KNApSAcK Metabolite C00030410
Metabolite
KNApSAcK Entry
| id | C00030410 |
|---|---|
| Name | Glycocholic acid |
| CAS RN | 475-31-0 |
| Standard InChI | InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 2182 |
Link
ChEMBL
| By standard InChI | CHEMBL411070 |
|---|---|
| By standard InChI Main Layer | CHEMBL411070 CHEMBL1354821 CHEMBL1474851 CHEMBL2074587 |
KEGG
| By LinkDB | C01921 |
|---|
CTD
| By CAS RN | D006000 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Aspergillaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Penicillium sp. SA29 | 445450 | Aspergillaceae | Fungi |
Human Protein / Gene in interaction
21 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL1474851 |
CHEMBL1741321
(1)
|
1 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | CHEMBL411070 CHEMBL2074587 |
CHEMBL2077533
(1)
CHEMBL2169429
(1)
|
1 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | CHEMBL411070 |
CHEMBL2169431
(1)
|
0 / 0 |
| O95342 | Bile salt export pump | drug | CHEMBL2074587 |
CHEMBL2077352
(1)
CHEMBL2075387
(1)
|
2 / 1 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | CHEMBL411070 |
CHEMBL949256
(1)
CHEMBL949257
(1)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL1474851 |
CHEMBL1741325
(1)
|
0 / 1 |
| Q14973 | Sodium/bile acid cotransporter | Bile acid | CHEMBL2074587 |
CHEMBL2077667
(1)
CHEMBL2078567
(1)
|
0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | CHEMBL1474851 |
CHEMBL1738606
(1)
|
0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | CHEMBL1354821 |
CHEMBL1794584
(1)
|
2 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL411070 CHEMBL1354821 |
CHEMBL2114780
(2)
|
0 / 0 |
| P46721 | Solute carrier organic anion transporter family member 1A2 | Unclassified protein | CHEMBL2074587 |
CHEMBL2077101
(1)
CHEMBL2076543
(1)
CHEMBL2076719 (1) |
0 / 0 |
| O15439 | Multidrug resistance-associated protein 4 | Unclassified protein | CHEMBL2074587 |
CHEMBL2078156
(1)
CHEMBL2078616
(1)
|
0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL411070 CHEMBL1354821 |
CHEMBL1794401
(2)
|
0 / 0 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | CHEMBL411070 CHEMBL2074587 |
CHEMBL2076238
(1)
CHEMBL2169430
(1)
|
1 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL1474851 |
CHEMBL1741322
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL1474851 |
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL1474851 |
CHEMBL1741324
(1)
|
0 / 1 |
| Q96QA9 | Multidrug resistance associated protein | Unclassified protein | CHEMBL2074587 |
CHEMBL2077089
(1)
CHEMBL2076984
(1)
CHEMBL2076985 (1) CHEMBL2077913 (1) |
0 / 0 |
| Q5T3U5 | Multidrug resistance-associated protein 7 | Unclassified protein | CHEMBL2074587 |
CHEMBL2077857
(1)
|
0 / 0 |
| Q9NYB5 | Solute carrier organic anion transporter family member 1C1 | Unclassified protein | CHEMBL2074587 |
CHEMBL2076222
(1)
|
0 / 0 |
| Q96J66 | ATP-binding cassette sub-family C member 11 | Unclassified protein | CHEMBL2074587 |
CHEMBL2077125
(1)
CHEMBL2076056
(1)
|
1 / 0 |
CTD interaction (3)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D006000 | 8647 |
ABCB11
ABC16 BRIC2 BSEP PFIC-2 PFIC2 PGY4 SPGP |
ATP-binding cassette, sub-family B (MDR/TAP), member 11 | ABCB11 protein affects the transport of Glycocholic Acid |
affects transport
|
protein |
15791618
|
| D006000 | 9971 |
NR1H4
BAR FXR HRR-1 HRR1 RIP14 |
nuclear receptor subfamily 1, group H, member 4 | Glycocholic Acid results in increased activity of NR1H4 protein |
increases activity
|
protein |
17567710
|
| D006000 | 10599 |
SLCO1B1
HBLRR LST-1 LST1 OATP-C OATP1B1 OATP2 OATPC SLC21A6 |
solute carrier organic anion transporter family, member 1B1 | SLCO1B1 SNP results in increased abundance of Glycocholic Acid |
increases abundance
|
SNP |
22022402
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (8)
| OMIM | preferred title | UniProt |
|---|---|---|
| #117800 | Apocrine gland secretion, variation in |
Q96J66
|
| #605479 | Cholestasis, benign recurrent intrahepatic, 2; bric2 |
O95342
|
| #601847 | Cholestasis, progressive familial intrahepatic, 2; pfic2 |
O95342
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|