PCIDB

KNApSAcK Metabolite C00031531

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases

Metabolite

KNApSAcK Entry

id	C00031531
Name	Galangal acetate / 1'-Acetoxychavicol acetate / 1'S-1'-Acetoxychavicol acetate
CAS RN	52946-22-2
Standard InChI	InChI=1S/C13H14O4/c1-4-13(17-10(3)15)11-5-7-12(8-6-11)16-9(2)14/h4-8,13H,1H2,2-3H3/t13-/m0/s1
Standard InChI (Main Layer)	InChI=1S/C13H14O4/c1-4-13(17-10(3)15)11-5-7-12(8-6-11)16-9(2)14/h4-8,13H,1H2,2-3H3

Cluster

Phytochemical cluster	No. 6
KCF-S cluster	No. 3071

Link

ChEMBL

By standard InChI	CHEMBL323727
By standard InChI Main Layer	CHEMBL323727 CHEMBL359887 CHEMBL414656

KEGG

By LinkDB	C10426

CTD

By CAS RN	C047948

Species

Summary

Plant class

class name	count
Liliopsida	1

Family

family name	count
Zingiberaceae	1

List (1)

* NCBI

KNApSAcK organism	*ID	*family	*plant class	*kingdom
Alpinia galanga	94327	Zingiberaceae	Liliopsida	Viridiplantae

Human Protein / Gene in interaction

CTD interaction (71)

compound	gene	gene name	gene description	interaction	interaction type	form	reference pmid
C047948	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BCL2 protein]	decreases reaction / increases expression	protein	15905586
C047948	597	BCL2A1 ACC-1 ACC-2 BCL2L5 BFL1 GRS HBPA1	BCL2-related protein A1	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]	decreases reaction / increases expression	protein	15905586
C047948	598	BCL2L1 BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS	BCL2-like 1	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]	decreases reaction / increases expression	protein	15905586
C047948	329	BIRC2 API1 HIAP2 Hiap-2 MIHB RNF48 c-IAP1 cIAP1	baculoviral IAP repeat containing 2	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]	decreases reaction / increases expression	protein	15905586
C047948	330	BIRC3 AIP1 API2 CIAP2 HAIP1 HIAP1 MALT2 MIHC RNF49 c-IAP2	baculoviral IAP repeat containing 3	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]	decreases reaction / increases expression	protein	15905586
C047948	332	BIRC5 API4 EPR-1	baculoviral IAP repeat containing 5	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]	decreases reaction / increases expression	protein	15905586
C047948	595	CCND1 BCL1 D11S287E PRAD1 U21B31	cyclin D1	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of CCND1 protein]	decreases reaction / increases expression	protein	15905586
C047948	8837	CFLAR CASH CASP8AP1 CLARP Casper FLAME FLAME-1 FLAME1 FLIP I-FLICE MRIT c-FLIP c-FLIPL c-FLIPR c-FLIPS	CASP8 and FADD-like apoptosis regulator	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of CFLAR protein]	decreases reaction / increases expression	protein	15905586
C047948	1147	CHUK IKBKA IKK-alpha IKK1 IKKA NFKBIKA TCF16	conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of CHUK protein]	decreases reaction / increases activity	protein	15905586
C047948	3383	ICAM1 BB2 CD54 P3.58	intercellular adhesion molecule 1	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]	decreases reaction / increases expression	protein	15905586
C047948	3551	IKBKB IKK-beta IKK2 IKKB NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of IKBKB protein]	decreases reaction / increases activity	protein	15905586
C047948	3551	IKBKB IKK-beta IKK2 IKKB NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of IKBKB protein]	decreases reaction / increases expression	protein	15905586
C047948	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	1'-acetoxychavicol acetate inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]	decreases reaction / increases activity	protein	15905586
C047948	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	1'-acetoxychavicol acetate inhibits the reaction [IL1B protein results in increased activity of RELA protein]	decreases reaction / increases activity	protein	15905586
C047948	9020	MAP3K14 FTDCR1B HS HSNIK NIK	mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25)	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of MAP3K14 protein]	decreases reaction / increases expression	protein	15905586
C047948	4318	MMP9 CLG4B GELB MANDP2 MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of MMP9 protein]	decreases reaction / increases expression	protein	15905586
C047948	4609	MYC MRTL MYCC bHLHe39 c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of MYC protein]	decreases reaction / increases expression	protein	15905586
C047948	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	1'-acetoxychavicol acetate inhibits the reaction [Doxorubicin results in increased activity of NFKB1 protein]	decreases reaction / increases activity	protein	15905586
C047948	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	1'-acetoxychavicol acetate inhibits the reaction [Hydrogen Peroxide results in increased activity of NFKB1 protein]	decreases reaction / increases activity	protein	15905586
C047948	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	1'-acetoxychavicol acetate inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]	decreases reaction / increases activity	protein	15905586
C047948	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	1'-acetoxychavicol acetate inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]	decreases reaction / increases activity	protein	15905586
C047948	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	1'-acetoxychavicol acetate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NFKB1 protein]	decreases reaction / increases activity	protein	15905586
C047948	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]	decreases reaction / increases activity	protein	15905586
C047948	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]	decreases reaction / increases degradation	protein	15905586
C047948	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]	decreases reaction / increases phosphorylation	protein	15905586
C047948	142	PARP1 ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	1'-acetoxychavicol acetate promotes the reaction [TNF protein results in increased cleavage of PARP1 protein]	increases cleavage / increases reaction	protein	15905586
C047948	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]	decreases reaction / increases expression	protein	15905586
C047948	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	1'-acetoxychavicol acetate inhibits the reaction [Doxorubicin results in increased activity of RELA protein]	decreases reaction / increases activity	protein	15905586
C047948	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	1'-acetoxychavicol acetate inhibits the reaction [Hydrogen Peroxide results in increased activity of RELA protein]	decreases reaction / increases activity	protein	15905586
C047948	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	1'-acetoxychavicol acetate inhibits the reaction [IL1B protein results in increased activity of RELA protein]	decreases reaction / increases activity	protein	15905586
C047948	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	1'-acetoxychavicol acetate inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]	decreases reaction / increases activity	protein	15905586
C047948	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	1'-acetoxychavicol acetate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]	decreases reaction / increases activity	protein	15905586
C047948	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	1'-acetoxychavicol acetate inhibits the reaction [TNF protein affects the localization of RELA protein]	affects localization / decreases reaction	protein	15905586
C047948	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of RELA protein]	decreases reaction / increases activity	protein	15905586
C047948	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]	decreases reaction / increases phosphorylation	protein	15905586
C047948	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	1'-acetoxychavicol acetate results in decreased activity of RELA protein	decreases activity	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein affects the localization of RELA protein]	affects localization / decreases reaction	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of CHUK protein]	decreases reaction / increases activity	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of IKBKB protein]	decreases reaction / increases activity	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]	decreases reaction / increases activity	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of RELA protein]	decreases reaction / increases activity	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]	decreases reaction / increases degradation	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BCL2 protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of CCND1 protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of CFLAR protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of IKBKB protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of MAP3K14 protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of MMP9 protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of MYC protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRADD protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRAF2 protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of VEGFA protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of XIAP protein]	decreases reaction / increases expression	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]	decreases reaction / increases phosphorylation	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]	decreases reaction / increases phosphorylation	protein	15905586
C047948	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	1'-acetoxychavicol acetate promotes the reaction [TNF protein results in increased cleavage of PARP1 protein]	increases cleavage / increases reaction	protein	15905586
C047948	7132	TNFRSF1A CD120a FPF MS5 TBP1 TNF-R TNF-R-I TNF-R55 TNFAR TNFR1 TNFR1-d2 TNFR55 TNFR60 p55 p55-R p60	tumor necrosis factor receptor superfamily, member 1A	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]	decreases reaction / increases expression	protein	15905586
C047948	8717	TRADD Hs.89862	TNFRSF1A-associated via death domain	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRADD protein]	decreases reaction / increases expression	protein	15905586
C047948	7185	TRAF1 EBI6 MGC:10353	TNF receptor-associated factor 1	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]	decreases reaction / increases expression	protein	15905586
C047948	7186	TRAF2 MGC:45012 TRAP TRAP3	TNF receptor-associated factor 2	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRAF2 protein]	decreases reaction / increases expression	protein	15905586
C047948	7422	VEGFA MVCD1 VEGF VPF	vascular endothelial growth factor A	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of VEGFA protein]	decreases reaction / increases expression	protein	15905586
C047948	331	XIAP API3 BIRC4 IAP-3 ILP1 MIHA XLP2 hIAP-3 hIAP3	X-linked inhibitor of apoptosis	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of XIAP protein]	decreases reaction / increases expression	protein	15905586

Related Disease

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease	OMIM	compound	disease name	evidence type	reference pmid
D002286		C047948	Carcinoma, Ehrlich Tumor	therapeutic	20230805

KNApSAcK Metabolite C00031531

Index Metabolite Species Human Protein / Gene in interactions Related Diseases

Metabolite

KNApSAcK Entry

Cluster

Link

ChEMBL

KEGG

CTD

Species

Summary

Plant class

Family

List (1)

* NCBI

Human Protein / Gene in interaction

CTD interaction (71)

Related Disease

Diseases related to CTD interactions

1 disease from interactions of metabolites

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases