PCIDB

KNApSAcK Metabolite C00003132

Metabolite

KNApSAcK Entry

id C00003132
Name trans,trans-Farnesol
CAS RN 4602-84-0
Standard InChI InChI=1S/C15H26O/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11,16H,5-6,8,10,12H2,1-4H3/b14-9+,15-11+
Standard InChI (Main Layer) InChI=1S/C15H26O/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11,16H,5-6,8,10,12H2,1-4H3

Cluster

Phytochemical cluster No. 38
KCF-S cluster No. 404

Link

ChEMBL

By standard InChI CHEMBL25308
By standard InChI Main Layer CHEMBL25308 CHEMBL488357

KEGG

By LinkDB C01493

CTD

By CAS RN D005204

Species

Summary

Plant class

class name count
rosids 2

Family

family name count
Malvaceae 2

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Abelmoschus moschatus 1170222 Malvaceae rosids Viridiplantae
Hibiscus abelmoschus 47605 Malvaceae rosids Viridiplantae

Human Protein / Gene in interaction

7 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL25308 CHEMBL1794467 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL25308 CHEMBL1614240 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL25308 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL25308 CHEMBL1614421 (1)
4 / 3
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL25308 CHEMBL1738442 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL25308 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL25308 CHEMBL1614531 (1)
1 / 3

CTD interaction (16)

compound gene gene name gene description interaction interaction type form reference
pmid
D005204 57016 AKR1B10
AKR1B11
AKR1B12
ALDRLn
ARL-1
ARL1
HIS
HSI
aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2) AKR1B10 protein results in increased chemical synthesis of Farnesol increases chemical synthesis
protein 21187079
D005204 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) AKR1C3 protein results in increased chemical synthesis of Farnesol increases chemical synthesis
protein 21187079
D005204 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) [Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol decreases activity
/ increases metabolic processing
protein 21187079
D005204 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) [tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol decreases activity
/ increases metabolic processing
protein 21187079
D005204 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Farnesol results in increased activity of CASP3 protein increases activity
protein 10733934
D005204 100328933 Farnesol results in increased expression of CYP2C mRNA increases expression
mRNA 15629189
D005204 9971 NR1H4
BAR
FXR
HRR-1
HRR1
RIP14
nuclear receptor subfamily 1, group H, member 4 Farnesol binds to and results in increased activity of NR1H4 protein affects binding
/ increases activity
protein 15491415
D005204 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] affects binding
/ decreases reaction
/ increases activity
/ increases reaction
protein 11779144
D005204 6256 RXRA
NR2B1
retinoid X receptor, alpha Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] affects binding
/ decreases reaction
/ increases activity
/ increases reaction
protein 11779144
D005204 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) UGT1A1 protein results in increased glucuronidation of Farnesol increases glucuronidation
protein 15320866
D005204 54659 UGT1A3
UDPGT
UDPGT_1-3
UGT-1C
UGT1-03
UGT1.3
UGT1C
UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) UGT1A3 protein results in increased glucuronidation of Farnesol increases glucuronidation
protein 15320866
D005204 54657 UGT1A4
HUG-BR2
UDPGT
UDPGT_1-4
UGT-1D
UGT1-04
UGT1.4
UGT1D
UDP glucuronosyltransferase 1 family, polypeptide A4 (EC:2.4.1.17) UGT1A4 protein results in increased glucuronidation of Farnesol increases glucuronidation
protein 15320866
D005204 54578 UGT1A6
GNT1
HLUGP
HLUGP1
UDPGT
UDPGT_1-6
UGT1
UGT1A6S
UGT1F
UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) UGT1A6 protein results in increased glucuronidation of Farnesol increases glucuronidation
protein 15320866
D005204 54600 UGT1A9
HLUGP4
LUGP4
UDPGT
UDPGT_1-9
UGT-1I
UGT1-09
UGT1-9
UGT1.9
UGT1AI
UGT1I
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) UGT1A9 protein results in increased glucuronidation of Farnesol increases glucuronidation
protein 15320866
D005204 7363 UGT2B4
HLUG25
UDPGT2B4
UDPGTH1
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B4 (EC:2.4.1.17) UGT2B4 protein results in increased glucuronidation of Farnesol increases glucuronidation
protein 15320866
D005204 7364 UGT2B7
UDPGT_2B9
UDPGT2B7
UDPGTH2
UGT2B9
UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) UGT2B7 protein results in increased glucuronidation of Farnesol increases glucuronidation
protein 15320866

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM preferred title UniProt
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (11)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)

Diseases related to CTD interactions

4 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D003108 D005204 Colonic Diseases therapeutic
21453689
D004487 D005204 Edema therapeutic
18793622
D055370 D005204 Lung Injury therapeutic
18793622
D011014 D005204 Pneumonia therapeutic
18793622