PCIDB

KNApSAcK Metabolite C00030498

Metabolite

KNApSAcK Entry

id C00030498
Name Hyodeoxycholic acid
CAS RN 83-49-8
Standard InChI InChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1
Standard InChI (Main Layer) InChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)

Cluster

Phytochemical cluster
KCF-S cluster No. 2182

Link

ChEMBL

By standard InChI CHEMBL272621
By standard InChI Main Layer CHEMBL272620 CHEMBL272621 CHEMBL1473584 CHEMBL2359483

KEGG

By LinkDB C15517

CTD

By CAS RN C010471

Species

Summary

Plant class

class name count

Family

family name count
Bovidae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Bos taurus domesticus GMELIN 9903 Bovidae Metazoa

Human Protein / Gene in interaction

13 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
O75795 UDP-glucuronosyltransferase 2B17 Enzyme CHEMBL272621 CHEMBL1908091 (2)
1 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme CHEMBL272621 CHEMBL1908087 (2)
0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor CHEMBL272620 CHEMBL272621 CHEMBL949256 (2) CHEMBL949257 (2)
0 / 0
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL1473584 CHEMBL1613776 (1)
3 / 1
P16662 UDP-glucuronosyltransferase 2B7 Enzyme CHEMBL272621 CHEMBL1908093 (2)
0 / 0
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme CHEMBL272621 CHEMBL1908084 (1)
0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme CHEMBL272621 CHEMBL1908090 (1)
0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme CHEMBL272621 CHEMBL1908085 (1)
0 / 0
P06133 UDP-glucuronosyltransferase 2B4 Enzyme CHEMBL272621 CHEMBL1743333 (1) CHEMBL1908092 (5)
0 / 0
P36537 UDP-glucuronosyltransferase 2B10 Enzyme CHEMBL272621 CHEMBL1908089 (1)
0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL272621 CHEMBL1908080 (1)
5 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1473584 CHEMBL1614421 (1)
4 / 3
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL2359483 CHEMBL2354287 (1)
1 / 1

CTD interaction (4)

compound gene gene name gene description interaction interaction type form reference
pmid
C010471 7363 UGT2B4
HLUG25
UDPGT2B4
UDPGTH1
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B4 (EC:2.4.1.17) UGT2B4 protein results in increased glucuronidation of hyodeoxycholic acid increases glucuronidation
protein 1909626
C010471 7364 UGT2B7
UDPGT_2B9
UDPGT2B7
UDPGTH2
UGT2B9
UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) UGT2B7 protein affects the metabolism of hyodeoxycholic acid affects metabolic processing
protein 21415305
C010471 7364 UGT2B7
UDPGT_2B9
UDPGT2B7
UDPGTH2
UGT2B9
UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) UGT2B7 protein alternative form results in increased glucuronidation of hyodeoxycholic acid increases glucuronidation
protein 8423545
C010471 7364 UGT2B7
UDPGT_2B9
UDPGT2B7
UDPGTH2
UGT2B9
UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) UGT2B7 protein results in increased glucuronidation of hyodeoxycholic acid increases glucuronidation
protein 8517101

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (14)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#612560 Bone mineral density quantitative trait locus 12; bmnd12 O75795
#218800 Crigler-najjar syndrome, type i P22309
#606785 Crigler-najjar syndrome, type ii P22309
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22309
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (5)

KEGG disease name UniProt
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00208 Hyperbilirubinemia P22309 (related)