Species

KNApSAcK Entry

Organism name Matricaria chamomilla
Genus Matricaria
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Matricaria chamomilla
Linked NCBI taxonomy ID 98504
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (17)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004343 External link 512 Luteolin 3'-methyl ether 7-rutinoside
No. 1 No. 15
C00005644 External link 512 Patuletin 7-glucoside
CHEMBL480855
No. 2 No. 15
C00004177 External link 512 Apigenin 7-(6''-acetylglucoside)
No. 2 No. 15
C00004176 External link 512 Apigenin 7-(2''-acetylglucoside)
No. 2 No. 15
C00004680 External link 512 Patuletin
/ 6-Methoxyquercetin
/ 3,5,7,3',4'-Pentahydroxy-6-methoxyflavone
/ 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4H-1-benzopyran-4-one
CHEMBL465155
C079162
No. 3 No. 15
C00004684 External link 512 Axillarin
/ Quercetagetin 3,6-dimethyl ether
/ 3,6-Dimethoxy-5,7,3',4'-tetrahydroxyflavone
/ 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3,6-dimethoxy-4H-1-benzopyran-4-one
CHEMBL487810
C056669
1 / 1 / 1 No. 3 No. 15
C00004593 External link 512 6-Methoxykaempferol
/ 3,5,7,4'-Tetrahydroxy-6-methoxyflavone
/ 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
CHEMBL462898
No. 3 No. 15
C00004189 External link 512 Apigenin 7-(3'',4''-diacetylglucoside)
No. 330
C00004188 External link 512 Apigenin 7-(2'',3''-diacetylglucoside)
No. 330
C00003103 External link 512 (+)-alpha-Bisabolol
CHEMBL519167
CHEMBL491186
CHEMBL477832
CHEMBL1096927
CHEMBL1171719
CHEMBL1561544
CHEMBL2104360
8 / 4 / 13 No. 541 No. 38
C00011607 External link 512 (-)-alpha-Bisabolol
CHEMBL519167
CHEMBL491186
CHEMBL477832
CHEMBL1096927
CHEMBL1171719
CHEMBL1561544
CHEMBL2104360
8 / 4 / 13 No. 541 No. 38
C00003138 External link 512 Guaiazulene
CHEMBL1408759
C004451
6 / 11 / 10 2 / 0 No. 647 No. 38
C00003321 External link 512 Matricin
CHEMBL497441
C039959
No. 1147 No. 38
C00011652 External link 512 Bisabolol oxide II
/ (-)-Bisabolol oxide B
/ alpha-Bisabolol oxide B
/ (-)-alpha-Bisabolol oxide B
No. 2789
C00011651 External link 512 Bisaboloxide A
/ Bisabolol oxide I
/ Bisabolol oxide A
/ alpha-Bisabolol oxide
/ alpha-Bisabolol oxide A
/ (-)-alpha-Bisabolol oxide A
C548414
No. 2789
C00011653 External link 512 Bisabolol oxide C
/ alpha-Bisabolol oxide C
No. 2909
C00003114 External link 512 Chamazulene
CHEMBL495665
C013872
No. 3472 No. 38

Human Protein / Gene in interactions

14 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003103 C00003138 C00011607 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003103 C00011607 0 / 1
O00255 Menin Unclassified protein C00003103 C00011607 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003103 C00011607 1 / 2
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00003103 C00011607 1 / 2
P16050 Arachidonate 15-lipoxygenase Enzyme C00003103 C00011607 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00003103 C00011607 0 / 3
P28482 Mitogen-activated protein kinase 1 Erk C00003103 C00011607 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00003138 0 / 0
O75496 Geminin Unclassified protein C00003138 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00003138 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00003138 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00004684 1 / 1
P02545 Prelamin-A/C Unclassified protein C00003138 11 / 10

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00003138
1277 COL1A1, OI4 collagen, type I, alpha 1 C00003138

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (16)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545
#278300 Xanthinuria, type i P47989

KEGG DISEASE (24)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00016 Oral cancer P40763 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)