Metabolite

KNApSAcK Entry

id C00003025
Name Zearalenone
CAS RN 17924-92-4
Standard InChI InChI=1S/C18H22O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,20-21H,2,4-6,8-9H2,1H3/b7-3+/t12-/m0/s1
Standard InChI (Main Layer) InChI=1S/C18H22O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,20-21H,2,4-6,8-9H2,1H3

Cluster

Phytochemical cluster
KCF-S cluster No. 790

Link

ChEMBL

By standard InChI CHEMBL454173
By standard InChI Main Layer CHEMBL454173 CHEMBL1330445 CHEMBL1397216

KEGG

By LinkDB C09981

CTD

By CAS RN D015025

Species

Summary

Plant class

class name count

Family

family name count
Nectriaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Gibberella zeae 5518 Nectriaceae Fungi

Human Protein / Gene in interaction

48 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL454173 CHEMBL2114895 (1)
7 / 44
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim CHEMBL454173 CHEMBL1004482 (1)
0 / 0
Q14289 Protein-tyrosine kinase 2-beta Fak CHEMBL1330445 CHEMBL1614388 (1)
0 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL454173 CHEMBL1330445 CHEMBL1613842 (2)
4 / 2
Q99700 Ataxin-2 Unclassified protein CHEMBL454173 CHEMBL2114784 (1)
1 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL454173 CHEMBL1794573 (2)
2 / 2
Q15759 Mitogen-activated protein kinase 11 p38 CHEMBL454173 CHEMBL1004486 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL1330445 CHEMBL1614103 (1) CHEMBL1614031 (1)
1 / 1
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL454173 CHEMBL1794524 (2) CHEMBL1794552 (3)
0 / 0
Q9H2G2 STE20-like serine/threonine-protein kinase STE serine/threonine protein kinase SLK subfamily CHEMBL454173 CHEMBL1004491 (1)
0 / 0
Q16659 Mitogen-activated protein kinase 6 CMGC serine/threonine protein kinase ERK3 subfamily CHEMBL454173 CHEMBL1004485 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL1330445 CHEMBL1614544 (1)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL454173 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL454173 CHEMBL1794399 (1)
3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 CHEMBL454173 CHEMBL1794471 (1)
0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim CHEMBL454173 CHEMBL1004481 (1)
0 / 0
O00444 Serine/threonine-protein kinase PLK4 PLK serine/threonine protein kinase subfamily CHEMBL454173 CHEMBL1004495 (1)
0 / 0
Q9NQU5 Serine/threonine-protein kinase PAK 6 STE serine/threonine protein kinase PAKB subfamily CHEMBL454173 CHEMBL1004496 (1)
0 / 0
O75828 Carbonyl reductase [NADPH] 3 Enzyme CHEMBL454173 CHEMBL1004501 (1) CHEMBL1004502 (1)
CHEMBL1004503 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL454173 CHEMBL1794376 (1) CHEMBL1794339 (1)
2 / 3
Q13188 Serine/threonine-protein kinase 3 STE serine/threonine protein kinase MST subfamily CHEMBL454173 CHEMBL1004490 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL454173 CHEMBL1330445 CHEMBL1397216 CHEMBL1614458 (4)
0 / 0
P07332 Tyrosine-protein kinase Fes/Fps Fer CHEMBL454173 CHEMBL1004488 (1)
0 / 0
P16152 Carbonyl reductase [NADPH] 1 Enzyme CHEMBL454173 CHEMBL1004498 (1) CHEMBL1004499 (1)
CHEMBL1004500 (1) CHEMBL1004504 (1)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL454173 CHEMBL992088 (1)
0 / 1
P10145 Interleukin-8 Secreted protein CHEMBL454173 CHEMBL2114835 (2)
0 / 0
Q99683 Mitogen-activated protein kinase kinase kinase 5 Ste11 CHEMBL454173 CHEMBL1004489 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL454173 CHEMBL1794382 (3) CHEMBL1794456 (1)
0 / 1
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL454173 CHEMBL1794510 (1)
5 / 3
P52564 Dual specificity mitogen-activated protein kinase kinase 6 Ste7 CHEMBL454173 CHEMBL1004493 (1)
0 / 0
Q96RI1 Bile acid receptor NR1H4 CHEMBL454173 CHEMBL1794437 (2)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL454173 CHEMBL1613808 (2)
0 / 0
O14976 Cyclin-G-associated kinase NAK serine/threonine protein kinase subfamily CHEMBL454173 CHEMBL1004484 (1)
0 / 0
O94804 Serine/threonine-protein kinase 10 STE serine/threonine protein kinase SLK subfamily CHEMBL454173 CHEMBL1004492 (1)
1 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL454173 CHEMBL1614227 (2)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL454173 CHEMBL1330445 CHEMBL1614038 (3)
2 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL454173 CHEMBL2114842 (2)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1330445 CHEMBL1738588 (1) CHEMBL1738317 (1)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL454173 CHEMBL1794364 (3) CHEMBL1794542 (3)
1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL454173 CHEMBL1614240 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL454173 CHEMBL1397216 CHEMBL1614108 (3) CHEMBL1613886 (3)
0 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL454173 CHEMBL2114890 (2)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL454173 CHEMBL1794321 (1) CHEMBL1794560 (2)
3 / 4
Q9HCP0 Casein kinase I isoform gamma-1 Ck1 CHEMBL454173 CHEMBL1004494 (1)
0 / 0
Q86V86 Serine/threonine-protein kinase pim-3 Pim CHEMBL454173 CHEMBL1004483 (1)
0 / 0
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein CHEMBL1330445 CHEMBL1613874 (1)
0 / 0
P08238 Heat shock protein HSP 90-beta Other cytosolic protein CHEMBL1330445 CHEMBL1613874 (1)
0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL454173 CHEMBL2354287 (1)
1 / 1

CTD interaction (193)

compound gene gene name gene description interaction interaction type form reference
pmid
D015025 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 ABCC1 protein results in increased transport of Zearalenone increases transport
protein 19647055
D015025 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 verlukast inhibits the reaction [ABCC1 protein results in increased transport of Zearalenone] decreases reaction
/ increases transport
protein 19647055
D015025 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Zearalenone inhibits the reaction [ABCC1 protein results in increased transport of calcein AM] decreases reaction
/ increases transport
protein 19647055
D015025 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Zearalenone results in increased expression of ABCC1 protein increases expression
protein 19580841
D015025 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 ABCC2 protein results in increased transport of Zearalenone increases transport
protein 19647055
D015025 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 verlukast inhibits the reaction [ABCC2 protein results in increased transport of Zearalenone] decreases reaction
/ increases transport
protein 19647055
D015025 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Zearalenone inhibits the reaction [ABCC2 protein results in increased transport of calcein AM] decreases reaction
/ increases transport
protein 19647055
D015025 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Zearalenone results in increased expression of ABCC2 mRNA increases expression
mRNA 19580841
D015025 8714 ABCC3
ABC31
EST90757
MLP2
MOAT-D
MRP3
cMOAT2
ATP-binding cassette, sub-family C (CFTR/MRP), member 3 Zearalenone inhibits the reaction [ABCC3 protein results in increased transport of calcein AM] decreases reaction
/ increases transport
protein 19647055
D015025 8714 ABCC3
ABC31
EST90757
MLP2
MOAT-D
MRP3
cMOAT2
ATP-binding cassette, sub-family C (CFTR/MRP), member 3 Zearalenone results in decreased expression of ABCC3 mRNA decreases expression
mRNA 19371625
D015025 9429 ABCG2
ABC15
ABCP
BCRP
BCRP1
BMDP
CD338
CDw338
EST157481
GOUT1
MRX
MXR
MXR1
UAQTL1
ATP-binding cassette, sub-family G (WHITE), member 2 Zearalenone results in increased expression of ABCG2 mRNA increases expression
mRNA 19580841
D015025 1238 ACKR2
CCBP2
CCR10
CCR9
CMKBR9
D6
hD6
atypical chemokine receptor 2 Zearalenone results in decreased expression of ACKR2 mRNA decreases expression
mRNA 19371625
D015025 56999 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9 Zearalenone results in increased expression of ADAMTS9 mRNA increases expression
mRNA 19371625
D015025 249 ALPL
AP-TNAP
APTNAP
HOPS
TNAP
TNSALP
alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) fulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein] affects binding
/ decreases reaction
/ increases activity
protein 12650720
D015025 249 ALPL
AP-TNAP
APTNAP
HOPS
TNAP
TNSALP
alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) [Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein affects binding
/ increases activity
protein 12650720
D015025 251 ALPPL2
ALPG
ALPPL
GCAP
alkaline phosphatase, placental-like 2 (EC:3.1.3.1) Zearalenone results in increased expression of ALPPL2 mRNA increases expression
mRNA 19371625
D015025 64682 ANAPC1
APC1
MCPR
TSG24
anaphase promoting complex subunit 1 Zearalenone results in increased expression of ANAPC1 mRNA increases expression
mRNA 19371625
D015025 55107 ANO1
DOG1
ORAOV2
TAOS2
TMEM16A
anoctamin 1, calcium activated chloride channel Zearalenone results in increased expression of ANO1 mRNA increases expression
mRNA 19371625
D015025 348 APOE
AD2
LDLCQ5
LPG
apolipoprotein E Zearalenone results in decreased expression of APOE mRNA decreases expression
mRNA 19371625
D015025 367 AR
AIS
DHTR
HUMARA
HYSP1
KD
NR3C4
SBMA
SMAX1
TFM
androgen receptor Zearalenone inhibits the reaction [Metribolone results in increased activity of AR protein] decreases reaction
/ increases activity
protein 18324785
D015025 367 AR
AIS
DHTR
HUMARA
HYSP1
KD
NR3C4
SBMA
SMAX1
TFM
androgen receptor Zearalenone inhibits the reaction [Testosterone binds to and results in increased activity of AR protein] affects binding
/ decreases reaction
/ increases activity
protein 21803136
D015025 427 ASAH1
AC
ACDase
ASAH
PHP
PHP32
SMAPME
N-acylsphingosine amidohydrolase (acid ceramidase) 1 (EC:3.5.1.23) Zearalenone results in decreased expression of ASAH1 mRNA decreases expression
mRNA 19371625
D015025 80150 ASRGL1
ALP
ALP1
CRASH
asparaginase like 1 (EC:3.5.1.1 3.4.19.5) Zearalenone results in increased expression of ASRGL1 mRNA increases expression
mRNA 19371625
D015025 64756 ATPAF1
ATP11
ATP11p
ATP synthase mitochondrial F1 complex assembly factor 1 Zearalenone results in decreased expression of ATPAF1 mRNA decreases expression
mRNA 19371625
D015025 581 BAX
BCL2L4
BCL2-associated X protein Zearalenone affects the localization of BAX protein affects localization
protein 19541794
D015025 636 BICD1
BICD
bicaudal D homolog 1 (Drosophila) Zearalenone results in increased expression of BICD1 mRNA increases expression
mRNA 19371625
D015025 662 BNIP1
NIP1
SEC20
TRG-8
BCL2/adenovirus E1B 19kDa interacting protein 1 Zearalenone results in increased expression of BNIP1 mRNA increases expression
mRNA 19371625
D015025 79680 C22orf29
BOP
chromosome 22 open reading frame 29 Zearalenone results in increased expression of C22ORF29 mRNA increases expression
mRNA 19371625
D015025 50854 C6orf48
D6S57
G8
chromosome 6 open reading frame 48 Zearalenone results in decreased expression of C6ORF48 mRNA decreases expression
mRNA 19371625
D015025 760 CA2
CA-II
CAC
CAII
Car2
carbonic anhydrase II (EC:4.2.1.1) Zearalenone results in increased expression of CA2 mRNA increases expression
mRNA 19371625
D015025 91768 CABLES1
CABL1
CABLES
HsT2563
IK3-1
Cdk5 and Abl enzyme substrate 1 Zearalenone results in increased expression of CABLES1 mRNA increases expression
mRNA 19371625
D015025 10753 CAPN9
GC36
nCL-4
calpain 9 (EC:3.4.22.-) Zearalenone results in increased expression of CAPN9 mRNA increases expression
mRNA 19371625
D015025 833 CARS
CARS1
CYSRS
MGC:11246
cysteinyl-tRNA synthetase (EC:6.1.1.16) Zearalenone results in increased expression of CARS mRNA increases expression
mRNA 19371625
D015025 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Zearalenone results in increased activity of CASP3 protein increases activity
protein 19541794
19705349
D015025 863 CBFA2T3
ETO2
MTG16
MTGR2
ZMYND4
core-binding factor, runt domain, alpha subunit 2; translocated to, 3 Zearalenone results in increased expression of CBFA2T3 mRNA increases expression
mRNA 19371625
D015025 1052 CEBPD
C/EBP-delta
CELF
CRP3
NF-IL6-beta
CCAAT/enhancer binding protein (C/EBP), delta Zearalenone results in increased expression of CEBPD mRNA increases expression
mRNA 19371625
D015025 1081 CGA
CG-ALPHA
FSHA
GPHA1
GPHa
HCG
LHA
TSHA
glycoprotein hormones, alpha polypeptide fulvestrant inhibits the reaction [Zearalenone results in increased expression of CGA protein] decreases reaction
/ increases expression
protein 19580841
D015025 1081 CGA
CG-ALPHA
FSHA
GPHA1
GPHa
HCG
LHA
TSHA
glycoprotein hormones, alpha polypeptide Zearalenone results in increased expression of CGA protein increases expression
protein 19580841
D015025 1082 CGB
CGB3
CGB5
CGB7
CGB8
hCGB
chorionic gonadotropin, beta polypeptide Zearalenone results in increased expression of CGB protein increases expression
protein 22310176
D015025 494143 CHAC2
ChaC, cation transport regulator homolog 2 (E. coli) Zearalenone results in increased expression of CHAC2 mRNA increases expression
mRNA 19371625
D015025 84518 CNFN
PLAC8L2
cornifelin Zearalenone results in decreased expression of CNFN mRNA decreases expression
mRNA 19371625
D015025 23603 CORO1C
HCRNN4
coronin, actin binding protein, 1C Zearalenone results in increased expression of CORO1C mRNA increases expression
mRNA 19371625
D015025 51596 CUTA
ACHAP
C6orf82
cutA divalent cation tolerance homolog (E. coli) Zearalenone results in decreased expression of CUTA mRNA decreases expression
mRNA 19371625
D015025 1523 CUX1
CASP
CDP
CDP/Cut
CDP1
COY1
CUTL1
CUX
Clox
Cux/CDP
GOLIM6
Nbla10317
p100
p110
p200
p75
cut-like homeobox 1 Zearalenone results in decreased expression of CUX1 mRNA decreases expression
mRNA 19371625
D015025 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic Zearalenone affects the localization of CYCS protein affects localization
protein 19541794
D015025 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) Zearalenone results in decreased activity of CYP19A1 protein decreases activity
protein 16023337
D015025 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Tamoxifen inhibits the reaction [Zearalenone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]] decreases reaction
/ increases activity
protein 15157572
D015025 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Tamoxifen inhibits the reaction [Zearalenone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]] decreases reaction
/ increases expression
mRNA 15157572
D015025 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Zearalenone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] decreases reaction
/ increases activity
protein 15157572
D015025 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Zearalenone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 15157572
D015025 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Zearalenone results in decreased activity of CYP1A1 protein decreases activity
protein 15157572
D015025 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Zearalenone results in decreased expression of CYP1A1 mRNA decreases expression
mRNA 15157572
D015025 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) CYP1A2 protein results in increased hydroxylation of Zearalenone increases hydroxylation
protein 19931366
D015025 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) [CYP1A2 protein results in increased hydroxylation of Zearalenone] which results in increased chemical synthesis of Catechols increases chemical synthesis
/ increases hydroxylation
protein 19931366
D015025 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) Zearalenone promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1B1 protein] increases activity
/ increases reaction
protein 15157572
D015025 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) Zearalenone results in increased activity of CYP1B1 protein increases activity
protein 15157572
D015025 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) Zearalenone results in increased expression of CYP3A4 mRNA increases expression
mRNA 15569515
D015025 308585 Zearalenone results in decreased expression of DHRS10 mRNA decreases expression
mRNA 19371625
D015025 9249 DHRS3
DD83.1
RDH17
Rsdr1
SDR1
SDR16C1
retSDR1
dehydrogenase/reductase (SDR family) member 3 (EC:1.1.1.300) Zearalenone results in increased expression of DHRS3 mRNA increases expression
mRNA 19371625
D015025 55715 DOK4
docking protein 4 Zearalenone results in increased expression of DOK4 mRNA increases expression
mRNA 19371625
D015025 1891 ECH1
HPXEL
enoyl CoA hydratase 1, peroxisomal Zearalenone results in decreased expression of ECH1 mRNA decreases expression
mRNA 19371625
D015025 2037 EPB41L2
4.1-G
4.1G
erythrocyte membrane protein band 4.1-like 2 Zearalenone results in increased expression of EPB41L2 mRNA increases expression
mRNA 19371625
D015025 55040 EPN3
epsin 3 Zearalenone results in decreased expression of EPN3 mRNA decreases expression
mRNA 19371625
D015025 2065 ERBB3
ErbB-3
HER3
LCCS2
MDA-BF-1
c-erbB-3
c-erbB3
erbB3-S
p180-ErbB3
p45-sErbB3
p85-sErbB3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (EC:2.7.10.1) Zearalenone results in decreased expression of ERBB3 mRNA decreases expression
mRNA 19371625
D015025 2071 ERCC3
BTF2
GTF2H
RAD25
TFIIH
XPB
excision repair cross-complementing rodent repair deficiency, complementation group 3 (EC:3.6.4.12) Zearalenone results in increased expression of ERCC3 mRNA increases expression
mRNA 19371625
D015025 121506 ERP27
C12orf46
PDIA8
endoplasmic reticulum protein 27 Zearalenone results in decreased expression of ERP27 mRNA decreases expression
mRNA 19371625
D015025 83715 ESPN
DFNB36
espin Zearalenone results in increased expression of ESPN mRNA increases expression
mRNA 19371625
D015025 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 fulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein] affects binding
/ decreases reaction
/ increases activity
protein 12650720
D015025 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Zearalenone binds to and results in decreased activity of ESR1 protein affects binding
/ decreases activity
protein 15084758
D015025 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Zearalenone binds to and results in increased activity of ESR1 protein affects binding
/ increases activity
protein 9751507
15084758
D015025 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Zearalenone binds to ESR1 protein affects binding
protein 11162928
12598185
15169976
19233257
19913605
D015025 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 [Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein affects binding
/ increases activity
protein 12650720
D015025 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Zearalenone promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form] affects binding
/ increases reaction
protein 19233257
D015025 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Zearalenone promotes the reaction [NCOA2 protein binds to ESR1 protein] affects binding
/ increases reaction
protein 15084758
D015025 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Zearalenone results in increased activity of ESR1 protein increases activity
protein 11331656
D015025 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) Zearalenone binds to and results in decreased activity of ESR2 protein affects binding
/ decreases activity
protein 15084758
D015025 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) Zearalenone binds to and results in increased activity of ESR2 protein affects binding
/ increases activity
protein 9751507
D015025 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) Zearalenone binds to ESR2 protein affects binding
protein 15169976
19913605
D015025 55224 ETNK2
EKI2
HMFT1716
ethanolamine kinase 2 (EC:2.7.1.82) Zearalenone results in increased expression of ETNK2 mRNA increases expression
mRNA 19371625
D015025 11170 FAM107A
DRR1
TU3A
family with sequence similarity 107, member A Zearalenone results in decreased expression of FAM107A mRNA decreases expression
mRNA 19371625
D015025 64855 FAM129B
C9orf88
MEG-3
MINERVA
OC58
bA356B19.6
family with sequence similarity 129, member B Zearalenone results in decreased expression of FAM129B mRNA decreases expression
mRNA 19371625
D015025 252995 FNDC5
FRCP2
irisin
fibronectin type III domain containing 5 Zearalenone results in decreased expression of FNDC5 mRNA decreases expression
mRNA 19371625
D015025 2348 FOLR1
FBP
FOLR
folate receptor 1 (adult) Zearalenone results in decreased expression of FOLR1 mRNA decreases expression
mRNA 19371625
D015025 2297 FOXD1
FKHL8
FREAC4
forkhead box D1 Zearalenone results in increased expression of FOXD1 mRNA increases expression
mRNA 19371625
D015025 2302 FOXJ1
FKHL13
HFH-4
HFH4
forkhead box J1 Zearalenone results in decreased expression of FOXJ1 mRNA decreases expression
mRNA 19371625
D015025 50486 G0S2
RP1-28O10.2
G0/G1switch 2 Zearalenone results in increased expression of G0S2 mRNA increases expression
mRNA 19371625
D015025 8693 GALNT4
GALNAC-T4
GALNACT4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4) (EC:2.4.1.41) Zearalenone results in increased expression of GALNT4 mRNA increases expression
mRNA 19371625
D015025 8811 GALR2
GAL2-R
GALNR2
GALR-2
galanin receptor 2 Zearalenone results in decreased expression of GALR2 mRNA decreases expression
mRNA 19371625
D015025 81544 GDPD5
GDE2
PP1665
glycerophosphodiester phosphodiesterase domain containing 5 Zearalenone results in increased expression of GDPD5 mRNA increases expression
mRNA 19371625
D015025 64785 GINS3
PSF3
GINS complex subunit 3 (Psf3 homolog) Zearalenone results in decreased expression of GINS3 mRNA decreases expression
mRNA 19371625
D015025 51022 GLRX2
CGI-133
GRX2
glutaredoxin 2 Zearalenone results in increased expression of GLRX2 mRNA increases expression
mRNA 19371625
D015025 2852 GPER1
CEPR
CMKRL2
DRY12
FEG-1
GPCR-Br
GPER
GPR30
LERGU
LERGU2
LyGPR
G protein-coupled estrogen receptor 1 Zearalenone binds to GPER1 protein affects binding
protein 17088055
D015025 350383 GPR142
PGR2
G protein-coupled receptor 142 Zearalenone results in increased expression of GPR142 mRNA increases expression
mRNA 19371625
D015025 9687 GREB1
growth regulation by estrogen in breast cancer 1 Zearalenone results in increased expression of GREB1 mRNA increases expression
mRNA 19371625
22494775
D015025 79792 GSDMD
DF5L
DFNA5L
GSDMDC1
gasdermin D Zearalenone results in decreased expression of GSDMD mRNA decreases expression
mRNA 19371625
D015025 145864 HAPLN3
EXLD1
HsT19883
hyaluronan and proteoglycan link protein 3 Zearalenone results in decreased expression of HAPLN3 mRNA decreases expression
mRNA 19371625
D015025 54626 HES2
bHLHb40
hes family bHLH transcription factor 2 Zearalenone results in increased expression of HES2 mRNA increases expression
mRNA 19371625
D015025 3017 HIST1H2BD
H2B.1B
H2B/b
H2BFB
HIRIP2
dJ221C16.6
histone cluster 1, H2bd Zearalenone results in decreased expression of HIST1H2BD mRNA decreases expression
mRNA 19371625
D015025 3096 HIVEP1
CIRIP
CRYBP1
MBP-1
PRDII-BF1
Schnurri-1
ZAS1
ZNF40
ZNF40A
human immunodeficiency virus type I enhancer binding protein 1 Zearalenone results in increased expression of HIVEP1 mRNA increases expression
mRNA 19371625
D015025 3151 HMGN2
HMG17
high mobility group nucleosomal binding domain 2 Zearalenone results in decreased expression of HMGN2 mRNA decreases expression
mRNA 19371625
D015025 3303 HSPA1A
HSP70-1
HSP70-1A
HSP70I
HSP72
HSPA1
heat shock 70kDa protein 1A Zearalenone results in increased expression of HSPA1A mRNA increases expression
mRNA 19051279
D015025 3303 HSPA1A
HSP70-1
HSP70-1A
HSP70I
HSP72
HSPA1
heat shock 70kDa protein 1A Zearalenone results in increased expression of HSPA1A protein increases expression
protein 19051279
D015025 3315 HSPB1
CMT2F
HMN2B
HS.76067
HSP27
HSP28
Hsp25
SRP27
heat shock 27kDa protein 1 Zearalenone results in increased expression of HSPB1 protein increases expression
protein 19051279
D015025 10410 IFITM3
1-8U
DSPA2b
IP15
interferon induced transmembrane protein 3 Zearalenone results in decreased expression of IFITM3 mRNA decreases expression
mRNA 19371625
D015025 3489 IGFBP6
IBP6
insulin-like growth factor binding protein 6 Zearalenone results in decreased expression of IGFBP6 mRNA decreases expression
mRNA 19371625
D015025 3566 IL4R
CD124
IL-4RA
IL4RA
interleukin 4 receptor Zearalenone results in increased expression of IL4R mRNA increases expression
mRNA 19371625
D015025 3615 IMPDH2
IMPD2
IMPDH-II
IMP (inosine 5'-monophosphate) dehydrogenase 2 (EC:1.1.1.205) Zearalenone results in increased expression of IMPDH2 mRNA increases expression
mRNA 19371625
D015025 9670 IPO13
IMP13
KAP13
LGL2
RANBP13
importin 13 Zearalenone results in increased expression of IPO13 mRNA increases expression
mRNA 19371625
D015025 3705 ITPK1
ITRPK1
inositol-tetrakisphosphate 1-kinase (EC:2.7.1.134 2.7.1.159) Zearalenone results in increased expression of ITPK1 mRNA increases expression
mRNA 19371625
D015025 3754 KCNF1
IK8
KCNF
KV5.1
kH1
potassium voltage-gated channel, subfamily F, member 1 Zearalenone results in increased expression of KCNF1 mRNA increases expression
mRNA 19371625
D015025 3762 KCNJ5
CIR
GIRK4
KATP1
KIR3.4
LQT13
potassium inwardly-rectifying channel, subfamily J, member 5 Zearalenone results in increased expression of KCNJ5 mRNA increases expression
mRNA 19371625
D015025 222658 KCTD20
C6orf69
dJ108K11.3
potassium channel tetramerization domain containing 20 Zearalenone results in increased expression of KCTD20 mRNA increases expression
mRNA 19371625
D015025 9768 NS5ATP9
OEATC
OEATC-1
OEATC1
PAF
PAF15
p15(PAF)
p15/PAF
p15PAF
KIAA0101 Zearalenone results in decreased expression of KIAA0101 mRNA decreases expression
mRNA 19371625
D015025 3872 KRT17
K17
PC
PC2
PCHC1
keratin 17 Zearalenone results in decreased expression of KRT17 mRNA decreases expression
mRNA 19371625
D015025 7044 LEFTY2
EBAF
LEFTA
LEFTYA
TGFB4
left-right determination factor 2 Zearalenone results in decreased expression of LEFTY2 mRNA decreases expression
mRNA 19371625
D015025 3956 LGALS1
GAL1
GBP
lectin, galactoside-binding, soluble, 1 Zearalenone results in decreased expression of LGALS1 mRNA decreases expression
mRNA 19371625
D015025 64748 LPPR2
PRG4
lipid phosphate phosphatase-related protein type 2 (EC:3.1.3.4) Zearalenone results in increased expression of LPPR2 mRNA increases expression
mRNA 19371625
D015025 5603 MAPK13
MAPK_13
MAPK-13
PRKM13
SAPK4
p38delta
mitogen-activated protein kinase 13 (EC:2.7.11.24) Zearalenone results in decreased expression of MAPK13 mRNA decreases expression
mRNA 19371625
D015025 4192 MDK
ARAP
MK
NEGF2
midkine (neurite growth-promoting factor 2) Zearalenone results in decreased expression of MDK mRNA decreases expression
mRNA 19371625
D015025 4222 MEOX1
KFS2
MOX1
mesenchyme homeobox 1 Zearalenone results in decreased expression of MEOX1 mRNA decreases expression
mRNA 19371625
D015025 4233 MET
AUTS9
HGFR
RCCP2
c-Met
met proto-oncogene (EC:2.7.10.1) Zearalenone results in increased expression of MET mRNA increases expression
mRNA 19371625
D015025 4240 MFGE8
BA46
EDIL1
HMFG
HsT19888
MFG-E8
MFGM
OAcGD3S
SED1
SPAG10
hP47
milk fat globule-EGF factor 8 protein Zearalenone results in decreased expression of MFGE8 mRNA decreases expression
mRNA 19371625
D015025 9927 MFN2
CMT2A
CMT2A2
CPRP1
HSG
MARF
mitofusin 2 Zearalenone results in increased expression of MFN2 mRNA increases expression
mRNA 19371625
D015025 79083 MLPH
SLAC2-A
melanophilin Zearalenone results in increased expression of MLPH mRNA increases expression
mRNA 19371625
D015025 4477 MSMB
HPC13
IGBF
MSP
MSPB
PN44
PRPS
PSP
PSP-94
PSP57
PSP94
microseminoprotein, beta- Zearalenone results in increased expression of MSMB mRNA increases expression
mRNA 19371625
D015025 400746 NCMAP
C1orf130
MP11
noncompact myelin associated protein Zearalenone results in increased expression of NCMAP mRNA increases expression
mRNA 19371625
D015025 10499 NCOA2
GRIP1
KAT13C
NCoA-2
SRC2
TIF2
bHLHe75
nuclear receptor coactivator 2 Zearalenone promotes the reaction [NCOA2 protein binds to ESR1 protein] affects binding
/ increases reaction
protein 15084758
D015025 252969 NEIL2
NEH2
NEI2
nei endonuclease VIII-like 2 (E. coli) (EC:4.2.99.18) Zearalenone results in increased expression of NEIL2 mRNA increases expression
mRNA 19371625
D015025 25791 NGEF
ARHGEF27
EPHEXIN
neuronal guanine nucleotide exchange factor Zearalenone results in decreased expression of NGEF mRNA decreases expression
mRNA 19371625
D015025 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 Zearalenone results in increased activity of NR1I2 protein increases activity
protein 15569515
D015025 8204 NRIP1
RIP140
nuclear receptor interacting protein 1 Zearalenone results in increased expression of NRIP1 mRNA increases expression
mRNA 19371625
D015025 4902 NRTN
NTN
neurturin Zearalenone results in increased expression of NRTN mRNA increases expression
mRNA 19371625
D015025 10439 OLFM1
AMY
NOE1
NOELIN1
OlfA
olfactomedin 1 Zearalenone results in increased expression of OLFM1 mRNA increases expression
mRNA 19371625
D015025 56944 OLFML3
HNOEL-iso
OLF44
olfactomedin-like 3 Zearalenone results in increased expression of OLFML3 mRNA increases expression
mRNA 19371625
D015025 10081 PDCD7
ES18
HES18
programmed cell death 7 Zearalenone results in increased expression of PDCD7 mRNA increases expression
mRNA 19371625
D015025 5208 PFKFB2
PFK-2/FBPase-2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (EC:2.7.1.105 3.1.3.46) Zearalenone results in decreased expression of PFKFB2 mRNA decreases expression
mRNA 19371625
D015025 5241 PGR
NR3C3
PR
progesterone receptor fulvestrant inhibits the reaction [Zearalenone results in increased expression of PGR protein] decreases reaction
/ increases expression
protein 21803136
D015025 5241 PGR
NR3C3
PR
progesterone receptor Zearalenone inhibits the reaction [Progesterone binds to and results in increased activity of PGR protein] affects binding
/ decreases reaction
/ increases activity
protein 21803136
D015025 5241 PGR
NR3C3
PR
progesterone receptor Zearalenone results in increased expression of PGR mRNA increases expression
mRNA 19371625
D015025 5241 PGR
NR3C3
PR
progesterone receptor Zearalenone results in increased expression of PGR protein increases expression
protein 21803136
D015025 51131 PHF11
APY
BCAP
IGEL
IGER
IGHER
NY-REN-34
NYREN34
PHD finger protein 11 Zearalenone results in decreased expression of PHF11 mRNA decreases expression
mRNA 19371625
D015025 5292 PIM1
PIM
pim-1 oncogene (EC:2.7.11.1) Zearalenone results in increased expression of PIM1 mRNA increases expression
mRNA 19371625
D015025 23236 PLCB1
EIEE12
PI-PLC
PLC-154
PLC-I
PLC154
PLCB1A
PLCB1B
phospholipase C, beta 1 (phosphoinositide-specific) (EC:3.1.4.11) Zearalenone results in increased expression of PLCB1 mRNA increases expression
mRNA 19371625
D015025 84898 PLXDC2
TEM7R
plexin domain containing 2 Zearalenone results in increased expression of PLXDC2 mRNA increases expression
mRNA 19371625
D015025 5432 POLR2C
RPB3
RPB31
hRPB33
hsRPB3
polymerase (RNA) II (DNA directed) polypeptide C, 33kDa (EC:2.7.7.6) Zearalenone results in increased expression of POLR2C mRNA increases expression
mRNA 19371625
D015025 63978 PRDM14
PFM11
PR domain containing 14 Zearalenone results in increased expression of PRDM14 mRNA increases expression
mRNA 19371625
D015025 5576 PRKAR2A
PKR2
PRKAR2
protein kinase, cAMP-dependent, regulatory, type II, alpha (EC:2.7.11.1) Zearalenone results in increased expression of PRKAR2A mRNA increases expression
mRNA 19371625
D015025 11098 PRSS23
SIG13
SPUVE
ZSIG13
protease, serine, 23 Zearalenone results in increased expression of PRSS23 mRNA increases expression
mRNA 22494775
D015025 55647 RAB20
RAB20, member RAS oncogene family Zearalenone results in decreased expression of RAB20 mRNA decreases expression
mRNA 19371625
D015025 31818 Zearalenone results in increased expression of RBM13 mRNA increases expression
mRNA 19371625
D015025 221662 RBM24
RNPC6
dJ259A10.1
RNA binding motif protein 24 Zearalenone results in increased expression of RBM24 mRNA increases expression
mRNA 19371625
D015025 5947 RBP1
CRABP-I
CRBP
CRBP1
CRBPI
RBPC
retinol binding protein 1, cellular Zearalenone results in decreased expression of RBP1 mRNA decreases expression
mRNA 19371625
D015025 26150 RIBC2
C22orf11
RIB43A domain with coiled-coils 2 Zearalenone results in decreased expression of RIBC2 mRNA decreases expression
mRNA 19371625
D015025 116028 RMI2
BLAP18
C16orf75
RecQ mediated genome instability 2 Zearalenone results in decreased expression of RMI2 mRNA decreases expression
mRNA 19371625
D015025 10325 RRAGB
RAGB
bA465E19.1
Ras-related GTP binding B Zearalenone results in decreased expression of RRAGB mRNA decreases expression
mRNA 19371625
D015025 1903 S1PR3
EDG-3
EDG3
LPB3
S1P3
sphingosine-1-phosphate receptor 3 Zearalenone results in increased expression of S1PR3 mRNA increases expression
mRNA 19371625
D015025 45384 Zearalenone results in decreased expression of SAT mRNA decreases expression
mRNA 19371625
D015025 54581 SCAND2P
SCAND2
SCAN domain containing 2 pseudogene Zearalenone results in increased expression of SCAND2P mRNA increases expression
mRNA 19371625
D015025 83443 SF3B5
SF3b10
Ysf3
splicing factor 3b, subunit 5, 10kDa Zearalenone results in increased expression of SF3B5 mRNA increases expression
mRNA 19371625
D015025 6477 SIAH1
SIAH1A
siah E3 ubiquitin protein ligase 1 (EC:6.3.2.-) Zearalenone results in decreased expression of SIAH1 mRNA decreases expression
mRNA 19371625
D015025 6510 SLC1A5
AAAT
ASCT2
ATBO
M7V1
M7VS1
R16
RDRC
solute carrier family 1 (neutral amino acid transporter), member 5 Zearalenone results in increased expression of SLC1A5 mRNA increases expression
mRNA 19371625
D015025 1317 SLC31A1
COPT1
CTR1
solute carrier family 31 (copper transporter), member 1 Zearalenone results in increased expression of SLC31A1 mRNA increases expression
mRNA 19371625
D015025 6520 SLC3A2
4F2
4F2HC
4T2HC
CD98
CD98HC
MDU1
NACAE
solute carrier family 3 (amino acid transporter heavy chain), member 2 Zearalenone results in increased expression of SLC3A2 mRNA increases expression
mRNA 19371625
D015025 54946 SLC41A3
SLC41A1-L2
solute carrier family 41, member 3 Zearalenone results in decreased expression of SLC41A3 mRNA decreases expression
mRNA 19371625
D015025 6533 SLC6A6
TAUT
solute carrier family 6 (neurotransmitter transporter), member 6 Zearalenone results in increased expression of SLC6A6 mRNA increases expression
mRNA 19371625
D015025 8140 SLC7A5
4F2LC
CD98
D16S469E
E16
LAT1
MPE16
hLAT1
solute carrier family 7 (amino acid transporter light chain, L system), member 5 Zearalenone results in increased expression of SLC7A5 mRNA increases expression
mRNA 19371625
D015025 90864 SPSB3
C16orf31
SSB3
splA/ryanodine receptor domain and SOCS box containing 3 Zearalenone results in decreased expression of SPSB3 mRNA decreases expression
mRNA 19371625
D015025 6713 SQLE
squalene epoxidase (EC:1.14.13.132) Zearalenone results in decreased expression of SQLE mRNA decreases expression
mRNA 19371625
D015025 136853 SRCRB4D
S4D-SRCRB
SRCRB-S4D
SSC4D
scavenger receptor cysteine rich domain containing, group B (4 domains) Zearalenone results in decreased expression of SRCRB4D mRNA decreases expression
mRNA 19371625
D015025 6783 SULT1E1
EST
EST-1
ST1E1
STE
sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4) Zearalenone results in decreased activity of SULT1E1 protein decreases activity
protein 16914110
D015025 7039 TGFA
TFGA
transforming growth factor, alpha Zearalenone results in increased expression of TGFA mRNA increases expression
mRNA 19371625
D015025 7057 THBS1
THBS
THBS-1
TSP
TSP-1
TSP1
thrombospondin 1 Zearalenone results in increased expression of THBS1 mRNA increases expression
mRNA 19371625
D015025 26277 TINF2
DKCA3
TIN2
TERF1 (TRF1)-interacting nuclear factor 2 Zearalenone results in decreased expression of TINF2 mRNA decreases expression
mRNA 19371625
D015025 80757 TMEM121
hole
transmembrane protein 121 Zearalenone results in decreased expression of TMEM121 mRNA decreases expression
mRNA 19371625
D015025 113452 TMEM54
BCLP
CAC-1
CAC1
transmembrane protein 54 Zearalenone results in decreased expression of TMEM54 mRNA decreases expression
mRNA 19371625
D015025 8718 TNFRSF25
APO-3
DDR3
DR3
LARD
TNFRSF12
TR3
TRAMP
WSL-1
WSL-LR
tumor necrosis factor receptor superfamily, member 25 Zearalenone results in decreased expression of TNFRSF25 mRNA decreases expression
mRNA 19371625
D015025 7138 TNNT1
ANM
NEM5
STNT
TNT
TNTS
troponin T type 1 (skeletal, slow) Zearalenone results in decreased expression of TNNT1 mRNA decreases expression
mRNA 19371625
D015025 8848 TSC22D1
Ptg-2
TGFB1I4
TSC22
TSC22 domain family, member 1 Zearalenone results in decreased expression of TSC22D1 mRNA decreases expression
mRNA 19371625
D015025 25987 TSKU
E2IG4
LRRC54
TSK
tsukushi, small leucine rich proteoglycan Zearalenone results in increased expression of TSKU mRNA increases expression
mRNA 19371625
D015025 83882 TSPAN10
OCSP
tetraspanin 10 Zearalenone results in decreased expression of TSPAN10 mRNA decreases expression
mRNA 19371625
D015025 23554 TSPAN12
EVR5
NET-2
NET2
TM4SF12
tetraspanin 12 Zearalenone results in decreased expression of TSPAN12 mRNA decreases expression
mRNA 19371625
D015025 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) UGT1A1 protein results in increased glucuronidation of Zearalenone increases glucuronidation
protein 14557274
D015025 54575 UGT1A10
UDPGT
UGT-1J
UGT1-10
UGT1.10
UGT1J
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) UGT1A10 protein results in increased glucuronidation of Zearalenone increases glucuronidation
protein 14557274
D015025 54577 UGT1A7
UDPGT
UDPGT_1-7
UGT-1G
UGT1-07
UGT1.7
UGT1G
UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) UGT1A7 protein results in increased glucuronidation of Zearalenone increases glucuronidation
protein 14557274
D015025 54576 UGT1A8
UDPGT
UDPGT_1-8
UGT-1H
UGT1-08
UGT1.8
UGT1A8S
UGT1H
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) UGT1A8 protein results in increased glucuronidation of Zearalenone increases glucuronidation
protein 14557274
D015025 54600 UGT1A9
HLUGP4
LUGP4
UDPGT
UDPGT_1-9
UGT-1I
UGT1-09
UGT1-9
UGT1.9
UGT1AI
UGT1I
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) UGT1A9 protein results in increased glucuronidation of Zearalenone increases glucuronidation
protein 14557274
D015025 84135 UTP15
NET21
UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae) Zearalenone results in increased expression of UTP15 mRNA increases expression
mRNA 19371625
D015025 79609 VCPKMT
C14orf138
METTL21D
VCP-KMT
valosin containing protein lysine (K) methyltransferase Zearalenone results in decreased expression of VCPKMT mRNA decreases expression
mRNA 19371625
D015025 7476 WNT7A
wingless-type MMTV integration site family, member 7A Zearalenone results in decreased expression of WNT7A mRNA decreases expression
mRNA 16534752
D015025 11060 WWP2
AIP2
WWp2-like
WW domain containing E3 ubiquitin protein ligase 2 Zearalenone results in decreased expression of WWP2 mRNA decreases expression
mRNA 19371625
D015025 342357 ZKSCAN2
ZNF694
ZSCAN31
ZSCAN34
zinc finger with KRAB and SCAN domains 2 Zearalenone results in increased expression of ZKSCAN2 mRNA increases expression
mRNA 19371625
D015025 9203 ZMYM3
DXS6673E
MYM
XFIM
ZNF198L2
ZNF261
zinc finger, MYM-type 3 Zearalenone results in increased expression of ZMYM3 mRNA increases expression
mRNA 19371625
D015025 51364 ZMYND10
BLU
FLU
zinc finger, MYND-type containing 10 Zearalenone results in decreased expression of ZMYND10 mRNA decreases expression
mRNA 19371625

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (50)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
%606641 Body mass index; bmi P37231
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#119900 Digital clubbing, isolated congenital P15428
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#137800 Glioma susceptibility 1; glm1 P37231
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#601665 Obesity P37231
#260500 Papilloma of choroid plexus; cpp P04637
#275210 Restrictive dermopathy, lethal P02545
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#273300 Testicular germ cell tumor; tgct O94804
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (70)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

5 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D052776 D015025 Female Urogenital Diseases marker/mechanism
22310176
D009336 D015025 Necrosis marker/mechanism
21767629
D011248 D015025 Pregnancy Complications marker/mechanism
23291560
D011297 D015025 Prenatal Exposure Delayed Effects marker/mechanism
22310176
D011629 D015025 Puberty, Precocious marker/mechanism
23291560