PCIDB

KNApSAcK Metabolite C00030512

Metabolite

KNApSAcK Entry

id C00030512
Name Indomethacin
CAS RN 53-86-1
Standard InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
Standard InChI (Main Layer) InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

Cluster

Phytochemical cluster
KCF-S cluster No. 6565

Link

ChEMBL

By standard InChI CHEMBL6
By standard InChI Main Layer CHEMBL6

KEGG

By LinkDB C01926

CTD

By CAS RN D007213

Species

Summary

Plant class

class name count
Liliopsida 1

Family

family name count
Zingiberaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Alpinia officinarum 199623 Zingiberaceae Liliopsida Viridiplantae

Human Protein / Gene in interaction

164 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL6 CHEMBL1614110 (1) CHEMBL1741321 (2)
CHEMBL1909136 (2) CHEMBL2071965 (1)
1 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme CHEMBL6 CHEMBL1613805 (1)
0 / 0
P33527 Multidrug resistance-associated protein 1 drugs CHEMBL6 CHEMBL975398 (1) CHEMBL1105611 (1)
CHEMBL1105612 (1) CHEMBL1177212 (1)
CHEMBL1687517 (1) CHEMBL2075753 (1)
CHEMBL2075757 (1) CHEMBL2078146 (1)
CHEMBL2174244 (1)
0 / 0
P17516 Aldo-keto reductase family 1 member C4 Enzyme CHEMBL6 CHEMBL2038587 (1) CHEMBL2174991 (1)
1 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter CHEMBL6 CHEMBL2169429 (1) CHEMBL2169432 (2)
1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL6 CHEMBL1738312 (1)
0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL6 CHEMBL2169431 (1) CHEMBL2169434 (2)
0 / 0
Q96FL8 Multidrug and toxin extrusion protein 1 Cation antiporter CHEMBL6 CHEMBL2320305 (1) CHEMBL2320306 (1)
0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase CHEMBL6 CHEMBL619886 (1) CHEMBL618030 (1)
CHEMBL1168963 (1) CHEMBL1168964 (1)
CHEMBL2176568 (1)
0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL6 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL6 CHEMBL655562 (1) CHEMBL655563 (1)
CHEMBL665718 (1) CHEMBL665720 (1)
CHEMBL665721 (1) CHEMBL884351 (1)
CHEMBL664079 (1) CHEMBL764999 (1)
CHEMBL765001 (1) CHEMBL765003 (1)
CHEMBL768142 (1) CHEMBL874013 (1)
CHEMBL763869 (1) CHEMBL767507 (1)
CHEMBL764081 (1) CHEMBL760081 (1)
CHEMBL760088 (1) CHEMBL763346 (1)
CHEMBL762906 (1) CHEMBL762908 (1)
CHEMBL762909 (1) CHEMBL762913 (1)
CHEMBL762914 (1) CHEMBL762917 (1)
CHEMBL762918 (1) CHEMBL763081 (1)
CHEMBL763082 (1) CHEMBL763088 (1)
CHEMBL873640 (1) CHEMBL763092 (1)
CHEMBL766721 (1) CHEMBL766722 (1)
CHEMBL766723 (1) CHEMBL766726 (1)
CHEMBL766727 (1) CHEMBL768682 (1)
CHEMBL856204 (1) CHEMBL768956 (1)
CHEMBL768958 (1) CHEMBL768962 (1)
CHEMBL768963 (1) CHEMBL769647 (1)
CHEMBL769651 (1) CHEMBL769652 (1)
CHEMBL769653 (1) CHEMBL769654 (1)
CHEMBL769656 (1) CHEMBL846704 (1)
CHEMBL846705 (1) CHEMBL847967 (1)
CHEMBL849098 (1) CHEMBL849410 (1)
CHEMBL849455 (1) CHEMBL848002 (1)
CHEMBL850630 (1) CHEMBL852071 (1)
CHEMBL850649 (1) CHEMBL849005 (1)
CHEMBL850706 (1) CHEMBL840975 (1)
CHEMBL826056 (1) CHEMBL838350 (1)
CHEMBL840448 (1) CHEMBL881971 (1)
CHEMBL869264 (1) CHEMBL868097 (1)
CHEMBL892200 (1) CHEMBL901402 (1)
CHEMBL901420 (1) CHEMBL901421 (1)
CHEMBL901422 (1) CHEMBL901423 (1)
CHEMBL901424 (1) CHEMBL944174 (1)
CHEMBL936639 (1) CHEMBL936641 (1)
CHEMBL1014031 (1) CHEMBL978330 (1)
CHEMBL970163 (1) CHEMBL1030673 (1)
CHEMBL1003453 (1) CHEMBL1008495 (1)
CHEMBL1008509 (1) CHEMBL1029442 (1)
CHEMBL1049838 (1) CHEMBL1068504 (1)
CHEMBL1166434 (1) CHEMBL1168961 (1)
CHEMBL1168969 (1) CHEMBL1177197 (1)
CHEMBL1218938 (1) CHEMBL1246811 (1)
CHEMBL1639617 (1) CHEMBL1639153 (1)
CHEMBL1686537 (1) CHEMBL1692420 (1)
CHEMBL1768320 (1) CHEMBL1775764 (1)
CHEMBL1781472 (1) CHEMBL1821165 (1)
CHEMBL1909131 (2) CHEMBL1948170 (2)
CHEMBL1948171 (2) CHEMBL1959074 (1)
CHEMBL1959768 (1) CHEMBL1958678 (1)
CHEMBL2024848 (1) CHEMBL2045294 (1)
CHEMBL2061526 (1) CHEMBL2065689 (1)
CHEMBL2066346 (1) CHEMBL2071740 (1)
CHEMBL2091105 (1) CHEMBL2092039 (1)
CHEMBL2161532 (1) CHEMBL2320715 (1)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL6 CHEMBL1676103 (1) CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL6 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL6 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL6 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL6 CHEMBL1909176 (2)
0 / 0
P04062 Glucosylceramidase Enzyme CHEMBL6 CHEMBL1613818 (1)
6 / 4
P29466 Caspase-1 C14 CHEMBL6 CHEMBL877919 (1) CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL6 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL6 CHEMBL1909199 (2)
0 / 0
Q99895 Chymotrypsin-C S1A CHEMBL6 CHEMBL660318 (1)
0 / 2
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL6 CHEMBL1794524 (2) CHEMBL1794552 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL6 CHEMBL1909197 (2)
2 / 2
P02545 Prelamin-A/C Unclassified protein CHEMBL6 CHEMBL1614544 (1)
11 / 10
P43119 Prostacyclin receptor Prostanoid receptor CHEMBL6 CHEMBL1815364 (1)
0 / 0
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL6 CHEMBL1794399 (2)
3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 CHEMBL6 CHEMBL1794371 (2) CHEMBL1794471 (2)
0 / 0
Q9UP65 Cytosolic phospholipase A2 gamma Enzyme CHEMBL6 CHEMBL665920 (1)
0 / 0
P00918 Carbonic anhydrase 2 Lyase CHEMBL6 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL6 CHEMBL650218 (1) CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL6 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL6 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL6 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL6 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL6 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL6 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL6 CHEMBL650218 (1) CHEMBL1909093 (2)
0 / 0
P02768 Serum albumin Secreted protein CHEMBL6 CHEMBL702884 (1) CHEMBL702885 (1)
CHEMBL827441 (1) CHEMBL835062 (1)
CHEMBL1805606 (1) CHEMBL1805607 (1)
CHEMBL1805608 (1) CHEMBL1805609 (1)
0 / 0
P40925 Malate dehydrogenase, cytoplasmic Enzyme CHEMBL6 CHEMBL709633 (1)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL6 CHEMBL2075175 (1) CHEMBL2076205 (1)
1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL6 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL6 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL6 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL6 CHEMBL1614027 (2) CHEMBL1741325 (2)
CHEMBL1909135 (2) CHEMBL2071963 (1)
0 / 1
Q9Y5Y4 Prostaglandin D2 receptor 2 Prostanoid receptor CHEMBL6 CHEMBL884789 (1) CHEMBL881340 (1)
CHEMBL2182584 (1)
0 / 0
P16662 UDP-glucuronosyltransferase 2B7 Enzyme CHEMBL6 CHEMBL1908093 (1)
0 / 0
O14684 Prostaglandin E synthase Enzyme CHEMBL6 CHEMBL1012767 (1) CHEMBL2176564 (1)
0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL6 CHEMBL1909203 (2)
1 / 11
P11473 Vitamin D3 receptor NR1I1 CHEMBL6 CHEMBL1794311 (1) CHEMBL1794376 (2)
CHEMBL1794339 (1)
2 / 3
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL6 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL6 CHEMBL884355 (1) CHEMBL664784 (1)
CHEMBL664788 (1) CHEMBL665706 (1)
CHEMBL767507 (1) CHEMBL767752 (1)
CHEMBL767754 (1) CHEMBL769635 (1)
CHEMBL769636 (1) CHEMBL766824 (1)
CHEMBL768737 (1) CHEMBL768738 (1)
CHEMBL878778 (1) CHEMBL768746 (1)
CHEMBL768749 (1) CHEMBL768750 (1)
CHEMBL768751 (1) CHEMBL768384 (1)
CHEMBL772765 (1) CHEMBL772917 (1)
CHEMBL772920 (1) CHEMBL772922 (1)
CHEMBL772924 (1) CHEMBL763301 (1)
CHEMBL763302 (1) CHEMBL873629 (1)
CHEMBL763483 (1) CHEMBL763484 (1)
CHEMBL768832 (1) CHEMBL768836 (1)
CHEMBL768837 (1) CHEMBL767822 (1)
CHEMBL767824 (1) CHEMBL765156 (1)
CHEMBL765157 (1) CHEMBL846704 (1)
CHEMBL846705 (1) CHEMBL847967 (1)
CHEMBL849098 (1) CHEMBL849410 (1)
CHEMBL849455 (1) CHEMBL848002 (1)
CHEMBL850630 (1) CHEMBL852071 (1)
CHEMBL850649 (1) CHEMBL849005 (1)
CHEMBL850706 (1) CHEMBL840975 (1)
CHEMBL826056 (1) CHEMBL838350 (1)
CHEMBL840448 (1) CHEMBL881871 (1)
CHEMBL866165 (1) CHEMBL868097 (1)
CHEMBL917001 (1) CHEMBL892199 (1)
CHEMBL901401 (1) CHEMBL900352 (1)
CHEMBL901417 (1) CHEMBL901418 (1)
CHEMBL901419 (1) CHEMBL944175 (1)
CHEMBL936638 (1) CHEMBL936640 (1)
CHEMBL1014034 (1) CHEMBL970164 (1)
CHEMBL1010180 (1) CHEMBL1023323 (1)
CHEMBL1003454 (1) CHEMBL1008496 (1)
CHEMBL1008500 (1) CHEMBL1008501 (1)
CHEMBL1008502 (1) CHEMBL1008506 (1)
CHEMBL1008511 (1) CHEMBL1029443 (1)
CHEMBL1049837 (1) CHEMBL1070519 (1)
CHEMBL1168960 (1) CHEMBL1168967 (1)
CHEMBL1218937 (1) CHEMBL1246810 (1)
CHEMBL1639154 (1) CHEMBL1686536 (1)
CHEMBL1686538 (1) CHEMBL1817368 (1)
CHEMBL1833642 (1) CHEMBL1909130 (2)
CHEMBL1948168 (2) CHEMBL1948169 (2)
CHEMBL2065688 (1) CHEMBL2066345 (1)
CHEMBL2071739 (1) CHEMBL2175785 (1)
CHEMBL2329809 (1)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL6 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL6 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL6 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL6 CHEMBL1909214 (2)
0 / 0
P34972 Cannabinoid receptor 2 Cannabinoid receptor CHEMBL6 CHEMBL658962 (1)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL6 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL6 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL6 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL6 CHEMBL1909166 (2)
1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL6 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL6 CHEMBL1614456 (3) CHEMBL1613803 (3)
0 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme CHEMBL6 CHEMBL2038586 (1) CHEMBL2174992 (1)
CHEMBL2175097 (1) CHEMBL2329801 (1)
CHEMBL2329815 (1)
0 / 0
Q9BPW9 Dehydrogenase/reductase SDR family member 9 Enzyme CHEMBL6 CHEMBL892201 (1)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL6 CHEMBL1613838 (1)
0 / 0
Q8TCC7 Solute carrier family 22 member 8 Antiporter CHEMBL6 CHEMBL2076647 (1) CHEMBL2076664 (1)
CHEMBL2078139 (1)
0 / 0
O15439 Multidrug resistance-associated protein 4 Unclassified protein CHEMBL6 CHEMBL2078538 (1) CHEMBL2077738 (1)
0 / 0
O60760 Hematopoietic prostaglandin D synthase Enzyme CHEMBL6 CHEMBL1044145 (1) CHEMBL1044146 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL6 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL6 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL6 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL6 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL6 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL6 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL6 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL6 CHEMBL1909104 (2)
0 / 0
P15121 Aldose reductase Enzyme CHEMBL6 CHEMBL642955 (1) CHEMBL642959 (1)
CHEMBL642961 (1) CHEMBL642962 (1)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL6 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL6 CHEMBL1909100 (2)
0 / 0
P10145 Interleukin-8 Secreted protein CHEMBL6 CHEMBL1052371 (1) CHEMBL2114835 (1)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL6 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL6 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL6 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL6 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL6 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL6 CHEMBL1909119 (2)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL6 CHEMBL2114817 (1)
7 / 3
Q4U2R8 Solute carrier family 22 member 6 Antiporter CHEMBL6 CHEMBL2077161 (1) CHEMBL2077500 (1)
CHEMBL2077510 (1) CHEMBL2077517 (1)
CHEMBL2077639 (1) CHEMBL2076247 (1)
0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter CHEMBL6 CHEMBL2169430 (1) CHEMBL2169433 (2)
1 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL6 CHEMBL1963893 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL6 CHEMBL1794456 (1) CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL6 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL6 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL6 CHEMBL657911 (1) CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL6 CHEMBL1909109 (2)
2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL6 CHEMBL979014 (1) CHEMBL968347 (1)
CHEMBL970212 (1) CHEMBL971104 (1)
CHEMBL1176274 (1) CHEMBL1176275 (1)
CHEMBL1794293 (1) CHEMBL1794510 (1)
5 / 3
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL6 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL6 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL6 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL6 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL6 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL6 CHEMBL1909108 (2)
0 / 0
Q96RI1 Bile acid receptor NR1H4 CHEMBL6 CHEMBL1794415 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL6 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL6 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL6 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL6 CHEMBL1741322 (2) CHEMBL1909132 (2)
CHEMBL2071962 (1)
0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette CHEMBL6 CHEMBL1177214 (1) CHEMBL1177215 (1)
2 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL6 CHEMBL975399 (1) CHEMBL1006005 (1)
CHEMBL1177213 (1) CHEMBL2077635 (1)
CHEMBL2075116 (1)
1 / 1
Q04828 Aldo-keto reductase family 1 member C1 Enzyme CHEMBL6 CHEMBL2038584 (1) CHEMBL2175095 (1)
0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL6 CHEMBL1614171 (1)
5 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL6 CHEMBL2114842 (1)
0 / 0
P06133 UDP-glucuronosyltransferase 2B4 Enzyme CHEMBL6 CHEMBL1908092 (1)
0 / 0
P36537 UDP-glucuronosyltransferase 2B10 Enzyme CHEMBL6 CHEMBL1908089 (1)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL6 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL6 CHEMBL1794364 (2) CHEMBL1794542 (1)
CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL6 CHEMBL650218 (1) CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL6 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL6 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL6 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL6 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL6 CHEMBL1909173 (2)
0 / 0
P21731 Thromboxane A2 receptor Prostanoid receptor CHEMBL6 CHEMBL1815363 (1)
1 / 1
P25103 Substance-P receptor Neurokinin receptor CHEMBL6 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL6 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL6 CHEMBL1909168 (2)
0 / 0
P34913 Bifunctional epoxide hydrolase 2 Serine protease S33 family CHEMBL6 CHEMBL1768321 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL6 CHEMBL1741323 (2) CHEMBL1909134 (2)
CHEMBL2071964 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL6 CHEMBL1741324 (2) CHEMBL1909138 (2)
CHEMBL2071966 (1) CHEMBL2071967 (1)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL6 CHEMBL1909137 (2)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL6 CHEMBL1794483 (1)
0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL6 CHEMBL1614052 (1)
1 / 0
P52895 Aldo-keto reductase family 1 member C2 Enzyme CHEMBL6 CHEMBL2038585 (1) CHEMBL2175094 (1)
CHEMBL2329816 (1)
1 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL6 CHEMBL1614421 (1)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL6 CHEMBL1738402 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL6 CHEMBL1737980 (1) CHEMBL2114890 (2)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL6 CHEMBL1794560 (1) CHEMBL2329799 (1)
CHEMBL2329800 (1)
3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL6 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL6 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL6 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL6 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL6 CHEMBL812994 (1) CHEMBL812848 (1)
CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL6 CHEMBL1909206 (2)
0 / 1
Q04760 Lactoylglutathione lyase Enzyme CHEMBL6 CHEMBL1670272 (1) CHEMBL1670273 (1)
CHEMBL1799085 (1)
0 / 0
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL6 CHEMBL1909128 (2)
0 / 0
Q99685 Monoglyceride lipase Enzyme CHEMBL6 CHEMBL1065626 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL6 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL6 CHEMBL1613914 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL6 CHEMBL1738442 (2)
0 / 0
O00255 Menin Unclassified protein CHEMBL6 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL6 CHEMBL1614531 (1)
1 / 3
O95255 Multidrug resistance-associated protein 6 Unclassified protein CHEMBL6 CHEMBL2077184 (1) CHEMBL2075457 (1)
2 / 1
Q96QA9 Multidrug resistance associated protein Unclassified protein CHEMBL6 CHEMBL2076175 (1) CHEMBL2076988 (1)
CHEMBL2076993 (1)
0 / 0
Q9NSA0 Solute carrier family 22 member 11 Transporter CHEMBL6 CHEMBL2075397 (1) CHEMBL2075404 (1)
CHEMBL2075521 (1)
0 / 0
Q96J66 ATP-binding cassette sub-family C member 11 Unclassified protein CHEMBL6 CHEMBL2077123 (1)
1 / 0
Q8WW43 Gamma-secretase subunit APH-1B Enzyme CHEMBL6 CHEMBL870687 (1)
0 / 0
P49768 Presenilin-1 A22A CHEMBL6 CHEMBL870687 (1)
4 / 4
Q96BI3 Gamma-secretase subunit APH-1A Enzyme CHEMBL6 CHEMBL870687 (1)
0 / 0
Q92542 Nicastrin Reg CHEMBL6 CHEMBL870687 (1)
1 / 1
Q9NZ42 Gamma-secretase subunit PEN-2 Enzyme CHEMBL6 CHEMBL870687 (1)
1 / 1
P49810 Presenilin-2 A22A CHEMBL6 CHEMBL870687 (1)
2 / 2
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x CHEMBL6 CHEMBL806153 (1) CHEMBL806154 (1)
0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x CHEMBL6 CHEMBL806153 (1) CHEMBL806154 (1)
2 / 2
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x CHEMBL6 CHEMBL806153 (1) CHEMBL806154 (1)
3 / 2

CTD interaction (619)

compound gene gene name gene description interaction interaction type form reference
pmid
D007213 21 ABCA3
ABC-C
ABC3
EST111653
LBM180
SMDP3
ATP-binding cassette, sub-family A (ABC1), member 3 Indomethacin results in decreased expression of ABCA3 mRNA decreases expression
mRNA 18360721
D007213 8647 ABCB11
ABC16
BRIC2
BSEP
PFIC-2
PFIC2
PGY4
SPGP
ATP-binding cassette, sub-family B (MDR/TAP), member 11 Indomethacin results in decreased activity of ABCB11 protein decreases activity
protein 20829430
22646477
D007213 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Doxorubicin results in decreased expression of ABCC1 mRNA] which results in increased susceptibility to Indomethacin decreases expression
/ increases response to substance
mRNA 16331495
D007213 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Indomethacin affects the reaction [ABCC1 protein results in increased transport of Valproic Acid] affects reaction
/ increases transport
protein 15066675
D007213 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Indomethacin analog affects the activity of ABCC1 protein affects activity
protein 15715484
D007213 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Indomethacin analog results in decreased activity of ABCC1 protein decreases activity
protein 12142058
D007213 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Indomethacin inhibits the reaction [ABCC1 protein affects the export of 5-carboxyfluorescein diacetate] affects export
/ decreases reaction
protein 16636798
D007213 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Indomethacin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin] decreases reaction
/ decreases response to substance
protein 17940500
D007213 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Indomethacin results in decreased activity of ABCC1 protein decreases activity
protein 15581599
15715484
15916776
17940500
D007213 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Indomethacin results in decreased expression of ABCC1 mRNA decreases expression
mRNA 18360721
D007213 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Indomethacin inhibits the reaction [ABCC2 protein affects the export of 5-carboxyfluorescein diacetate] affects export
/ decreases reaction
protein 16636798
D007213 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Indomethacin promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide] affects transport
/ increases reaction
protein 12702717
12704183
D007213 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Indomethacin results in decreased activity of ABCC2 protein decreases activity
protein 22646477
D007213 8714 ABCC3
ABC31
EST90757
MLP2
MOAT-D
MRP3
cMOAT2
ATP-binding cassette, sub-family C (CFTR/MRP), member 3 Indomethacin inhibits the reaction [ABCC3 protein affects the export of 5-carboxyfluorescein diacetate] affects export
/ decreases reaction
protein 16636798
D007213 8714 ABCC3
ABC31
EST90757
MLP2
MOAT-D
MRP3
cMOAT2
ATP-binding cassette, sub-family C (CFTR/MRP), member 3 Indomethacin inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide] affects transport
/ decreases reaction
protein 12704183
D007213 8714 ABCC3
ABC31
EST90757
MLP2
MOAT-D
MRP3
cMOAT2
ATP-binding cassette, sub-family C (CFTR/MRP), member 3 Indomethacin results in increased expression of ABCC3 protein increases expression
protein 11820781
D007213 368 ABCC6
ABC34
ARA
EST349056
GACI2
MLP1
MOAT-E
MOATE
MRP6
PXE
PXE1
URG7
ATP-binding cassette, sub-family C (CFTR/MRP), member 6 Indomethacin inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione] affects transport
/ decreases reaction
protein 11880368
D007213 368 ABCC6
ABC34
ARA
EST349056
GACI2
MLP1
MOAT-E
MOATE
MRP6
PXE
PXE1
URG7
ATP-binding cassette, sub-family C (CFTR/MRP), member 6 Indomethacin results in decreased activity of ABCC6 protein decreases activity
protein 14667841
D007213 1636 ACE
ACE1
CD143
DCP
DCP1
ICH
MVCD3
angiotensin I converting enzyme (EC:3.4.15.1) Indomethacin promotes the reaction [VEGFA protein results in increased expression of ACE protein] increases expression
/ increases reaction
protein 11158990
D007213 84519 ACRBP
CT23
OY-TES-1
SP32
acrosin binding protein Indomethacin results in increased expression of ACRBP mRNA increases expression
mRNA 16984733
D007213 9510 ADAMTS1
C3-C5
METH1
ADAM metallopeptidase with thrombospondin type 1 motif, 1 Indomethacin results in decreased expression of ADAMTS1 mRNA decreases expression
mRNA 16984733
D007213 9370 ADIPOQ
ACDC
ACRP30
ADIPQTL1
ADPN
APM-1
APM1
GBP28
adiponectin, C1Q and collagen domain containing [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of ADIPOQ mRNA affects cotreatment
/ increases expression
mRNA 23086663
D007213 9370 ADIPOQ
ACDC
ACRP30
ADIPQTL1
ADPN
APM-1
APM1
GBP28
adiponectin, C1Q and collagen domain containing [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of ADIPOQ mRNA affects cotreatment
/ increases expression
mRNA 23086663
D007213 23394 ADNP
ADNP1
activity-dependent neuroprotector homeobox Indomethacin results in decreased expression of ADNP mRNA decreases expression
mRNA 16984733
D007213 140 ADORA3
A3AR
AD026
bA552M11.5
adenosine A3 receptor Indomethacin results in increased expression of ADORA3 mRNA increases expression
mRNA 17568578
D007213 121536 AEBP2
AE binding protein 2 Indomethacin results in decreased expression of AEBP2 mRNA decreases expression
mRNA 16984733
D007213 183 AGT
ANHU
SERPINA8
angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Indomethacin results in decreased expression of AGT protein decreases expression
protein 3038419
D007213 1645 AKR1C1
2-ALPHA-HSD
20-ALPHA-HSD
C9
DD1
DD1/DD2
DDH
DDH1
H-37
HAKRC
HBAB
MBAB
aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) Indomethacin results in decreased activity of AKR1C1 protein decreases activity
protein 8573067
12604236
19010312
D007213 1646 AKR1C2
AKR1C-pseudo
BABP
DD
DD2
DDH2
HAKRD
HBAB
MCDR2
SRXY8
aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) Indomethacin results in decreased activity of AKR1C2 protein decreases activity
protein 8573067
12604236
19010312
D007213 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) Indomethacin analog inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone] decreases reaction
/ increases metabolic processing
protein 17950253
D007213 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) Indomethacin analog inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione] decreases reaction
/ increases reduction
protein 17950253
D007213 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) Indomethacin analog results in decreased activity of AKR1C3 protein decreases activity
protein 17950253
19010312
D007213 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) Indomethacin binds to AKR1C3 protein affects binding
protein 14996743
D007213 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) Indomethacin inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone] decreases reaction
/ increases metabolic processing
protein 17950253
D007213 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) Indomethacin inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione] decreases reaction
/ increases reduction
protein 17950253
D007213 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) Indomethacin results in decreased activity of AKR1C3 protein decreases activity
protein 12604236
17950253
19010312
D007213 1109 AKR1C4
3-alpha-HSD
C11
CDR
CHDR
DD-4
DD4
HAKRA
aldo-keto reductase family 1, member C4 (EC:1.1.1.225 1.1.1.357) Indomethacin results in decreased activity of AKR1C4 protein decreases activity
protein 12604236
D007213 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Indomethacin results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 17341418
D007213 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Indomethacin results in decreased expression of AKT1 protein modified form decreases expression
protein 17654042
D007213 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Indomethacin results in increased phosphorylation of AKT1 protein increases phosphorylation
protein 17341418
D007213 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) SB 203580 inhibits the reaction [Indomethacin results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 17341418
D007213 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) TXN protein inhibits the reaction [Indomethacin results in decreased expression of AKT1 protein modified form] decreases expression
/ decreases reaction
protein 17654042
D007213 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) U 0126 inhibits the reaction [Indomethacin results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 17341418
D007213 160428 ALDH1L2
mtFDH
aldehyde dehydrogenase 1 family, member L2 (EC:1.5.1.6) Indomethacin results in increased expression of ALDH1L2 mRNA increases expression
mRNA 17401462
D007213 262 AMD1
ADOMETDC
AMD
SAMDC
adenosylmethionine decarboxylase 1 (EC:4.1.1.50) Indomethacin results in decreased expression of AMD1 mRNA decreases expression
mRNA 16984733
D007213 347902 AMIGO2
ALI1
AMIGO-2
DEGA
adhesion molecule with Ig-like domain 2 Indomethacin results in increased expression of AMIGO2 mRNA increases expression
mRNA 16984733
D007213 51129 ANGPTL4
ANGPTL2
ARP4
FIAF
HARP
HFARP
NL2
PGAR
UNQ171
pp1158
angiopoietin-like 4 Indomethacin results in increased expression of ANGPTL4 mRNA increases expression
mRNA 16984733
19415698
D007213 81573 ANKRD13C
RP4-677H15.5
dJ677H15.3
ankyrin repeat domain 13C Indomethacin results in decreased expression of ANKRD13C mRNA decreases expression
mRNA 16984733
D007213 308 ANXA5
ANX5
ENX2
PP4
RPRGL3
annexin A5 Indomethacin results in increased expression of ANXA5 protein increases expression
protein 18678619
D007213 324 APC
BTPS2
DP2
DP2.5
DP3
GS
PPP1R46
adenomatous polyposis coli Indomethacin results in increased expression of APC mRNA increases expression
mRNA 15963497
D007213 324 APC
BTPS2
DP2
DP2.5
DP3
GS
PPP1R46
adenomatous polyposis coli Indomethacin results in increased expression of APC protein increases expression
protein 15963497
D007213 351 APP
AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
amyloid beta (A4) precursor protein Indomethacin affects the cleavage of APP protein affects cleavage
protein 11700559
D007213 351 APP
AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
amyloid beta (A4) precursor protein Indomethacin inhibits the reaction [APP protein alternative form results in increased expression of IL6 protein] decreases reaction
/ increases expression
protein 16111494
D007213 351 APP
AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
amyloid beta (A4) precursor protein Indomethacin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased metabolism of and results in increased secretion of APP protein alternative form] affects cotreatment
/ decreases reaction
/ increases metabolic processing
/ increases secretion
protein 14586007
D007213 8289 ARID1A
B120
BAF250
BAF250a
BM029
C1orf4
ELD
MRD14
OSA1
P270
SMARCF1
hELD
hOSA1
AT rich interactive domain 1A (SWI-like) Indomethacin results in decreased expression of ARID1A mRNA decreases expression
mRNA 16984733
D007213 84159 ARID5B
DESRT
MRF-2
MRF2
AT rich interactive domain 5B (MRF1-like) Indomethacin results in decreased expression of ARID5B mRNA decreases expression
mRNA 16984733
D007213 10123 ARL4C
ARL7
LAK
ADP-ribosylation factor-like 4C Indomethacin results in decreased expression of ARL4C mRNA decreases expression
mRNA 16984733
D007213 10123 ARL4C
ARL7
LAK
ADP-ribosylation factor-like 4C Indomethacin results in increased expression of ARL4C mRNA increases expression
mRNA 16984733
D007213 57561 ARRDC3
TLIMP
arrestin domain containing 3 Indomethacin results in increased expression of ARRDC3 mRNA increases expression
mRNA 16984733
D007213 440 ASNS
TS11
asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4) Indomethacin results in increased expression of ASNS mRNA increases expression
mRNA 17401462
D007213 22926 ATF6
ATF6A
activating transcription factor 6 Indomethacin results in increased activity of ATF6 protein increases activity
protein 17341418
D007213 521 ATP5I
ATP5K
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E (EC:3.6.1.14) Indomethacin results in increased expression of ATP5I mRNA increases expression
mRNA 16984733
D007213 5205 ATP8B1
ATPIC
BRIC
FIC1
ICP1
PFIC
PFIC1
ATPase, aminophospholipid transporter, class I, type 8B, member 1 (EC:3.6.3.1) Indomethacin results in decreased expression of ATP8B1 mRNA decreases expression
mRNA 16984733
D007213 551 AVP
ADH
ARVP
AVP-NPII
AVRP
VP
arginine vasopressin Indomethacin results in decreased secretion of AVP protein decreases secretion
protein 16133044
D007213 23621 BACE1
ASP2
BACE
HSPC104
beta-site APP-cleaving enzyme 1 (EC:3.4.23.46) GW0072 inhibits the reaction [Indomethacin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 14586007
D007213 572 BAD
BBC2
BCL2L8
BCL2-associated agonist of cell death Indomethacin results in decreased expression of BAD protein decreases expression
protein 18678619
D007213 572 BAD
BBC2
BCL2L8
BCL2-associated agonist of cell death [Indomethacin results in decreased expression of YWHAE protein] which results in increased localization of BAD protein decreases expression
/ increases localization
protein 17409426
D007213 578 BAK1
BAK
BAK-LIKE
BCL2L7
CDN1
BCL2-antagonist/killer 1 Indomethacin results in increased expression of BAK1 protein increases expression
protein 11532860
D007213 581 BAX
BCL2L4
BCL2-associated X protein Indomethacin results in increased expression of BAX protein increases expression
protein 11005569
11062132
11532860
D007213 11177 BAZ1A
ACF1
WALp1
WCRF180
hACF1
bromodomain adjacent to zinc finger domain, 1A Indomethacin results in decreased expression of BAZ1A mRNA decreases expression
mRNA 16984733
D007213 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Indomethacin results in decreased expression of BCL2 mRNA decreases expression
mRNA 10785260
11721434
D007213 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Indomethacin results in decreased expression of BCL2 protein decreases expression
protein 10785260
18678619
D007213 597 BCL2A1
ACC-1
ACC-2
BCL2L5
BFL1
GRS
HBPA1
BCL2-related protein A1 Indomethacin results in decreased expression of BCL2A1 mRNA decreases expression
mRNA 17054584
D007213 597 BCL2A1
ACC-1
ACC-2
BCL2L5
BFL1
GRS
HBPA1
BCL2-related protein A1 Indomethacin results in decreased expression of BCL2A1 protein decreases expression
protein 17054584
D007213 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 Indomethacin results in decreased expression of BCL2L1 protein decreases expression
protein 11062132
16572323
D007213 8553 BHLHE40
BHLHB2
DEC1
HLHB2
SHARP-2
STRA13
Stra14
basic helix-loop-helix family, member e40 Indomethacin results in increased expression of BHLHE40 mRNA increases expression
mRNA 16984733
D007213 637 BID
FP497
BH3 interacting domain death agonist Indomethacin results in increased cleavage of BID protein increases cleavage
protein 15812552
D007213 637 BID
FP497
BH3 interacting domain death agonist [Indomethacin results in increased cleavage of BID protein] which results in increased susceptibility to Doxorubicin increases cleavage
/ increases response to substance
protein 15812552
D007213 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 Indomethacin inhibits the reaction [LTA protein results in increased expression of BIRC3 protein] decreases reaction
/ increases expression
protein 17873517
D007213 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 Indomethacin results in decreased expression of BIRC3 mRNA decreases expression
mRNA 16984733
D007213 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 Indomethacin results in decreased expression of BIRC5 mRNA decreases expression
mRNA 15248904
17270149
D007213 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 Indomethacin results in decreased expression of BIRC5 protein decreases expression
protein 17270149
D007213 55589 BMP2K
BIKE
BMP2 inducible kinase (EC:2.7.11.1) Indomethacin results in decreased expression of BMP2K mRNA decreases expression
mRNA 16984733
D007213 694 BTG1
B-cell translocation gene 1, anti-proliferative Indomethacin results in increased expression of BTG1 mRNA increases expression
mRNA 16984733
D007213 11067 C10orf10
DEPP
FIG
chromosome 10 open reading frame 10 Indomethacin results in decreased expression of C10ORF10 mRNA decreases expression
mRNA 17401462
D007213 347744 C6orf52
chromosome 6 open reading frame 52 Indomethacin results in increased expression of C6ORF52 mRNA increases expression
mRNA 16984733
D007213 759 CA1
CA-I
CAB
Car1
carbonic anhydrase I (EC:4.2.1.1) Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA1 protein] decreases activity
/ decreases reaction
protein 11430635
D007213 759 CA1
CA-I
CAB
Car1
carbonic anhydrase I (EC:4.2.1.1) Indomethacin results in increased activity of CA1 protein increases activity
protein 11430635
D007213 760 CA2
CA-II
CAC
CAII
Car2
carbonic anhydrase II (EC:4.2.1.1) Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA2 protein] decreases activity
/ decreases reaction
protein 11430635
D007213 760 CA2
CA-II
CAC
CAII
Car2
carbonic anhydrase II (EC:4.2.1.1) Indomethacin results in increased activity of CA2 protein increases activity
protein 11430635
D007213 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Indomethacin results in increased activity of CASP3 protein] affects reaction
/ increases activity
protein 17341418
D007213 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Indomethacin results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 17341418
D007213 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Anisomycin promotes the reaction [Indomethacin results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 17341418
D007213 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Indomethacin results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 17341418
D007213 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) [Indomethacin co-treated with Doxorubicin] results in increased activity of CASP3 protein affects cotreatment
/ increases activity
protein 15812552
D007213 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Indomethacin promotes the reaction [LTA protein results in increased cleavage of CASP3 protein] increases cleavage
/ increases reaction
protein 17873517
D007213 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Indomethacin results in increased activity of CASP3 protein increases activity
protein 12485869
17341418
D007213 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Indomethacin results in increased cleavage of and results in increased activity of CASP3 protein increases activity
/ increases cleavage
protein 11532860
15804060
D007213 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Indomethacin results in increased expression of and results in increased activity of CASP3 protein increases activity
/ increases expression
protein 15265368
D007213 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) SB 203580 inhibits the reaction [Indomethacin results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 17341418
D007213 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) U 0126 inhibits the reaction [Indomethacin results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 17341418
D007213 839 CASP6
MCH2
caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Indomethacin results in increased activity of CASP6 protein] affects reaction
/ increases activity
protein 17341418
D007213 839 CASP6
MCH2
caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Indomethacin results in increased activity of CASP6 protein] decreases reaction
/ increases activity
protein 17341418
D007213 839 CASP6
MCH2
caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) Anisomycin promotes the reaction [Indomethacin results in increased activity of CASP6 protein] increases activity
/ increases reaction
protein 17341418
D007213 839 CASP6
MCH2
caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Indomethacin results in increased activity of CASP6 protein] decreases reaction
/ increases activity
protein 17341418
D007213 839 CASP6
MCH2
caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) Indomethacin results in increased activity of CASP6 protein increases activity
protein 17341418
D007213 839 CASP6
MCH2
caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) SB 203580 inhibits the reaction [Indomethacin results in increased activity of CASP6 protein] decreases reaction
/ increases activity
protein 17341418
D007213 839 CASP6
MCH2
caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) U 0126 inhibits the reaction [Indomethacin results in increased activity of CASP6 protein] decreases reaction
/ increases activity
protein 17341418
D007213 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) [Indomethacin results in increased activity of CASP8 protein] which results in increased susceptibility to Doxorubicin increases activity
/ increases response to substance
protein 15812552
D007213 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) Indomethacin results in increased cleavage of and results in increased activity of CASP8 protein increases activity
/ increases cleavage
protein 15812552
D007213 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) Indomethacin results in increased expression of and results in increased activity of CASP8 protein increases activity
/ increases expression
protein 15265368
D007213 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Indomethacin results in increased activity of CASP9 protein] affects reaction
/ increases activity
protein 17341418
D007213 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Indomethacin results in increased activity of CASP9 protein] decreases reaction
/ increases activity
protein 17341418
D007213 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Anisomycin promotes the reaction [Indomethacin results in increased activity of CASP9 protein] increases activity
/ increases reaction
protein 17341418
D007213 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Indomethacin results in increased activity of CASP9 protein] decreases reaction
/ increases activity
protein 17341418
D007213 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Indomethacin results in increased activity of CASP9 protein increases activity
protein 11005569
15812552
17341418
D007213 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) [Indomethacin results in increased activity of CASP9 protein] which results in increased susceptibility to Doxorubicin increases activity
/ increases response to substance
protein 15812552
D007213 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Indomethacin results in increased cleavage of and results in increased activity of CASP9 protein increases activity
/ increases cleavage
protein 15804060
D007213 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) SB 203580 inhibits the reaction [Indomethacin results in increased activity of CASP9 protein] decreases reaction
/ increases activity
protein 17341418
D007213 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) U 0126 inhibits the reaction [Indomethacin results in increased activity of CASP9 protein] decreases reaction
/ increases activity
protein 17341418
D007213 875 CBS
HIP4
cystathionine-beta-synthase (EC:4.2.1.22) Indomethacin results in increased expression of CBS mRNA increases expression
mRNA 17401462
D007213 152137 CCDC50
C3orf6
DFNA44
YMER
coiled-coil domain containing 50 Indomethacin results in increased expression of CCDC50 mRNA increases expression
mRNA 16984733
D007213 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]] decreases reaction
/ increases secretion
protein 21913898
D007213 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Indomethacin inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein] decreases reaction
/ increases secretion
protein 11230753
D007213 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]] decreases reaction
/ increases secretion
protein 21913898
D007213 6348 CCL3
G0S19-1
LD78ALPHA
MIP-1-alpha
MIP1A
SCYA3
chemokine (C-C motif) ligand 3 Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]] decreases reaction
/ increases secretion
protein 21913898
D007213 6348 CCL3
G0S19-1
LD78ALPHA
MIP-1-alpha
MIP1A
SCYA3
chemokine (C-C motif) ligand 3 Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]] decreases reaction
/ increases secretion
protein 21913898
D007213 6351 CCL4
ACT2
AT744.1
G-26
HC21
LAG-1
LAG1
MIP-1-beta
MIP1B
MIP1B1
SCYA2
SCYA4
chemokine (C-C motif) ligand 4 Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]] decreases reaction
/ increases secretion
protein 21913898
D007213 6351 CCL4
ACT2
AT744.1
G-26
HC21
LAG-1
LAG1
MIP-1-beta
MIP1B
MIP1B1
SCYA2
SCYA4
chemokine (C-C motif) ligand 4 Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]] decreases reaction
/ increases secretion
protein 21913898
D007213 891 CCNB1
CCNB
cyclin B1 Indomethacin results in decreased expression of CCNB1 protein decreases expression
protein 11504793
D007213 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Indomethacin inhibits the reaction [[CTNNB1 protein binds to TCF7L2 protein] which binds to CCND1 promoter] affects binding
/ decreases reaction
promoter 11756231
D007213 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Indomethacin inhibits the reaction [TNF protein results in increased expression of CCND1 protein] decreases reaction
/ increases expression
protein 15489888
D007213 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Indomethacin results in decreased expression of CCND1 mRNA decreases expression
mRNA 11313997
11756231
D007213 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Indomethacin results in decreased expression of CCND1 protein decreases expression
protein 11313997
11504793
11756231
12606626
15188006
17270149
D007213 894 CCND2
KIAK0002
cyclin D2 Indomethacin results in decreased expression of CCND2 mRNA decreases expression
mRNA 19428934
D007213 894 CCND2
KIAK0002
cyclin D2 Indomethacin results in decreased expression of CCND2 protein decreases expression
protein 19428934
D007213 901 CCNG2
cyclin G2 Indomethacin results in increased expression of CCNG2 mRNA increases expression
mRNA 16984733
D007213 9236 CCPG1
CPR8
cell cycle progression 1 Indomethacin results in increased expression of CCPG1 mRNA increases expression
mRNA 17401462
D007213 1232 CCR3
CC-CKR-3
CD193
CKR3
CMKBR3
chemokine (C-C motif) receptor 3 Indomethacin results in decreased expression of CCR3 protein decreases expression
protein 11980903
D007213 999 CDH1
Arc-1
CD324
CDHE
ECAD
LCAM
UVO
cadherin 1, type 1, E-cadherin (epithelial) Indomethacin results in increased expression of CDH1 mRNA increases expression
mRNA 15963497
D007213 999 CDH1
Arc-1
CD324
CDHE
ECAD
LCAM
UVO
cadherin 1, type 1, E-cadherin (epithelial) Indomethacin results in increased expression of CDH1 protein increases expression
protein 15963497
D007213 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) Indomethacin promotes the reaction [CDKN1A protein results in decreased activity of CDK2 protein] decreases activity
/ increases reaction
protein 14566837
D007213 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) Indomethacin results in decreased activity of CDK2 protein decreases activity
protein 14566837
D007213 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) Indomethacin results in decreased expression of CDK2 protein decreases expression
protein 15786552
D007213 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) Indomethacin results in decreased expression of CDK2 protein modified form decreases expression
protein 19428934
D007213 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) Indomethacin results in decreased expression of CDK4 protein decreases expression
protein 15786552
D007213 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Indomethacin promotes the reaction [CDKN1A protein results in decreased activity of CDK2 protein] decreases activity
/ increases reaction
protein 14566837
D007213 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Indomethacin results in increased activity of CDKN1A protein increases activity
protein 14566837
D007213 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Indomethacin results in increased expression of CDKN1A protein increases expression
protein 15786552
D007213 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) Indomethacin results in decreased expression of CDKN1B mRNA decreases expression
mRNA 16984733
D007213 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) Indomethacin results in increased expression of CDKN1B mRNA increases expression
mRNA 19428934
D007213 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) Indomethacin results in increased expression of CDKN1B protein increases expression
protein 11260862
19428934
D007213 8837 CFLAR
CASH
CASP8AP1
CLARP
Casper
FLAME
FLAME-1
FLAME1
FLIP
I-FLICE
MRIT
c-FLIP
c-FLIPL
c-FLIPR
c-FLIPS
CASP8 and FADD-like apoptosis regulator Indomethacin inhibits the reaction [LTA protein results in increased expression of CFLAR protein] decreases reaction
/ increases expression
protein 17873517
D007213 1082 CGB
CGB3
CGB5
CGB7
CGB8
hCGB
chorionic gonadotropin, beta polypeptide Indomethacin inhibits the reaction [CGB protein results in increased chemical synthesis of Dinoprost] decreases reaction
/ increases chemical synthesis
protein 18555068
D007213 79094 CHAC1
ChaC, cation transport regulator homolog 1 (E. coli) Indomethacin results in increased expression of CHAC1 mRNA increases expression
mRNA 17401462
D007213 1105 CHD1
chromodomain helicase DNA binding protein 1 (EC:3.6.4.12) Indomethacin results in decreased expression of CHD1 mRNA decreases expression
mRNA 16984733
D007213 63924 CIDEC
CIDE-3
CIDE3
FPLD5
FSP27
cell death-inducing DFFA-like effector c [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of CIDEC mRNA affects cotreatment
/ increases expression
mRNA 23086663
D007213 63924 CIDEC
CIDE-3
CIDE3
FPLD5
FSP27
cell death-inducing DFFA-like effector c [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of CIDEC mRNA affects cotreatment
/ increases expression
mRNA 23086663
D007213 10370 CITED2
ASD8
MRG-1
MRG1
P35SRJ
VSD2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 Indomethacin results in decreased expression of CITED2 mRNA decreases expression
mRNA 16984733
D007213 1277 COL1A1
OI4
collagen, type I, alpha 1 Indomethacin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA] decreases expression
/ decreases reaction
mRNA 8971655
D007213 11052 CPSF6
CFIM
CFIM68
HPBRII-4
HPBRII-7
cleavage and polyadenylation specific factor 6, 68kDa Indomethacin results in decreased expression of CPSF6 mRNA decreases expression
mRNA 16984733
D007213 1389 CREBL2
cAMP responsive element binding protein-like 2 Indomethacin results in decreased expression of CREBL2 mRNA decreases expression
mRNA 16984733
D007213 1437 CSF2
GMCSF
colony stimulating factor 2 (granulocyte-macrophage) Indomethacin results in increased expression of CSF2 mRNA increases expression
mRNA 16984733
D007213 79848 CSPP1
CSPP
centrosome and spindle pole associated protein 1 Indomethacin results in decreased expression of CSPP1 mRNA decreases expression
mRNA 16984733
D007213 1491 CTH
cystathionase (cystathionine gamma-lyase) (EC:4.4.1.1) Indomethacin results in increased expression of CTH mRNA increases expression
mRNA 17401462
D007213 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa Indomethacin affects the localization of CTNNB1 protein affects localization
protein 15963497
D007213 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa Indomethacin inhibits the reaction [[CTNNB1 protein binds to TCF7L2 protein] which binds to CCND1 promoter] affects binding
/ decreases reaction
protein 11756231
D007213 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa Indomethacin results in decreased expression of CTNNB1 mRNA decreases expression
mRNA 11756231
D007213 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa Indomethacin results in decreased expression of CTNNB1 protein decreases expression
protein 11756231
15188006
D007213 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa Indomethacin results in increased phosphorylation of CTNNB1 protein increases phosphorylation
protein 12813129
D007213 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa lactacystin inhibits the reaction [Indomethacin results in decreased expression of CTNNB1 protein] decreases expression
/ decreases reaction
protein 11756231
D007213 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa Lithium Chloride inhibits the reaction [Indomethacin results in increased phosphorylation of CTNNB1 protein] decreases reaction
/ increases phosphorylation
protein 12813129
D007213 1508 CTSB
APPS
CPSB
cathepsin B (EC:3.4.22.1) Indomethacin inhibits the reaction [CTSB protein results in increased degradation of MBP protein] decreases reaction
/ increases degradation
protein 11071371
D007213 1508 CTSB
APPS
CPSB
cathepsin B (EC:3.4.22.1) Indomethacin results in decreased activity of CTSB protein decreases activity
protein 11071371
D007213 3627 CXCL10
C7
IFI10
INP10
IP-10
SCYB10
crg-2
gIP-10
mob-1
chemokine (C-X-C motif) ligand 10 Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]] decreases reaction
/ increases secretion
protein 21913898
D007213 3627 CXCL10
C7
IFI10
INP10
IP-10
SCYB10
crg-2
gIP-10
mob-1
chemokine (C-X-C motif) ligand 10 Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]] decreases reaction
/ increases secretion
protein 21913898
D007213 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic Indomethacin affects the localization of CYCS protein affects localization
protein 11005569
D007213 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) Indomethacin results in decreased activity of CYP19A1 protein decreases activity
protein 15964185
D007213 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) Indomethacin results in decreased expression of CYP19A1 mRNA decreases expression
mRNA 15964185
D007213 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Indomethacin results in increased expression of DDIT3 protein] decreases reaction
/ increases expression
protein 17341418
D007213 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 Indomethacin results in increased expression of DDIT3 protein increases expression
protein 17341418
D007213 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 SB 203580 inhibits the reaction [Indomethacin results in increased expression of DDIT3 protein] decreases reaction
/ increases expression
protein 17341418
D007213 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 U 0126 inhibits the reaction [Indomethacin results in increased expression of DDIT3 protein] decreases reaction
/ increases expression
protein 17341418
D007213 11083 DIDO1
BYE1
C20orf158
DATF-1
DATF1
DIDO2
DIDO3
DIO-1
DIO1
dJ885L7.8
death inducer-obliterator 1 Indomethacin results in decreased expression of DIDO1 mRNA decreases expression
mRNA 16984733
D007213 10294 DNAJA2
CPR3
DJ3
DJA2
DNAJ
DNJ3
HIRIP4
PRO3015
RDJ2
DnaJ (Hsp40) homolog, subfamily A, member 2 Indomethacin results in decreased expression of DNAJA2 mRNA decreases expression
mRNA 16984733
D007213 3338 DNAJC4
DANJC4
HSPF2
MCG18
DnaJ (Hsp40) homolog, subfamily C, member 4 Indomethacin results in increased expression of DNAJC4 mRNA increases expression
mRNA 16984733
D007213 667 DST
BP240
BPA
BPAG1
CATX-15
CATX15
D6S1101
DMH
DT
EBSB2
HSAN6
MACF2
dystonin Indomethacin results in decreased expression of DST mRNA decreases expression
mRNA 16984733
D007213 1843 DUSP1
CL100
HVH1
MKP-1
MKP1
PTPN10
dual specificity phosphatase 1 (EC:3.1.3.16 3.1.3.48) Indomethacin results in increased expression of DUSP1 mRNA increases expression
mRNA 16984733
D007213 1848 DUSP6
HH19
MKP3
PYST1
dual specificity phosphatase 6 (EC:3.1.3.16 3.1.3.48) Indomethacin results in decreased expression of DUSP6 mRNA decreases expression
mRNA 16984733
D007213 1871 E2F3
E2F-3
E2F transcription factor 3 Indomethacin results in decreased expression of E2F3 mRNA decreases expression
mRNA 16984733
D007213 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 BQ 788 inhibits the reaction [EDN1 protein results in decreased activity of Indomethacin] decreases activity
/ decreases reaction
protein 12906840
D007213 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in decreased activity of Indomethacin] decreases activity
/ decreases reaction
protein 12906840
D007213 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 EDN1 protein results in decreased activity of Indomethacin decreases activity
protein 12906840
D007213 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 Indomethacin results in decreased secretion of EDN1 protein decreases secretion
protein 16133044
D007213 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 Indomethacin results in increased expression of EDN1 mRNA increases expression
mRNA 16984733
D007213 1910 EDNRB
ABCDS
ET-B
ET-BR
ETB
ETBR
ETRB
HSCR
HSCR2
WS4A
endothelin receptor type B Indomethacin inhibits the reaction [IL1B results in increased activity of EDNRB] decreases reaction
/ increases activity
12126971
D007213 23167 EFR3A
EFR3 homolog A (S. cerevisiae) Indomethacin results in decreased expression of EFR3A mRNA decreases expression
mRNA 16984733
D007213 1950 EGF
HOMG4
URG
epidermal growth factor Indomethacin inhibits the reaction [EGF protein affects the localization of PTK2 protein] affects localization
/ decreases reaction
protein 12037131
D007213 1950 EGF
HOMG4
URG
epidermal growth factor Indomethacin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein] decreases reaction
/ increases phosphorylation
protein 12037131
D007213 1950 EGF
HOMG4
URG
epidermal growth factor Indomethacin promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]] decreases reaction
/ increases abundance
/ increases reaction
protein 17805209
D007213 1958 EGR1
AT225
G0S30
KROX-24
NGFI-A
TIS8
ZIF-268
ZNF225
early growth response 1 Indomethacin inhibits the reaction [VEGFA protein results in increased expression of EGR1 mRNA] decreases reaction
/ increases expression
mRNA 11595463
D007213 1958 EGR1
AT225
G0S30
KROX-24
NGFI-A
TIS8
ZIF-268
ZNF225
early growth response 1 Indomethacin inhibits the reaction [VEGFA protein results in increased expression of EGR1 protein] decreases reaction
/ increases expression
protein 11595463
D007213 1958 EGR1
AT225
G0S30
KROX-24
NGFI-A
TIS8
ZIF-268
ZNF225
early growth response 1 Indomethacin results in increased expression of EGR1 mRNA increases expression
mRNA 15509713
16227405
D007213 1958 EGR1
AT225
G0S30
KROX-24
NGFI-A
TIS8
ZIF-268
ZNF225
early growth response 1 Indomethacin results in increased expression of EGR1 protein increases expression
protein 16227405
D007213 1964 EIF1AX
EIF1A
EIF1AP1
EIF4C
eIF-1A
eIF-4C
eukaryotic translation initiation factor 1A, X-linked Indomethacin results in decreased expression of EIF1AX mRNA decreases expression
mRNA 16984733
D007213 2150 F2RL1
GPR11
PAR2
coagulation factor II (thrombin) receptor-like 1 Indomethacin inhibits the reaction [F2RL1 protein results in increased transport of Chlorides] decreases reaction
/ increases transport
protein 11804840
D007213 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) Indomethacin promotes the reaction [cangrelor results in decreased expression of and results in decreased activity of F3 protein] decreases activity
/ decreases expression
/ increases reaction
protein 20200314
D007213 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) Indomethacin results in decreased expression of and results in decreased activity of F3 protein decreases activity
/ decreases expression
protein 20200314
D007213 2167 FABP4
A-FABP
AFABP
ALBP
aP2
fatty acid binding protein 4, adipocyte [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of FABP4 mRNA affects cotreatment
/ increases expression
mRNA 23086663
D007213 2167 FABP4
A-FABP
AFABP
ALBP
aP2
fatty acid binding protein 4, adipocyte T 0070907 inhibits the reaction [[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of FABP4 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 23086663
D007213 2167 FABP4
A-FABP
AFABP
ALBP
aP2
fatty acid binding protein 4, adipocyte T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of FABP4 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 23086663
D007213 2167 FABP4
A-FABP
AFABP
ALBP
aP2
fatty acid binding protein 4, adipocyte [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of FABP4 mRNA affects cotreatment
/ increases expression
mRNA 23086663
D007213 26190 FBXW2
FBW2
Fwd2
Md6
F-box and WD repeat domain containing 2 Indomethacin results in decreased expression of FBXW2 mRNA decreases expression
mRNA 16984733
D007213 2335 FN1
CIG
ED-B
FINC
FN
FNZ
GFND
GFND2
LETS
MSF
fibronectin 1 Indomethacin inhibits the reaction [Glucose results in increased secretion of FN1 protein] decreases reaction
/ increases secretion
protein 16320596
D007213 2335 FN1
CIG
ED-B
FINC
FN
FNZ
GFND
GFND2
LETS
MSF
fibronectin 1 Indomethacin inhibits the reaction [Lipopolysaccharides results in increased secretion of FN1 protein] decreases reaction
/ increases secretion
protein 16320596
D007213 94234 FOXQ1
HFH1
forkhead box Q1 Indomethacin results in increased expression of FOXQ1 mRNA increases expression
mRNA 16984733
D007213 8324 FZD7
FzE3
frizzled family receptor 7 Indomethacin results in decreased expression of FZD7 mRNA decreases expression
mRNA 16984733
D007213 4616 GADD45B
GADD45BETA
MYD118
growth arrest and DNA-damage-inducible, beta Indomethacin results in increased expression of GADD45B mRNA increases expression
mRNA 16984733
D007213 2627 GATA6
GATA binding protein 6 Indomethacin results in increased expression of GATA6 mRNA increases expression
mRNA 16984733
D007213 2633 GBP1
guanylate binding protein 1, interferon-inducible Indomethacin results in decreased expression of GBP1 mRNA decreases expression
mRNA 16984733
D007213 2729 GCLC
GCL
GCS
GLCL
GLCLC
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Indomethacin results in increased expression of GCLC mRNA] decreases reaction
/ increases expression
mRNA 11909699
D007213 2729 GCLC
GCL
GCS
GLCL
GLCLC
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) Acetylcysteine inhibits the reaction [Indomethacin results in increased expression of GCLC mRNA] decreases reaction
/ increases expression
mRNA 11909699
D007213 2729 GCLC
GCL
GCS
GLCL
GLCLC
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) Indomethacin results in increased expression of GCLC mRNA increases expression
mRNA 11909699
D007213 2729 GCLC
GCL
GCS
GLCL
GLCLC
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) Indomethacin results in increased expression of GCLC protein increases expression
protein 11820781
D007213 2729 GCLC
GCL
GCS
GLCL
GLCLC
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) KEAP1 protein inhibits the reaction [Indomethacin results in increased expression of GCLC mRNA] decreases reaction
/ increases expression
mRNA 11909699
D007213 2730 GCLM
GLCLR
glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) Indomethacin results in increased expression of GCLM mRNA increases expression
mRNA 11909699
D007213 9518 GDF15
GDF-15
MIC-1
MIC1
NAG-1
PDF
PLAB
PTGFB
growth differentiation factor 15 GDF15 protein results in decreased susceptibility to Indomethacin decreases response to substance
protein 22615612
D007213 9518 GDF15
GDF-15
MIC-1
MIC1
NAG-1
PDF
PLAB
PTGFB
growth differentiation factor 15 Indomethacin results in increased expression of GDF15 mRNA increases expression
mRNA 15509713
16984733
17401462
D007213 9518 GDF15
GDF-15
MIC-1
MIC1
NAG-1
PDF
PLAB
PTGFB
growth differentiation factor 15 Indomethacin results in increased expression of GDF15 protein increases expression
protein 15180942
15509713
15555568
18076062
D007213 2744 GLS
AAD20
GAC
GAM
GLS1
KGA
glutaminase (EC:3.5.1.2) Indomethacin results in decreased expression of GLS mRNA decreases expression
mRNA 16984733
D007213 2752 GLUL
GLNS
GS
PIG43
PIG59
glutamate-ammonia ligase (EC:4.1.1.15 6.3.1.2) Indomethacin results in decreased expression of GLUL mRNA decreases expression
mRNA 17401462
D007213 57531 HACE1
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 Indomethacin results in decreased expression of HACE1 mRNA decreases expression
mRNA 16984733
D007213 256158 HMCN2
hemicentin 2 Indomethacin results in increased expression of HMCN2 mRNA increases expression
mRNA 16984733
D007213 3248 HPGD
15-PGDH
PGDH
PGDH1
PHOAR1
SDR36C1
hydroxyprostaglandin dehydrogenase 15-(NAD) (EC:1.1.1.141) Indomethacin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of HPGD mRNA] increases expression
/ increases reaction
mRNA 11237475
D007213 3248 HPGD
15-PGDH
PGDH
PGDH1
PHOAR1
SDR36C1
hydroxyprostaglandin dehydrogenase 15-(NAD) (EC:1.1.1.141) Indomethacin results in increased activity of HPGD protein increases activity
protein 19501039
D007213 3248 HPGD
15-PGDH
PGDH
PGDH1
PHOAR1
SDR36C1
hydroxyprostaglandin dehydrogenase 15-(NAD) (EC:1.1.1.141) Indomethacin results in increased expression of and results in increased activity of HPGD protein increases activity
/ increases expression
protein 11352223
14736730
D007213 3248 HPGD
15-PGDH
PGDH
PGDH1
PHOAR1
SDR36C1
hydroxyprostaglandin dehydrogenase 15-(NAD) (EC:1.1.1.141) Indomethacin results in increased expression of HPGD mRNA increases expression
mRNA 19501039
D007213 3291 HSD11B2
AME
AME1
HSD11K
HSD2
SDR9C3
hydroxysteroid (11-beta) dehydrogenase 2 (EC:1.1.1.146) Indomethacin results in decreased activity of HSD11B2 protein decreases activity
protein 10377029
D007213 3297 HSF1
HSTF1
heat shock transcription factor 1 Indomethacin results in increased activity of HSF1 protein increases activity
protein 10701834
12065054
D007213 3303 HSPA1A
HSP70-1
HSP70-1A
HSP70I
HSP72
HSPA1
heat shock 70kDa protein 1A Indomethacin affects the localization of HSPA1A protein affects localization
protein 16239242
D007213 3303 HSPA1A
HSP70-1
HSP70-1A
HSP70I
HSP72
HSPA1
heat shock 70kDa protein 1A Indomethacin results in increased expression of HSPA1A protein increases expression
protein 16239242
D007213 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Indomethacin results in increased expression of HSPA5 protein] decreases reaction
/ increases expression
protein 17341418
D007213 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Indomethacin results in increased expression of HSPA5 protein increases expression
protein 17341418
D007213 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) SB 203580 inhibits the reaction [Indomethacin results in increased expression of HSPA5 protein] decreases reaction
/ increases expression
protein 17341418
D007213 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) U 0126 inhibits the reaction [Indomethacin results in increased expression of HSPA5 protein] decreases reaction
/ increases expression
protein 17341418
D007213 3312 HSPA8
HSC54
HSC70
HSC71
HSP71
HSP73
HSPA10
LAP1
NIP71
heat shock 70kDa protein 8 Indomethacin affects the localization of HSPA8 protein affects localization
protein 14706622
16239242
D007213 3458 IFNG
IFG
IFI
interferon, gamma GW0072 inhibits the reaction [Indomethacin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]] affects cotreatment
/ decreases reaction
/ increases expression
protein 14586007
D007213 3458 IFNG
IFG
IFI
interferon, gamma Indomethacin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased metabolism of and results in increased secretion of APP protein alternative form] affects cotreatment
/ decreases reaction
/ increases metabolic processing
/ increases secretion
protein 14586007
D007213 3458 IFNG
IFG
IFI
interferon, gamma Indomethacin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of PPARG mRNA] affects cotreatment
/ decreases expression
/ decreases reaction
protein 16407166
D007213 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 Indomethacin inhibits the reaction [interferon alfa-n1 results in increased secretion of IL10 protein] decreases reaction
/ increases secretion
protein 15135802
D007213 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 Indomethacin results in decreased secretion of IL10 protein decreases secretion
protein 15135802
D007213 3589 IL11
AGIF
IL-11
interleukin 11 Indomethacin results in increased expression of IL11 mRNA increases expression
mRNA 16984733
D007213 3552 IL1A
IL-1A
IL1
IL1-ALPHA
IL1F1
interleukin 1, alpha Indomethacin inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein] decreases reaction
/ increases secretion
protein 11230753
D007213 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Indomethacin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA] decreases expression
/ decreases reaction
protein 8971655
D007213 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Indomethacin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone] decreases reaction
/ increases abundance
protein 12512699
12517972
D007213 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Indomethacin inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein] decreases reaction
/ increases activity
protein 12517972
15705740
D007213 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Indomethacin inhibits the reaction [IL1B results in increased activity of EDNRB] decreases reaction
/ increases activity
12126971
D007213 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Indomethacin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha] decreases reaction
/ increases chemical synthesis
16529823
D007213 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Indomethacin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone] decreases reaction
/ increases chemical synthesis
16529823
D007213 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Indomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Dinoprostone] affects cotreatment
/ decreases reaction
/ increases abundance
protein 12743569
D007213 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Indomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Prostaglandin D2] affects cotreatment
/ decreases reaction
/ increases abundance
protein 12743569
D007213 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Indomethacin promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA] increases expression
/ increases reaction
protein 12517972
D007213 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Indomethacin promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] increases reaction
/ increases secretion
protein 10772282
D007213 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Indomethacin results in decreased secretion of IL1B protein decreases secretion
protein 10388637
10393680
D007213 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Indomethacin results in increased expression of [IL1B protein results in increased expression of PTGS2 protein] increases expression
protein 12517972
D007213 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Indomethacin results in increased secretion of IL1B protein increases secretion
protein 10772282
D007213 3557 IL1RN
DIRA
ICIL-1RA
IL-1RN
IL-1ra
IL-1ra3
IL1F3
IL1RA
IRAP
MVCD4
interleukin 1 receptor antagonist IL1RN protein inhibits the reaction [Dinoprostone inhibits the reaction [Indomethacin results in decreased expression of IL6 protein]] decreases expression
/ decreases reaction
protein 8520508
D007213 3557 IL1RN
DIRA
ICIL-1RA
IL-1RN
IL-1ra
IL-1ra3
IL1F3
IL1RA
IRAP
MVCD4
interleukin 1 receptor antagonist Indomethacin results in decreased secretion of IL1RN protein decreases secretion
protein 12169827
D007213 3558 IL2
IL-2
TCGF
lymphokine
interleukin 2 Indomethacin promotes the reaction [interferon alfa-n1 results in increased secretion of IL2 protein] increases reaction
/ increases secretion
protein 15135802
D007213 3565 IL4
BCGF-1
BCGF1
BSF-1
BSF1
IL-4
interleukin 4 Indomethacin inhibits the reaction [interferon alfa-n1 results in increased secretion of IL4 protein] decreases reaction
/ increases secretion
protein 15135802
D007213 3565 IL4
BCGF-1
BCGF1
BSF-1
BSF1
IL-4
interleukin 4 Indomethacin results in decreased secretion of IL4 protein decreases secretion
protein 15135802
D007213 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Dinoprostone inhibits the reaction [Indomethacin results in decreased expression of IL6 protein] decreases expression
/ decreases reaction
protein 8520508
D007213 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) IL1RN protein inhibits the reaction [Dinoprostone inhibits the reaction [Indomethacin results in decreased expression of IL6 protein]] decreases expression
/ decreases reaction
protein 8520508
D007213 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Indomethacin inhibits the reaction [APP protein alternative form results in increased expression of IL6 protein] decreases reaction
/ increases expression
protein 16111494
D007213 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Indomethacin promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] increases reaction
/ increases secretion
protein 15379866
D007213 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Indomethacin results in decreased expression of IL6 protein decreases expression
protein 8520508
D007213 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Indomethacin results in decreased secretion of IL6 protein decreases secretion
protein 10388637
10393680
D007213 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Indomethacin results in increased secretion of IL6 protein increases secretion
protein 10772282
D007213 3572 IL6ST
CD130
CDW130
GP130
IL-6RB
interleukin 6 signal transducer (gp130, oncostatin M receptor) Indomethacin results in decreased expression of IL6ST mRNA decreases expression
mRNA 16984733
D007213 3574 IL7
IL-7
interleukin 7 Indomethacin results in decreased expression of IL7 mRNA decreases expression
mRNA 16984733
D007213 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 [Indomethacin co-treated with isoeugenol] results in increased expression of IL8 mRNA affects cotreatment
/ increases expression
mRNA 21284934
D007213 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Indomethacin results in decreased expression of IL8 mRNA decreases expression
mRNA 16984733
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin [Indomethacin co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PPARG mRNA affects cotreatment
/ increases expression
protein 20206132
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin [Indomethacin co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PPARG protein affects cotreatment
/ increases expression
protein 20206132
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin Indomethacin results in decreased secretion of INS protein decreases secretion
protein 10909992
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of ADIPOQ mRNA affects cotreatment
/ increases expression
protein 23086663
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of CIDEC mRNA affects cotreatment
/ increases expression
protein 23086663
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of FABP4 mRNA affects cotreatment
/ increases expression
protein 23086663
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA affects cotreatment
/ increases expression
protein 23086663
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LPL mRNA affects cotreatment
/ increases expression
protein 23086663
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin T 0070907 inhibits the reaction [[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of FABP4 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
protein 23086663
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin T 0070907 inhibits the reaction [[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA] affects cotreatment
/ decreases reaction
/ increases expression
protein 23086663
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin T 0070907 inhibits the reaction [[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LPL mRNA] affects cotreatment
/ decreases reaction
/ increases expression
protein 23086663
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of FABP4 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
protein 23086663
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA] affects cotreatment
/ decreases reaction
/ increases expression
protein 23086663
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LPL mRNA] affects cotreatment
/ decreases reaction
/ increases expression
protein 23086663
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of ADIPOQ mRNA affects cotreatment
/ increases expression
protein 23086663
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of CIDEC mRNA affects cotreatment
/ increases expression
protein 23086663
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of FABP4 mRNA affects cotreatment
/ increases expression
protein 23086663
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA affects cotreatment
/ increases expression
protein 23086663
D007213 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LPL mRNA affects cotreatment
/ increases expression
protein 23086663
D007213 3843 IPO5
IMB3
KPNB3
Pse1
RANBP5
imp5
importin 5 Indomethacin results in decreased expression of IPO5 mRNA decreases expression
mRNA 16984733
D007213 81875 ISG20L2
interferon stimulated exonuclease gene 20kDa-like 2 Indomethacin results in decreased expression of ISG20L2 mRNA decreases expression
mRNA 16984733
D007213 3684 ITGAM
CD11B
CR3A
MAC-1
MAC1A
MO1A
SLEB6
integrin, alpha M (complement component 3 receptor 3 subunit) 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Indomethacin results in increased expression of ITGAM protein] decreases reaction
/ increases expression
protein 11980903
D007213 3684 ITGAM
CD11B
CR3A
MAC-1
MAC1A
MO1A
SLEB6
integrin, alpha M (complement component 3 receptor 3 subunit) Indomethacin results in increased expression of ITGAM protein increases expression
protein 11980903
D007213 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Indomethacin results in increased expression of JUN mRNA increases expression
mRNA 16984733
D007213 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Indomethacin results in increased phosphorylation of JUN protein increases phosphorylation
protein 15804060
D007213 3726 JUNB
AP-1
jun B proto-oncogene Indomethacin results in increased expression of JUNB mRNA increases expression
mRNA 16984733
D007213 115207 KCTD12
C13orf2
PFET1
PFETIN
potassium channel tetramerization domain containing 12 Indomethacin results in decreased expression of KCTD12 mRNA decreases expression
mRNA 16984733
D007213 9817 KEAP1
INrf2
KLHL19
kelch-like ECH-associated protein 1 Acetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] affects binding
/ decreases reaction
protein 11909699
D007213 9817 KEAP1
INrf2
KLHL19
kelch-like ECH-associated protein 1 Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein] affects binding
/ decreases reaction
protein 11909699
D007213 9817 KEAP1
INrf2
KLHL19
kelch-like ECH-associated protein 1 KEAP1 protein inhibits the reaction [Indomethacin results in increased expression of GCLC mRNA] decreases reaction
/ increases expression
protein 11909699
D007213 55196 C12orf35
KIAA1551 Indomethacin results in decreased expression of KIAA1551 mRNA decreases expression
mRNA 16984733
D007213 9314 KLF4
EZF
GKLF
Kruppel-like factor 4 (gut) Indomethacin results in increased expression of KLF4 mRNA increases expression
mRNA 16984733
D007213 3827 KNG1
BDK
BK
KNG
kininogen 1 Indomethacin results in decreased activity of KNG1 protein decreases activity
protein 1371395
D007213 3915 LAMC1
LAMB2
laminin, gamma 1 (formerly LAMB2) Indomethacin results in decreased expression of LAMC1 mRNA decreases expression
mRNA 15561105
D007213 3915 LAMC1
LAMB2
laminin, gamma 1 (formerly LAMB2) Indomethacin results in decreased expression of LAMC1 protein decreases expression
protein 15561105
D007213 81606 LBH
limb bud and heart development Indomethacin results in increased expression of LBH mRNA increases expression
mRNA 16984733
D007213 3949 LDLR
FH
FHC
LDLCQ2
low density lipoprotein receptor fluvastatin promotes the reaction [Indomethacin promotes the reaction [Cholesterol, LDL binds to LDLR protein]] affects binding
/ increases reaction
protein 10395027
D007213 3949 LDLR
FH
FHC
LDLCQ2
low density lipoprotein receptor Indomethacin promotes the reaction [Cholesterol, LDL binds to LDLR protein] affects binding
/ increases reaction
protein 10395027
D007213 3949 LDLR
FH
FHC
LDLCQ2
low density lipoprotein receptor Indomethacin promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL] affects binding
/ increases degradation
/ increases reaction
protein 10395027
D007213 3949 LDLR
FH
FHC
LDLCQ2
low density lipoprotein receptor Indomethacin results in increased expression of LDLR mRNA increases expression
mRNA 10395027
D007213 3949 LDLR
FH
FHC
LDLCQ2
low density lipoprotein receptor Indomethacin results in increased expression of LDLR protein increases expression
protein 10395027
D007213 3952 LEP
LEPD
OB
OBS
leptin [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA affects cotreatment
/ increases expression
mRNA 23086663
D007213 3952 LEP
LEPD
OB
OBS
leptin T 0070907 inhibits the reaction [[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 23086663
D007213 3952 LEP
LEPD
OB
OBS
leptin T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 23086663
D007213 3952 LEP
LEPD
OB
OBS
leptin [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA affects cotreatment
/ increases expression
mRNA 23086663
D007213 4023 LPL
HDLCQ11
LIPD
lipoprotein lipase (EC:3.1.1.34) [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LPL mRNA affects cotreatment
/ increases expression
mRNA 23086663
D007213 4023 LPL
HDLCQ11
LIPD
lipoprotein lipase (EC:3.1.1.34) T 0070907 inhibits the reaction [[rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LPL mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 23086663
D007213 4023 LPL
HDLCQ11
LIPD
lipoprotein lipase (EC:3.1.1.34) T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LPL mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 23086663
D007213 4023 LPL
HDLCQ11
LIPD
lipoprotein lipase (EC:3.1.1.34) [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LPL mRNA affects cotreatment
/ increases expression
mRNA 23086663
D007213 4049 LTA
LT
TNFB
TNFSF1
lymphotoxin alpha Indomethacin inhibits the reaction [LTA protein results in increased expression of BIRC3 protein] decreases reaction
/ increases expression
protein 17873517
D007213 4049 LTA
LT
TNFB
TNFSF1
lymphotoxin alpha Indomethacin inhibits the reaction [LTA protein results in increased expression of CFLAR protein] decreases reaction
/ increases expression
protein 17873517
D007213 4049 LTA
LT
TNFB
TNFSF1
lymphotoxin alpha Indomethacin inhibits the reaction [LTA protein results in increased expression of XIAP protein] decreases reaction
/ increases expression
protein 17873517
D007213 4049 LTA
LT
TNFB
TNFSF1
lymphotoxin alpha Indomethacin inhibits the reaction [LTA protein results in increased phosphorylation of NFKBIA protein] decreases reaction
/ increases phosphorylation
protein 17873517
D007213 4049 LTA
LT
TNFB
TNFSF1
lymphotoxin alpha Indomethacin inhibits the reaction [LTA protein results in increased phosphorylation of RELA protein] decreases reaction
/ increases phosphorylation
protein 17873517
D007213 4049 LTA
LT
TNFB
TNFSF1
lymphotoxin alpha Indomethacin promotes the reaction [LTA protein results in increased cleavage of CASP3 protein] increases cleavage
/ increases reaction
protein 17873517
D007213 4049 LTA
LT
TNFB
TNFSF1
lymphotoxin alpha Indomethacin promotes the reaction [LTA protein results in increased cleavage of PARP1 protein] increases cleavage
/ increases reaction
protein 17873517
D007213 4067 LYN
JTK8
p53Lyn
p56Lyn
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) Indomethacin results in decreased expression of LYN mRNA decreases expression
mRNA 16984733
D007213 6416 MAP2K4
JNKK
JNKK1
MAPKK4
MEK4
MKK4
PRKMK4
SAPKK-1
SAPKK1
SEK1
SERK1
SKK1
mitogen-activated protein kinase kinase 4 (EC:2.7.12.2) Indomethacin results in increased expression of MAP2K4 protein increases expression
protein 15804060
D007213 9448 MAP4K4
FLH21957
HGK
MEKKK4
NIK
mitogen-activated protein kinase kinase kinase kinase 4 (EC:2.7.11.1) Indomethacin results in decreased expression of MAP4K4 mRNA decreases expression
mRNA 16984733
D007213 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Indomethacin results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 17341418
D007213 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Indomethacin results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 17341418
D007213 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Indomethacin results in increased phosphorylation of MAPK1 protein increases phosphorylation
protein 12485869
17341418
D007213 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Indomethacin results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 17341418
D007213 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Indomethacin results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 17341418
D007213 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Indomethacin results in increased phosphorylation of MAPK3 protein increases phosphorylation
protein 12485869
17341418
D007213 4154 MBNL1
EXP
EXP35
EXP40
EXP42
MBNL
muscleblind-like splicing regulator 1 Indomethacin results in decreased expression of MBNL1 mRNA decreases expression
mRNA 16984733
D007213 4155 MBP
myelin basic protein Indomethacin inhibits the reaction [CTSB protein results in increased degradation of MBP protein] decreases reaction
/ increases degradation
protein 11071371
D007213 124512 METTL23
C17orf95
methyltransferase like 23 Indomethacin results in increased expression of METTL23 mRNA increases expression
mRNA 16984733
D007213 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Indomethacin results in decreased expression of and results in decreased activity of MMP2 protein decreases activity
/ decreases expression
protein 11719597
D007213 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Indomethacin results in decreased expression of and results in decreased activity of MMP9 protein decreases activity
/ decreases expression
protein 11719597
D007213 6307 MSMO1
DESP4
ERG25
SC4MOL
methylsterol monooxygenase 1 (EC:1.14.13.72) Indomethacin results in increased expression of MSMO1 mRNA increases expression
mRNA 17401462
D007213 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog Indomethacin results in increased expression of MYC mRNA increases expression
mRNA 10403534
11756231
D007213 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog Indomethacin results in increased expression of MYC protein increases expression
protein 10403534
11260862
D007213 4739 NEDD9
CAS-L
CAS2
CASL
CASS2
HEF1
neural precursor cell expressed, developmentally down-regulated 9 Indomethacin results in increased expression of NEDD9 mRNA increases expression
mRNA 16984733
D007213 10276 NET1
ARHGEF8
NET1A
neuroepithelial cell transforming 1 Indomethacin results in increased expression of NET1 mRNA increases expression
mRNA 16984733
D007213 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 Acetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] affects binding
/ decreases reaction
protein 11909699
D007213 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 Acetylcysteine inhibits the reaction [Indomethacin results in increased localization of NFE2L2 protein] decreases reaction
/ increases localization
protein 11909699
D007213 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein] affects binding
/ decreases reaction
protein 11909699
D007213 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 Indomethacin results in increased localization of NFE2L2 protein increases localization
protein 11909699
D007213 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Indomethacin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] decreases reaction
/ increases activity
protein 15489888
D007213 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Indomethacin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] affects binding
/ decreases reaction
/ increases activity
protein 15489888
D007213 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Indomethacin inhibits the reaction [LTA protein results in increased phosphorylation of NFKBIA protein] decreases reaction
/ increases phosphorylation
protein 17873517
D007213 4803 NGF
Beta-NGF
HSAN5
NGFB
nerve growth factor (beta polypeptide) Indomethacin results in increased expression of NGF mRNA increases expression
mRNA 16984733
D007213 57224 NHSL1
C6orf63
NHS-like 1 Indomethacin results in decreased expression of NHSL1 mRNA decreases expression
mRNA 16984733
D007213 4824 NKX3-1
BAPX2
NKX3
NKX3.1
NKX3A
NK3 homeobox 1 Indomethacin results in increased expression of NKX3-1 mRNA increases expression
mRNA 16984733
D007213 4830 NME1
AWD
GAAD
NB
NBS
NDKA
NDPK-A
NDPKA
NM23
NM23-H1
NME/NM23 nucleoside diphosphate kinase 1 (EC:2.7.4.6) Indomethacin results in increased expression of NME1 mRNA increases expression
mRNA 12192599
D007213 4869 NPM1
B23
NPM
nucleophosmin (nucleolar phosphoprotein B23, numatrin) Indomethacin results in decreased expression of NPM1 mRNA decreases expression
mRNA 10619186
D007213 4878 NPPA
ANF
ANP
ATFB6
CDD-ANF
PND
natriuretic peptide A Indomethacin results in decreased expression of NPPA protein decreases expression
protein 1421905
D007213 7026 NR2F2
ARP1
COUPTFB
COUPTFII
NF-E3
NR2F1
SVP40
TFCOUP2
nuclear receptor subfamily 2, group F, member 2 Indomethacin results in decreased expression of NR2F2 mRNA decreases expression
mRNA 16984733
D007213 3164 NR4A1
GFRP1
HMR
N10
NAK-1
NGFIB
NP10
NUR77
TR3
nuclear receptor subfamily 4, group A, member 1 Indomethacin results in increased expression of and results in increased activity of NR4A1 protein increases activity
/ increases expression
protein 10919358
D007213 3164 NR4A1
GFRP1
HMR
N10
NAK-1
NGFIB
NP10
NUR77
TR3
nuclear receptor subfamily 4, group A, member 1 Indomethacin results in increased expression of NR4A1 mRNA increases expression
mRNA 10919358
D007213 3164 NR4A1
GFRP1
HMR
N10
NAK-1
NGFIB
NP10
NUR77
TR3
nuclear receptor subfamily 4, group A, member 1 Tretinoin inhibits the reaction [Indomethacin results in increased expression of NR4A1 mRNA] decreases reaction
/ increases expression
mRNA 10919358
D007213 4897 NRCAM
neuronal cell adhesion molecule Indomethacin results in decreased expression of NRCAM mRNA decreases expression
mRNA 16984733
D007213 4907 NT5E
CALJA
CD73
E5NT
NT
NT5
NTE
eN
eNT
5'-nucleotidase, ecto (CD73) (EC:3.1.3.5) Indomethacin results in increased expression of and results in increased activity of NT5E protein increases activity
/ increases expression
protein 17568578
D007213 4907 NT5E
CALJA
CD73
E5NT
NT
NT5
NTE
eN
eNT
5'-nucleotidase, ecto (CD73) (EC:3.1.3.5) Indomethacin results in increased expression of NT5E mRNA increases expression
mRNA 17568578
D007213 9891 NUAK1
ARK5
NUAK family, SNF1-like kinase, 1 (EC:2.7.11.1) Indomethacin results in increased expression of NUAK1 mRNA increases expression
mRNA 16984733
D007213 57532 NUFIP2
182-FIP
82-FIP
FIP-82
nuclear fragile X mental retardation protein interacting protein 2 Indomethacin results in decreased expression of NUFIP2 mRNA decreases expression
mRNA 16984733
D007213 8106 PABPN1
OPMD
PAB2
PABII
PABP-2
PABP2
poly(A) binding protein, nuclear 1 Indomethacin inhibits the reaction [PABPN1 protein mutant form binds to PABPN1 protein mutant form] affects binding
/ decreases reaction
protein 16239242
D007213 53354 PANK1
PANK
pantothenate kinase 1 (EC:2.7.1.33) Indomethacin results in decreased expression of PANK1 mRNA decreases expression
mRNA 16984733
D007213 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) GW0742 promotes the reaction [Indomethacin results in increased cleavage of PARP1 protein] increases cleavage
/ increases reaction
protein 21400612
D007213 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) GW 501516 promotes the reaction [Indomethacin results in increased cleavage of PARP1 protein] increases cleavage
/ increases reaction
protein 21400612
D007213 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Indomethacin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PARP1 protein] decreases reaction
/ increases activity
protein 2126186
D007213 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Indomethacin promotes the reaction [LTA protein results in increased cleavage of PARP1 protein] increases cleavage
/ increases reaction
protein 17873517
D007213 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Indomethacin results in increased cleavage of PARP1 protein increases cleavage
protein 11532860
12663503
15804060
15812552
21400612
D007213 5111 PCNA
proliferating cell nuclear antigen Indomethacin results in decreased expression of PCNA mRNA decreases expression
mRNA 17054584
D007213 5111 PCNA
proliferating cell nuclear antigen Indomethacin results in decreased expression of PCNA protein decreases expression
protein 17054584
D007213 54704 PDP1
PDH
PDP
PDPC
PPM2C
pyruvate dehyrogenase phosphatase catalytic subunit 1 (EC:3.1.3.43) Indomethacin results in decreased expression of PDP1 mRNA decreases expression
mRNA 16984733
D007213 9867 PJA2
Neurodap1
RNF131
praja ring finger 2, E3 ubiquitin protein ligase (EC:6.3.2.-) Indomethacin results in decreased expression of PJA2 mRNA decreases expression
mRNA 16984733
D007213 8502 PKP4
p0071
plakophilin 4 Indomethacin results in decreased expression of PKP4 mRNA decreases expression
mRNA 16984733
D007213 5328 PLAU
ATF
BDPLT5
QPD
UPA
URK
u-PA
plasminogen activator, urokinase (EC:3.4.21.73) Indomethacin results in increased expression of PLAU mRNA increases expression
mRNA 16984733
D007213 123 PLIN2
ADFP
ADRP
perilipin 2 Indomethacin results in increased expression of PLIN2 mRNA increases expression
mRNA 19415698
D007213 10769 PLK2
SNK
hPlk2
hSNK
polo-like kinase 2 (EC:2.7.11.21) Indomethacin results in decreased expression of PLK2 mRNA decreases expression
mRNA 16984733
D007213 5366 PMAIP1
APR
NOXA
phorbol-12-myristate-13-acetate-induced protein 1 Indomethacin results in increased expression of PMAIP1 mRNA increases expression
mRNA 17401462
D007213 56937 PMEPA1
STAG1
TMEPAI
prostate transmembrane protein, androgen induced 1 Indomethacin results in increased expression of PMEPA1 mRNA increases expression
mRNA 16984733
D007213 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha Indomethacin binds to and results in increased activity of PPARA protein affects binding
/ increases activity
protein 9013583
D007213 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha Indomethacin results in increased expression of PPARA mRNA increases expression
mRNA 19415698
D007213 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha Indomethacin results in increased expression of PPARA protein increases expression
protein 19415698
D007213 5467 PPARD
FAAR
NR1C2
NUC1
NUCI
NUCII
PPARB
peroxisome proliferator-activated receptor delta anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Indomethacin results in increased expression of PPARD protein] decreases reaction
/ increases expression
protein 17341418
D007213 5467 PPARD
FAAR
NR1C2
NUC1
NUCI
NUCII
PPARB
peroxisome proliferator-activated receptor delta Indomethacin results in decreased activity of PPARD protein decreases activity
protein 10555149
D007213 5467 PPARD
FAAR
NR1C2
NUC1
NUCI
NUCII
PPARB
peroxisome proliferator-activated receptor delta Indomethacin results in decreased expression of PPARD protein decreases expression
protein 18678619
D007213 5467 PPARD
FAAR
NR1C2
NUC1
NUCI
NUCII
PPARB
peroxisome proliferator-activated receptor delta Indomethacin results in increased expression of PPARD mRNA increases expression
mRNA 19415698
D007213 5467 PPARD
FAAR
NR1C2
NUC1
NUCI
NUCII
PPARB
peroxisome proliferator-activated receptor delta Indomethacin results in increased expression of PPARD protein increases expression
protein 17341418
19415698
21400612
D007213 5467 PPARD
FAAR
NR1C2
NUC1
NUCI
NUCII
PPARB
peroxisome proliferator-activated receptor delta PPARD protein affects the reaction [Indomethacin results in decreased expression of YWHAE protein] affects reaction
/ decreases expression
protein 17409426
D007213 5467 PPARD
FAAR
NR1C2
NUC1
NUCI
NUCII
PPARB
peroxisome proliferator-activated receptor delta SB 203580 inhibits the reaction [Indomethacin results in increased expression of PPARD protein] decreases reaction
/ increases expression
protein 17341418
D007213 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Indomethacin results in increased activity of PPARG protein] decreases reaction
/ increases activity
protein 12485869
D007213 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Indomethacin affects the localization of PPARG protein affects localization
protein 15899809
D007213 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Indomethacin analog results in increased activity of PPARG protein increases activity
protein 17602619
D007213 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Indomethacin binds to and results in increased activity of PPARG protein affects binding
/ increases activity
protein 9013583
D007213 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma [Indomethacin co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PPARG mRNA affects cotreatment
/ increases expression
mRNA 20206132
D007213 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma [Indomethacin co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PPARG protein affects cotreatment
/ increases expression
protein 20206132
D007213 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma [Indomethacin co-treated with L 663536] affects the localization of PPARG protein affects cotreatment
/ affects localization
protein 15899809
D007213 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Indomethacin inhibits the reaction [rosiglitazone binds to PPARG protein] affects binding
/ decreases reaction
protein 9013583
D007213 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Indomethacin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of PPARG mRNA] affects cotreatment
/ decreases expression
/ decreases reaction
mRNA 16407166
D007213 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Indomethacin promotes the reaction [L 663536 results in increased activity of PPARG protein] increases activity
/ increases reaction
protein 15899809
D007213 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Indomethacin results in increased activity of PPARG protein increases activity
protein 12065695
12485869
12606626
15899809
17602619
D007213 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Indomethacin results in increased expression of PPARG mRNA increases expression
mRNA 12483719
D007213 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Indomethacin results in increased expression of PPARG protein increases expression
protein 17341418
D007213 151987 PPP4R2
PP4R2
protein phosphatase 4, regulatory subunit 2 Indomethacin results in decreased expression of PPP4R2 mRNA decreases expression
mRNA 16984733
D007213 5579 PRKCB
PKC-beta
PKCB
PRKCB1
PRKCB2
protein kinase C, beta (EC:2.7.11.13) Indomethacin results in decreased expression of PRKCB protein alternative form decreases expression
protein 10702201
D007213 5579 PRKCB
PKC-beta
PKCB
PRKCB1
PRKCB2
protein kinase C, beta (EC:2.7.11.13) Indomethacin results in increased expression of PRKCB protein alternative form increases expression
protein 10702201
D007213 5579 PRKCB
PKC-beta
PKCB
PRKCB1
PRKCB2
protein kinase C, beta (EC:2.7.11.13) PRKCB protein alternative form results in decreased susceptibility to Indomethacin decreases response to substance
protein 10702201
D007213 5581 PRKCE
PKCE
nPKC-epsilon
protein kinase C, epsilon (EC:2.7.11.13) Indomethacin results in increased expression of PRKCE protein increases expression
protein 10702201
D007213 5583 PRKCH
PKC-L
PKCL
PRKCL
nPKC-eta
protein kinase C, eta (EC:2.7.11.13) Indomethacin results in increased expression of PRKCH protein increases expression
protein 10702201
D007213 5584 PRKCI
DXS1179E
PKCI
nPKC-iota
protein kinase C, iota (EC:2.7.11.13) Indomethacin results in decreased expression of PRKCI mRNA decreases expression
mRNA 16984733
D007213 8899 PRPF4B
PR4H
PRP4
PRP4H
PRP4K
dJ1013A10.1
pre-mRNA processing factor 4B (EC:2.7.11.1) Indomethacin results in decreased expression of PRPF4B mRNA decreases expression
mRNA 16984733
D007213 5723 PSPH
PSP
PSPHD
phosphoserine phosphatase (EC:3.1.3.3) Indomethacin results in increased expression of PSPH mRNA increases expression
mRNA 17401462
D007213 11251 PTGDR2
CD294
CRTH2
DL1R
DP2
GPR44
prostaglandin D2 receptor 2 Indomethacin binds to and results in increased activity of PTGDR2 protein affects binding
/ increases activity
protein 16256979
D007213 11251 PTGDR2
CD294
CRTH2
DL1R
DP2
GPR44
prostaglandin D2 receptor 2 Indomethacin results in increased activity of PTGDR2 protein increases activity
protein 11801628
D007213 11251 PTGDR2
CD294
CRTH2
DL1R
DP2
GPR44
prostaglandin D2 receptor 2 ramatroban inhibits the reaction [Indomethacin binds to and results in increased activity of PTGDR2 protein] affects binding
/ decreases reaction
/ increases activity
protein 16256979
D007213 5732 PTGER2
EP2
prostaglandin E receptor 2 (subtype EP2), 53kDa Indomethacin results in decreased expression of PTGER2 mRNA decreases expression
mRNA 17555711
D007213 5732 PTGER2
EP2
prostaglandin E receptor 2 (subtype EP2), 53kDa Indomethacin results in decreased expression of PTGER2 protein decreases expression
protein 17555711
D007213 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin analog results in decreased activity of PTGS1 protein decreases activity
protein 16141368
D007213 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin binds to and results in decreased activity of PTGS1 protein affects binding
/ decreases activity
protein 9146894
D007213 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin inhibits the reaction [PTGS1 protein results in increased chemical synthesis of Dinoprostone] decreases reaction
/ increases chemical synthesis
protein 16354411
D007213 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin results in decreased activity of PTGS1 protein decreases activity
protein 16141368
20933508
D007213 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin results in decreased expression of PTGS1 protein decreases expression
protein 14736730
D007213 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin results in increased expression of PTGS1 protein increases expression
protein 15482327
D007213 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin analog results in decreased activity of PTGS2 protein decreases activity
protein 12142058
16690318
D007213 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin binds to and results in decreased activity of PTGS2 protein affects binding
/ decreases activity
protein 9146894
D007213 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein] decreases reaction
/ increases activity
protein 12517972
15705740
D007213 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 15489888
D007213 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA] increases expression
/ increases reaction
mRNA 12517972
D007213 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin results in decreased activity of PTGS2 protein decreases activity
protein 12517972
16190777
20933508
D007213 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin results in decreased expression of PTGS2 protein decreases expression
protein 10866311
11504793
19014992
D007213 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin results in increased expression of [IL1B protein results in increased expression of PTGS2 protein] increases expression
protein 12517972
D007213 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin results in increased expression of PTGS2 increases expression
11840453
D007213 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin results in increased expression of PTGS2 mRNA increases expression
mRNA 10594327
12517972
D007213 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Indomethacin results in increased expression of PTGS2 protein increases expression
protein 10866999
12517972
15482327
D007213 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) Indomethacin affects the localization of PTK2 protein affects localization
protein 12037131
D007213 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) Indomethacin inhibits the reaction [EGF protein affects the localization of PTK2 protein] affects localization
/ decreases reaction
protein 12037131
D007213 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) Indomethacin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein] decreases reaction
/ increases phosphorylation
protein 12037131
D007213 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) Indomethacin results in decreased phosphorylation of PTK2 protein decreases phosphorylation
protein 12037131
D007213 5782 PTPN12
PTP-PEST
PTPG1
protein tyrosine phosphatase, non-receptor type 12 (EC:3.1.3.48) Indomethacin results in decreased expression of PTPN12 mRNA decreases expression
mRNA 16984733
D007213 221749 PXDC1
C6orf145
PX domain containing 1 Indomethacin results in increased expression of PXDC1 mRNA increases expression
mRNA 16984733
D007213 5887 RAD23B
HHR23B
HR23B
P58
RAD23 homolog B (S. cerevisiae) Indomethacin results in decreased expression of RAD23B mRNA decreases expression
mRNA 16984733
D007213 51735 RAPGEF6
KIA001LB
PDZ-GEF2
PDZGEF2
RA-GEF-2
RAGEF2
Rap guanine nucleotide exchange factor (GEF) 6 Indomethacin results in decreased expression of RAPGEF6 mRNA decreases expression
mRNA 16984733
D007213 65059 RAPH1
ALS2CR18
ALS2CR9
LPD
PREL-2
PREL2
RMO1
RalGDS/AF-6
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 Indomethacin results in decreased expression of RAPH1 mRNA decreases expression
mRNA 16984733
D007213 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 Indomethacin results in decreased phosphorylation of RB1 protein decreases phosphorylation
protein 18791128
D007213 64783 RBM15
OTT
OTT1
SPEN
RNA binding motif protein 15 Indomethacin results in decreased expression of RBM15 mRNA decreases expression
mRNA 16984733
D007213 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Indomethacin affects the localization of RELA protein affects localization
protein 18059344
D007213 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Indomethacin inhibits the reaction [LTA protein results in increased phosphorylation of RELA protein] decreases reaction
/ increases phosphorylation
protein 17873517
D007213 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Indomethacin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] affects binding
/ decreases reaction
/ increases activity
protein 15489888
D007213 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Indomethacin inhibits the reaction [TNF protein results in increased activity of RELA protein] decreases reaction
/ increases activity
protein 15489888
D007213 5972 REN
HNFJ2
renin (EC:3.4.23.15) [Indomethacin co-treated with Amlodipine] results in decreased expression of REN protein affects cotreatment
/ decreases expression
protein 11078175
D007213 5972 REN
HNFJ2
renin (EC:3.4.23.15) [Indomethacin co-treated with Enalapril] results in decreased expression of REN protein affects cotreatment
/ decreases expression
protein 11078175
D007213 5972 REN
HNFJ2
renin (EC:3.4.23.15) Indomethacin inhibits the reaction [Bumetanide results in increased activity of REN protein] decreases reaction
/ increases activity
protein 6756707
D007213 5972 REN
HNFJ2
renin (EC:3.4.23.15) Indomethacin inhibits the reaction [Furosemide results in increased expression of REN protein] decreases reaction
/ increases expression
protein 3530574
4028619
D007213 5972 REN
HNFJ2
renin (EC:3.4.23.15) Indomethacin results in decreased activity of REN protein decreases activity
protein 929154
3884224
7035040
7049707
D007213 5972 REN
HNFJ2
renin (EC:3.4.23.15) Indomethacin results in decreased expression of and results in decreased activity of REN protein decreases activity
/ decreases expression
protein 6756707
D007213 5972 REN
HNFJ2
renin (EC:3.4.23.15) Indomethacin results in decreased expression of REN protein decreases expression
protein 119300
3530574
4028619
6758745
D007213 5972 REN
HNFJ2
renin (EC:3.4.23.15) [Oxprenolol co-treated with Indomethacin] results in decreased activity of REN protein affects cotreatment
/ decreases activity
protein 7049707
D007213 51455 REV1
REV1L
REV1, polymerase (DNA directed) Indomethacin results in decreased expression of REV1 mRNA decreases expression
mRNA 16984733
D007213 388 RHOB
ARH6
ARHB
MST081
MSTP081
RHOH6
ras homolog family member B Indomethacin results in increased expression of RHOB mRNA increases expression
mRNA 16984733
D007213 255488 RNF144B
IBRDC2
PIR2
bA528A10.3
p53RFP
ring finger protein 144B Indomethacin results in decreased expression of RNF144B mRNA decreases expression
mRNA 16984733
D007213 153830 RNF145
ring finger protein 145 Indomethacin results in decreased expression of RNF145 mRNA decreases expression
mRNA 16984733
D007213 9475 ROCK2
ROCK-II
Rho-associated, coiled-coil containing protein kinase 2 (EC:2.7.11.1) Indomethacin results in decreased expression of ROCK2 mRNA decreases expression
mRNA 16984733
D007213 6256 RXRA
NR2B1
retinoid X receptor, alpha [L 663536 co-treated with Indomethacin] results in increased expression of RXRA mRNA affects cotreatment
/ increases expression
mRNA 15899809
D007213 6299 SALL1
HSAL1
Sal-1
TBS
ZNF794
spalt-like transcription factor 1 Indomethacin results in increased expression of SALL1 mRNA increases expression
mRNA 16984733
D007213 6301 SARS
SERRS
SERS
seryl-tRNA synthetase (EC:6.1.1.11) Indomethacin results in increased expression of SARS mRNA increases expression
mRNA 17401462
D007213 6303 SAT1
DC21
KFSD
KFSDX
SAT
SSAT
SSAT-1
spermidine/spermine N1-acetyltransferase 1 (EC:2.3.1.57) Indomethacin results in increased expression of SAT1 mRNA increases expression
mRNA 16262603
D007213 11341 SCRG1
SCRG-1
stimulator of chondrogenesis 1 Indomethacin results in increased expression of SCRG1 mRNA increases expression
mRNA 17401462
D007213 11231 SEC63
DNAJC23
ERdj2
PRO2507
SEC63L
SEC63 homolog (S. cerevisiae) Indomethacin results in decreased expression of SEC63 mRNA decreases expression
mRNA 16984733
D007213 6402 SELL
CD62L
LAM1
LECAM1
LEU8
LNHR
LSEL
LYAM1
PLNHR
TQ1
selectin L Indomethacin results in decreased expression of SELL protein decreases expression
protein 11980903
12147693
D007213 5265 SERPINA1
A1A
A1AT
AAT
PI
PI1
PRO2275
alpha1AT
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 SERPINA1 protein mutant form results in increased susceptibility to Indomethacin increases response to substance
protein 17006946
D007213 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Indomethacin inhibits the reaction [Glucose results in increased secretion of SERPINE1 protein] decreases reaction
/ increases secretion
protein 16320596
D007213 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Indomethacin inhibits the reaction [Lipopolysaccharides results in increased secretion of SERPINE1 protein] decreases reaction
/ increases secretion
protein 16320596
D007213 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Indomethacin results in increased expression of SERPINE1 mRNA increases expression
mRNA 16984733
D007213 6566 SLC16A1
HHF7
MCT
MCT1
solute carrier family 16 (monocarboxylate transporter), member 1 Indomethacin inhibits the reaction [SLC16A1 protein results in increased uptake of Butyrates] decreases reaction
/ increases uptake
protein 19023563
D007213 6566 SLC16A1
HHF7
MCT
MCT1
solute carrier family 16 (monocarboxylate transporter), member 1 Indomethacin results in decreased expression of SLC16A1 mRNA decreases expression
mRNA 16984733
D007213 6573 SLC19A1
CHMD
FOLT
IFC1
REFC
RFC1
solute carrier family 19 (folate transporter), member 1 [Indomethacin results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid decreases activity
/ decreases uptake
protein 17034785
D007213 10560 SLC19A2
TC1
THMD1
THT1
THTR1
TRMA
solute carrier family 19 (thiamine transporter), member 2 Indomethacin results in increased expression of SLC19A2 mRNA increases expression
mRNA 16984733
D007213 6580 SLC22A1
HOCT1
OCT1
oct1_cds
solute carrier family 22 (organic cation transporter), member 1 Indomethacin results in decreased activity of SLC22A1 protein decreases activity
protein 12388633
D007213 55867 SLC22A11
OAT4
hOAT4
solute carrier family 22 (organic anion/urate transporter), member 11 Indomethacin inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate] affects transport
/ decreases reaction
protein 10660625
D007213 55867 SLC22A11
OAT4
hOAT4
solute carrier family 22 (organic anion/urate transporter), member 11 Indomethacin results in decreased activity of SLC22A11 protein decreases activity
protein 12388633
D007213 116085 SLC22A12
OAT4L
RST
URAT1
solute carrier family 22 (organic anion/urate transporter), member 12 Indomethacin inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] decreases reaction
/ increases uptake
protein 21272127
D007213 6582 SLC22A2
OCT2
solute carrier family 22 (organic cation transporter), member 2 Indomethacin results in decreased activity of SLC22A2 protein decreases activity
protein 12388633
D007213 9356 SLC22A6
HOAT1
OAT1
PAHT
ROAT1
solute carrier family 22 (organic anion transporter), member 6 Indomethacin results in decreased activity of SLC22A6 protein decreases activity
protein 12388633
D007213 9356 SLC22A6
HOAT1
OAT1
PAHT
ROAT1
solute carrier family 22 (organic anion transporter), member 6 SLC22A6 protein results in increased uptake of Indomethacin increases uptake
protein 12388633
D007213 10864 SLC22A7
NLT
OAT2
solute carrier family 22 (organic anion transporter), member 7 Indomethacin inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline] decreases reaction
/ increases transport
protein 15901346
D007213 10864 SLC22A7
NLT
OAT2
solute carrier family 22 (organic anion transporter), member 7 Indomethacin results in decreased activity of SLC22A7 protein decreases activity
protein 12388633
D007213 9376 SLC22A8
OAT3
solute carrier family 22 (organic anion transporter), member 8 Indomethacin inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate] affects transport
/ decreases reaction
protein 11306713
D007213 114571 SLC22A9
HOAT4
OAT4
OAT7
UST3H
ust3
solute carrier family 22 (organic anion transporter), member 9 Indomethacin results in decreased activity of SLC22A9 protein decreases activity
protein 12388633
D007213 114571 SLC22A9
HOAT4
OAT4
OAT7
UST3H
ust3
solute carrier family 22 (organic anion transporter), member 9 SLC22A9 protein results in increased uptake of Indomethacin increases uptake
protein 12388633
D007213 9962 SLC23A2
NBTL1
SLC23A1
SVCT2
YSPL2
solute carrier family 23 (ascorbic acid transporter), member 2 Indomethacin inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid] decreases reaction
/ increases uptake
protein 17092984
D007213 6520 SLC3A2
4F2
4F2HC
4T2HC
CD98
CD98HC
MDU1
NACAE
solute carrier family 3 (amino acid transporter heavy chain), member 2 Indomethacin results in increased expression of SLC3A2 mRNA increases expression
mRNA 17401462
D007213 23657 SLC7A11
CCBR1
xCT
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 Indomethacin results in increased expression of SLC7A11 mRNA increases expression
mRNA 17401462
D007213 6578 SLCO2A1
MATR1
OATP2A1
PGT
PHOAR2
SLC21A2
solute carrier organic anion transporter family, member 2A1 Indomethacin promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] increases reaction
/ increases transport
protein 19843975
D007213 4092 SMAD7
CRCS3
MADH7
MADH8
SMAD family member 7 Indomethacin results in increased expression of SMAD7 mRNA increases expression
mRNA 16984733
D007213 6591 SNAI2
SLUG
SLUGH1
SNAIL2
WS2D
snail family zinc finger 2 Indomethacin results in increased expression of SNAI2 mRNA increases expression
mRNA 16984733
D007213 9655 SOCS5
CIS6
CISH6
Cish5
SOCS-5
suppressor of cytokine signaling 5 Indomethacin results in decreased expression of SOCS5 mRNA decreases expression
mRNA 16984733
D007213 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Indomethacin inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA] decreases reaction
/ increases expression
mRNA 12031898
D007213 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Indomethacin inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein] decreases reaction
/ increases expression
protein 12031898
D007213 6651 SON
BASS1
C21orf50
DBP-5
NREBP
SON3
SON DNA binding protein Indomethacin results in decreased expression of SON mRNA decreases expression
mRNA 16984733
D007213 54345 SOX18
HLTS
SRY (sex determining region Y)-box 18 Indomethacin results in increased expression of SOX18 mRNA increases expression
mRNA 16984733
D007213 83595 SOX7
SRY (sex determining region Y)-box 7 Indomethacin results in decreased expression of SOX7 mRNA decreases expression
mRNA 16984733
D007213 30014 SPANXA1
CT11.1
NAP-X
SPAN-Xa
SPAN-Xb
SPANX
sperm protein associated with the nucleus, X-linked, family member A1 Indomethacin results in increased expression of SPANXA1 mRNA increases expression
mRNA 16984733
D007213 132671 SPATA18
Mieap
SPETEX1
spermatogenesis associated 18 Indomethacin results in decreased expression of SPATA18 mRNA decreases expression
mRNA 16984733
D007213 221409 SPATS1
DDIP
SPATA8
SRSP1
spermatogenesis associated, serine-rich 1 Indomethacin results in decreased expression of SPATS1 mRNA decreases expression
mRNA 17401462
D007213 6431 SRSF6
B52
SFRS6
SRP55
serine/arginine-rich splicing factor 6 Indomethacin results in decreased expression of SRSF6 mRNA decreases expression
mRNA 16984733
D007213 6772 STAT1
CANDF7
ISGF-3
STAT91
signal transducer and activator of transcription 1, 91kDa Indomethacin results in decreased expression of and results in decreased phosphorylation of STAT1 protein decreases expression
/ decreases phosphorylation
protein 16572323
D007213 6772 STAT1
CANDF7
ISGF-3
STAT91
signal transducer and activator of transcription 1, 91kDa Indomethacin results in decreased expression of STAT1 protein decreases expression
protein 15631656
D007213 6772 STAT1
CANDF7
ISGF-3
STAT91
signal transducer and activator of transcription 1, 91kDa Indomethacin results in decreased expression of STAT1 protein modified form decreases expression
protein 16572323
D007213 6781 STC1
STC
stanniocalcin 1 Indomethacin results in decreased expression of STC1 mRNA decreases expression
mRNA 17401462
D007213 6934 TCF7L2
TCF-4
TCF4
transcription factor 7-like 2 (T-cell specific, HMG-box) Indomethacin inhibits the reaction [[CTNNB1 protein binds to TCF7L2 protein] which binds to CCND1 promoter] affects binding
/ decreases reaction
protein 11756231
D007213 6996 TDG
hTDG
thymine-DNA glycosylase (EC:3.2.2.29) Indomethacin results in decreased expression of TDG mRNA decreases expression
mRNA 16984733
D007213 7037 TFRC
CD71
T9
TFR
TFR1
TR
TRFR
p90
transferrin receptor Indomethacin results in decreased expression of TFRC mRNA decreases expression
mRNA 16984733
D007213 96764 TGS1
NCOA6IP
PIMT
PIPMT
trimethylguanosine synthase 1 (EC:2.1.1.-) Indomethacin results in decreased expression of TGS1 mRNA decreases expression
mRNA 16984733
D007213 7056 THBD
AHUS6
BDCA3
CD141
THPH12
THRM
TM
thrombomodulin Indomethacin results in decreased expression of THBD mRNA decreases expression
mRNA 16984733
D007213 7057 THBS1
THBS
THBS-1
TSP
TSP-1
TSP1
thrombospondin 1 Indomethacin results in decreased expression of THBS1 mRNA decreases expression
mRNA 16984733
D007213 7057 THBS1
THBS
THBS-1
TSP
TSP-1
TSP1
thrombospondin 1 Indomethacin results in increased expression of THBS1 mRNA increases expression
mRNA 18261746
D007213 7057 THBS1
THBS
THBS-1
TSP
TSP-1
TSP1
thrombospondin 1 Indomethacin results in increased expression of THBS1 protein increases expression
protein 16227405
18261746
D007213 7076 TIMP1
CLGI
EPA
EPO
HCI
TIMP
TIMP metallopeptidase inhibitor 1 Indomethacin results in increased expression of TIMP1 protein increases expression
protein 11719597
D007213 23671 TMEFF2
CT120.2
HPP1
TENB2
TPEF
TR
transmembrane protein with EGF-like and two follistatin-like domains 2 Indomethacin results in decreased expression of TMEFF2 mRNA decreases expression
mRNA 16984733
D007213 65062 TMEM237
ALS2CR4
JBTS14
transmembrane protein 237 Indomethacin results in decreased expression of TMEM237 mRNA decreases expression
mRNA 16984733
D007213 7114 TMSB4X
FX
PTMB4
TB4X
TMSB4
thymosin beta 4, X-linked Indomethacin results in increased expression of TMSB4X mRNA increases expression
mRNA 15292456
D007213 83857 TMTC1
OLF
TMTC1A
transmembrane and tetratricopeptide repeat containing 1 Indomethacin results in decreased expression of TMTC1 mRNA decreases expression
mRNA 16984733
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]] decreases reaction
/ increases secretion
protein 21913898
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor GW0072 inhibits the reaction [Indomethacin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]] affects cotreatment
/ decreases reaction
/ increases expression
protein 14586007
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Indomethacin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased metabolism of and results in increased secretion of APP protein alternative form] affects cotreatment
/ decreases reaction
/ increases metabolic processing
/ increases secretion
protein 14586007
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Indomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Dinoprostone] affects cotreatment
/ decreases reaction
/ increases abundance
protein 12743569
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Indomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Prostaglandin D2] affects cotreatment
/ decreases reaction
/ increases abundance
protein 12743569
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] decreases reaction
/ increases secretion
protein 21913898
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Indomethacin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of PPARG mRNA] affects cotreatment
/ decreases expression
/ decreases reaction
protein 16407166
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Indomethacin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone] decreases reaction
/ increases abundance
protein 1993070
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Indomethacin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] decreases reaction
/ increases activity
protein 15489888
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Indomethacin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] affects binding
/ decreases reaction
/ increases activity
protein 15489888
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Indomethacin inhibits the reaction [TNF protein results in increased activity of RELA protein] decreases reaction
/ increases activity
protein 15489888
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Indomethacin inhibits the reaction [TNF protein results in increased expression of CCND1 protein] decreases reaction
/ increases expression
protein 15489888
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Indomethacin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 15489888
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Indomethacin inhibits the reaction [TNF protein results in increased expression of TNFRSF21 protein] decreases reaction
/ increases expression
protein 11753679
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Indomethacin promotes the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased expression of TNF protein] increases expression
/ increases reaction
protein 12874281
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Indomethacin promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein] increases reaction
/ increases secretion
protein 10772282
15379866
D007213 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Indomethacin results in increased secretion of TNF protein increases secretion
protein 10772282
D007213 27242 TNFRSF21
BM-018
CD358
DR6
tumor necrosis factor receptor superfamily, member 21 Indomethacin inhibits the reaction [TNF protein results in increased expression of TNFRSF21 protein] decreases reaction
/ increases expression
protein 11753679
D007213 27242 TNFRSF21
BM-018
CD358
DR6
tumor necrosis factor receptor superfamily, member 21 Indomethacin results in decreased expression of TNFRSF21 protein decreases expression
protein 11753679
D007213 10140 TOB1
APRO6
PIG49
TOB
TROB
TROB1
transducer of ERBB2, 1 Indomethacin results in decreased expression of TOB1 mRNA decreases expression
mRNA 16984733
D007213 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Indomethacin results in increased expression of TP53 protein increases expression
protein 10403534
11260862
D007213 7164 TPD52L1
D53
hD53
tumor protein D52-like 1 Indomethacin results in decreased expression of TPD52L1 mRNA decreases expression
mRNA 16984733
D007213 57761 TRIB3
C20orf97
NIPK
SINK
SKIP3
TRB3
tribbles pseudokinase 3 Indomethacin results in increased expression of TRIB3 mRNA increases expression
mRNA 17401462
D007213 10626 TRIM16
EBBP
tripartite motif containing 16 [Indomethacin co-treated with isoeugenol] results in increased expression of TRIM16 mRNA affects cotreatment
/ increases expression
mRNA 21284934
D007213 6738 TROVE2
RO60
RORNP
SSA2
TROVE domain family, member 2 Indomethacin results in decreased expression of TROVE2 mRNA decreases expression
mRNA 16984733
D007213 8848 TSC22D1
Ptg-2
TGFB1I4
TSC22
TSC22 domain family, member 1 Indomethacin results in increased expression of TSC22D1 mRNA increases expression
mRNA 16984733
D007213 51175 TUBE1
TUBE
dJ142L7.2
tubulin, epsilon 1 Indomethacin results in increased expression of TUBE1 mRNA increases expression
mRNA 17401462
D007213 10426 TUBGCP3
104p
GCP3
Grip104
SPBC98
Spc98
Spc98p
tubulin, gamma complex associated protein 3 Indomethacin results in decreased expression of TUBGCP3 mRNA decreases expression
mRNA 16984733
D007213 7295 TXN
TRDX
TRX
TRX1
thioredoxin TXN protein inhibits the reaction [Indomethacin results in decreased expression of AKT1 protein modified form] decreases expression
/ decreases reaction
protein 17654042
D007213 7295 TXN
TRDX
TRX
TRX1
thioredoxin TXN protein inhibits the reaction [Indomethacin results in increased abundance of Reactive Oxygen Species] decreases reaction
/ increases abundance
protein 17654042
D007213 10628 TXNIP
EST01027
HHCPA78
THIF
VDUP1
thioredoxin interacting protein Indomethacin results in decreased expression of TXNIP mRNA decreases expression
mRNA 16984733
D007213 23350 U2SURP
SR140
fSAPa
U2 snRNP-associated SURP domain containing Indomethacin results in decreased expression of U2SURP mRNA decreases expression
mRNA 16984733
D007213 134510 UBLCP1
CPUB1
ubiquitin-like domain containing CTD phosphatase 1 (EC:3.1.3.16) Indomethacin results in decreased expression of UBLCP1 mRNA decreases expression
mRNA 16984733
D007213 51366 UBR5
DD5
EDD
EDD1
HYD
ubiquitin protein ligase E3 component n-recognin 5 Indomethacin results in decreased expression of UBR5 mRNA decreases expression
mRNA 16984733
D007213 7351 UCP2
BMIQ4
SLC25A8
UCPH
uncoupling protein 2 (mitochondrial, proton carrier) Indomethacin results in increased expression of UCP2 mRNA increases expression
mRNA 16984733
D007213 7357 UGCG
GCS
GLCT1
UDP-glucose ceramide glucosyltransferase (EC:2.4.1.80) Indomethacin results in decreased expression of UGCG mRNA decreases expression
mRNA 16984733
D007213 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) Indomethacin results in decreased activity of UGT1A1 protein decreases activity
protein 15593333
D007213 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) UGT1A1 protein results in increased glucuronidation of Indomethacin increases glucuronidation
protein 15843492
D007213 54575 UGT1A10
UDPGT
UGT-1J
UGT1-10
UGT1.10
UGT1J
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) UGT1A10 protein results in increased glucuronidation of Indomethacin increases glucuronidation
protein 15117964
22265884
D007213 54659 UGT1A3
UDPGT
UDPGT_1-3
UGT-1C
UGT1-03
UGT1.3
UGT1C
UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) UGT1A3 protein results in increased glucuronidation of Indomethacin increases glucuronidation
protein 15117964
15843492
D007213 54657 UGT1A4
HUG-BR2
UDPGT
UDPGT_1-4
UGT-1D
UGT1-04
UGT1.4
UGT1D
UDP glucuronosyltransferase 1 family, polypeptide A4 (EC:2.4.1.17) UGT1A4 protein results in increased glucuronidation of Indomethacin increases glucuronidation
protein 15843492
D007213 54578 UGT1A6
GNT1
HLUGP
HLUGP1
UDPGT
UDPGT_1-6
UGT1
UGT1A6S
UGT1F
UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) Indomethacin inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol] decreases reaction
/ increases glucuronidation
protein 22265884
D007213 54577 UGT1A7
UDPGT
UDPGT_1-7
UGT-1G
UGT1-07
UGT1.7
UGT1G
UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) UGT1A7 protein results in increased glucuronidation of Indomethacin increases glucuronidation
protein 15117964
15843492
D007213 54576 UGT1A8
UDPGT
UDPGT_1-8
UGT-1H
UGT1-08
UGT1.8
UGT1A8S
UGT1H
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) UGT1A8 protein results in increased glucuronidation of Indomethacin increases glucuronidation
protein 15117964
15843492
D007213 54600 UGT1A9
HLUGP4
LUGP4
UDPGT
UDPGT_1-9
UGT-1I
UGT1-09
UGT1-9
UGT1.9
UGT1AI
UGT1I
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) UGT1A9 protein results in increased glucuronidation of Indomethacin increases glucuronidation
protein 15843492
D007213 10941 UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus (EC:2.4.1.17) UGT2A1 protein results in increased glucuronidation of Indomethacin increases glucuronidation
protein 22265884
D007213 7364 UGT2B7
UDPGT_2B9
UDPGT2B7
UDPGTH2
UGT2B9
UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) Indomethacin inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide] decreases reaction
/ increases chemical synthesis
protein 19740398
D007213 7364 UGT2B7
UDPGT_2B9
UDPGT2B7
UDPGTH2
UGT2B9
UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) Indomethacin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone] decreases reaction
/ increases glucuronidation
protein 19740398
D007213 7364 UGT2B7
UDPGT_2B9
UDPGT2B7
UDPGTH2
UGT2B9
UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) UGT2B7 protein alternative form results in increased glucuronidation of Indomethacin increases glucuronidation
protein 8423545
D007213 7364 UGT2B7
UDPGT_2B9
UDPGT2B7
UDPGTH2
UGT2B9
UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) UGT2B7 protein results in increased glucuronidation of Indomethacin increases glucuronidation
protein 8517101
15843492
22265884
D007213 133688 UGT3A1
UDP glycosyltransferase 3 family, polypeptide A1 (EC:2.4.1.17) Indomethacin results in decreased expression of UGT3A1 mRNA decreases expression
mRNA 16984733
D007213 7378 UPP1
UDRPASE
UP
UPASE
UPP
uridine phosphorylase 1 (EC:2.4.2.3) Indomethacin results in increased expression of UPP1 mRNA increases expression
mRNA 16984733
D007213 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Indomethacin inhibits the reaction [VEGFA protein results in increased expression of EGR1 mRNA] decreases reaction
/ increases expression
protein 11595463
D007213 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Indomethacin inhibits the reaction [VEGFA protein results in increased expression of EGR1 protein] decreases reaction
/ increases expression
protein 11595463
D007213 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Indomethacin promotes the reaction [VEGFA protein results in increased expression of ACE protein] increases expression
/ increases reaction
protein 11158990
D007213 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Indomethacin results in decreased expression of VEGFA protein decreases expression
protein 15637740
D007213 81671 VMP1
EPG3
TANGO5
TMEM49
vacuole membrane protein 1 Indomethacin results in increased expression of VMP1 mRNA increases expression
mRNA 16984733
D007213 23063 WAPAL
FOE
KIAA0261
WAPL
wings apart-like homolog (Drosophila) Indomethacin results in decreased expression of WAPAL mRNA decreases expression
mRNA 16984733
D007213 8840 WISP1
CCN4
WISP1c
WISP1i
WISP1tc
WNT1 inducible signaling pathway protein 1 Indomethacin results in decreased expression of WISP1 mRNA decreases expression
mRNA 17054584
D007213 8840 WISP1
CCN4
WISP1c
WISP1i
WISP1tc
WNT1 inducible signaling pathway protein 1 Indomethacin results in decreased expression of WISP1 protein decreases expression
protein 17054584
D007213 7494 XBP1
TREB5
XBP-1
XBP2
X-box binding protein 1 Indomethacin results in increased expression of XBP1 mRNA increases expression
mRNA 17401462
D007213 7498 XDH
XO
XOR
xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) Indomethacin results in increased activity of XDH protein increases activity
protein 19470405
D007213 7498 XDH
XO
XOR
xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) methyl arachidonylfluorophosphonate inhibits the reaction [Indomethacin results in increased activity of XDH protein] decreases reaction
/ increases activity
protein 19470405
D007213 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis Indomethacin inhibits the reaction [LTA protein results in increased expression of XIAP protein] decreases reaction
/ increases expression
protein 17873517
D007213 55432 YOD1
DUBA8
OTUD2
PRO0907
YOD1 deubiquitinase (EC:3.4.19.12) Indomethacin results in decreased expression of YOD1 mRNA decreases expression
mRNA 16984733
D007213 51441 YTHDF2
HGRG8
NY-REN-2
YTH domain family, member 2 Indomethacin results in decreased expression of YTHDF2 mRNA decreases expression
mRNA 16984733
D007213 253943 YTHDF3
YTH domain family, member 3 Indomethacin results in decreased expression of YTHDF3 mRNA decreases expression
mRNA 16984733
D007213 7531 YWHAE
14-3-3E
KCIP-1
MDCR
MDS
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Indomethacin results in decreased expression of YWHAE protein decreases expression
protein 17409426
18678619
D007213 7531 YWHAE
14-3-3E
KCIP-1
MDCR
MDS
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide [Indomethacin results in decreased expression of YWHAE protein] which results in increased localization of BAD protein decreases expression
/ increases localization
protein 17409426
D007213 7531 YWHAE
14-3-3E
KCIP-1
MDCR
MDS
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide PPARD protein affects the reaction [Indomethacin results in decreased expression of YWHAE protein] affects reaction
/ decreases expression
protein 17409426
D007213 27107 ZBTB11
ZNF-U69274
ZNF913
zinc finger and BTB domain containing 11 Indomethacin results in decreased expression of ZBTB11 mRNA decreases expression
mRNA 16984733
D007213 10472 ZBTB18
C2H2-171
RP58
TAZ-1
ZNF238
zinc finger and BTB domain containing 18 Indomethacin results in decreased expression of ZBTB18 mRNA decreases expression
mRNA 16984733
D007213 360023 ZBTB41
FRBZ1
RP11-469L3.1
ZNF924
zinc finger and BTB domain containing 41 Indomethacin results in decreased expression of ZBTB41 mRNA decreases expression
mRNA 16984733
D007213 29068 ZBTB44
BTBD15
HSPC063
ZNF851
zinc finger and BTB domain containing 44 Indomethacin results in decreased expression of ZBTB44 mRNA decreases expression
mRNA 16984733
D007213 23091 ZC3H13
KIAA0853
zinc finger CCCH-type containing 13 Indomethacin results in decreased expression of ZC3H13 mRNA decreases expression
mRNA 16984733
D007213 56829 ZC3HAV1
ARTD13
FLB6421
PARP13
ZAP
ZC3H2
ZC3HDC2
zinc finger CCCH-type, antiviral 1 Indomethacin results in increased expression of ZC3HAV1 mRNA increases expression
mRNA 16984733
D007213 92092 ZC3HAV1L
C7orf39
zinc finger CCCH-type, antiviral 1-like Indomethacin results in increased expression of ZC3HAV1L mRNA increases expression
mRNA 16984733
D007213 6935 ZEB1
AREB6
BZP
DELTAEF1
FECD6
NIL2A
PPCD3
TCF8
ZFHEP
ZFHX1A
zinc finger E-box binding homeobox 1 Indomethacin results in increased expression of ZEB1 mRNA increases expression
mRNA 16984733
D007213 7707 ZNF148
BERF-1
BFCOL1
HT-BETA
ZBP-89
ZFP148
pHZ-52
zinc finger protein 148 Indomethacin results in decreased expression of ZNF148 mRNA decreases expression
mRNA 16984733
D007213 57541 ZNF398
P51
P71
ZER6
zinc finger protein 398 Indomethacin results in decreased expression of ZNF398 mRNA decreases expression
mRNA 16984733
D007213 54680 ZNHIT6
BCD1
C1orf181
NY-BR-75
zinc finger, HIT-type containing 6 Indomethacin results in decreased expression of ZNHIT6 mRNA decreases expression
mRNA 16984733

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (106)

OMIM preferred title UniProt
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#142690 Acne inversa, familial, 1; acninv1 Q92542
#613736 Acne inversa, familial, 2; acninv2 Q9NZ42
#613737 Acne inversa, familial, 3; acninv3 P49768
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103780 Alcohol dependence P08172
P14416
P31645
#607822 Alzheimer disease 3 P49768
#606889 Alzheimer disease 4 P49810
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#117800 Apocrine gland secretion, variation in Q96J66
#614473 Arterial calcification, generalized, of infancy, 2; gaci2 O95255
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614009 Bleeding disorder, platelet-type, 13, susceptibility to; bdplt13 P21731
#614490 Blood group, junior system; jr Q9UNQ0
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#613694 Cardiomyopathy, dilated, 1u; cmd1u P49768
#613697 Cardiomyopathy, dilated, 1v; cmd1v P49810
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#607208 Dravet syndrome P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
P49768
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
P37231
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#145000 Hyperparathyroidism 1; hrpt1 O00255
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#264800 Pseudoxanthoma elasticum; pxe O95255
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (80)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00560 Pseudoxanthoma elasticum O95255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
P49768 (related)
P49810 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
P49768 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H01235 Bleeding disorder platelet-type P21731 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00783 Febrile seizures P35498 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00056 Alzheimer's disease (AD) P49768 (related)
P49810 (related)
H00681 Acne inversa P49768 (related)
Q92542 (related)
Q9NZ42 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)
H00932 Tropical calcific pancreatitis Q99895 (related)
H00933 Hereditary pancreatitis Q99895 (related)

Diseases related to CTD interactions

271 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D015746 D007213 Abdominal Pain marker/mechanism
therapeutic
1065802
6023693
7268625
17478464
D058186 D007213 Acute Kidney Injury marker/mechanism
448822
464454
718323
2191029
2872506
2886806
3071148
3600902
3616022
3727353
3975749
3978662
3980192
4000350
4071154
6589647
6781208
6949485
6952058
7017180
7305576
7375974
7386499
8163032
8240599
8671983
9052853
15007713
D000230 D007213 Adenocarcinoma marker/mechanism
therapeutic
7614682
16537180
D000236 D007213 Adenoma therapeutic
11497255
D000380 D007213 Agranulocytosis marker/mechanism
3747087
D016301 D007213 Alveolar Bone Loss therapeutic
17225004
D000544 D007213 Alzheimer Disease therapeutic
15579461
17627676
D000707 D007213 Anaphylaxis marker/mechanism
9220183
D000740 D007213 Anemia marker/mechanism
5723725
D000741 D007213 Anemia, Aplastic marker/mechanism
122219
620377
872001
3747087
5638712
6801896
7263204
D000743 D007213 Anemia, Hemolytic marker/mechanism
17381629
D018798 D007213 Anemia, Iron-Deficiency marker/mechanism
7986967
D000783 D007213 Aneurysm therapeutic
10189013
D000787 D007213 Angina Pectoris marker/mechanism
9220183
D000799 D007213 Angioedema marker/mechanism
1115460
D000855 D007213 Anorexia marker/mechanism
therapeutic
4916769
22902858
D000860 D007213 Anoxia marker/mechanism
3579483
D001002 D007213 Anuria marker/mechanism
311647
1870807
6772782
8092206
8308583
D001008 D007213 Anxiety Disorders marker/mechanism
8219437
D001014 D007213 Aortic Aneurysm therapeutic
10231640
D017544 D007213 Aortic Aneurysm, Abdominal therapeutic
10388637
D018771 D007213 Arthralgia therapeutic
1540795
2160914
D001168 D007213 Arthritis therapeutic
6881008
D015210 D007213 Arthritis, Gouty therapeutic
6023116
17276548
D001170 D007213 Arthritis, Infectious therapeutic
983356
D001171 D007213 Arthritis, Juvenile therapeutic
6125715
6772782
D001172 D007213 Arthritis, Rheumatoid therapeutic
277165
790554
824725
922402
983356
1096903
1682578
1833009
3375885
4538611
4916769
5420190
7241487
8219437
8222739
8778950
11248219
D001201 D007213 Ascites marker/mechanism
3579483
4071154
18227818
D001265 D007213 Athletic Injuries therapeutic
3305036
D053099 D007213 Azotemia marker/mechanism
3362274
7033849
8308583
D001477 D007213 Bartter Syndrome therapeutic
119300
10684365
16303714
D001714 D007213 Bipolar Disorder marker/mechanism
3597814
D001919 D007213 Bradycardia therapeutic
6804092
D001927 D007213 Brain Diseases marker/mechanism
2257989
16203592
D001929 D007213 Brain Edema therapeutic
11481608
D001930 D007213 Brain Injuries therapeutic
9500967
16223416
D002545 D007213 Brain Ischemia marker/mechanism
therapeutic
2084459
2329439
12524144
16223416
D001932 D007213 Brain Neoplasms therapeutic
16223416
D001943 D007213 Breast Neoplasms therapeutic
17401462
D001997 D007213 Bronchopulmonary Dysplasia marker/mechanism
12241754
D002056 D007213 Burns therapeutic
10459503
D002100 D007213 Cachexia therapeutic
11239499
15141370
15625704
16537180
D006528 D007213 Carcinoma, Hepatocellular therapeutic
16391822
D018827 D007213 Carcinoma, Lewis Lung therapeutic
11053908
D018276 D007213 Carcinoma, Medullary therapeutic
11352223
14736730
18791128
D002292 D007213 Carcinoma, Renal Cell therapeutic
17341418
D002294 D007213 Carcinoma, Squamous Cell therapeutic
12636206
15482327
D006332 D007213 Cardiomegaly marker/mechanism
11677312
D018376 D007213 Cardiovascular Abnormalities marker/mechanism
7719872
D002318 D007213 Cardiovascular Diseases marker/mechanism
1478511
D002375 D007213 Catalepsy therapeutic
1378634
3362928
6440863
D002429 D007213 Cecal Diseases marker/mechanism
7986967
D002493 D007213 Central Nervous System Diseases marker/mechanism
3329590
8222739
D002543 D007213 Cerebral Hemorrhage marker/mechanism
therapeutic
8885773
9521382
16223416
D002764 D007213 Cholecystitis therapeutic
11181007
D002779 D007213 Cholestasis marker/mechanism
3047224
D002780 D007213 Cholestasis, Intrahepatic marker/mechanism
1084454
1250131
D002805 D007213 Chondrocalcinosis therapeutic
620153
D003027 D007213 Cluster Headache therapeutic
16601942
D003072 D007213 Cognition Disorders marker/mechanism
2084459
D003110 D007213 Colonic Neoplasms therapeutic
11260862
15625704
15637740
15786552
15936596
15963497
D015179 D007213 Colorectal Neoplasms therapeutic
11197048
12606626
17054584
18059344
20035423
D003128 D007213 COMA therapeutic
3921582
D003221 D007213 Confusion marker/mechanism
6132175
D003229 D007213 Conjunctival Diseases marker/mechanism
1115460
D003244 D007213 Consciousness Disorders marker/mechanism
1654720
D003251 D007213 Constriction, Pathologic marker/mechanism
445754
985646
1923225
1930046
2140240
2405319
2524291
3393194
8498410
11770593
D054059 D007213 Coronary Occlusion therapeutic
8721639
D003329 D007213 Coronary Vasospasm marker/mechanism
9220183
D018352 D007213 Coronavirus Infections therapeutic
17302372
D003556 D007213 Cystitis therapeutic
15322343
17638016
D018856 D007213 Cystitis, Interstitial marker/mechanism
12559315
D003693 D007213 Delirium marker/mechanism
6881008
D018500 D007213 Diabetes Insipidus, Nephrogenic therapeutic
41818
1490662
2123565
2719505
3856211
7865979
8351566
9044466
9121593
D003967 D007213 Diarrhea marker/mechanism
therapeutic
7237001
7907874
16240705
D004211 D007213 Disseminated Intravascular Coagulation marker/mechanism
8163032
D004213 D007213 Dissociative Disorders marker/mechanism
6844980
D004244 D007213 Dizziness marker/mechanism
4164930
8219437
D003875 D007213 Drug Eruptions marker/mechanism
therapeutic
1371395
11792017
D004342 D007213 Drug Hypersensitivity marker/mechanism
2872904
16943303
D056486 D007213 Drug-Induced Liver Injury marker/mechanism
therapeutic
3442185
3602573
6071328
7654905
18227818
22107987
D004374 D007213 Ductus Arteriosus, Patent marker/mechanism
therapeutic
471605
1421905
1432432
1790251
2311476
2766920
3070369
3616022
3816491
3855253
3883305
6377215
6747765
7019841
7108667
7117089
8048989
8232428
9284854
9521382
9794986
10516392
10592922
10625080
10908230
10974130
12137683
12241754
12632374
12774134
12970633
15046280
15232757
15567009
16133044
16260891
16326151
17190690
18043480
18446180
19187396
D004381 D007213 Duodenal Ulcer marker/mechanism
1718290
10671773
11535926
11595415
11595431
11991626
16699067
17045617
17151854
17202747
17329845
17351913
D004409 D007213 Dyskinesia, Drug-Induced therapeutic
11711046
D004412 D007213 Dysmenorrhea therapeutic
333681
627337
D004415 D007213 Dyspepsia marker/mechanism
4916769
5723725
6023693
D020920 D007213 Dyssomnias marker/mechanism
6132175
D004487 D007213 Edema marker/mechanism
therapeutic
1870807
3050004
3579483
7508328
7735198
7907874
7990266
8190018
8273558
8985016
10653021
11820457
12424497
14515793
16100529
16155371
19212002
19703484
20054000
20108268
21731166
D004715 D007213 Endometriosis therapeutic
15652904
D019446 D007213 Endotoxemia therapeutic
18509659
D004751 D007213 Enteritis marker/mechanism
10567023
16328016
17763956
D020345 D007213 Enterocolitis, Necrotizing marker/mechanism
8232428
17980183
D004802 D007213 Eosinophilia therapeutic
11298111
D004938 D007213 Esophageal Neoplasms therapeutic
11005569
D005076 D007213 Exanthema marker/mechanism
16943303
D005119 D007213 Extravasation of Diagnostic and Therapeutic Materials therapeutic
7238673
D005198 D007213 Fanconi Syndrome therapeutic
3856211
D005315 D007213 Fetal Diseases marker/mechanism
112867
445754
1478511
1870807
1923225
1930046
2335261
2405319
2524291
3393194
8498410
8645379
8843476
11677312
D005317 D007213 Fetal Growth Retardation marker/mechanism
6772782
D005334 D007213 Fever therapeutic
6409656
10431976
11852909
17627676
D005354 D007213 Fibrosarcoma therapeutic
10962813
D005355 D007213 Fibrosis marker/mechanism
7986967
17994277
D005499 D007213 Folliculitis therapeutic
11298111
D005756 D007213 Gastritis marker/mechanism
2266080
15046732
16080005
D005767 D007213 Gastrointestinal Diseases marker/mechanism
333681
3329590
3896659
8222739
8949638
9502396
16187199
19220725
20035423
D006471 D007213 Gastrointestinal Hemorrhage marker/mechanism
311647
1870807
3050004
4548752
6614039
7019841
9017686
15651117
D005909 D007213 Glioblastoma therapeutic
12870263
D005910 D007213 Glioma therapeutic
16487511
18371953
D005921 D007213 Glomerulonephritis marker/mechanism
therapeutic
860058
4106997
9848785
D005923 D007213 Glomerulosclerosis, Focal Segmental therapeutic
11849393
D006042 D007213 Goiter therapeutic
22387750
D006073 D007213 Gout therapeutic
3711369
7017180
7033849
7411769
7435695
11248219
17478464
20650042
D006099 D007213 Granuloma therapeutic
21731166
D006212 D007213 Hallucinations marker/mechanism
3559156
D006261 D007213 Headache marker/mechanism
therapeutic
4164930
6023693
6612404
17478464
19080105
20197477
D020773 D007213 Headache Disorders therapeutic
8262795
D006258 D007213 Head and Neck Neoplasms therapeutic
15482327
D006319 D007213 Hearing Loss, Sensorineural marker/mechanism
20650042
D006356 D007213 Heartburn marker/mechanism
1065802
D006330 D007213 Heart Defects, Congenital marker/mechanism
445754
11023164
D006331 D007213 Heart Diseases marker/mechanism
8498410
8645379
D006333 D007213 Heart Failure marker/mechanism
2524291
8843476
17394181
D006396 D007213 Hematemesis marker/mechanism
3777737
D006417 D007213 Hematuria marker/mechanism
7880236
D006470 D007213 Hemorrhage marker/mechanism
therapeutic
6747765
12632374
17638016
18996434
D006501 D007213 Hepatic Encephalopathy marker/mechanism
15633222
D019693 D007213 Hepatitis, Autoimmune marker/mechanism
18227818
D006509 D007213 Hepatitis B therapeutic
15784032
D019698 D007213 Hepatitis C, Chronic therapeutic
15135802
D015160 D007213 Hydrops Fetalis marker/mechanism
11770593
D006930 D007213 Hyperalgesia marker/mechanism
therapeutic
2128375
2998815
10422945
10813554
10920437
12220967
12727271
15010267
16507304
17989504
18810243
19815945
20601862
D034321 D007213 Hyperamylasemia therapeutic
17883296
D006934 D007213 Hypercalcemia therapeutic
1152883
2248514
4032577
4835887
D006940 D007213 Hyperemia marker/mechanism
therapeutic
10792963
12524144
18688582
D006941 D007213 Hyperesthesia therapeutic
8190269
D006947 D007213 Hyperkalemia marker/mechanism
3362274
3375885
3560096
4071154
6814155
7017180
7033849
7411769
8203268
D006949 D007213 Hyperlipidemias therapeutic
17546600
D006955 D007213 Hypernatremia therapeutic
3921582
D006965 D007213 Hyperplasia marker/mechanism
therapeutic
1477515
22387750
D006973 D007213 Hypertension marker/mechanism
therapeutic
86834
202775
493002
983862
1957896
3283878
6758745
6953356
7238673
7386499
7438969
8755685
14981414
20632668
D006976 D007213 Hypertension, Pulmonary marker/mechanism
therapeutic
445754
2014850
7574058
7758553
11340680
12391278
14668575
D006977 D007213 Hypertension, Renal marker/mechanism
4375905
D017379 D007213 Hypertrophy, Left Ventricular marker/mechanism
2524291
D017380 D007213 Hypertrophy, Right Ventricular marker/mechanism
2524291
11340680
D034141 D007213 Hypoalbuminemia marker/mechanism
7986967
D006994 D007213 Hypoaldosteronism marker/mechanism
3375885
6814155
D007008 D007213 Hypokalemia marker/mechanism
3727353
D007010 D007213 Hyponatremia marker/mechanism
12632374
D007022 D007213 Hypotension marker/mechanism
therapeutic
439781
1888233
1908582
2196965
2404862
2880686
3541005
3706053
6804092
7413993
D007024 D007213 Hypotension, Orthostatic therapeutic
6498036
14727996
D007077 D007213 Ileal Diseases marker/mechanism
10574470
18306037
D007079 D007213 Ileitis marker/mechanism
10647630
10651667
12706472
16133968
D007177 D007213 Inappropriate ADH Syndrome marker/mechanism
1871284
D007232 D007213 Infant, Newborn, Diseases marker/mechanism
6772782
8092206
8308583
8379817
D007235 D007213 Infant, Premature, Diseases marker/mechanism
therapeutic
2766920
3050004
6377215
7019841
7108667
10516392
10974130
12970633
15046280
16133044
D007249 D007213 Inflammation marker/mechanism
therapeutic
1065802
3291741
7812673
9181689
10792963
12568917
14518223
16113981
19517896
19839048
21731166
22387750
D007410 D007213 Intestinal Diseases marker/mechanism
10210152
11686837
11713966
11855677
15610444
15831440
16944022
17329856
17994277
18236018
D007414 D007213 Intestinal Neoplasms marker/mechanism
1477515
D007416 D007213 Intestinal Perforation marker/mechanism
3050004
12632374
D007417 D007213 Intestinal Polyps therapeutic
14991580
D020300 D007213 Intracranial Hemorrhages marker/mechanism
8232428
15861198
D019586 D007213 Intracranial Hypertension therapeutic
15241188
15752400
16223416
D007511 D007213 Ischemia marker/mechanism
8092206
8949638
D007565 D007213 Jaundice marker/mechanism
18227818
D007579 D007213 Jejunal Diseases marker/mechanism
10574470
16133968
18306037
D007674 D007213 Kidney Diseases marker/mechanism
1489412
1913620
2112558
2284768
2424533
2766920
7019841
7108667
7661171
7791169
8308589
8440438
9284854
9507041
9521382
10516392
12970633
15037210
17190690
19445918
19761811
20035423
D052177 D007213 Kidney Diseases, Cystic marker/mechanism
8092206
D007676 D007213 Kidney Failure, Chronic marker/mechanism
6986554
D007680 D007213 Kidney Neoplasms marker/mechanism
7614682
D007681 D007213 Kidney Papillary Necrosis marker/mechanism
277165
861066
972771
3102426
4548752
6125715
6953356
9502396
12512867
D007683 D007213 Kidney Tubular Necrosis, Acute marker/mechanism
860058
D016773 D007213 Leishmaniasis, Cutaneous therapeutic
10320625
11703811
12228301
D015464 D007213 Leukemia, Myelogenous, Chronic, BCR-ABL Positive therapeutic
10785260
15631656
16572323
D015470 D007213 Leukemia, Myeloid, Acute therapeutic
18360721
D007964 D007213 Leukocytosis therapeutic
16537180
D007969 D007213 Leukomalacia, Periventricular marker/mechanism
2329439
17980183
D007970 D007213 Leukopenia marker/mechanism
16240705
D007984 D007213 Leydig Cell Tumor marker/mechanism
1477515
D008101 D007213 Liver Abscess, Amebic therapeutic
11479899
D008103 D007213 Liver Cirrhosis marker/mechanism
4071154
D008106 D007213 Liver Cirrhosis, Experimental therapeutic
18194892
D008107 D007213 Liver Diseases marker/mechanism
2112558
15784032
D008113 D007213 Liver Neoplasms marker/mechanism
1477515
D008171 D007213 Lung Diseases marker/mechanism
11340680
D008175 D007213 Lung Neoplasms therapeutic
11053908
11497255
16537180
D008180 D007213 Lupus Erythematosus, Systemic therapeutic
3600902
6694957
D015674 D007213 Mammary Neoplasms, Animal marker/mechanism
7614682
D008415 D007213 Mastocytosis marker/mechanism
12559315
D008581 D007213 Meningitis marker/mechanism
20197477
D001523 D007213 Mental Disorders marker/mechanism
10205728
D008881 D007213 Migraine Disorders therapeutic
8869763
11903285
12220967
D028361 D007213 Mitochondrial Diseases marker/mechanism
22214982
D009062 D007213 Mouth Neoplasms therapeutic
12636206
D009325 D007213 Nausea marker/mechanism
627337
4916769
7268625
D009336 D007213 Necrosis marker/mechanism
therapeutic
112867
1640321
2015844
4087309
8157128
8949638
16187199
20190399
22107987
D009362 D007213 Neoplasm Metastasis therapeutic
11053908
11239499
16537180
D009374 D007213 Neoplasms, Experimental therapeutic
10663608
15625704
D009395 D007213 Nephritis, Interstitial marker/mechanism
3071148
3975749
3980192
10534532
16943303
D009401 D007213 Nephrosis marker/mechanism
6618773
D009404 D007213 Nephrotic Syndrome therapeutic
844248
7172499
D019636 D007213 Neurodegenerative Diseases therapeutic
12349958
D007752 D007213 Obstetric Labor, Premature therapeutic
985646
1478511
1923225
1930046
2006947
2014850
2257989
2329439
2335261
2405319
2525744
3393194
3579483
6374098
8119479
8203268
8232428
8240599
8308583
8308589
8379817
8418619
8498410
8843476
8885773
9215169
9369826
9521382
9794986
11384697
11420315
11770593
12368969
15861198
16203592
D016104 D007213 Oligohydramnios marker/mechanism
1923225
2006947
3050004
3191072
6772782
8163032
8308583
D009846 D007213 Oliguria marker/mechanism
471605
1432432
2112558
3050004
3915162
4071154
7117089
7977526
8048989
8203268
10974130
12137683
12632374
16240705
D009999 D007213 Ossification, Heterotopic therapeutic
10512453
D010003 D007213 Osteoarthritis therapeutic
1096903
3812531
3896659
7009135
7441660
D015207 D007213 Osteoarthritis, Hip therapeutic
18227818
D016471 D007213 Ovarian Hyperstimulation Syndrome therapeutic
2112558
D010146 D007213 Pain therapeutic
2872506
3145369
3291741
3777737
6814155
7735198
8778950
10813554
13679232
14598202
15994849
16099101
16113981
16563475
17440234
17627676
18227818
19517896
D010149 D007213 Pain, Postoperative therapeutic
12538197
18702446
D010195 D007213 Pancreatitis marker/mechanism
therapeutic
15028970
17883296
D010257 D007213 Paraneoplastic Syndromes therapeutic
16537180
D020734 D007213 Parkinsonian Disorders therapeutic
12349958
D051302 D007213 Paroxysmal Hemicrania therapeutic
9529768
11903285
16686914
17645760
D010437 D007213 Peptic Ulcer marker/mechanism
5569832
11148446
15322343
20586863
D010490 D007213 Pericardial Effusion marker/mechanism
1923225
2140240
D010493 D007213 Pericarditis therapeutic
7752506
D010518 D007213 Periodontitis therapeutic
17225004
D010523 D007213 Peripheral Nervous System Diseases marker/mechanism
165855
8219437
D010547 D007213 Persistent Fetal Circulation Syndrome marker/mechanism
7294953
7450523
15008397
D010996 D007213 Pleural Effusion marker/mechanism
3579483
D011014 D007213 Pneumonia therapeutic
21983654
D006831 D007213 Polyhydramnios therapeutic
1748938
2405319
8163032
8379817
8498410
8843476
9507041
11677312
D011141 D007213 Polyuria marker/mechanism
therapeutic
2123565
2454589
2719505
2949606
3568719
3921582
8132200
9044466
D047928 D007213 Premature Birth therapeutic
7469626
12861172
17000239
D011507 D007213 Proteinuria marker/mechanism
therapeutic
844248
2478751
7386499
9507210
11849393
16943303
D011546 D007213 Pseudohypoaldosteronism therapeutic
3856211
D011559 D007213 Pseudotumor Cerebri marker/mechanism
634325
D011605 D007213 Psychoses, Substance-Induced marker/mechanism
7956191
10512453
D011654 D007213 Pulmonary Edema therapeutic
2125593
D011660 D007213 Pulmonary Heart Disease marker/mechanism
4071154
D011693 D007213 Purpura marker/mechanism
4106997
D011704 D007213 Pyelonephritis therapeutic
448822
D011928 D007213 Raynaud Disease therapeutic
6614039
D012021 D007213 Reflex, Abnormal therapeutic
8032584
D056844 D007213 Renal Colic therapeutic
3720020
6854762
D051437 D007213 Renal Insufficiency marker/mechanism
496125
2325052
3050004
3129900
3340956
3347121
3736188
6792007
6814155
6953356
7411769
8092206
8203268
8308583
8379817
8530800
10592922
12137683
12368969
16240705
D051436 D007213 Renal Insufficiency, Chronic marker/mechanism
11079628
D015427 D007213 Reperfusion Injury marker/mechanism
10588920
10594344
D012216 D007213 Rheumatic Diseases therapeutic
3329590
D012585 D007213 Sciatica therapeutic
4232743
D012640 D007213 Seizures marker/mechanism
therapeutic
8119479
9500967
10195372
10528118
18178179
D018805 D007213 Sepsis marker/mechanism
12632374
D012735 D007213 Sexual Dysfunction, Physiological marker/mechanism
2526860
D012871 D007213 Skin Diseases marker/mechanism
1864449
D012893 D007213 Sleep Disorders marker/mechanism
11677312
D013119 D007213 Spinal Cord Injuries therapeutic
8157128
D013167 D007213 Spondylitis, Ankylosing therapeutic
861066
1096903
3381715
3518435
4164930
4595274
5640611
D013226 D007213 Status Epilepticus marker/mechanism
1979027
D013272 D007213 Stomach Diseases marker/mechanism
6443622
10192188
10215738
10486359
11292068
15038085
15472012
15996031
16113693
16184426
16280098
17160473
17207306
17570478
17638125
18209964
18545984
20678495
D013274 D007213 Stomach Neoplasms therapeutic
15609394
D013276 D007213 Stomach Ulcer marker/mechanism
1323529
1887894
4548752
5723725
9055195
10423059
10594344
10674923
10750652
10878458
11145282
11376495
11390426
11523592
11595415
11595431
11729361
11906479
12077510
12467913
12498302
12500499
12787963
14567935
15104355
15138204
15255614
16015682
16150113
16155371
16169175
16252198
16397915
16631530
16755016
16804302
16934674
17135157
17139445
17372719
17409556
17627676
17654042
17657623
17895592
17918041
17977527
18087811
18181030
18193104
18209962
18237397
18299717
18375387
18431645
18543354
18726076
19034656
19066340
19497431
19783516
20035423
20067468
20361948
20374237
20723003
20934418
21315700
D013610 D007213 Tachycardia marker/mechanism
11677312
D052256 D007213 Tendinopathy therapeutic
1864449
D013921 D007213 Thrombocytopenia marker/mechanism
12632374
16240705
D013964 D007213 Thyroid Neoplasms therapeutic
11352223
14736730
18791128
D014202 D007213 Tremor marker/mechanism
8219437
D014262 D007213 Tricuspid Valve Insufficiency marker/mechanism
1923225
2405319
3393194
3579483
7719872
11677312
11770593
D014456 D007213 Ulcer marker/mechanism
2345457
7986967
10574470
12529378
17380554
21691039
D014511 D007213 Uremia marker/mechanism
311647
3933537
D014514 D007213 Ureteral Calculi therapeutic
3720020
D001745 D007213 Urinary Bladder Diseases therapeutic
8486095
D001749 D007213 Urinary Bladder Neoplasms therapeutic
6202890
17093206
D014571 D007213 Urologic Neoplasms marker/mechanism
7614682
D014581 D007213 Urticaria marker/mechanism
1115460
11792017
15969659
D014652 D007213 Vascular Diseases marker/mechanism
985646
D018366 D007213 Vasculitis, Leukocytoclastic, Cutaneous marker/mechanism
3381715
D020301 D007213 Vasospasm, Intracranial therapeutic
8138965
D018497 D007213 Ventricular Dysfunction, Right marker/mechanism
1923225
D014717 D007213 Vertigo marker/mechanism
627337
7268625
17478464
D014839 D007213 Vomiting marker/mechanism
therapeutic
11897121
16240705