PCIDB

KNApSAcK Metabolite C00003138

Metabolite

KNApSAcK Entry

id C00003138
Name Guaiazulene
CAS RN 489-84-9
Standard InChI InChI=1S/C15H18/c1-10(2)13-7-5-11(3)14-8-6-12(4)15(14)9-13/h5-10H,1-4H3
Standard InChI (Main Layer) InChI=1S/C15H18/c1-10(2)13-7-5-11(3)14-8-6-12(4)15(14)9-13/h5-10H,1-4H3

Cluster

Phytochemical cluster No. 38
KCF-S cluster No. 647

Link

ChEMBL

By standard InChI CHEMBL1408759
By standard InChI Main Layer CHEMBL1408759

KEGG

By LinkDB C09675

CTD

By CAS RN C004451

Human Protein / Gene in interaction

6 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P02545 Prelamin-A/C Unclassified protein CHEMBL1408759 CHEMBL1614544 (1)
11 / 10
O75496 Geminin Unclassified protein CHEMBL1408759 CHEMBL2114843 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL1408759 CHEMBL1794401 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1408759 CHEMBL1794467 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL1408759 CHEMBL1737991 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1408759 CHEMBL1738442 (1)
0 / 0

CTD interaction (3)

compound gene gene name gene description interaction interaction type form reference
pmid
C004451 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) guaiazulene results in increased activity of CASP3 protein increases activity
protein 20854889
C004451 1277 COL1A1
OI4
collagen, type I, alpha 1 guaiazulene results in decreased expression of COL1A1 mRNA decreases expression
mRNA 20854889
C004451 1277 COL1A1
OI4
collagen, type I, alpha 1 guaiazulene results in decreased expression of COL1A1 protein decreases expression
protein 20854889

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545

KEGG DISEASE (10)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)