KNApSAcK Metabolite C00030117
Metabolite
KNApSAcK Entry
| id | C00030117 |
|---|---|
| Name | Deoxycholic acid / 3alpha,12alpha-Dihydroxy-5.beta.-cholanoic acid |
| CAS RN | 83-44-3 |
| Standard InChI | InChI=1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 2182 |
Link
ChEMBL
| By standard InChI | CHEMBL406393 |
|---|---|
| By standard InChI Main Layer | CHEMBL348338 CHEMBL412516 CHEMBL410872 CHEMBL406393 CHEMBL1609669 CHEMBL2078862 CHEMBL2092842 CHEMBL2356050 |
KEGG
| By LinkDB | C04483 |
|---|
CTD
| By CAS RN | D003840 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Bovidae | 1 |
| Flavobacteriaceae | 1 |
| Aspergillaceae | 1 |
List (3)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Bos taurus domesticus GMELIN | 9903 | Bovidae | Metazoa | |
| Myroides sp. SM1 | 270914 | Flavobacteriaceae | Bacteria | |
| Penicillium sp. SA29 | 445450 | Aspergillaceae | Fungi |
Human Protein / Gene in interaction
16 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL2078862 |
CHEMBL1741321
(1)
|
1 / 0 |
| O95342 | Bile salt export pump | drug | CHEMBL406393 |
CHEMBL2077353
(2)
|
2 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | CHEMBL406393 |
CHEMBL1794585
(1)
|
0 / 0 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | CHEMBL406393 CHEMBL1609669 |
CHEMBL949256
(2)
CHEMBL949257
(2)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL2078862 |
CHEMBL1741325
(1)
|
0 / 1 |
| Q14973 | Sodium/bile acid cotransporter | Bile acid | CHEMBL406393 |
CHEMBL2075815
(2)
|
0 / 0 |
| Q12908 | Ileal sodium/bile acid cotransporter | Bile acid | CHEMBL406393 |
CHEMBL2076042
(2)
|
1 / 1 |
| O75496 | Geminin | Unclassified protein | CHEMBL406393 |
CHEMBL2114780
(1)
|
0 / 0 |
| P18433 | Receptor-type tyrosine-protein phosphatase alpha | Receptor tyrosine-protein phosphatase | CHEMBL2092842 |
CHEMBL1252117
(1)
CHEMBL1252118
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL2078862 |
CHEMBL1741322
(1)
|
0 / 0 |
| P23467 | Receptor-type tyrosine-protein phosphatase beta | Receptor tyrosine-protein phosphatase | CHEMBL2092842 |
CHEMBL1252119
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL2078862 |
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL2078862 |
CHEMBL1741324
(1)
|
0 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL406393 |
CHEMBL1738184
(1)
|
0 / 0 |
| P31939 | Bifunctional purine biosynthesis protein PURH | Enzyme | CHEMBL412516 |
CHEMBL914875
(1)
|
1 / 1 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | CHEMBL406393 |
CHEMBL2354287
(1)
|
1 / 1 |
CTD interaction (84)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D003840 | 8647 |
ABCB11
ABC16 BRIC2 BSEP PFIC-2 PFIC2 PGY4 SPGP |
ATP-binding cassette, sub-family B (MDR/TAP), member 11 | Deoxycholic Acid results in increased expression of ABCB11 mRNA |
increases expression
|
mRNA |
14684751
|
| D003840 | 8714 |
ABCC3
ABC31 EST90757 MLP2 MOAT-D MRP3 cMOAT2 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | Deoxycholic Acid results in increased activity of ABCC3 protein |
increases activity
|
protein |
17569508
|
| D003840 | 374 |
AREG
AR CRDGF SDGF |
amphiregulin | Deoxycholic Acid results in increased secretion of AREG protein |
increases secretion
|
protein |
16213893
|
| D003840 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | BCL2 protein results in decreased susceptibility to Deoxycholic Acid |
decreases response to substance
|
protein |
12507930
|
| D003840 | 664 |
BNIP3
NIP3 |
BCL2/adenovirus E1B 19kDa interacting protein 3 | BNIP3 protein affects the susceptibility to Deoxycholic Acid |
affects response to substance
|
protein |
12507930
|
| D003840 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Aspirin inhibits the reaction [Deoxycholic Acid results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
17644113
|
| D003840 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | CASP3 protein affects the susceptibility to Deoxycholic Acid |
affects response to substance
|
protein |
12507930
|
| D003840 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | cobaltiprotoporphyrin inhibits the reaction [Deoxycholic Acid results in increased cleavage of CASP3 protein] |
decreases reaction
/ increases cleavage |
protein |
21362092
|
| D003840 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Deoxycholic Acid results in increased activity of CASP3 protein |
increases activity
|
protein |
16573382
17644113 |
| D003840 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Deoxycholic Acid results in increased cleavage of CASP3 protein |
increases cleavage
|
protein |
21362092
|
| D003840 | 839 |
CASP6
MCH2 |
caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) | Aspirin inhibits the reaction [Deoxycholic Acid results in increased activity of CASP6 protein] |
decreases reaction
/ increases activity |
protein |
17644113
|
| D003840 | 839 |
CASP6
MCH2 |
caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) | CASP6 protein affects the susceptibility to Deoxycholic Acid |
affects response to substance
|
protein |
12507930
|
| D003840 | 839 |
CASP6
MCH2 |
caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) | Deoxycholic Acid results in increased activity of CASP6 protein |
increases activity
|
protein |
17644113
|
| D003840 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | Aspirin inhibits the reaction [Deoxycholic Acid results in increased activity of CASP9 protein] |
decreases reaction
/ increases activity |
protein |
17644113
|
| D003840 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | cobaltiprotoporphyrin inhibits the reaction [Deoxycholic Acid results in increased cleavage of CASP9 protein] |
decreases reaction
/ increases cleavage |
protein |
21362092
|
| D003840 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | Deoxycholic Acid results in increased activity of CASP9 protein |
increases activity
|
protein |
17644113
|
| D003840 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | Deoxycholic Acid results in increased cleavage of CASP9 protein |
increases cleavage
|
protein |
21362092
|
| D003840 | 1051 |
CEBPB
C/EBP-beta CRP2 IL6DBP LAP LIP NF-IL6 TCF5 |
CCAAT/enhancer binding protein (C/EBP), beta | Deoxycholic Acid results in increased expression of CEBPB |
increases expression
|
18444174
|
|
| D003840 | 1051 |
CEBPB
C/EBP-beta CRP2 IL6DBP LAP LIP NF-IL6 TCF5 |
CCAAT/enhancer binding protein (C/EBP), beta | NRAS affects the reaction [Deoxycholic Acid results in increased expression of CEBPB] |
affects reaction
/ increases expression |
18444174
|
|
| D003840 | 1051 |
CEBPB
C/EBP-beta CRP2 IL6DBP LAP LIP NF-IL6 TCF5 |
CCAAT/enhancer binding protein (C/EBP), beta | Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased expression of CEBPB] |
decreases reaction
/ increases expression |
18444174
|
|
| D003840 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | CYP3A4 protein affects the metabolism of Deoxycholic Acid |
affects metabolic processing
|
protein |
15708356
|
| D003840 | 1581 |
CYP7A1
CP7A CYP7 CYPVII |
cytochrome P450, family 7, subfamily A, polypeptide 1 (EC:1.14.13.17) | Deoxycholic Acid results in decreased expression of CYP7A1 mRNA |
decreases expression
|
mRNA |
14684751
|
| D003840 | 1956 |
EGFR
ERBB ERBB1 HER1 PIG61 mENA |
epidermal growth factor receptor (EC:2.7.10.1) | Deoxycholic Acid results in increased activity of EGFR protein |
increases activity
|
protein |
16213893
|
| D003840 | 1956 |
EGFR
ERBB ERBB1 HER1 PIG61 mENA |
epidermal growth factor receptor (EC:2.7.10.1) | Deoxycholic Acid results in increased phosphorylation of EGFR protein |
increases phosphorylation
|
protein |
14747693
|
| D003840 | 1956 |
EGFR
ERBB ERBB1 HER1 PIG61 mENA |
epidermal growth factor receptor (EC:2.7.10.1) | EGFR protein results in decreased susceptibility to Deoxycholic Acid |
decreases response to substance
|
protein |
12507930
|
| D003840 | 1956 |
EGFR
ERBB ERBB1 HER1 PIG61 mENA |
epidermal growth factor receptor (EC:2.7.10.1) | Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of EGFR protein] |
decreases reaction
/ increases phosphorylation |
protein |
14747693
|
| D003840 | 2172 |
FABP6
I-15P I-BABP I-BALB I-BAP ILBP ILBP3 ILLBP |
fatty acid binding protein 6, ileal | Deoxycholic Acid results in increased expression of FABP6 |
increases expression
|
22268002
|
|
| D003840 | 9965 |
FGF19
|
fibroblast growth factor 19 | Deoxycholic Acid results in increased expression of FGF19 |
increases expression
|
22268002
|
|
| D003840 | 2950 |
GSTP1
DFN7 FAEES3 GST3 GSTP PI |
glutathione S-transferase pi 1 (EC:2.5.1.18) | Deoxycholic Acid binds to GSTP1 protein |
affects binding
|
protein |
15300575
|
| D003840 | 2950 |
GSTP1
DFN7 FAEES3 GST3 GSTP PI |
glutathione S-transferase pi 1 (EC:2.5.1.18) | gamma-Glu-S-BzCys-PhGly diethyl ester inhibits the reaction [GSTP1 protein results in increased susceptibility to Deoxycholic Acid] |
decreases reaction
/ increases response to substance |
protein |
15300575
|
| D003840 | 2950 |
GSTP1
DFN7 FAEES3 GST3 GSTP PI |
glutathione S-transferase pi 1 (EC:2.5.1.18) | GSTP1 protein results in increased susceptibility to Deoxycholic Acid |
increases response to substance
|
protein |
15300575
|
| D003840 | 2978 |
GUCA1A
C6orf131 COD3 CORD14 GCAP GCAP1 GUCA GUCA1 dJ139D8.6 |
guanylate cyclase activator 1A (retina) | GUCA1A protein results in decreased susceptibility to Deoxycholic Acid |
decreases response to substance
|
protein |
12507930
|
| D003840 | 3082 |
HGF
DFNB39 F-TCF HGFB HPTA SF |
hepatocyte growth factor (hepapoietin A; scatter factor) | Deoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF protein] |
decreases reaction
/ increases expression |
protein |
15802798
|
| D003840 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | HMOX1 protein results in decreased susceptibility to Deoxycholic Acid |
decreases response to substance
|
protein |
21362092
|
| D003840 | 3265 |
HRAS
C-BAS/HAS C-H-RAS C-HA-RAS1 CTLO H-RASIDX HAMSV HRAS1 K-RAS N-RAS RASH1 |
Harvey rat sarcoma viral oncogene homolog | Deoxycholic Acid results in increased activity of HRAS protein |
increases activity
|
protein |
18444174
|
| D003840 | 3309 |
HSPA5
BIP GRP78 MIF2 |
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | HSPA5 protein results in decreased susceptibility to Deoxycholic Acid |
decreases response to substance
|
protein |
12507930
|
| D003840 | 5654 |
HTRA1
ARMD7 CARASIL HtrA L56 ORF480 PRSS11 |
HtrA serine peptidase 1 (EC:3.4.21.-) | HTRA1 protein affects the susceptibility to Deoxycholic Acid |
affects response to substance
|
protein |
12507930
|
| D003840 | 4000 |
LMNA
CDCD1 CDDC CMD1A CMT2B1 EMD2 FPL FPLD FPLD2 HGPS IDC LDP1 LFP LGMD1B LMN1 LMNC LMNL1 PRO1 |
lamin A/C | Aspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of LMNA protein] |
decreases reaction
/ increases cleavage |
protein |
17644113
|
| D003840 | 4000 |
LMNA
CDCD1 CDDC CMD1A CMT2B1 EMD2 FPL FPLD FPLD2 HGPS IDC LDP1 LFP LGMD1B LMN1 LMNC LMNL1 PRO1 |
lamin A/C | Deoxycholic Acid results in increased cleavage of LMNA protein |
increases cleavage
|
protein |
17644113
|
| D003840 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | Deoxycholic Acid results in increased phosphorylation of and results in increased activity of MAPK1 protein |
increases activity
/ increases phosphorylation |
protein |
14747693
|
| D003840 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of and results in increased activity of MAPK1 protein] |
decreases reaction
/ increases activity / increases phosphorylation |
protein |
14747693
|
| D003840 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | Deoxycholic Acid results in increased phosphorylation of and results in increased activity of MAPK3 protein |
increases activity
/ increases phosphorylation |
protein |
14747693
|
| D003840 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
decreases reaction
/ increases activity / increases phosphorylation |
protein |
14747693
|
| D003840 | 4671 |
NAIP
BIRC1 NLRB1 psiNAIP |
NLR family, apoptosis inhibitory protein | NAIP protein results in decreased susceptibility to Deoxycholic Acid |
decreases response to substance
|
protein |
12507930
|
| D003840 | 4790 |
NFKB1
EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | NFKB1 protein results in decreased susceptibility to Deoxycholic Acid |
decreases response to substance
|
protein |
12507930
|
| D003840 | 4792 |
NFKBIA
IKBA MAD-3 NFKBI |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | benzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal promotes the reaction [Deoxycholic Acid results in increased phosphorylation of NFKBIA protein] |
increases phosphorylation
/ increases reaction |
protein |
17644113
|
| D003840 | 4792 |
NFKBIA
IKBA MAD-3 NFKBI |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Deoxycholic Acid results in increased phosphorylation of NFKBIA protein] |
increases phosphorylation
/ increases reaction |
protein |
17644113
|
| D003840 | 4792 |
NFKBIA
IKBA MAD-3 NFKBI |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | Deoxycholic Acid results in increased phosphorylation of NFKBIA protein |
increases phosphorylation
|
protein |
17644113
|
| D003840 | 4792 |
NFKBIA
IKBA MAD-3 NFKBI |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | lactacystin promotes the reaction [Deoxycholic Acid results in increased phosphorylation of NFKBIA protein] |
increases phosphorylation
/ increases reaction |
protein |
17644113
|
| D003840 | 9971 |
NR1H4
BAR FXR HRR-1 HRR1 RIP14 |
nuclear receptor subfamily 1, group H, member 4 | Deoxycholic Acid results in increased activity of NR1H4 protein |
increases activity
|
protein |
17567710
|
| D003840 | 9971 |
NR1H4
BAR FXR HRR-1 HRR1 RIP14 |
nuclear receptor subfamily 1, group H, member 4 | Deoxycholic Acid results in increased expression of NR1H4 protein |
increases expression
|
protein |
14684751
|
| D003840 | 4893 |
NRAS
ALPS4 N-ras NRAS1 NS6 |
neuroblastoma RAS viral (v-ras) oncogene homolog | NRAS affects the reaction [Deoxycholic Acid results in increased expression of CEBPB] |
affects reaction
/ increases expression |
18444174
|
|
| D003840 | 4893 |
NRAS
ALPS4 N-ras NRAS1 NS6 |
neuroblastoma RAS viral (v-ras) oncogene homolog | NRAS affects the reaction [Deoxycholic Acid results in increased expression of PTGS2] |
affects reaction
/ increases expression |
18444174
|
|
| D003840 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | Aspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of PARP1 protein] |
decreases reaction
/ increases cleavage |
protein |
17644113
|
| D003840 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | cobaltiprotoporphyrin inhibits the reaction [Deoxycholic Acid results in increased cleavage of PARP1 protein] |
decreases reaction
/ increases cleavage |
protein |
21362092
|
| D003840 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | Deoxycholic Acid results in increased cleavage of PARP1 protein |
increases cleavage
|
protein |
17644113
21362092 |
| D003840 | 23396 |
PIP5K1C
LCCS3 PIP5K-GAMMA PIP5Kgamma PIPKIg_v4 |
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma (EC:2.7.1.68) | PIP5K1C protein results in decreased susceptibility to Deoxycholic Acid |
decreases response to substance
|
protein |
12507930
|
| D003840 | 7001 |
PRDX2
NKEF-B NKEFB PRP PRX2 PRXII PTX1 TDPX1 TPX1 TSA |
peroxiredoxin 2 (EC:1.11.1.15) | PRDX2 protein results in decreased susceptibility to Deoxycholic Acid |
decreases response to substance
|
protein |
12507930
|
| D003840 | 10549 |
PRDX4
AOE37-2 PRX-4 |
peroxiredoxin 4 (EC:1.11.1.15) | PRDX4 protein results in decreased susceptibility to Deoxycholic Acid |
decreases response to substance
|
protein |
12507930
|
| D003840 | 5564 |
PRKAB1
AMPK HAMPKb |
protein kinase, AMP-activated, beta 1 non-catalytic subunit | PRKAB1 protein results in decreased susceptibility to Deoxycholic Acid |
decreases response to substance
|
protein |
12507930
|
| D003840 | 5579 |
PRKCB
PKC-beta PKCB PRKCB1 PRKCB2 |
protein kinase C, beta (EC:2.7.11.13) | Aspirin inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein] |
decreases reaction
/ increases expression |
protein |
17644113
|
| D003840 | 5579 |
PRKCB
PKC-beta PKCB PRKCB1 PRKCB2 |
protein kinase C, beta (EC:2.7.11.13) | benzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein] |
decreases reaction
/ increases expression |
protein |
17644113
|
| D003840 | 5579 |
PRKCB
PKC-beta PKCB PRKCB1 PRKCB2 |
protein kinase C, beta (EC:2.7.11.13) | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein] |
decreases reaction
/ increases expression |
protein |
17644113
|
| D003840 | 5579 |
PRKCB
PKC-beta PKCB PRKCB1 PRKCB2 |
protein kinase C, beta (EC:2.7.11.13) | Deoxycholic Acid results in increased activity of PRKCB protein |
increases activity
|
protein |
7705931
|
| D003840 | 5579 |
PRKCB
PKC-beta PKCB PRKCB1 PRKCB2 |
protein kinase C, beta (EC:2.7.11.13) | Deoxycholic Acid results in increased expression of PRKCB protein |
increases expression
|
protein |
17644113
|
| D003840 | 5579 |
PRKCB
PKC-beta PKCB PRKCB1 PRKCB2 |
protein kinase C, beta (EC:2.7.11.13) | lactacystin inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein] |
decreases reaction
/ increases expression |
protein |
17644113
|
| D003840 | 5581 |
PRKCE
PKCE nPKC-epsilon |
protein kinase C, epsilon (EC:2.7.11.13) | Aspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of PRKCE protein] |
decreases reaction
/ increases cleavage |
protein |
17644113
|
| D003840 | 5581 |
PRKCE
PKCE nPKC-epsilon |
protein kinase C, epsilon (EC:2.7.11.13) | Deoxycholic Acid results in increased cleavage of PRKCE protein |
increases cleavage
|
protein |
17644113
|
| D003840 | 5590 |
PRKCZ
PKC-ZETA PKC2 |
protein kinase C, zeta (EC:2.7.11.13) | PRKCZ protein results in decreased susceptibility to Deoxycholic Acid |
decreases response to substance
|
protein |
12507930
|
| D003840 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | Deoxycholic Acid results in increased expression of PTGS2 |
increases expression
|
18444174
|
|
| D003840 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | NRAS affects the reaction [Deoxycholic Acid results in increased expression of PTGS2] |
affects reaction
/ increases expression |
18444174
|
|
| D003840 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased expression of PTGS2] |
decreases reaction
/ increases expression |
18444174
|
|
| D003840 | 5894 |
RAF1
CRAF NS5 Raf-1 c-Raf |
v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) | Deoxycholic Acid results in increased phosphorylation of and results in increased activity of RAF1 protein |
increases activity
/ increases phosphorylation |
protein |
14747693
|
| D003840 | 5894 |
RAF1
CRAF NS5 Raf-1 c-Raf |
v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) | Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of and results in increased activity of RAF1 protein] |
decreases reaction
/ increases activity / increases phosphorylation |
protein |
14747693
|
| D003840 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | benzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal inhibits the reaction [Deoxycholic Acid results in increased localization of RELA protein] |
decreases reaction
/ increases localization |
protein |
17644113
|
| D003840 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Deoxycholic Acid results in increased localization of RELA protein] |
decreases reaction
/ increases localization |
protein |
17644113
|
| D003840 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | Deoxycholic Acid results in increased expression of RELA protein |
increases expression
|
protein |
17644113
|
| D003840 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | Deoxycholic Acid results in increased localization of RELA protein |
increases localization
|
protein |
17644113
|
| D003840 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | lactacystin inhibits the reaction [Deoxycholic Acid results in increased localization of RELA protein] |
decreases reaction
/ increases localization |
protein |
17644113
|
| D003840 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | RELA protein results in decreased susceptibility to Deoxycholic Acid |
decreases response to substance
|
protein |
12507930
|
| D003840 | 5268 |
SERPINB5
PI5 maspin |
serpin peptidase inhibitor, clade B (ovalbumin), member 5 | SERPINB5 protein results in decreased susceptibility to Deoxycholic Acid |
decreases response to substance
|
protein |
12507930
|
| D003840 | 200931 |
SLC51A
OSTA OSTalpha |
solute carrier family 51, alpha subunit | Deoxycholic Acid results in increased expression of SLC51A |
increases expression
|
22268002
|
|
| D003840 | 123264 |
SLC51B
OSTB OSTBETA |
solute carrier family 51, beta subunit | Deoxycholic Acid results in increased expression of SLC51B |
increases expression
|
22268002
|
|
| D003840 | 7186 |
TRAF2
MGC:45012 TRAP TRAP3 |
TNF receptor-associated factor 2 | TRAF2 protein results in decreased susceptibility to Deoxycholic Acid |
decreases response to substance
|
protein |
12507930
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (7)
| OMIM | preferred title | UniProt |
|---|---|---|
| #608688 | Aicar transformylase/imp cyclohydrolase deficiency |
P31939
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #613291 | Bile acid malabsorption, primary; pbam |
Q12908
|
| #605479 | Cholestasis, benign recurrent intrahepatic, 2; bric2 |
O95342
|
| #601847 | Cholestasis, progressive familial intrahepatic, 2; pfic2 |
O95342
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
KEGG DISEASE (7)
| KEGG | disease name | UniProt |
|---|---|---|
| H00624 | Familial cholestasis |
O95342
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00966 | AICA-ribosiduria |
P31939
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H01016 | Primary bile acid malabsorption |
Q12908
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
Diseases related to CTD interactions
12 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D058739 | D003840 | Aberrant Crypt Foci |
marker/mechanism
|
12636105
|
|
| D001930 | D003840 | Brain Injuries |
marker/mechanism
|
17188501
|
|
| D003110 | D003840 | Colonic Neoplasms |
marker/mechanism
|
16213893
18444174 |
|
| D056486 | D003840 | Drug-Induced Liver Injury |
marker/mechanism
|
1641875
10453939 21747115 21914718 |
|
| D005911 | D003840 | Gliosis |
marker/mechanism
|
17188501
|
|
| D006965 | D003840 | Hyperplasia |
marker/mechanism
|
8095246
|
|
| D008113 | D003840 | Liver Neoplasms |
marker/mechanism
|
1641875
|
|
| D008114 | D003840 | Liver Neoplasms, Experimental |
marker/mechanism
|
6150873
6150874 |
|
| D009069 | D003840 | Movement Disorders |
marker/mechanism
|
17188501
|
|
| D009336 | D003840 | Necrosis |
marker/mechanism
|
21362627
|
|
| D011230 | D003840 | Precancerous Conditions |
marker/mechanism
|
1974829
8095246 8593453 |
|
| D013274 | D003840 | Stomach Neoplasms |
marker/mechanism
|
2704366
|