochratoxin A results in increased expression of NDUFA10 mRNA	increases expression	mRNA	17316727
C025589	4696	NDUFA3 B9 CI-B9	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa	ochratoxin A results in increased expression of NDUFA3 mRNA	increases expression	mRNA	17316727
C025589	4701	NDUFA7 B14.5a	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa	ochratoxin A results in increased expression of NDUFA7 mRNA	increases expression	mRNA	17316727
C025589	4708	NDUFB2 AGGG CI-AGGG	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa (EC:1.6.5.3 1.6.99.3)	ochratoxin A results in increased expression of NDUFB2 mRNA	increases expression	mRNA	17316727
C025589	4713	NDUFB7 B18 CI-B18	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa (EC:1.6.5.3 1.6.99.3)	ochratoxin A results in increased expression of NDUFB7 mRNA	increases expression	mRNA	17316727
C025589	4717	NDUFC1 KFYI	NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa	ochratoxin A results in increased expression of NDUFC1 mRNA	increases expression	mRNA	17316727
C025589	4726	NDUFS6 CI-13kA CI-13kD-A CI13KDA	NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) (EC:1.6.5.3 1.6.99.3)	ochratoxin A results in increased expression of NDUFS6 mRNA	increases expression	mRNA	17316727
C025589	374291	NDUFS7 CI-20 CI-20KD MY017 PSST	NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) (EC:1.6.5.3 1.6.99.3)	ochratoxin A results in increased expression of NDUFS7 mRNA	increases expression	mRNA	17316727
C025589	1728	NQO1 DHQU DIA4 DTD NMOR1 NMORI QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	ochratoxin A results in increased expression of NQO1 mRNA	increases expression	mRNA	17316727
C025589	3084	NRG1 ARIA GGF GGF2 HGL HRG HRG1 HRGA MST131 NDF SMDF	neuregulin 1	ochratoxin A results in decreased expression of NRG1 mRNA	decreases expression	mRNA	22124623
C025589	29095	ORMDL2 MST095 MSTP095 adoplin-2	ORM1-like 2 (S. cerevisiae)	ochratoxin A results in decreased expression of ORMDL2 mRNA	decreases expression	mRNA	19287073
C025589	10914	PAPOLA PAP	poly(A) polymerase alpha (EC:2.7.7.19)	ochratoxin A results in decreased expression of PAPOLA mRNA	decreases expression	mRNA	22124623
C025589	5106	PCK2 PEPCK PEPCK-M PEPCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial) (EC:4.1.1.32)	ochratoxin A results in decreased expression of PCK2 mRNA	decreases expression	mRNA	19287073
C025589	5111	PCNA	proliferating cell nuclear antigen	ochratoxin A results in decreased expression of PCNA mRNA	decreases expression	mRNA	17316727
C025589	5165	PDK3 CMTX6	pyruvate dehydrogenase kinase, isozyme 3 (EC:2.7.11.2)	ochratoxin A results in decreased expression of PDK3 mRNA	decreases expression	mRNA	19287073
C025589	55825	PECR DCRRP HPDHASE HSA250303 PVIARL SDR29C1 TERP	peroxisomal trans-2-enoyl-CoA reductase (EC:1.3.1.38)	ochratoxin A results in decreased expression of PECR mRNA	decreases expression	mRNA	19287073
C025589	5211	PFKL PFK-B	phosphofructokinase, liver (EC:2.7.1.11)	ochratoxin A results in decreased expression of PFKL mRNA	decreases expression	mRNA	19287073
C025589	5230	PGK1 MIG10 PGKA	phosphoglycerate kinase 1 (EC:2.7.2.3)	ochratoxin A results in decreased expression of PGK1 mRNA	decreases expression	mRNA	19287073
C025589	55650	PIGV GPI-MT-II HPMRS1 PIG-V	phosphatidylinositol glycan anchor biosynthesis, class V	ochratoxin A results in decreased expression of PIGV mRNA	decreases expression	mRNA	19287073
C025589	80235	PIGZ GPI-MT-IV PIG-Z SMP3	phosphatidylinositol glycan anchor biosynthesis, class Z	ochratoxin A results in decreased expression of PIGZ mRNA	decreases expression	mRNA	19287073
C025589	5329	PLAUR CD87 U-PAR UPAR URKR	plasminogen activator, urokinase receptor	ochratoxin A results in increased expression of PLAUR mRNA	increases expression	mRNA	22124623
C025589	5468	PPARG CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma	peroxisome proliferator-activated receptor gamma	ochratoxin A results in decreased activity of PPARG protein	decreases activity	protein	20590410
C025589	5468	PPARG CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma	peroxisome proliferator-activated receptor gamma	ochratoxin A results in decreased expression of PPARG	decreases expression		20590410
C025589	5468	PPARG CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma	peroxisome proliferator-activated receptor gamma	ochratoxin A results in increased phosphorylation of PPARG protein	increases phosphorylation	protein	20590410
C025589	5519	PPP2R1B PP2A-Abeta PR65B	protein phosphatase 2, regulatory subunit A, beta (EC:3.1.3.16)	ochratoxin A results in decreased expression of PPP2R1B mRNA	decreases expression	mRNA	19287073
C025589	5532	PPP3CB CALNA2 CALNB CNA2 PP2Bbeta	protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)	ochratoxin A results in decreased expression of PPP3CB mRNA	decreases expression	mRNA	19287073 22124623
C025589	10113	PREB SEC12	prolactin regulatory element binding	ochratoxin A results in decreased expression of PREB mRNA	decreases expression	mRNA	19287073
C025589	5553	PRG2 BMPG MBP MBP1	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	ochratoxin A results in increased expression of PRG2 mRNA	increases expression	mRNA	22124623
C025589	5629	PROX1	prospero homeobox 1	ochratoxin A results in decreased expression of PROX1 mRNA	decreases expression	mRNA	19287073
C025589	8899	PRPF4B PR4H PRP4 PRP4H PRP4K dJ1013A10.1	pre-mRNA processing factor 4B (EC:2.7.11.1)	ochratoxin A results in decreased expression of PRPF4B mRNA	decreases expression	mRNA	22124623
C025589	5728	PTEN 10q23del BZS CWS1 DEC GLM2 MHAM MMAC1 PTEN1 TEP1	phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48)	ochratoxin A results in decreased expression of PTEN mRNA	decreases expression	mRNA	19287073
C025589	5912	RAP2B	RAP2B, member of RAS oncogene family	ochratoxin A results in decreased expression of RAP2B mRNA	decreases expression	mRNA	22124623
C025589	10125	RASGRP1 CALDAG-GEFI CALDAG-GEFII RASGRP V hRasGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	ochratoxin A results in decreased expression of RASGRP1 mRNA	decreases expression	mRNA	22124623
C025589	5928	RBBP4 NURF55 RBAP48	retinoblastoma binding protein 4	ochratoxin A results in decreased expression of RBBP4 mRNA	decreases expression	mRNA	19287073
C025589	5984	RFC4 A1 RFC37	replication factor C (activator 1) 4, 37kDa	ochratoxin A results in decreased expression of RFC4 mRNA	decreases expression	mRNA	22124623
C025589	388	RHOB ARH6 ARHB MST081 MSTP081 RHOH6	ras homolog family member B	ochratoxin A results in decreased expression of RHOB mRNA	decreases expression	mRNA	19287073
C025589	6117	RPA1 HSSB MST075 REPA1 RF-A RP-A RPA70	replication protein A1, 70kDa	ochratoxin A results in increased expression of RPA1 mRNA	increases expression	mRNA	22124623
C025589	6137	RPL13 BBC1 D16S444E D16S44E L13	ribosomal protein L13 (EC:3.6.5.3)	ochratoxin A results in increased expression of RPL13 mRNA	increases expression	mRNA	22124623
C025589	10556	RPP30 TSG15	ribonuclease P/MRP 30kDa subunit (EC:3.1.26.5)	ochratoxin A results in increased expression of RPP30 mRNA	increases expression	mRNA	22124623
C025589	6209	RPS15 RIG S15	ribosomal protein S15	ochratoxin A results in increased expression of RPS15 mRNA	increases expression	mRNA	22124623
C025589	80230	RUFY1 RABIP4 ZFYVE12	RUN and FYVE domain containing 1	ochratoxin A results in decreased expression of RUFY1 mRNA	decreases expression	mRNA	22124623
C025589	6305	SBF1 CMT4B3 DENND7A MTMR5	SET binding factor 1	ochratoxin A results in decreased expression of SBF1 mRNA	decreases expression	mRNA	19287073
C025589	6309	SC5D ERG3 S5DES SC5DL	sterol-C5-desaturase (EC:1.14.21.6)	ochratoxin A results in decreased expression of SC5D mRNA	decreases expression	mRNA	19287073
C025589	22828	SCAF8 RBM16	SR-related CTD-associated factor 8	ochratoxin A results in decreased expression of SCAF8 mRNA	decreases expression	mRNA	22124623
C025589	6319	SCD FADS5 MSTP008 SCD1 SCDOS	stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1)	ochratoxin A results in decreased expression of SCD mRNA	decreases expression	mRNA	19287073
C025589	5055	SERPINB2 HsT1201 PAI PAI-2 PAI2 PLANH2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINB2 mRNA]	decreases reaction / increases expression	mRNA	18289624
C025589	5055	SERPINB2 HsT1201 PAI PAI-2 PAI2 PLANH2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINB2 protein]	decreases reaction / increases expression	protein	18289624
C025589	6464	SHC1 SHC SHCA	SHC (Src homology 2 domain containing) transforming protein 1	ochratoxin A results in decreased expression of SHC1 mRNA	decreases expression	mRNA	19287073
C025589	4891	SLC11A2 DCT1 DMT1 NRAMP2	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2	ochratoxin A results in decreased expression of SLC11A2 mRNA	decreases expression	mRNA	19287073 22124623
C025589	55867	SLC22A11 OAT4 hOAT4	solute carrier family 22 (organic anion/urate transporter), member 11	SLC22A11 protein affects the transport of ochratoxin A	affects transport	protein	10660625
C025589	9356	SLC22A6 HOAT1 OAT1 PAHT ROAT1	solute carrier family 22 (organic anion transporter), member 6	Chlorides promotes the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]	increases reaction / increases uptake	protein	17353191
C025589	9356	SLC22A6 HOAT1 OAT1 PAHT ROAT1	solute carrier family 22 (organic anion transporter), member 6	SLC22A6 protein results in increased uptake of ochratoxin A	increases uptake	protein	16098483 17353191
C025589	9376	SLC22A8 OAT3	solute carrier family 22 (organic anion transporter), member 8	SLC22A8 protein affects the transport of ochratoxin A	affects transport	protein	11306713
C025589	9376	SLC22A8 OAT3	solute carrier family 22 (organic anion transporter), member 8	SLC22A8 protein results in increased uptake of ochratoxin A	increases uptake	protein	16098483
C025589	7779	SLC30A1 ZNT1 ZRC1	solute carrier family 30 (zinc transporter), member 1	ochratoxin A promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A1 mRNA]	decreases expression / increases reaction	mRNA	19720134
C025589	7779	SLC30A1 ZNT1 ZRC1	solute carrier family 30 (zinc transporter), member 1	Zinc inhibits the reaction [ochratoxin A promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A1 mRNA]]	decreases expression / decreases reaction / increases reaction	mRNA	19720134
C025589	64924	SLC30A5 ZNT5 ZNTL1 ZTL1 ZnT-5	solute carrier family 30 (zinc transporter), member 5	[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with ochratoxin A] results in decreased expression of SLC30A5 mRNA	affects cotreatment / decreases expression	mRNA	19720134
C025589	55676	SLC30A6 MST103 MSTP103 ZNT6	solute carrier family 30 (zinc transporter), member 6	[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with ochratoxin A] results in decreased expression of SLC30A6 mRNA	affects cotreatment / decreases expression	mRNA	19720134
C025589	148867	SLC30A7 ZNT7 ZnT-7 ZnTL2	solute carrier family 30 (zinc transporter), member 7	[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with ochratoxin A co-treated with Zinc] results in decreased expression of SLC30A7 mRNA	affects cotreatment / decreases expression	mRNA	19720134
C025589	148867	SLC30A7 ZNT7 ZnT-7 ZnTL2	solute carrier family 30 (zinc transporter), member 7	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [ochratoxin A results in decreased expression of SLC30A7 mRNA]	decreases expression / increases reaction	mRNA	19720134
C025589	148867	SLC30A7 ZNT7 ZnT-7 ZnTL2	solute carrier family 30 (zinc transporter), member 7	ochratoxin A results in decreased expression of SLC30A7 mRNA	decreases expression	mRNA	19720134
C025589	27173	SLC39A1 ZIP1 ZIRTL	solute carrier family 39 (zinc transporter), member 1	ochratoxin A results in decreased expression of SLC39A1 mRNA	decreases expression	mRNA	19720134
C025589	27173	SLC39A1 ZIP1 ZIRTL	solute carrier family 39 (zinc transporter), member 1	Zinc deficiency promotes the reaction [ochratoxin A results in decreased expression of SLC39A1 mRNA]	decreases expression / increases reaction	mRNA	19720134
C025589	57181	SLC39A10 LZT-Hs2	solute carrier family 39 (zinc transporter), member 10	[ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in decreased expression of SLC39A10 mRNA	affects cotreatment / decreases expression	mRNA	19720134
C025589	57181	SLC39A10 LZT-Hs2	solute carrier family 39 (zinc transporter), member 10	[ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of SLC39A10 mRNA	affects cotreatment / decreases expression	mRNA	19720134
C025589	23516	SLC39A14 LZT-Hs4 NET34 ZIP14 cig19	solute carrier family 39 (zinc transporter), member 14	[ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of SLC39A14 mRNA	affects cotreatment / decreases expression	mRNA	19720134
C025589	7922	SLC39A7 D6S115E D6S2244E H2-KE4 HKE4 KE4 RING5 ZIP7	solute carrier family 39 (zinc transporter), member 7	ochratoxin A results in decreased expression of SLC39A7 mRNA	decreases expression	mRNA	19720134
C025589	55334	SLC39A9 ZIP-9 ZIP9	solute carrier family 39, member 9	ochratoxin A results in decreased expression of SLC39A9 mRNA	decreases expression	mRNA	19720134
C025589	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	ochratoxin A results in increased expression of SOD2 mRNA	increases expression	mRNA	17316727
C025589	6649	SOD3 EC-SOD	superoxide dismutase 3, extracellular (EC:1.15.1.1)	ochratoxin A results in increased expression of SOD3 mRNA	increases expression	mRNA	17316727
C025589	6652	SORD SORD1	sorbitol dehydrogenase (EC:1.1.1.14)	ochratoxin A results in increased expression of SORD mRNA	increases expression	mRNA	22124623
C025589	6655	SOS2	son of sevenless homolog 2 (Drosophila)	ochratoxin A results in decreased expression of SOS2 mRNA	decreases expression	mRNA	22124623
C025589	55812	SPATA7 HSD-3.1 HSD3 LCA3	spermatogenesis associated 7	ochratoxin A results in decreased expression of SPATA7 mRNA	decreases expression	mRNA	22124623
C025589	26010	SPATS2L DNAPTP6 SGNP	spermatogenesis associated, serine-rich 2-like	ochratoxin A results in increased expression of SPATS2L mRNA	increases expression	mRNA	22124623
C025589	6711	SPTBN1 ELF SPTB2 betaSpII	spectrin, beta, non-erythrocytic 1	ochratoxin A results in decreased expression of SPTBN1 mRNA	decreases expression	mRNA	19287073
C025589	10254	STAM2 Hbp STAM2A STAM2B	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	ochratoxin A results in decreased expression of STAM2 mRNA	decreases expression	mRNA	19287073
C025589	6781	STC1 STC	stanniocalcin 1	ochratoxin A results in increased expression of STC1 mRNA	increases expression	mRNA	22124623
C025589	8417	STX7	syntaxin 7	ochratoxin A results in decreased expression of STX7 mRNA	decreases expression	mRNA	22124623
C025589	23435	TARDBP ALS10 TDP-43	TAR DNA binding protein	ochratoxin A results in decreased expression of TARDBP mRNA	decreases expression	mRNA	19287073
C025589	140738	TMEM37 PR PR1	transmembrane protein 37	ochratoxin A results in decreased expression of TMEM37 mRNA	decreases expression	mRNA	22124623
C025589	757	TMEM50B C21orf4 HCVP7TP3	transmembrane protein 50B	ochratoxin A results in decreased expression of TMEM50B mRNA	decreases expression	mRNA	22124623
C025589	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	ochratoxin A inhibits the reaction [TNF protein results in increased expression of F3 protein]	decreases reaction / increases expression	protein	18289624
C025589	7132	TNFRSF1A CD120a FPF MS5 TBP1 TNF-R TNF-R-I TNF-R55 TNFAR TNFR1 TNFR1-d2 TNFR55 TNFR60 p55 p55-R p60	tumor necrosis factor receptor superfamily, member 1A	ochratoxin A results in decreased expression of TNFRSF1A mRNA	decreases expression	mRNA	17316727
C025589	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	ochratoxin A results in increased expression of TP53 protein	increases expression	protein	19367635
C025589	7170	TPM3 CAPM1 CFTD NEM1 OK/SW-cl.5 TM-5 TM3 TM30 TM30nm TM5 TPMsk3 TRK hscp30	tropomyosin 3	ochratoxin A results in increased expression of TPM3 mRNA	increases expression	mRNA	22124623
C025589	22906	TRAK1 MILT1 OIP106	trafficking protein, kinesin binding 1	ochratoxin A results in decreased expression of TRAK1 mRNA	decreases expression	mRNA	22124623
C025589	8805	TRIM24 PTC6 RNF82 TF1A TIF1 TIF1A TIF1ALPHA hTIF1	tripartite motif containing 24	ochratoxin A results in decreased expression of TRIM24 mRNA	decreases expression	mRNA	22124623
C025589	8295	TRRAP PAF350/400 PAF400 STAF40 TR-AP Tra1	transformation/transcription domain-associated protein	ochratoxin A results in decreased expression of TRRAP mRNA	decreases expression	mRNA	19287073
C025589	81027	TUBB1	tubulin, beta 1 class VI	ochratoxin A results in decreased expression of TUBB1 mRNA	decreases expression	mRNA	19287073
C025589	25828	TXN2 MT-TRX MTRX TRX2	thioredoxin 2	ochratoxin A results in increased expression of TXN2 mRNA	increases expression	mRNA	17316727
C025589	7351	UCP2 BMIQ4 SLC25A8 UCPH	uncoupling protein 2 (mitochondrial, proton carrier)	ochratoxin A results in decreased expression of UCP2 mRNA	decreases expression	mRNA	19287073 22124623
C025589	7351	UCP2 BMIQ4 SLC25A8 UCPH	uncoupling protein 2 (mitochondrial, proton carrier)	ochratoxin A results in increased expression of UCP2 mRNA	increases expression	mRNA	17316727
C025589	7352	UCP3 SLC25A9	uncoupling protein 3 (mitochondrial, proton carrier)	ochratoxin A results in increased expression of UCP3 mRNA	increases expression	mRNA	17316727 22124623
C025589	54578	UGT1A6 GNT1 HLUGP HLUGP1 UDPGT UDPGT_1-6 UGT1 UGT1A6S UGT1F	UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17)	ochratoxin A results in increased expression of UGT1A6 mRNA	increases expression	mRNA	17316727
C025589	65109	UPF3B HUPF3B MRXS14 RENT3B UPF3X	UPF3 regulator of nonsense transcripts homolog B (yeast)	ochratoxin A results in decreased expression of UPF3B mRNA	decreases expression	mRNA	22124623
C025589	708396			ochratoxin A results in increased expression of UQCR mRNA	increases expression	mRNA	17316727
C025589	7388	UQCRH QCR6 UQCR8	ubiquinol-cytochrome c reductase hinge protein (EC:1.10.2.2)	ochratoxin A results in increased expression of UQCRH mRNA	increases expression	mRNA	17316727
C025589	27089	UQCRQ MC3DN4 QCR8 QP-C QPC UQCR7	ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa (EC:1.10.2.2)	ochratoxin A results in increased expression of UQCRQ mRNA	increases expression	mRNA	17316727
C025589	7422	VEGFA MVCD1 VEGF VPF	vascular endothelial growth factor A	EPAS1 protein inhibits the reaction [ochratoxin A results in decreased expression of VEGFA protein]	decreases expression / decreases reaction	protein	21554934
C025589	7422	VEGFA MVCD1 VEGF VPF	vascular endothelial growth factor A	ochratoxin A results in decreased expression of VEGFA protein	decreases expression	protein	21554934
C025589	7422	VEGFA MVCD1 VEGF VPF	vascular endothelial growth factor A	Oxygen deficiency inhibits the reaction [ochratoxin A results in decreased expression of VEGFA protein]	decreases expression / decreases reaction	protein	21554934
C025589	55339	WDR33 NET14 WDC146	WD repeat domain 33	ochratoxin A results in decreased expression of WDR33 mRNA	decreases expression	mRNA	22124623
C025589	7498	XDH XO XOR	xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2)	ochratoxin A results in increased expression of XDH mRNA	increases expression	mRNA	17316727
C025589	22834	ZNF652	zinc finger protein 652	ochratoxin A results in decreased expression of ZNF652 mRNA	decreases expression	mRNA	19287073

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (32)

OMIM	preferred title	UniProt
#202300	Adrenocortical carcinoma, hereditary; adcc	P04637
#300068	Androgen insensitivity syndrome; ais	P10275
#312300	Androgen insensitivity, partial; pais	P10275
#614740	Basal cell carcinoma, susceptibility to, 7; bcc7	P04637
%606641	Body mass index; bmi	P37231
#609338	Carotid intimal medial thickness 1	P37231
#119900	Digital clubbing, isolated congenital	P15428
#237500	Dubin-johnson syndrome; djs	Q92887
#133239	Esophageal cancer	P04637
#615363	Estrogen resistance; estrr	P03372
#301500	Fabry disease	P06280
#608013	Gaucher disease, perinatal lethal	P04062
#230800	Gaucher disease, type i	P04062
#230900	Gaucher disease, type ii	P04062
#231000	Gaucher disease, type iii	P04062
#231005	Gaucher disease, type iiic	P04062
#137800	Glioma susceptibility 1; glm1	P37231
#232300	Glycogen storage disease ii	P10253
#259100	Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1	P15428
#151623	Li-fraumeni syndrome 1; lfs1	P04637
#604367	Lipodystrophy, familial partial, type 3; fpld3	P37231
#211980	Lung cancer	P04637
#607948	Mycobacterium tuberculosis, susceptibility to	P11473
#601665	Obesity	P37231
#260500	Papilloma of choroid plexus; cpp	P04637
#168600	Parkinson disease, late-onset; pd	P04062
#313200	Spinal and bulbar muscular atrophy, x-linked 1; smax1	P10275
#275355	Squamous cell carcinoma, head and neck; hnscc	P04637
#188570	Thyroid hormone resistance, generalized, autosomal dominant; grth	P10828
#274300	Thyroid hormone resistance, generalized, autosomal recessive; grth	P10828
#145650	Thyroid hormone resistance, selective pituitary; prth	P10828
#277440	Vitamin d-dependent rickets, type 2a; vddr2a	P11473

KEGG DISEASE (57)

KEGG	disease name	UniProt
H00026	Endometrial Cancer	P03372 (marker) P04637 (related)
H00066	Lewy body dementia (LBD)	P04062 (related)
H00126	Gaucher disease	P04062 (related)
H00426	Defects in the degradation of ganglioside	P04062 (related)
H00810	Progressive myoclonic epilepsy (PME)	P04062 (related)
H00599	46,XX disorders of sex development (Disorders related to androgen excess)	P04150 (related)
H00004	Chronic myeloid leukemia (CML)	P04637 (related)
H00005	Chronic lymphocytic leukemia (CLL)	P04637 (related)
H00006	Hairy-cell leukemia	P04637 (related)
H00008	Burkitt lymphoma	P04637 (related)
H00009	Adult T-cell leukemia	P04637 (related)
H00010	Multiple myeloma	P04637 (related)
H00013	Small cell lung cancer	P04637 (related)
H00014	Non-small cell lung cancer	P04637 (related)
H00015	Malignant pleural mesothelioma	P04637 (related)
H00016	Oral cancer	P04637 (related) P04637 (marker)
H00017	Esophageal cancer	P04637 (related) P04637 (marker)
H00018	Gastric cancer	P04637 (related)
H00019	Pancreatic cancer	P04637 (related) P04637 (marker)
H00020	Colorectal cancer	P04637 (related) P04637 (marker)
H00022	Bladder cancer	P04637 (related)
H00025	Penile cancer	P04637 (related) P04637 (marker)
H00027	Ovarian cancer	P04637 (related)
H00028	Choriocarcinoma	P04637 (related)
H00029	Vulvar cancer	P04637 (related)
H00031	Breast cancer	P04637 (related)
H00032	Thyroid cancer	P04637 (related) P37231 (related)
H00033	Adrenal carcinoma	P04637 (related)
H00036	Osteosarcoma	P04637 (related)
H00038	Malignant melanoma	P04637 (related)
H00039	Basal cell carcinoma	P04637 (related)
H00040	Squamous cell carcinoma	P04637 (related)
H00041	Kaposi's sarcoma	P04637 (related)
H00042	Glioma	P04637 (related) P04637 (marker)
H00044	Cancer of the anal canal	P04637 (related)
H00046	Cholangiocarcinoma	P04637 (related)
H00047	Gallbladder cancer	P04637 (related)
H00048	Hepatocellular carcinoma	P04637 (related)
H00055	Laryngeal cancer	P04637 (related) P04637 (marker)
H00881	Li-Fraumeni syndrome	P04637 (related)
H01007	Choroid plexus papilloma	P04637 (related)
H00021	Renal cell carcinoma	P04637 (marker)
H00125	Fabry disease	P06280 (related)
H00069	Glycogen storage diseases (GSD)	P10253 (related)
H00024	Prostate cancer	P10275 (related)
H00062	Spinal and bulbar muscular atrophy (SBMA)	P10275 (related)
H00608	46,XY disorders of sex development (Disorders in androgen synthesis or action)	P10275 (related)
H00609	46,XY disorders of sex development (Other)	P10275 (related)
H00249	Thyroid hormone resistance syndrome	P10828 (related)
H00342	Tuberculosis	P11473 (related)
H00784	Localized autosomal recessive hypotrichosis	P11473 (related)
H01143	Vitamin D-dependent rickets	P11473 (related)
H00457	Primary hypertrophic osteoarthropathy (PHO)	P15428 (related)
H01246	Isolated congenital nail clubbing (ICNC)	P15428 (related)
H00409	Type II diabetes mellitus	P37231 (related)
H00420	Familial partial lipodystrophy (FPL)	P37231 (related)
H00208	Hyperbilirubinemia	Q92887 (related)

Diseases related to CTD interactions

18 disease from interactions of metabolites

MeSH disease	compound	disease name	evidence type	reference pmid
D000236	C025589	Adenoma	marker/mechanism	17344223
D001943	C025589	Breast Neoplasms	marker/mechanism	11921183
D002277	C025589	Carcinoma	marker/mechanism	17344223
D019465	C025589	Craniofacial Abnormalities	marker/mechanism	20036863
D005355	C025589	Fibrosis	marker/mechanism	16622519
D042822	C025589	Genomic Instability	marker/mechanism	21551354 21622941
D007674	C025589	Kidney Diseases	marker/mechanism	11409539 14994279 19490938 21554934 21781659 22124623
D007680	C025589	Kidney Neoplasms	marker/mechanism	1820338 16251485 17316727 17344223 17483316 17651772 18417182 21622941 22124623 22403158
D008103	C025589	Liver Cirrhosis	marker/mechanism	16857307
D008113	C025589	Liver Neoplasms	marker/mechanism	1820338 11711124
D008325	C025589	Mammary Neoplasms, Experimental	marker/mechanism	11921183
D008850	C025589	Microphthalmos	marker/mechanism	20036863
D009436	C025589	Neural Tube Defects	marker/mechanism	16922921 17688467 20036863 20201966
D011041	C025589	Poisoning	marker/mechanism	17449898
D011201	C025589	Poultry Diseases	marker/mechanism	20460662
D011230	C025589	Precancerous Conditions	marker/mechanism	19717638
D013736	C025589	Testicular Neoplasms	marker/mechanism	22069556
D014571	C025589	Urologic Neoplasms	marker/mechanism	21781659

KNApSAcK Metabolite C00003008

Index Metabolite Species Human Protein / Gene in interactions Related Diseases

Metabolite

KNApSAcK Entry

Cluster

Link

ChEMBL

KEGG

CTD

Species

Summary

Plant class

Family

List (3)

* NCBI

Human Protein / Gene in interaction

20 ChEMBL Protein in interactions

CTD interaction (340)

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (32)

KEGG DISEASE (57)

Diseases related to CTD interactions

18 disease from interactions of metabolites

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases