Plant Species


Cumulative plant class count

class name count

Cumulative family count

class name count
Bovidae 3
Aspergillaceae 3
Flavobacteriaceae 1

KEGG BRITE br08003 External link 512


Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00030117 External link 512 Deoxycholic acid
/ 3alpha,12alpha-Dihydroxy-5.beta.-cholanoic acid
CHEMBL348338
CHEMBL412516
CHEMBL410872
CHEMBL406393
CHEMBL1609669
CHEMBL2078862
CHEMBL2092842
CHEMBL2356050
D003840
16 / 7 / 7 44 / 12
C00030410 External link 512 Glycocholic acid
CHEMBL411070
CHEMBL1354821
CHEMBL1474851
CHEMBL2074587
D006000
21 / 8 / 4 3 / 0
C00030411 External link 512 Glycodeoxycholic acid
CHEMBL258605
D006002
5 / 2 / 1 1 / 1
C00030498 External link 512 Hyodeoxycholic acid
CHEMBL272620
CHEMBL272621
CHEMBL1473584
CHEMBL2359483
C010471
13 / 14 / 5 2 / 0
C00032464 External link 512 Ursodeoxycholic acid
CHEMBL156266
CHEMBL240597
CHEMBL1551
CHEMBL1395373
CHEMBL1439625
CHEMBL1520183
CHEMBL1981518
CHEMBL1988085
CHEMBL2074643
D014580
31 / 42 / 36 120 / 39

Human Protein / Gene in interactions

55 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00030117 C00030410 C00030411 C00030498 C00032464 0 / 0
O75496 Geminin Unclassified protein C00030117 C00030410 C00032464 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00030117 C00030410 C00032464 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00030117 C00030410 C00032464 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00030117 C00030410 C00032464 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00030117 C00030410 C00032464 0 / 1
Q12908 Ileal sodium/bile acid cotransporter Bile acid C00030117 C00030411 C00032464 1 / 1
O95342 Bile salt export pump drug C00030117 C00030410 C00032464 2 / 1
Q14973 Sodium/bile acid cotransporter Bile acid C00030117 C00030410 C00032464 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00030117 C00030410 C00032464 0 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein C00030117 C00030498 C00032464 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00030410 C00032464 0 / 0
P06133 UDP-glucuronosyltransferase 2B4 Enzyme C00030498 C00032464 0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00030410 C00030411 1 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00030410 C00030411 1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00030410 C00030411 0 / 0
O15439 Multidrug resistance-associated protein 4 Unclassified protein C00030410 C00032464 0 / 0
P46721 Solute carrier organic anion transporter family member 1A2 Unclassified protein C00030410 C00032464 0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00032464 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00032464 2 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00030410 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00030410 2 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00030498 0 / 0
P04062 Glucosylceramidase Enzyme C00032464 6 / 4
P16662 UDP-glucuronosyltransferase 2B7 Enzyme C00030498 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00030498 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00032464 7 / 3
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00030117 0 / 0
P02768 Serum albumin Secreted protein C00032464 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00032464 0 / 1
Q96RI1 Bile acid receptor NR1H4 C00032464 0 / 0
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00030117 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00030498 3 / 1
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme C00030498 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00030498 0 / 0
P37840 Alpha-synuclein Unclassified protein C00032464 4 / 2
P36537 UDP-glucuronosyltransferase 2B10 Enzyme C00030498 0 / 0
P23467 Receptor-type tyrosine-protein phosphatase beta Receptor tyrosine-protein phosphatase C00030117 0 / 0
O75795 UDP-glucuronosyltransferase 2B17 Enzyme C00030498 1 / 0
O75469 Nuclear receptor subfamily 1 group I member 2 NR1I2 C00032464 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00030498 5 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00030498 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00030117 0 / 0
P08235 Mineralocorticoid receptor NR3C2 C00032464 2 / 2
P31939 Bifunctional purine biosynthesis protein PURH Enzyme C00030117 1 / 1
P04054 Phospholipase A2 Enzyme C00032464 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00032464 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00032464 1 / 1
O00255 Menin Unclassified protein C00032464 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00032464 1 / 2
Q96QA9 Multidrug resistance associated protein Unclassified protein C00030410 0 / 0
Q5T3U5 Multidrug resistance-associated protein 7 Unclassified protein C00030410 0 / 0
Q9NYB5 Solute carrier organic anion transporter family member 1C1 Unclassified protein C00030410 0 / 0
Q96J66 ATP-binding cassette sub-family C member 11 Unclassified protein C00030410 1 / 0
P02545 Prelamin-A/C Unclassified protein C00032464 11 / 10

147 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
9971 NR1H4, BAR, FXR, HRR-1, HRR1, RIP14 nuclear receptor subfamily 1, group H, member 4 C00030117 C00030410 C00030411 C00032464
8647 ABCB11, ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP ATP-binding cassette, sub-family B (MDR/TAP), member 11 C00030117 C00030410 C00032464
1051 CEBPB, C/EBP-beta, CRP2, IL6DBP, LAP, LIP, NF-IL6, TCF5 CCAAT/enhancer binding protein (C/EBP), beta C00030117 C00032464
5579 PRKCB, PKC-beta, PKCB, PRKCB1, PRKCB2 protein kinase C, beta (EC:2.7.11.13) C00030117 C00032464
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00030117 C00032464
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00030117 C00032464
5894 RAF1, CRAF, NS5, Raf-1, c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) C00030117 C00032464
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00030117 C00032464
839 CASP6, MCH2 caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) C00030117 C00032464
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00030117 C00032464
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00030117 C00032464
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00030117 C00032464
1581 CYP7A1, CP7A, CYP7, CYPVII cytochrome P450, family 7, subfamily A, polypeptide 1 (EC:1.14.13.17) C00030117 C00032464
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00030117 C00032464
2172 FABP6, I-15P, I-BABP, I-BALB, I-BAP, ILBP, ILBP3, ILLBP fatty acid binding protein 6, ileal C00030117 C00032464
9965 FGF19 fibroblast growth factor 19 C00030117 C00032464
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00030117 C00032464
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00030117 C00032464
3082 HGF, DFNB39, F-TCF, HGFB, HPTA, SF hepatocyte growth factor (hepapoietin A; scatter factor) C00030117 C00032464
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00030117 C00032464
8431 NR0B2, SHP, SHP1 nuclear receptor subfamily 0, group B, member 2 C00032464
3309 HSPA5, BIP, GRP78, MIF2 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) C00030117
5654 HTRA1, ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11 HtrA serine peptidase 1 (EC:3.4.21.-) C00030117
4000 LMNA, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1 lamin A/C C00030117
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00030117
2978 GUCA1A, C6orf131, COD3, CORD14, GCAP, GCAP1, GUCA, GUCA1, dJ139D8.6 guanylate cyclase activator 1A (retina) C00030117
4671 NAIP, BIRC1, NLRB1, psiNAIP NLR family, apoptosis inhibitory protein C00030117
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00030117
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00030117
664 BNIP3, NIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 C00030117
4893 NRAS, ALPS4, N-ras, NRAS1, NS6 neuroblastoma RAS viral (v-ras) oncogene homolog C00030117
374 AREG, AR, CRDGF, SDGF amphiregulin C00030117
23396 PIP5K1C, LCCS3, PIP5K-GAMMA, PIP5Kgamma, PIPKIg_v4 phosphatidylinositol-4-phosphate 5-kinase, type I, gamma (EC:2.7.1.68) C00030117
7001 PRDX2, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA peroxiredoxin 2 (EC:1.11.1.15) C00030117
10549 PRDX4, AOE37-2, PRX-4 peroxiredoxin 4 (EC:1.11.1.15) C00030117
5564 PRKAB1, AMPK, HAMPKb protein kinase, AMP-activated, beta 1 non-catalytic subunit C00030117
8714 ABCC3, ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 C00030117
5581 PRKCE, PKCE, nPKC-epsilon protein kinase C, epsilon (EC:2.7.11.13) C00030117
5590 PRKCZ, PKC-ZETA, PKC2 protein kinase C, zeta (EC:2.7.11.13) C00030117
7363 UGT2B4, HLUG25, UDPGT2B4, UDPGTH1, UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B4 (EC:2.4.1.17) C00030498
7364 UGT2B7, UDPGT_2B9, UDPGT2B7, UDPGTH2, UGT2B9 UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) C00030498
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00030117
5268 SERPINB5, PI5, maspin serpin peptidase inhibitor, clade B (ovalbumin), member 5 C00030117
200931 SLC51A, OSTA, OSTalpha solute carrier family 51, alpha subunit C00030117
123264 SLC51B, OSTB, OSTBETA solute carrier family 51, beta subunit C00030117
7186 TRAF2, MGC:45012, TRAP, TRAP3 TNF receptor-associated factor 2 C00030117
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00030410
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00032464
1244 ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP ATP-binding cassette, sub-family C (CFTR/MRP), member 2 C00032464
1645 AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) C00032464
1646 AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) C00032464
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) C00032464
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00032464
23243 ANKRD28, PITK, PPP1R65 ankyrin repeat domain 28 C00032464
1173 AP2M1, AP50, CLAPM1, mu2 adaptor-related protein complex 2, mu 1 subunit C00032464
335 APOA1 apolipoprotein A-I C00032464
55937 APOM, G3a, HSPC336, NG20, apo-M apolipoprotein M C00032464
581 BAX, BCL2L4 BCL2-associated X protein C00032464
644 BLVRA, BLVR, BVR, BVRA biliverdin reductase A (EC:1.3.1.24) C00032464
722 C4BPA, C4BP, PRP complement component 4 binding protein, alpha C00032464
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00032464
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00032464
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00032464
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00032464
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00032464
896 CCND3 cyclin D3 C00032464
7203 CCT3, CCT-gamma, CCTG, PIG48, TCP-1-gamma, TRIC5 chaperonin containing TCP1, subunit 3 (gamma) C00032464
22948 CCT5, CCT-epsilon, CCTE, TCP-1-epsilon chaperonin containing TCP1, subunit 5 (epsilon) C00032464
57124 CD248, CD164L1, TEM1 CD248 molecule, endosialin C00032464
8837 CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS CASP8 and FADD-like apoptosis regulator C00032464
1267 CNP, CNP1 2',3'-cyclic nucleotide 3' phosphodiesterase (EC:3.1.4.37) C00032464
1434 CSE1L, CAS, CSE1, XPO2 CSE1 chromosome segregation 1-like (yeast) C00032464
1464 CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2 chondroitin sulfate proteoglycan 4 C00032464
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00032464
7818 DAP3, DAP-3, MRP-S29, MRPS29, bMRP-10 death associated protein 3 C00032464
1660 DHX9, DDX9, LKP, NDH2, NDHII, RHA DEAH (Asp-Glu-Ala-His) box helicase 9 (EC:3.6.4.13) C00032464
1737 DLAT, DLTA, PDC-E2, PDCE2 dihydrolipoamide S-acetyltransferase (EC:2.3.1.12) C00032464
10395 DLC1, ARHGAP7, HP, STARD12, p122-RhoGAP deleted in liver cancer 1 C00032464
1906 EDN1, ET1, HDLCQ7, PPET1 endothelin 1 C00032464
1907 EDN2, ET2, PPET2 endothelin 2 C00032464
10209 EIF1, A121, EIF-1, EIF1A, ISO1, SUI1 eukaryotic translation initiation factor 1 C00032464
2033 EP300, KAT3B, RSTS2, p300 E1A binding protein p300 (EC:2.3.1.48) C00032464
79956 ERMP1, FXNA, KIAA1815, bA207C16.3 endoplasmic reticulum metallopeptidase 1 C00032464
8772 FADD, MORT1 Fas (TNFRSF6)-associated via death domain C00032464
26049 FAM169A, SLAP75 family with sequence similarity 169, member A C00032464
54537 FAM35A, FAM35A1, bA163M19.1 family with sequence similarity 35, member A C00032464
2266 FGG fibrinogen gamma chain C00032464
2267 FGL1, HFREP1, HP-041, LFIRE-1, LFIRE1 fibrinogen-like 1 C00032464
2617 GARS, CMT2D, DSMAV, GlyRS, HMN5, SMAD1 glycyl-tRNA synthetase (EC:6.1.1.14) C00032464
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00032464
2730 GCLM, GLCLR glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) C00032464
100119944 C00032464
2937 GSS, GSHS glutathione synthetase (EC:6.3.2.3) C00032464
3122 HLA-DRA, HLA-DRA1, MLRW major histocompatibility complex, class II, DR alpha C00032464
6927 HNF1A, HNF-1A, HNF1, IDDM20, LFB1, MODY3, TCF-1, TCF1 HNF1 homeobox A C00032464
6928 HNF1B, FJHN, HNF-1B, HNF1beta, HNF2, HPC11, LF-B3, LFB3, MODY5, TCF-2, TCF2, VHNF1 HNF1 homeobox B C00032464
3385 ICAM3, CD50, CDW50, ICAM-R intercellular adhesion molecule 3 C00032464
3458 IFNG, IFG, IFI interferon, gamma C00032464
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00032464
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00032464
3615 IMPDH2, IMPD2, IMPDH-II IMP (inosine 5'-monophosphate) dehydrogenase 2 (EC:1.1.1.205) C00032464
3713 IVL involucrin C00032464
4155 MBP myelin basic protein C00032464
4170 MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT myeloid cell leukemia sequence 1 (BCL2-related) C00032464
4193 MDM2, ACTFS, HDMX, hdm2 MDM2 oncogene, E3 ubiquitin protein ligase C00032464
406991 MIR21, MIRN21, hsa-mir-21, miR-21, miRNA21 microRNA 21 C00032464
4673 NAP1L1, NAP1, NAP1L, NRP nucleosome assembly protein 1-like 1 C00032464
283131 NEAT1, LINC00084, NCRNA00084, TncRNA, VINC nuclear paraspeckle assembly transcript 1 (non-protein coding) C00032464
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00032464
3265 HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1 Harvey rat sarcoma viral oncogene homolog C00030117
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00032464
220323 OAF, NS5ATP13TP2 OAF homolog (Drosophila) C00032464
5005 ORM2, AGP-B, AGP-B', AGP2 orosomucoid 2 C00032464
5580 PRKCD, MAY1, PKCD, nPKC-delta protein kinase C, delta (EC:2.7.10.2 2.7.11.13) C00032464
5879 RAC1, Rac-1, TC-25, p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) C00032464
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00032464
5930 RBBP6, MY038, P2P-R, PACT, RBQ-1, SNAMA retinoblastoma binding protein 6 C00032464
117584 RFFL, CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L ring finger and FYVE-like domain containing E3 ubiquitin protein ligase C00032464
387 RHOA, ARH12, ARHA, RHO12, RHOH12 ras homolog family member A C00032464
22836 RHOBTB3 Rho-related BTB domain containing 3 C00032464
8737 RIPK1, RIP, RIP1 receptor (TNFRSF)-interacting serine-threonine kinase 1 (EC:2.7.11.1) C00032464
6134 RPL10, AUTSX5, DXS648, DXS648E, L10, NOV, QM ribosomal protein L10 C00032464
6155 RPL27, L27 ribosomal protein L27 (EC:3.6.5.3) C00032464
6161 RPL32, L32 ribosomal protein L32 C00032464
6165 RPL35A, DBA5, L35A ribosomal protein L35a C00032464
116832 RPL39L, RPL39L1 ribosomal protein L39-like C00032464
6128 RPL6, L6, SHUJUN-2, TAXREB107, TXREB1 ribosomal protein L6 C00032464
6181 RPLP2, D11S2243E, LP2, P2, RPP2 ribosomal protein, large, P2 C00032464
6207 RPS13, S13 ribosomal protein S13 (EC:3.6.5.3) C00032464
51065 RPS27L ribosomal protein S27-like C00032464
6234 RPS28, S28 ribosomal protein S28 C00032464
145767 C00032464
55095 SAMD4B, SMGB, hSmaug2 sterile alpha motif domain containing 4B C00032464
23451 SF3B1, Hsh155, MDS, PRP10, PRPF10, SAP155, SF3b155 splicing factor 3b, subunit 1, 155kDa C00032464
9963 SLC23A1, SLC23A2, SVCT1, YSPL3 solute carrier family 23 (ascorbic acid transporter), member 1 C00032464
9962 SLC23A2, NBTL1, SLC23A1, SVCT2, YSPL2 solute carrier family 23 (ascorbic acid transporter), member 2 C00032464
292 SLC25A5, 2F1, AAC2, ANT2, T2, T3 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 C00032464
6522 SLC4A2, AE2, BND3L, EPB3L1, HKB3, NBND3 solute carrier family 4 (anion exchanger), member 2 C00032464
81848 SPRY4, HH17 sprouty homolog 4 (Drosophila) C00032464
6742 SSBP1, Mt-SSB, SOSS-B1, SSBP, mtSSB single-stranded DNA binding protein 1, mitochondrial C00032464
6772 STAT1, CANDF7, ISGF-3, STAT91 signal transducer and activator of transcription 1, 91kDa C00032464
6788 STK3, KRS1, MST2 serine/threonine kinase 3 (EC:2.7.11.1) C00032464
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00032464
7128 TNFAIP3, A20, OTUD7C, TNFA1P2 tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12) C00032464
8795 TNFRSF10B, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 tumor necrosis factor receptor superfamily, member 10b C00032464
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00032464
55339 WDR33, NET14, WDC146 WD repeat domain 33 C00032464

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (60)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#608688 Aicar transformylase/imp cyclohydrolase deficiency P31939
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#117800 Apocrine gland secretion, variation in Q96J66
#613291 Bile acid malabsorption, primary; pbam Q12908
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#612560 Bone mineral density quantitative trait locus 12; bmnd12 O75795
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#605479 Cholestasis, benign recurrent intrahepatic, 2; bric2 O95342
#601847 Cholestasis, progressive familial intrahepatic, 2; pfic2 O95342
#114500 Colorectal cancer; crc P84022
#218800 Crigler-najjar syndrome, type i P22309
#606785 Crigler-najjar syndrome, type ii P22309
#127750 Dementia, lewy body; dlb P37840
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22309
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#605115 Hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy P08235
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P04062
P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#177735 Pseudohypoaldosteronism, type i, autosomal dominant; pha1a P08235
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (40)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00624 Familial cholestasis O95342 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
P37840 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00243 Hyperkalemic distal renal tubular acidosis (RTA type 4) P08235 (related)
H00603 Hypertension exacerbated in pregnancy P08235 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00208 Hyperbilirubinemia P22309 (related)
Q92887 (related)
H00966 AICA-ribosiduria P31939 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H01016 Primary bile acid malabsorption Q12908 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

47 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D058739 Aberrant Crypt Foci C00030117
C00032464
D010195 Pancreatitis C00030411
C00032464
D003110 Colonic Neoplasms C00030117
C00032464
D056486 Drug-Induced Liver Injury C00030117
C00032464
D009336 Necrosis C00030117
C00032464
D005234 Fatty Liver C00032464
D008113 Liver Neoplasms C00030117
D008114 Liver Neoplasms, Experimental C00030117
D009069 Movement Disorders C00030117
D005911 Gliosis C00030117
D011230 Precancerous Conditions C00030117
D013274 Stomach Neoplasms C00030117
D001930 Brain Injuries C00030117
D001649 Bile Duct Diseases C00032464
D002761 Cholangitis C00032464
D015209 Cholangitis, Sclerosing C00032464
D002769 Cholelithiasis C00032464
D002779 Cholestasis C00032464
D002780 Cholestasis, Intrahepatic C00032464
C535932 Cholestasis, intrahepatic of pregnancy C00032464
C535933 Cholestasis, progressive familial intrahepatic 1 C00032464
D003550 Cystic Fibrosis C00032464
D005221 Fatigue C00032464
D006965 Hyperplasia C00030117
D005355 Fibrosis C00032464
D005705 Gallbladder Diseases C00032464
D042882 Gallstones C00032464
D019698 Hepatitis C, Chronic C00032464
D006521 Hepatitis, Chronic C00032464
D006943 Hyperglycemia C00032464
D006980 Hyperthyroidism C00032464
D007037 Hypothyroidism C00032464
D007249 Inflammation C00032464
D007333 Insulin Resistance C00032464
D007565 Jaundice C00032464
D041781 Jaundice, Obstructive C00032464
D008103 Liver Cirrhosis C00032464
D008105 Liver Cirrhosis, Biliary C00032464
D008106 Liver Cirrhosis, Experimental C00032464
D008107 Liver Diseases C00032464
D017114 Liver Failure, Acute C00032464
D009078 Mucocele C00032464
D009369 Neoplasms C00032464
D017094 Porphyrias, Hepatic C00032464
D011183 Postoperative Complications C00032464
D011537 Pruritus C00032464
D015431 Weight Loss C00032464