Species

KNApSAcK Entry

Organism name Myroides sp. SM1
Genus Myroides
Family Myroidaceae
Kingdom Bacteria

NCBI taxonomy

Entry

Linked NCBI taxonomy name Myroides pelagicus
Linked NCBI taxonomy ID 270914
Linked level species

Family

Family in NCBI taxonomy Flavobacteriaceae
ID 49546

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Bacteria
ID 2

Plant class

Plant class
ID

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00029948 External link 512 Methyl chlorogenate
/ Methyl 5-O-caffeoylquinate
/ Chlorogenic acid methyl ester
CHEMBL416955
CHEMBL596924
CHEMBL1765881
CHEMBL1765882
CHEMBL2048503
CHEMBL2349427
6 / 5 / 4 No. 314 No. 6
C00030117 External link 512 Deoxycholic acid
/ 3alpha,12alpha-Dihydroxy-5.beta.-cholanoic acid
CHEMBL348338
CHEMBL412516
CHEMBL410872
CHEMBL406393
CHEMBL1609669
CHEMBL2078862
CHEMBL2092842
CHEMBL2356050
D003840
16 / 7 / 7 44 / 12 No. 2182

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00030117 1 / 0
O95342 Bile salt export pump drug C00030117 2 / 1
P39900 Macrophage metalloelastase M10A C00029948 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00029948 2 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00030117 0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00030117 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00030117 0 / 1
Q14973 Sodium/bile acid cotransporter Bile acid C00030117 0 / 0
Q12908 Ileal sodium/bile acid cotransporter Bile acid C00030117 1 / 1
O75496 Geminin Unclassified protein C00030117 0 / 0
P03956 Interstitial collagenase M10A C00029948 0 / 1
P45452 Collagenase 3 M10A C00029948 1 / 1
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00030117 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00030117 0 / 0
P08253 72 kDa type IV collagenase M10A C00029948 1 / 3
P23467 Receptor-type tyrosine-protein phosphatase beta Receptor tyrosine-protein phosphatase C00030117 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00030117 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00030117 0 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00030117 0 / 0
P31939 Bifunctional purine biosynthesis protein PURH Enzyme C00030117 1 / 1
P08254 Stromelysin-1 M10A C00029948 1 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00030117 1 / 1

44 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
8647 ABCB11, ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP ATP-binding cassette, sub-family B (MDR/TAP), member 11 C00030117
8714 ABCC3, ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 C00030117
374 AREG, AR, CRDGF, SDGF amphiregulin C00030117
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00030117
664 BNIP3, NIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 C00030117
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00030117
839 CASP6, MCH2 caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) C00030117
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00030117
1051 CEBPB, C/EBP-beta, CRP2, IL6DBP, LAP, LIP, NF-IL6, TCF5 CCAAT/enhancer binding protein (C/EBP), beta C00030117
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00030117
1581 CYP7A1, CP7A, CYP7, CYPVII cytochrome P450, family 7, subfamily A, polypeptide 1 (EC:1.14.13.17) C00030117
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00030117
2172 FABP6, I-15P, I-BABP, I-BALB, I-BAP, ILBP, ILBP3, ILLBP fatty acid binding protein 6, ileal C00030117
9965 FGF19 fibroblast growth factor 19 C00030117
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00030117
2978 GUCA1A, C6orf131, COD3, CORD14, GCAP, GCAP1, GUCA, GUCA1, dJ139D8.6 guanylate cyclase activator 1A (retina) C00030117
3082 HGF, DFNB39, F-TCF, HGFB, HPTA, SF hepatocyte growth factor (hepapoietin A; scatter factor) C00030117
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00030117
3265 HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1 Harvey rat sarcoma viral oncogene homolog C00030117
3309 HSPA5, BIP, GRP78, MIF2 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) C00030117
5654 HTRA1, ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11 HtrA serine peptidase 1 (EC:3.4.21.-) C00030117
4000 LMNA, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1 lamin A/C C00030117
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00030117
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00030117
4671 NAIP, BIRC1, NLRB1, psiNAIP NLR family, apoptosis inhibitory protein C00030117
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00030117
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00030117
9971 NR1H4, BAR, FXR, HRR-1, HRR1, RIP14 nuclear receptor subfamily 1, group H, member 4 C00030117
4893 NRAS, ALPS4, N-ras, NRAS1, NS6 neuroblastoma RAS viral (v-ras) oncogene homolog C00030117
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00030117
23396 PIP5K1C, LCCS3, PIP5K-GAMMA, PIP5Kgamma, PIPKIg_v4 phosphatidylinositol-4-phosphate 5-kinase, type I, gamma (EC:2.7.1.68) C00030117
7001 PRDX2, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA peroxiredoxin 2 (EC:1.11.1.15) C00030117
10549 PRDX4, AOE37-2, PRX-4 peroxiredoxin 4 (EC:1.11.1.15) C00030117
5564 PRKAB1, AMPK, HAMPKb protein kinase, AMP-activated, beta 1 non-catalytic subunit C00030117
5579 PRKCB, PKC-beta, PKCB, PRKCB1, PRKCB2 protein kinase C, beta (EC:2.7.11.13) C00030117
5581 PRKCE, PKCE, nPKC-epsilon protein kinase C, epsilon (EC:2.7.11.13) C00030117
5590 PRKCZ, PKC-ZETA, PKC2 protein kinase C, zeta (EC:2.7.11.13) C00030117
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00030117
5894 RAF1, CRAF, NS5, Raf-1, c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) C00030117
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00030117
5268 SERPINB5, PI5, maspin serpin peptidase inhibitor, clade B (ovalbumin), member 5 C00030117
200931 SLC51A, OSTA, OSTalpha solute carrier family 51, alpha subunit C00030117
123264 SLC51B, OSTB, OSTBETA solute carrier family 51, beta subunit C00030117
7186 TRAF2, MGC:45012, TRAP, TRAP3 TNF receptor-associated factor 2 C00030117

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#608688 Aicar transformylase/imp cyclohydrolase deficiency P31939
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#613291 Bile acid malabsorption, primary; pbam Q12908
#605479 Cholestasis, benign recurrent intrahepatic, 2; bric2 O95342
#601847 Cholestasis, progressive familial intrahepatic, 2; pfic2 O95342
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452

KEGG DISEASE (11)

KEGG name UniProt
H00624 Familial cholestasis O95342 (related)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00966 AICA-ribosiduria P31939 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H01016 Primary bile acid malabsorption Q12908 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)

Diseases related to CTD interactions

12 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D058739 Aberrant Crypt Foci C00030117
D001930 Brain Injuries C00030117
D003110 Colonic Neoplasms C00030117
D056486 Drug-Induced Liver Injury C00030117
D005911 Gliosis C00030117
D006965 Hyperplasia C00030117
D008113 Liver Neoplasms C00030117
D008114 Liver Neoplasms, Experimental C00030117
D009069 Movement Disorders C00030117
D009336 Necrosis C00030117
D011230 Precancerous Conditions C00030117
D013274 Stomach Neoplasms C00030117