KNApSAcK Metabolite C00030781
Metabolite
KNApSAcK Entry
| id | C00030781 |
|---|---|
| Name | Mollugin |
| CAS RN | 55481-88-4 |
| Standard InChI | InChI=1S/C17H16O4/c1-17(2)9-8-12-13(16(19)20-3)14(18)10-6-4-5-7-11(10)15(12)21-17/h4-9,18H,1-3H3 |
| Standard InChI (Main Layer) | InChI=1S/C17H16O4/c1-17(2)9-8-12-13(16(19)20-3)14(18)10-6-4-5-7-11(10)15(12)21-17/h4-9,18H,1-3H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 5069 |
Link
ChEMBL
| By standard InChI | CHEMBL446008 |
|---|---|
| By standard InChI Main Layer | CHEMBL446008 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | C046245 |
|---|
Species
Summary
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Rubia cordifolia L. | 339321 | Rubiaceae | asterids | Viridiplantae |
Human Protein / Gene in interaction
CTD interaction (30)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C046245 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP12 protein] |
decreases reaction
/ increases activity |
protein |
19716835
|
| C046245 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
19716835
|
| C046245 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP7 protein] |
decreases reaction
/ increases activity |
protein |
19716835
|
| C046245 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP8 protein] |
decreases reaction
/ increases activity |
protein |
19716835
|
| C046245 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP9 protein] |
decreases reaction
/ increases activity |
protein |
19716835
|
| C046245 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of BID protein] |
decreases reaction
/ increases cleavage |
protein |
19716835
|
| C046245 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of CFLAR protein] |
decreases reaction
/ increases cleavage |
protein |
19716835
|
| C046245 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | BCL2L1 protein inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein] |
decreases reaction
/ increases degradation |
protein |
19716835
|
| C046245 | 637 |
BID
FP497 |
BH3 interacting domain death agonist | BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of BID protein] |
decreases reaction
/ increases cleavage |
protein |
19716835
|
| C046245 | 637 |
BID
FP497 |
BH3 interacting domain death agonist | benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased cleavage of BID protein] |
decreases reaction
/ increases cleavage |
protein |
19716835
|
| C046245 | 637 |
BID
FP497 |
BH3 interacting domain death agonist | rubimaillin results in increased cleavage of BID protein |
increases cleavage
|
protein |
19716835
|
| C046245 | 100506742 |
CASP12
CASP-12 CASP12P1 |
caspase 12 (gene/pseudogene) | BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP12 protein] |
decreases reaction
/ increases activity |
protein |
19716835
|
| C046245 | 100506742 |
CASP12
CASP-12 CASP12P1 |
caspase 12 (gene/pseudogene) | rubimaillin results in increased activity of CASP12 protein |
increases activity
|
protein |
19716835
|
| C046245 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
19716835
|
| C046245 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone affects the reaction [rubimaillin results in increased activity of CASP3 protein] |
affects reaction
/ increases activity |
protein |
19716835
|
| C046245 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | rubimaillin results in increased activity of CASP3 protein |
increases activity
|
protein |
19716835
|
| C046245 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP7 protein] |
decreases reaction
/ increases activity |
protein |
19716835
|
| C046245 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP7 protein] |
decreases reaction
/ increases activity |
protein |
19716835
|
| C046245 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | rubimaillin results in increased activity of CASP7 protein |
increases activity
|
protein |
19716835
|
| C046245 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP8 protein] |
decreases reaction
/ increases activity |
protein |
19716835
|
| C046245 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP8 protein] |
decreases reaction
/ increases activity |
protein |
19716835
|
| C046245 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | rubimaillin results in increased activity of CASP8 protein |
increases activity
|
protein |
19716835
|
| C046245 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP9 protein] |
decreases reaction
/ increases activity |
protein |
19716835
|
| C046245 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone affects the reaction [rubimaillin results in increased activity of CASP9 protein] |
affects reaction
/ increases activity |
protein |
19716835
|
| C046245 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | rubimaillin results in increased activity of CASP9 protein |
increases activity
|
protein |
19716835
|
| C046245 | 8837 |
CFLAR
CASH CASP8AP1 CLARP Casper FLAME FLAME-1 FLAME1 FLIP I-FLICE MRIT c-FLIP c-FLIPL c-FLIPR c-FLIPS |
CASP8 and FADD-like apoptosis regulator | BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of CFLAR protein] |
decreases reaction
/ increases cleavage |
protein |
19716835
|
| C046245 | 8837 |
CFLAR
CASH CASP8AP1 CLARP Casper FLAME FLAME-1 FLAME1 FLIP I-FLICE MRIT c-FLIP c-FLIPL c-FLIPR c-FLIPS |
CASP8 and FADD-like apoptosis regulator | rubimaillin results in increased cleavage of CFLAR protein |
increases cleavage
|
protein |
19716835
|
| C046245 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | BCL2L1 protein inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein] |
decreases reaction
/ increases degradation |
protein |
19716835
|
| C046245 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein] |
decreases reaction
/ increases degradation |
protein |
19716835
|
| C046245 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | rubimaillin results in increased degradation of PARP1 protein |
increases degradation
|
protein |
19716835
|