Species

KNApSAcK Entry

Organism name Alpinia galanga
Genus Alpinia
Family Zingiberaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Alpinia galanga
Linked NCBI taxonomy ID 94327
Linked level species

Family

Family in NCBI taxonomy Zingiberaceae
ID 4642

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (16)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00022438 External link 512 Labda-8beta(17),12E-diene-15,16-dial
CHEMBL112830
CHEMBL491531
No. 165
C00031798 External link 512 Galanganol A
No. 922 No. 24
C00031799 External link 512 Galanganol B
No. 922 No. 24
C00031797 External link 512 Galanganal
No. 922 No. 24
C00034848 External link 512 Galanolactone
CHEMBL322730
C069419
No. 1300 No. 46
C00002741 External link 512 Methyleugenol
/ 4-Allylveratrole
/ Eugenol methyl ether
CHEMBL108861
C005223
12 / 13 / 9 3 / 9 No. 1412
C00022440 External link 512 Miogadial
/ Aframodial
/ 8beta,17-Epoxyl-12E-labdene-15,16-dial
CHEMBL463904
No. 1599
C00034847 External link 512 Galanal A
C476264
No. 1599
C00031420 External link 512 trans-p-Coumaryl alcohol
CHEMBL109034
No. 1979 No. 6
C00031422 External link 512 trans-p-Hydroxycinnamaldehyde
CHEMBL431836
CHEMBL1956164
3 / 4 / 3 No. 1979 No. 6
C00002657 External link 512 p-Formylphenol
/ 4-Hydroxybenzaldehyde
/ p-Hydroxybenzaldehyde
CHEMBL14193
C011483
3 / 2 / 2 No. 2076
C00031421 External link 512 trans-p-Coumaryl diacetate
CHEMBL444328
No. 3071 No. 6
C00002712 External link 512 1'-Acetoxyeugenol acetate
CHEMBL111484
C057996
0 / 1 No. 3071 No. 6
C00002711 External link 512 1'-Acetoxychavicol acetate
CHEMBL323727
CHEMBL359887
CHEMBL414656
No. 3071 No. 6
C00031531 External link 512 Galangal acetate
/ 1'-Acetoxychavicol acetate
/ 1'S-1'-Acetoxychavicol acetate
CHEMBL323727
CHEMBL359887
CHEMBL414656
C047948
27 / 1 No. 3071 No. 6
C00031800 External link 512 Galanganol C
No. 6956

Human Protein / Gene in interactions

17 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P00352 Retinal dehydrogenase 1 Enzyme C00002741 C00031422 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00002741 5 / 3
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial Oxidoreductase C00002657 1 / 1
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00002741 0 / 0
P14902 Indoleamine 2,3-dioxygenase 1 Enzyme C00002657 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002741 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00002741 2 / 0
P04150 Glucocorticoid receptor NR3C1 C00002741 0 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00002741 3 / 1
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase C00002657 1 / 1
Q96RI1 Bile acid receptor NR1H4 C00002741 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002741 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00031422 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002741 0 / 0
P10275 Androgen receptor NR3C4 C00002741 3 / 4
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00002741 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00031422 0 / 0

30 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
2938 GSTA1, GST2, GSTA1-1, GTH1 glutathione S-transferase alpha 1 (EC:2.5.1.18) C00002741
2944 GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 glutathione S-transferase mu 1 (EC:2.5.1.18) C00002741
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00002741
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00031531
597 BCL2A1, ACC-1, ACC-2, BCL2L5, BFL1, GRS, HBPA1 BCL2-related protein A1 C00031531
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00031531
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00031531
330 BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 baculoviral IAP repeat containing 3 C00031531
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00031531
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00031531
8837 CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS CASP8 and FADD-like apoptosis regulator C00031531
1147 CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) C00031531
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00031531
3551 IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) C00031531
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00031531
9020 MAP3K14, FTDCR1B, HS, HSNIK, NIK mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25) C00031531
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00031531
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00031531
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00031531
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00031531
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00031531
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00031531
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00031531
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00031531
7132 TNFRSF1A, CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60 tumor necrosis factor receptor superfamily, member 1A C00031531
8717 TRADD, Hs.89862 TNFRSF1A-associated via death domain C00031531
7185 TRAF1, EBI6, MGC:10353 TNF receptor-associated factor 1 C00031531
7186 TRAF2, MGC:45012, TRAP, TRAP3 TNF receptor-associated factor 2 C00031531
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00031531
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00031531

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM preferred title UniProt
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
#600274 Frontotemporal dementia; ftd P10636
#613163 Gaba-transaminase deficiency P80404
#137800 Glioma susceptibility 1; glm1 P37231
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#601665 Obesity P37231
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#271980 Succinic semialdehyde dehydrogenase deficiency; ssadhd P51649
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (14)

KEGG name UniProt
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00835 Succinic semialdehyde dehydrogenase (SSADH) deficiency P51649 (related)
H01257 GABA-transaminase deficiency P80404 (related)

Diseases related to CTD interactions

10 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001943 Breast Neoplasms C00002741
C00002712
D008113 Liver Neoplasms C00002741
D003328 Coronary Thrombosis C00002741
D006529 Hepatomegaly C00002741
D006930 Hyperalgesia C00002741
D000707 Anaphylaxis C00002741
D008114 Liver Neoplasms, Experimental C00002741
D008325 Mammary Neoplasms, Experimental C00002741
D009374 Neoplasms, Experimental C00002741
D002286 Carcinoma, Ehrlich Tumor C00031531