PCIDB

KNApSAcK Metabolite C00003201

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases

Metabolite

KNApSAcK Entry

id	C00003201
Name	Vomitoxin
CAS RN	51481-10-8
Standard InChI	InChI=1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1
Standard InChI (Main Layer)	InChI=1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3

Cluster

Phytochemical cluster
KCF-S cluster	No. 4211

Link

ChEMBL

By standard InChI	CHEMBL513300
By standard InChI Main Layer	CHEMBL513300

KEGG

By LinkDB	C09747

CTD

By CAS RN	C007262

Species

Summary

Plant class

class name	count

Family

family name	count
Nectriaceae	1

List (2)

* NCBI

KNApSAcK organism	*ID	*family	*plant class	*kingdom
Fusarium graminearum	5518	Nectriaceae		Fungi
Fusarium roseum

Human Protein / Gene in interaction

CTD interaction (242)

compound	gene	gene name	gene description	interaction	interaction type	form	reference pmid
C007262	248	ALPI IAP	alkaline phosphatase, intestinal (EC:3.1.3.1)	deoxynivalenol results in decreased expression of and results in decreased activity of ALPI protein	decreases activity / decreases expression	protein	20362602
C007262	430	ASCL2 ASH2 HASH2 MASH2 bHLHa45	achaete-scute family bHLH transcription factor 2	deoxynivalenol results in increased expression of ASCL2 mRNA	increases expression	mRNA	19438726
C007262	466	ATF1 EWS-ATF1 FUS/ATF-1 TREB36	activating transcription factor 1	deoxynivalenol results in increased expression of ATF1 mRNA	increases expression	mRNA	22846391
C007262	1386	ATF2 CRE-BP1 CREB2 HB16 TREB7	activating transcription factor 2 (EC:2.3.1.48)	deoxynivalenol results in increased expression of ATF2 mRNA	increases expression	mRNA	22846391
C007262	467	ATF3	activating transcription factor 3	[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of ATF3 mRNA]	affects binding / increases activity / increases expression / increases reaction	mRNA	22003189
C007262	467	ATF3	activating transcription factor 3	[[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which affects the localization of ELAVL1 protein] which co-treated with deoxynivalenol] promotes the reaction [[ELAVL1 protein binds to ATF3 3' UTR] which results in increased stability of ATF3 mRNA]	affects binding / affects cotreatment / affects localization / increases activity / increases reaction / increases stability	3' UTR / mRNA	22003189
C007262	467	ATF3	activating transcription factor 3	[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of ATF3 mRNA	affects binding / affects cotreatment / increases activity / increases stability	mRNA	22003189
C007262	467	ATF3	activating transcription factor 3	ATF3 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the phosphorylation of RELA protein]	affects binding / affects cotreatment / affects phosphorylation / affects reaction / increases activity	protein	22003189
C007262	467	ATF3	activating transcription factor 3	ATF3 protein results in increased susceptibility to deoxynivalenol	increases response to substance	protein	19101521
C007262	467	ATF3	activating transcription factor 3	deoxynivalenol results in decreased degradation of ATF3 mRNA	decreases degradation	mRNA	19101521
C007262	467	ATF3	activating transcription factor 3	deoxynivalenol results in decreased degradation of ATF3 protein	decreases degradation	protein	19101521
C007262	467	ATF3	activating transcription factor 3	deoxynivalenol results in increased expression of ATF3 mRNA	increases expression	mRNA	19101521 19360757 22003189 22846391
C007262	467	ATF3	activating transcription factor 3	deoxynivalenol results in increased expression of ATF3 protein	increases expression	protein	19360757
C007262	467	ATF3	activating transcription factor 3	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [deoxynivalenol results in decreased degradation of ATF3 protein]	decreases degradation / decreases reaction	protein	19101521
C007262	467	ATF3	activating transcription factor 3	SB 203580 inhibits the reaction [deoxynivalenol results in decreased degradation of ATF3 mRNA]	decreases degradation / decreases reaction	mRNA	19101521
C007262	467	ATF3	activating transcription factor 3	SB 203580 inhibits the reaction [deoxynivalenol results in decreased degradation of ATF3 protein]	decreases degradation / decreases reaction	protein	19101521
C007262	22926	ATF6 ATF6A	activating transcription factor 6	deoxynivalenol results in increased expression of ATF6 mRNA	increases expression	mRNA	20682335 22846391
C007262	9531	BAG3 BAG-3 BIS CAIR-1 MFM6	BCL2-associated athanogene 3	deoxynivalenol results in increased expression of BAG3 mRNA	increases expression	mRNA	22846391
C007262	578	BAK1 BAK BAK-LIKE BCL2L7 CDN1	BCL2-antagonist/killer 1	deoxynivalenol results in increased expression of BAK1 mRNA	increases expression	mRNA	20702593
C007262	581	BAX BCL2L4	BCL2-associated X protein	Ascorbic Acid inhibits the reaction [deoxynivalenol results in increased expression of BAX protein]	decreases reaction / increases expression	protein	17166419
C007262	581	BAX BCL2L4	BCL2-associated X protein	deoxynivalenol results in decreased expression of BAX mRNA	decreases expression	mRNA	22269384
C007262	581	BAX BCL2L4	BCL2-associated X protein	deoxynivalenol results in increased expression of BAX mRNA	increases expression	mRNA	22269384
C007262	581	BAX BCL2L4	BCL2-associated X protein	deoxynivalenol results in increased expression of BAX protein	increases expression	protein	17166419
C007262	27113	BBC3 JFY-1 JFY1 PUMA	BCL2 binding component 3	deoxynivalenol results in increased expression of BBC3 mRNA	increases expression	mRNA	22846391
C007262	8915	BCL10 CARMEN CIPER CLAP c-E10 mE10	B-cell CLL/lymphoma 10	deoxynivalenol results in increased expression of BCL10 mRNA	increases expression	mRNA	22846391
C007262	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	Ascorbic Acid inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]	decreases expression / decreases reaction	protein	17166419
C007262	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	deoxynivalenol results in decreased expression of BCL2 mRNA	decreases expression	mRNA	22269384
C007262	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	deoxynivalenol results in decreased expression of BCL2 protein	decreases expression	protein	17166419
C007262	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	deoxynivalenol results in increased expression of BCL2 mRNA	increases expression	mRNA	22269384
C007262	598	BCL2L1 BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS	BCL2-like 1	deoxynivalenol results in decreased expression of BCL2L1 mRNA	decreases expression	mRNA	22846391
C007262	23786	BCL2L13 BCL-RAMBO Bcl2-L-13 MIL1	BCL2-like 13 (apoptosis facilitator)	deoxynivalenol results in increased expression of BCL2L13 mRNA	increases expression	mRNA	22846391
C007262	9774	BCLAF1 BTF bK211L9.1	BCL2-associated transcription factor 1	deoxynivalenol results in increased expression of BCLAF1 mRNA	increases expression	mRNA	22846391
C007262	637	BID FP497	BH3 interacting domain death agonist	deoxynivalenol results in decreased expression of BID mRNA	decreases expression	mRNA	22269384
C007262	662	BNIP1 NIP1 SEC20 TRG-8	BCL2/adenovirus E1B 19kDa interacting protein 1	deoxynivalenol results in increased expression of BNIP1 mRNA	increases expression	mRNA	22846391
C007262	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	Ascorbic Acid inhibits the reaction [deoxynivalenol results in increased expression of CASP3 protein]	decreases reaction / increases expression	protein	17166419
C007262	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	deoxynivalenol results in decreased expression of CASP3 protein	decreases expression	protein	22269384
C007262	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	deoxynivalenol results in increased activity of CASP3 protein	increases activity	protein	19664677 22269384
C007262	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	deoxynivalenol results in increased expression of CASP3 protein	increases expression	protein	17166419 22269384
C007262	841	CASP8 ALPS2B CAP4 Casp-8 FLICE MACH MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	deoxynivalenol results in increased expression of CASP8 mRNA	increases expression	mRNA	22846391
C007262	842	CASP9 APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	deoxynivalenol results in decreased expression of CASP9 protein	decreases expression	protein	22269384
C007262	842	CASP9 APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	deoxynivalenol results in increased activity of CASP9 protein	increases activity	protein	22269384
C007262	842	CASP9 APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	deoxynivalenol results in increased expression of CASP9 protein	increases expression	protein	22269384
C007262	847	CAT	catalase (EC:1.11.1.6)	deoxynivalenol results in increased expression of CAT protein	increases expression	protein	20347963
C007262	847	CAT	catalase (EC:1.11.1.6)	Lutein inhibits the reaction [deoxynivalenol results in increased expression of CAT protein]	decreases reaction / increases expression	protein	20347963
C007262	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	deoxynivalenol results in increased expression of CCL2 mRNA	increases expression	mRNA	22846391
C007262	6348	CCL3 G0S19-1 LD78ALPHA MIP-1-alpha MIP1A SCYA3	chemokine (C-C motif) ligand 3	deoxynivalenol results in increased expression of CCL3 mRNA	increases expression	mRNA	22846391
C007262	6351	CCL4 ACT2 AT744.1 G-26 HC21 LAG-1 LAG1 MIP-1-beta MIP1B MIP1B1 SCYA2 SCYA4	chemokine (C-C motif) ligand 4	deoxynivalenol results in increased expression of CCL4 mRNA	increases expression	mRNA	22846391
C007262	929	CD14	CD14 molecule	deoxynivalenol inhibits the reaction [IFNG protein results in increased expression of CD14 protein]	decreases reaction / increases expression	protein	19549553
C007262	1604	CD55 CR CROM DAF TC	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	deoxynivalenol results in increased expression of CD55 mRNA	increases expression	mRNA	22846391
C007262	969	CD69 AIM BL-AC/P26 CLEC2C EA1 GP32/28 MLR-3	CD69 molecule	deoxynivalenol results in increased expression of CD69 mRNA	increases expression	mRNA	22846391
C007262	1026	CDKN1A CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	deoxynivalenol results in decreased degradation of CDKN1A mRNA	decreases degradation	mRNA	18006205
C007262	1026	CDKN1A CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	deoxynivalenol results in increased expression of CDKN1A protein	increases expression	protein	18006205
C007262	1026	CDKN1A CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	U 0126 inhibits the reaction [deoxynivalenol results in decreased degradation of CDKN1A mRNA]	decreases degradation / decreases reaction	mRNA	18006205
C007262	1147	CHUK IKBKA IKK-alpha IKK1 IKKA NFKBIKA TCF16	conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)	deoxynivalenol results in increased phosphorylation of CHUK protein	increases phosphorylation	protein	20633634
C007262	1364	CLDN4 CPE-R CPER CPETR CPETR1 WBSCR8 hCPE-R	claudin 4	deoxynivalenol results in decreased expression of CLDN4 protein	decreases expression	protein	19289138 20362602
C007262	1364	CLDN4 CPE-R CPER CPETR CPETR1 WBSCR8 hCPE-R	claudin 4	deoxynivalenol results in increased expression of CLDN4 mRNA	increases expression	mRNA	20362602
C007262	6376	CX3CL1 ABCD-3 C3Xkine CXC3 CXC3C NTN NTT SCYD1 fractalkine neurotactin	chemokine (C-X3-C motif) ligand 1	deoxynivalenol results in increased expression of CX3CL1 mRNA	increases expression	mRNA	22846391
C007262	2919	CXCL1 FSP GRO1 GROa MGSA MGSA-a NAP-3 SCYB1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of CXCL1 mRNA]	affects binding / increases activity / increases expression / increases reaction	mRNA	22003189
C007262	2919	CXCL1 FSP GRO1 GROa MGSA MGSA-a NAP-3 SCYB1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA	affects binding / affects cotreatment / increases activity / increases stability	mRNA	22003189
C007262	2919	CXCL1 FSP GRO1 GROa MGSA MGSA-a NAP-3 SCYB1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	deoxynivalenol results in increased expression of CXCL1 mRNA	increases expression	mRNA	22003189
C007262	2919	CXCL1 FSP GRO1 GROa MGSA MGSA-a NAP-3 SCYB1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA]	affects binding / affects cotreatment / affects reaction / increases activity / increases stability	mRNA	22003189
C007262	7852	CXCR4 CD184 D2S201E FB22 HM89 HSY3RR LAP3 LCR1 LESTR NPY3R NPYR NPYRL NPYY3R WHIM	chemokine (C-X-C motif) receptor 4	deoxynivalenol results in increased expression of CXCR4 mRNA	increases expression	mRNA	22846391
C007262	54205	CYCS CYC HCS THC4	cytochrome c, somatic	deoxynivalenol results in decreased expression of CYCS protein	decreases expression	protein	22269384
C007262	54205	CYCS CYC HCS THC4	cytochrome c, somatic	deoxynivalenol results in increased activity of CYCS protein	increases activity	protein	22269384
C007262	54205	CYCS CYC HCS THC4	cytochrome c, somatic	deoxynivalenol results in increased expression of CYCS mRNA	increases expression	mRNA	22846391
C007262	54205	CYCS CYC HCS THC4	cytochrome c, somatic	deoxynivalenol results in increased expression of CYCS protein	increases expression	protein	22269384
C007262	1584	CYP11B1 CPN1 CYP11B FHI P450C11	cytochrome P450, family 11, subfamily B, polypeptide 1 (EC:1.14.15.4)	deoxynivalenol results in increased expression of CYP11B1 mRNA	increases expression	mRNA	22982764
C007262	1585	CYP11B2 ALDOS CPN2 CYP11B CYP11BL CYPXIB2 P-450C18 P450C18 P450aldo	cytochrome P450, family 11, subfamily B, polypeptide 2 (EC:1.14.15.4 1.14.15.5)	deoxynivalenol results in increased expression of CYP11B2 mRNA	increases expression	mRNA	22982764
C007262	1586	CYP17A1 CPT7 CYP17 P450C17 S17AH	cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30)	deoxynivalenol results in increased expression of CYP17A1 mRNA	increases expression	mRNA	22982764
C007262	1588	CYP19A1 ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM	cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)	deoxynivalenol results in decreased expression of CYP19A1 mRNA	decreases expression	mRNA	22982764
C007262	1543	CYP1A1 AHH AHRR CP11 CYP1 P1-450 P450-C P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	deoxynivalenol results in increased expression of CYP1A1 mRNA	increases expression	mRNA	22982764
C007262	1545	CYP1B1 CP1B CYPIB1 GLC3A P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	deoxynivalenol results in decreased expression of CYP1B1 mRNA	decreases expression	mRNA	20702593
C007262	1589	CYP21A2 CA21H CAH1 CPS1 CYP21 CYP21B P450c21B	cytochrome P450, family 21, subfamily A, polypeptide 2 (EC:1.14.99.10)	deoxynivalenol results in increased expression of CYP21A2 mRNA	increases expression	mRNA	22982764
C007262	1649	DDIT3 CEBPZ CHOP CHOP-10 CHOP10 GADD153	DNA-damage-inducible transcript 3	deoxynivalenol results in increased expression of DDIT3 mRNA	increases expression	mRNA	22846391
C007262	1843	DUSP1 CL100 HVH1 MKP-1 MKP1 PTPN10	dual specificity phosphatase 1 (EC:3.1.3.16 3.1.3.48)	deoxynivalenol results in increased expression of DUSP1 mRNA	increases expression	mRNA	20708668
C007262	1843	DUSP1 CL100 HVH1 MKP-1 MKP1 PTPN10	dual specificity phosphatase 1 (EC:3.1.3.16 3.1.3.48)	deoxynivalenol results in increased expression of DUSP1 protein	increases expression	protein	20708668
C007262	1843	DUSP1 CL100 HVH1 MKP-1 MKP1 PTPN10	dual specificity phosphatase 1 (EC:3.1.3.16 3.1.3.48)	[deoxynivalenol results in increased expression of DUSP1 protein] which results in decreased activity of MAPK8 protein	decreases activity / increases expression	protein	20708668
C007262	1843	DUSP1 CL100 HVH1 MKP-1 MKP1 PTPN10	dual specificity phosphatase 1 (EC:3.1.3.16 3.1.3.48)	[deoxynivalenol results in increased expression of DUSP1 protein] which results in decreased activity of MAPK9 protein	decreases activity / increases expression	protein	20708668
C007262	1958	EGR1 AT225 G0S30 KROX-24 NGFI-A TIS8 ZIF-268 ZNF225	early growth response 1	deoxynivalenol results in increased expression of and results in increased phosphorylation of EGR1 protein	increases expression / increases phosphorylation	protein	19360757
C007262	1958	EGR1 AT225 G0S30 KROX-24 NGFI-A TIS8 ZIF-268 ZNF225	early growth response 1	deoxynivalenol results in increased expression of EGR1 mRNA	increases expression	mRNA	18485432 19360757
C007262	1958	EGR1 AT225 G0S30 KROX-24 NGFI-A TIS8 ZIF-268 ZNF225	early growth response 1	deoxynivalenol results in increased expression of EGR1 protein	increases expression	protein	17707346
C007262	1958	EGR1 AT225 G0S30 KROX-24 NGFI-A TIS8 ZIF-268 ZNF225	early growth response 1	[deoxynivalenol results in increased expression of EGR1 protein] which results in increased expression of IL8 protein	increases expression	protein	17707346
C007262	1958	EGR1 AT225 G0S30 KROX-24 NGFI-A TIS8 ZIF-268 ZNF225	early growth response 1	EGR1 protein promotes the reaction [deoxynivalenol results in increased expression of PPARG mRNA]	increases expression / increases reaction	protein	18485432
C007262	83939	EIF2A EIF-2A MST089 MSTP004 MSTP089	eukaryotic translation initiation factor 2A, 65kDa	deoxynivalenol results in increased phosphorylation of EIF2A protein	increases phosphorylation	protein	20682335
C007262	5610	EIF2AK2 EIF2AK1 PKR PRKR	eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1 2.7.10.2)	EIF2AK2 protein promotes the reaction [deoxynivalenol results in increased expression of IL8 mRNA]	increases expression / increases reaction	protein	18599499
C007262	1994	ELAVL1 ELAV1 HUR Hua MelG	ELAV like RNA binding protein 1	[[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which affects the localization of ELAVL1 protein] which co-treated with deoxynivalenol] promotes the reaction [[ELAVL1 protein binds to ATF3 3' UTR] which results in increased stability of ATF3 mRNA]	affects binding / affects cotreatment / affects localization / increases activity / increases reaction / increases stability	protein	22003189
C007262	1994	ELAVL1 ELAV1 HUR Hua MelG	ELAV like RNA binding protein 1	[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the localization of ELAVL1 protein	affects binding / affects cotreatment / affects localization / increases activity	protein	22003189
C007262	1994	ELAVL1 ELAV1 HUR Hua MelG	ELAV like RNA binding protein 1	deoxynivalenol results in increased expression of and results in increased localization of ELAVL1 protein	increases expression / increases localization	protein	19591856
C007262	1994	ELAVL1 ELAV1 HUR Hua MelG	ELAV like RNA binding protein 1	[deoxynivalenol results in increased expression of ELAVL1 protein] which results in decreased degradation of IL8 mRNA	decreases degradation / increases expression	protein	19591856
C007262	1994	ELAVL1 ELAV1 HUR Hua MelG	ELAV like RNA binding protein 1	ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA]	affects binding / affects cotreatment / affects reaction / increases activity / increases stability	protein	22003189
C007262	1994	ELAVL1 ELAV1 HUR Hua MelG	ELAV like RNA binding protein 1	ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of IL8 mRNA]	affects binding / affects cotreatment / affects reaction / increases activity / increases stability	protein	22003189
C007262	1994	ELAVL1 ELAV1 HUR Hua MelG	ELAV like RNA binding protein 1	ELAVL1 protein affects the reaction [deoxynivalenol results in increased expression of IL8 mRNA]	affects reaction / increases expression	protein	19591856
C007262	1994	ELAVL1 ELAV1 HUR Hua MelG	ELAV like RNA binding protein 1	ELAVL1 protein affects the reaction [deoxynivalenol results in increased expression of IL8 protein]	affects reaction / increases expression	protein	19591856
C007262	2081	ERN1 IRE1 IRE1P IRE1a hIRE1p	endoplasmic reticulum to nucleus signaling 1 (EC:2.7.11.1)	deoxynivalenol results in decreased expression of ERN1 mRNA	decreases expression	mRNA	20682335
C007262	2353	FOS AP-1 C-FOS p55	FBJ murine osteosarcoma viral oncogene homolog	deoxynivalenol results in increased expression of FOS mRNA	increases expression	mRNA	19360757
C007262	3055	HCK JTK9 p59Hck p61Hck	hemopoietic cell kinase (EC:2.7.10.2)	deoxynivalenol results in increased phosphorylation of HCK protein	increases phosphorylation	protein	20181660
C007262	3156	HMGCR LDLCQ3	3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34)	deoxynivalenol results in decreased expression of HMGCR mRNA	decreases expression	mRNA	22982764
C007262	3204	HOXA7 ANTP HOX1 HOX1.1 HOX1A	homeobox A7	AG 1879 inhibits the reaction [deoxynivalenol results in increased expression of HOXA7 mRNA]	decreases reaction / increases expression	mRNA	19438726
C007262	3204	HOXA7 ANTP HOX1 HOX1.1 HOX1A	homeobox A7	deoxynivalenol results in increased expression of HOXA7 mRNA	increases expression	mRNA	19438726
C007262	3284	HSD3B2 HSD3B HSDB SDR11E2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1)	deoxynivalenol results in increased expression of HSD3B2 mRNA	increases expression	mRNA	22982764
C007262	3309	HSPA5 BIP GRP78 MIF2	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	deoxynivalenol results in decreased expression of HSPA5 mRNA	decreases expression	mRNA	20682335
C007262	3383	ICAM1 BB2 CD54 P3.58	intercellular adhesion molecule 1	deoxynivalenol inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]	decreases reaction / increases expression	protein	19549553
C007262	3458	IFNG IFG IFI	interferon, gamma	deoxynivalenol affects the expression of IFNG mRNA	affects expression	mRNA	17166736
C007262	3458	IFNG IFG IFI	interferon, gamma	deoxynivalenol inhibits the reaction [IFNG protein results in increased expression of CD14 protein]	decreases reaction / increases expression	protein	19549553
C007262	3458	IFNG IFG IFI	interferon, gamma	deoxynivalenol inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]	decreases reaction / increases expression	protein	19549553
C007262	3458	IFNG IFG IFI	interferon, gamma	deoxynivalenol inhibits the reaction [IFNG protein results in increased expression of IFNGR1 protein]	decreases reaction / increases expression	protein	19549553
C007262	3458	IFNG IFG IFI	interferon, gamma	deoxynivalenol results in increased expression of IFNG mRNA	increases expression	mRNA	20702593
C007262	3459	IFNGR1 CD119 IFNGR	interferon gamma receptor 1	deoxynivalenol inhibits the reaction [IFNG protein results in increased expression of IFNGR1 protein]	decreases reaction / increases expression	protein	19549553
C007262	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	deoxynivalenol inhibits the reaction [IL1B protein results in increased expression of IL8 protein]	decreases reaction / increases expression	protein	18308354
C007262	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]	increases expression / increases reaction	mRNA	16687389
C007262	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	deoxynivalenol results in decreased expression of IL1B mRNA	decreases expression	mRNA	20702593
C007262	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	deoxynivalenol results in increased expression of IL1B mRNA	increases expression	mRNA	16364386
C007262	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	deoxynivalenol results in increased expression of IL1B protein	increases expression	protein	16364386
C007262	3558	IL2 IL-2 TCGF lymphokine	interleukin 2	deoxynivalenol affects the expression of IL2 mRNA	affects expression	mRNA	17166736
C007262	3565	IL4 BCGF-1 BCGF1 BSF-1 BSF1 IL-4	interleukin 4	deoxynivalenol results in increased expression of IL4 mRNA	increases expression	mRNA	22846391
C007262	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	deoxynivalenol results in decreased expression of IL6 mRNA	decreases expression	mRNA	20702593
C007262	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	deoxynivalenol results in increased expression of IL6 mRNA	increases expression	mRNA	16364386
C007262	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	deoxynivalenol results in increased expression of IL6 protein	increases expression	protein	16364386
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [deoxynivalenol results in decreased degradation of IL8 mRNA]	decreases degradation / decreases reaction	mRNA	18485432
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased secretion of IL8 protein]	decreases reaction / increases secretion	protein	20633634
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	2-Aminopurine inhibits the reaction [deoxynivalenol results in increased expression of IL8 mRNA]	decreases reaction / increases expression	mRNA	18599499
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	2-Aminopurine inhibits the reaction [deoxynivalenol results in increased expression of IL8 protein]	decreases reaction / increases expression	protein	18599499
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	2-chloro-5-nitrobenzanilide promotes the reaction [deoxynivalenol results in decreased degradation of IL8 mRNA]	decreases degradation / increases reaction	mRNA	18485432
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of IL8 mRNA]	affects binding / increases activity / increases expression / increases reaction	mRNA	22003189
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of IL8 mRNA	affects binding / affects cotreatment / increases activity / increases stability	mRNA	22003189
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Adenine inhibits the reaction [deoxynivalenol results in increased expression of IL8 protein]	decreases reaction / increases expression	protein	18308354
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	AG 1879 inhibits the reaction [deoxynivalenol results in increased expression of IL8 protein]	decreases reaction / increases expression	protein	20181660
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Cycloheximide inhibits the reaction [deoxynivalenol results in increased expression of IL8 protein]	decreases reaction / increases expression	protein	18308354
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Dactinomycin inhibits the reaction [deoxynivalenol results in increased expression of IL8 protein]	decreases reaction / increases expression	protein	18308354
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	deoxynivalenol inhibits the reaction [IL1B protein results in increased expression of IL8 protein]	decreases reaction / increases expression	protein	18308354
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	deoxynivalenol inhibits the reaction [NFKB2 protein binds to IL8 promoter]	affects binding / decreases reaction	promoter	17636245
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	deoxynivalenol promotes the reaction [RELA protein binds to IL8 promoter]	affects binding / increases reaction	promoter	17636245
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	deoxynivalenol results in decreased degradation of IL8 mRNA	decreases degradation	mRNA	18485432
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	[deoxynivalenol results in increased expression of EGR1 protein] which results in increased expression of IL8 protein	increases expression	protein	17707346
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	[deoxynivalenol results in increased expression of ELAVL1 protein] which results in decreased degradation of IL8 mRNA	decreases degradation / increases expression	mRNA	19591856
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	deoxynivalenol results in increased expression of IL8 mRNA	increases expression	mRNA	16364386 17166736 17636245 18308354 18485432 18599499 19591856 20633634 22003189
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	deoxynivalenol results in increased expression of IL8 protein	increases expression	protein	16364386 17636245 17707346 18308354 18485432 18599499 19591856 20181660
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	[deoxynivalenol results in increased phosphorylation of MAPK1 protein] which results in increased expression of IL8 protein	increases expression / increases phosphorylation	protein	17707346
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	[deoxynivalenol results in increased phosphorylation of MAPK3 protein] which results in increased expression of IL8 protein	increases expression / increases phosphorylation	protein	17707346
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	deoxynivalenol results in increased secretion of IL8 protein	increases secretion	protein	20633634
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	EIF2AK2 protein promotes the reaction [deoxynivalenol results in increased expression of IL8 mRNA]	increases expression / increases reaction	mRNA	18599499
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of IL8 mRNA]	affects binding / affects cotreatment / affects reaction / increases activity / increases stability	mRNA	22003189
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	ELAVL1 protein affects the reaction [deoxynivalenol results in increased expression of IL8 mRNA]	affects reaction / increases expression	mRNA	19591856
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	ELAVL1 protein affects the reaction [deoxynivalenol results in increased expression of IL8 protein]	affects reaction / increases expression	protein	19591856
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	lipopolysaccharide, E coli O55-B5 inhibits the reaction [deoxynivalenol results in increased expression of IL8 mRNA]	decreases reaction / increases expression	mRNA	18485432
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	lipopolysaccharide, E coli O55-B5 inhibits the reaction [deoxynivalenol results in increased expression of IL8 protein]	decreases reaction / increases expression	protein	18485432
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	PPARG protein affects the reaction [deoxynivalenol results in decreased degradation of IL8 mRNA]	affects reaction / decreases degradation	mRNA	18485432
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	prolinedithiocarbamate inhibits the reaction [deoxynivalenol results in increased expression of IL8 protein]	decreases reaction / increases expression	protein	18308354
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	RELA protein promotes the reaction [deoxynivalenol results in increased expression of IL8 mRNA]	increases expression / increases reaction	mRNA	17636245 18599499
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	SB 203580 inhibits the reaction [deoxynivalenol results in increased expression of IL8 mRNA]	decreases reaction / increases expression	mRNA	16364386
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	SB 203580 inhibits the reaction [deoxynivalenol results in increased expression of IL8 protein]	decreases reaction / increases expression	protein	16364386 18308354
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	SB 203580 inhibits the reaction [deoxynivalenol results in increased secretion of IL8 protein]	decreases reaction / increases secretion	protein	20633634
C007262	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	triptolide inhibits the reaction [deoxynivalenol results in increased secretion of IL8 protein]	decreases reaction / increases secretion	protein	20633634
C007262	3725	JUN AP-1 AP1 c-Jun	jun proto-oncogene	deoxynivalenol results in increased expression of and results in increased phosphorylation of JUN protein	increases expression / increases phosphorylation	protein	19360757
C007262	3725	JUN AP-1 AP1 c-Jun	jun proto-oncogene	deoxynivalenol results in increased expression of JUN mRNA	increases expression	mRNA	19360757
C007262	3727	JUND AP-1	jun D proto-oncogene	deoxynivalenol results in increased expression of JUND mRNA	increases expression	mRNA	22846391
C007262	4297	KMT2A ALL-1 CXXC7 HRX HTRX1 MLL MLL/GAS7 MLL1A TET1-MLL TRX1 WDSTS	lysine (K)-specific methyltransferase 2A (EC:2.1.1.43)	AG 1879 inhibits the reaction [deoxynivalenol results in increased expression of KMT2A mRNA]	decreases reaction / increases expression	mRNA	19438726
C007262	4297	KMT2A ALL-1 CXXC7 HRX HTRX1 MLL MLL/GAS7 MLL1A TET1-MLL TRX1 WDSTS	lysine (K)-specific methyltransferase 2A (EC:2.1.1.43)	deoxynivalenol promotes the reaction [SP1 protein binds to KMT2A promoter]	affects binding / increases reaction	promoter	19438726
C007262	4297	KMT2A ALL-1 CXXC7 HRX HTRX1 MLL MLL/GAS7 MLL1A TET1-MLL TRX1 WDSTS	lysine (K)-specific methyltransferase 2A (EC:2.1.1.43)	deoxynivalenol results in increased expression of KMT2A mRNA	increases expression	mRNA	19438726
C007262	4297	KMT2A ALL-1 CXXC7 HRX HTRX1 MLL MLL/GAS7 MLL1A TET1-MLL TRX1 WDSTS	lysine (K)-specific methyltransferase 2A (EC:2.1.1.43)	SP1 protein promotes the reaction [deoxynivalenol results in increased expression of KMT2A mRNA]	increases expression / increases reaction	mRNA	19438726
C007262	5608	MAP2K6 MAPKK6 MEK6 MKK6 PRKMK6 SAPKK-3 SAPKK3	mitogen-activated protein kinase kinase 6 (EC:2.7.12.2)	AG 1879 inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAP2K6 protein]	decreases reaction / increases phosphorylation	protein	20181660
C007262	5608	MAP2K6 MAPKK6 MEK6 MKK6 PRKMK6 SAPKK-3 SAPKK3	mitogen-activated protein kinase kinase 6 (EC:2.7.12.2)	deoxynivalenol results in increased phosphorylation of MAP2K6 protein	increases phosphorylation	protein	20181660
C007262	4217	MAP3K5 ASK1 MAPKKK5 MEKK5	mitogen-activated protein kinase kinase kinase 5 (EC:2.7.11.25)	AG 1879 inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAP3K5 protein]	decreases reaction / increases phosphorylation	protein	20181660
C007262	4217	MAP3K5 ASK1 MAPKKK5 MEKK5	mitogen-activated protein kinase kinase kinase 5 (EC:2.7.11.25)	deoxynivalenol results in increased phosphorylation of MAP3K5 protein	increases phosphorylation	protein	20181660
C007262	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	deoxynivalenol results in increased phosphorylation of and results in increased activity of MAPK1 protein	increases activity / increases phosphorylation	protein	18006205 18485432 19360757
C007262	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	deoxynivalenol results in increased phosphorylation of MAPK1 protein	increases phosphorylation	protein	17707346 20633634
C007262	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	[deoxynivalenol results in increased phosphorylation of MAPK1 protein] which results in increased expression of IL8 protein	increases expression / increases phosphorylation	protein	17707346
C007262	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	MAPK1 protein promotes the reaction [deoxynivalenol results in increased expression of PPARG mRNA]	increases expression / increases reaction	protein	18485432
C007262	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	deoxynivalenol results in increased expression of MAPK14 mRNA	increases expression	mRNA	20702593
C007262	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	deoxynivalenol results in increased phosphorylation of and results in increased activity of MAPK14 protein	increases activity / increases phosphorylation	protein	16364386
C007262	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	deoxynivalenol results in increased phosphorylation of and results in increased activity of MAPK3 protein	increases activity / increases phosphorylation	protein	18006205 18485432 19360757
C007262	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	deoxynivalenol results in increased phosphorylation of MAPK3 protein	increases phosphorylation	protein	17707346 20633634
C007262	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	[deoxynivalenol results in increased phosphorylation of MAPK3 protein] which results in increased expression of IL8 protein	increases expression / increases phosphorylation	protein	17707346
C007262	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	MAPK3 protein promotes the reaction [deoxynivalenol results in increased expression of PPARG mRNA]	increases expression / increases reaction	protein	18485432
C007262	5599	MAPK8 JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	deoxynivalenol results in decreased activity of MAPK8 protein	decreases activity	protein	20708668
C007262	5599	MAPK8 JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	[deoxynivalenol results in increased expression of DUSP1 protein] which results in decreased activity of MAPK8 protein	decreases activity / increases expression	protein	20708668
C007262	5599	MAPK8 JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	deoxynivalenol results in increased phosphorylation of and results in increased activity of MAPK8 protein	increases activity / increases phosphorylation	protein	18485432 19360757
C007262	5601	MAPK9 JNK-55 JNK2 JNK2A JNK2ALPHA JNK2B JNK2BETA PRKM9 SAPK SAPK1a p54a p54aSAPK	mitogen-activated protein kinase 9 (EC:2.7.11.24)	deoxynivalenol results in decreased activity of MAPK9 protein	decreases activity	protein	20708668
C007262	5601	MAPK9 JNK-55 JNK2 JNK2A JNK2ALPHA JNK2B JNK2BETA PRKM9 SAPK SAPK1a p54a p54aSAPK	mitogen-activated protein kinase 9 (EC:2.7.11.24)	[deoxynivalenol results in increased expression of DUSP1 protein] which results in decreased activity of MAPK9 protein	decreases activity / increases expression	protein	20708668
C007262	5601	MAPK9 JNK-55 JNK2 JNK2A JNK2ALPHA JNK2B JNK2BETA PRKM9 SAPK SAPK1a p54a p54aSAPK	mitogen-activated protein kinase 9 (EC:2.7.11.24)	deoxynivalenol results in increased phosphorylation of and results in increased activity of MAPK9 protein	increases activity / increases phosphorylation	protein	18485432 19360757
C007262	5601	MAPK9 JNK-55 JNK2 JNK2A JNK2ALPHA JNK2B JNK2BETA PRKM9 SAPK SAPK1a p54a p54aSAPK	mitogen-activated protein kinase 9 (EC:2.7.11.24)	deoxynivalenol results in increased phosphorylation of MAPK9 protein	increases phosphorylation	protein	20633634
C007262	4194	MDM4 HDMX MDMX MRP1	Mdm4 p53 binding protein homolog (mouse)	deoxynivalenol results in increased expression of MDM4 mRNA	increases expression	mRNA	22846391
C007262	4772	NFATC1 NF-ATC NFAT2 NFATc	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	deoxynivalenol affects the localization of NFATC1 protein	affects localization	protein	22846391
C007262	4791	NFKB2 H2TF1 LYT-10 LYT10 NF-kB2 p105 p52	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	deoxynivalenol inhibits the reaction [NFKB2 protein binds to IL8 promoter]	affects binding / decreases reaction	protein	17636245
C007262	4791	NFKB2 H2TF1 LYT-10 LYT10 NF-kB2 p105 p52	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	deoxynivalenol results in increased expression of NFKB2 mRNA	increases expression	mRNA	22846391
C007262	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	deoxynivalenol results in increased degradation of NFKBIA protein	increases degradation	protein	18485432
C007262	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	lipopolysaccharide, E coli O55-B5 inhibits the reaction [deoxynivalenol results in increased degradation of NFKBIA protein]	decreases reaction / increases degradation	protein	18485432
C007262	4793	NFKBIB IKBB TRIP9	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	deoxynivalenol results in increased expression of NFKBIB mRNA	increases expression	mRNA	22846391
C007262	64127	NOD2 ACUG BLAU CARD15 CD CLR16.3 IBD1 NLRC2 NOD2B PSORAS1	nucleotide-binding oligomerization domain containing 2	[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of ATF3 mRNA]	affects binding / increases activity / increases expression / increases reaction	protein	22003189
C007262	64127	NOD2 ACUG BLAU CARD15 CD CLR16.3 IBD1 NLRC2 NOD2B PSORAS1	nucleotide-binding oligomerization domain containing 2	[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of CXCL1 mRNA]	affects binding / increases activity / increases expression / increases reaction	protein	22003189
C007262	64127	NOD2 ACUG BLAU CARD15 CD CLR16.3 IBD1 NLRC2 NOD2B PSORAS1	nucleotide-binding oligomerization domain containing 2	[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of IL8 mRNA]	affects binding / increases activity / increases expression / increases reaction	protein	22003189
C007262	64127	NOD2 ACUG BLAU CARD15 CD CLR16.3 IBD1 NLRC2 NOD2B PSORAS1	nucleotide-binding oligomerization domain containing 2	[[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which affects the localization of ELAVL1 protein] which co-treated with deoxynivalenol] promotes the reaction [[ELAVL1 protein binds to ATF3 3' UTR] which results in increased stability of ATF3 mRNA]	affects binding / affects cotreatment / affects localization / increases activity / increases reaction / increases stability	protein	22003189
C007262	64127	NOD2 ACUG BLAU CARD15 CD CLR16.3 IBD1 NLRC2 NOD2B PSORAS1	nucleotide-binding oligomerization domain containing 2	[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the localization of ELAVL1 protein	affects binding / affects cotreatment / affects localization / increases activity	protein	22003189
C007262	64127	NOD2 ACUG BLAU CARD15 CD CLR16.3 IBD1 NLRC2 NOD2B PSORAS1	nucleotide-binding oligomerization domain containing 2	[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the phosphorylation of RELA protein	affects binding / affects cotreatment / affects phosphorylation / increases activity	protein	22003189
C007262	64127	NOD2 ACUG BLAU CARD15 CD CLR16.3 IBD1 NLRC2 NOD2B PSORAS1	nucleotide-binding oligomerization domain containing 2	[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of ATF3 mRNA	affects binding / affects cotreatment / increases activity / increases stability	protein	22003189
C007262	64127	NOD2 ACUG BLAU CARD15 CD CLR16.3 IBD1 NLRC2 NOD2B PSORAS1	nucleotide-binding oligomerization domain containing 2	[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA	affects binding / affects cotreatment / increases activity / increases stability	protein	22003189
C007262	64127	NOD2 ACUG BLAU CARD15 CD CLR16.3 IBD1 NLRC2 NOD2B PSORAS1	nucleotide-binding oligomerization domain containing 2	[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of IL8 mRNA	affects binding / affects cotreatment / increases activity / increases stability	protein	22003189
C007262	64127	NOD2 ACUG BLAU CARD15 CD CLR16.3 IBD1 NLRC2 NOD2B PSORAS1	nucleotide-binding oligomerization domain containing 2	ATF3 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the phosphorylation of RELA protein]	affects binding / affects cotreatment / affects phosphorylation / affects reaction / increases activity	protein	22003189
C007262	64127	NOD2 ACUG BLAU CARD15 CD CLR16.3 IBD1 NLRC2 NOD2B PSORAS1	nucleotide-binding oligomerization domain containing 2	ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA]	affects binding / affects cotreatment / affects reaction / increases activity / increases stability	protein	22003189
C007262	64127	NOD2 ACUG BLAU CARD15 CD CLR16.3 IBD1 NLRC2 NOD2B PSORAS1	nucleotide-binding oligomerization domain containing 2	ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of IL8 mRNA]	affects binding / affects cotreatment / affects reaction / increases activity / increases stability	protein	22003189
C007262	9572	NR1D1 EAR1 THRA1 THRAL ear-1 hRev	nuclear receptor subfamily 1, group D, member 1	deoxynivalenol results in increased expression of NR1D1 mRNA	increases expression	mRNA	22846391
C007262	2516	NR5A1 AD4BP ELP FTZ1 FTZF1 POF7 SF-1 SF1 SPGF8 SRXY3	nuclear receptor subfamily 5, group A, member 1	deoxynivalenol results in decreased expression of NR5A1 mRNA	decreases expression	mRNA	22982764
C007262	100506658	OCLN BLCPMG	occludin (EC:2.1.1.67)	deoxynivalenol results in increased expression of OCLN mRNA	increases expression	mRNA	20362602
C007262	5366	PMAIP1 APR NOXA	phorbol-12-myristate-13-acetate-induced protein 1	deoxynivalenol results in increased expression of PMAIP1 mRNA	increases expression	mRNA	22846391
C007262	5468	PPARG CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma	peroxisome proliferator-activated receptor gamma	15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [deoxynivalenol results in increased expression of PPARG protein]	decreases reaction / increases expression	protein	18485432
C007262	5468	PPARG CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma	peroxisome proliferator-activated receptor gamma	deoxynivalenol results in increased expression of PPARG mRNA	increases expression	mRNA	18485432
C007262	5468	PPARG CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma	peroxisome proliferator-activated receptor gamma	EGR1 protein promotes the reaction [deoxynivalenol results in increased expression of PPARG mRNA]	increases expression / increases reaction	mRNA	18485432
C007262	5468	PPARG CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma	peroxisome proliferator-activated receptor gamma	lipopolysaccharide, E coli O55-B5 affects the reaction [deoxynivalenol results in increased expression of PPARG mRNA]	affects reaction / increases expression	mRNA	18485432
C007262	5468	PPARG CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma	peroxisome proliferator-activated receptor gamma	MAPK1 protein promotes the reaction [deoxynivalenol results in increased expression of PPARG mRNA]	increases expression / increases reaction	mRNA	18485432
C007262	5468	PPARG CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma	peroxisome proliferator-activated receptor gamma	MAPK3 protein promotes the reaction [deoxynivalenol results in increased expression of PPARG mRNA]	increases expression / increases reaction	mRNA	18485432
C007262	5468	PPARG CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma	peroxisome proliferator-activated receptor gamma	PPARG protein affects the reaction [deoxynivalenol results in decreased degradation of IL8 mRNA]	affects reaction / decreases degradation	protein	18485432
C007262	5468	PPARG CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma	peroxisome proliferator-activated receptor gamma	U 0126 inhibits the reaction [deoxynivalenol results in increased expression of PPARG mRNA]	decreases reaction / increases expression	mRNA	18485432
C007262	5728	PTEN 10q23del BZS CWS1 DEC GLM2 MHAM MMAC1 PTEN1 TEP1	phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48)	deoxynivalenol results in increased expression of PTEN mRNA	increases expression	mRNA	22846391
C007262	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	deoxynivalenol results in increased expression of PTGS2 mRNA	increases expression	mRNA	20633634
C007262	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	deoxynivalenol results in increased expression of PTGS2 protein	increases expression	protein	20347963
C007262	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	Lutein inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]	decreases reaction / increases expression	protein	20347963
C007262	5929	RBBP5 RBQ3 SWD1	retinoblastoma binding protein 5	deoxynivalenol results in increased expression of RBBP5 mRNA	increases expression	mRNA	19438726
C007262	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the phosphorylation of RELA protein	affects binding / affects cotreatment / affects phosphorylation / increases activity	protein	22003189
C007262	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	ATF3 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the phosphorylation of RELA protein]	affects binding / affects cotreatment / affects phosphorylation / affects reaction / increases activity	protein	22003189
C007262	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	deoxynivalenol affects the localization of RELA protein	affects localization	protein	20347963
C007262	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	deoxynivalenol promotes the reaction [RELA protein binds to IL8 promoter]	affects binding / increases reaction	protein	17636245
C007262	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	deoxynivalenol results in increased activity of RELA protein	increases activity	protein	18599499
C007262	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	deoxynivalenol results in increased expression of RELA mRNA	increases expression	mRNA	22846391
C007262	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	deoxynivalenol results in increased expression of RELA protein	increases expression	protein	20347963
C007262	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Lutein inhibits the reaction [deoxynivalenol affects the localization of RELA protein]	affects localization / decreases reaction	protein	20347963
C007262	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Lutein inhibits the reaction [deoxynivalenol results in increased expression of RELA protein]	decreases reaction / increases expression	protein	20347963
C007262	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	RELA protein promotes the reaction [deoxynivalenol results in increased expression of IL8 mRNA]	increases expression / increases reaction	protein	17636245 18599499
C007262	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	SB 203580 inhibits the reaction [deoxynivalenol results in increased activity of RELA protein]	decreases reaction / increases activity	protein	18599499
C007262	5971	RELB I-REL IREL REL-B	v-rel avian reticuloendotheliosis viral oncogene homolog B	deoxynivalenol results in increased expression of RELB mRNA	increases expression	mRNA	22846391
C007262	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	deoxynivalenol results in decreased expression of SOD2 mRNA	decreases expression	mRNA	20702593
C007262	6659	SOX4 EVI16	SRY (sex determining region Y)-box 4	deoxynivalenol results in increased expression of SOX4 mRNA	increases expression	mRNA	22846391
C007262	6667	SP1	Sp1 transcription factor	deoxynivalenol promotes the reaction [SP1 protein binds to KMT2A promoter]	affects binding / increases reaction	protein	19438726
C007262	6667	SP1	Sp1 transcription factor	deoxynivalenol results in increased phosphorylation of SP1 protein	increases phosphorylation	protein	19438726
C007262	6667	SP1	Sp1 transcription factor	SP1 protein promotes the reaction [deoxynivalenol results in increased expression of KMT2A mRNA]	increases expression / increases reaction	protein	19438726
C007262	6890	TAP1 ABC17 ABCB2 APT1 D6S114E PSF-1 PSF1 RING4 TAP1*0102N TAP1N	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	deoxynivalenol results in decreased expression of TAP1 mRNA	decreases expression	mRNA	15766417
C007262	6890	TAP1 ABC17 ABCB2 APT1 D6S114E PSF-1 PSF1 RING4 TAP1*0102N TAP1N	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	deoxynivalenol results in decreased expression of TAP1 protein	decreases expression	protein	15766417
C007262	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	deoxynivalenol results in increased activity of TP53 protein	increases activity	protein	19664677
C007262	7185	TRAF1 EBI6 MGC:10353	TNF receptor-associated factor 1	deoxynivalenol results in increased expression of TRAF1 mRNA	increases expression	mRNA	22846391
C007262	7189	TRAF6 MGC:3310 RNF85	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	deoxynivalenol results in increased expression of TRAF6 mRNA	increases expression	mRNA	22846391
C007262	54482	TRMT13 CCDC76	tRNA methyltransferase 13 homolog (S. cerevisiae) (EC:2.1.1.225)	deoxynivalenol results in increased expression of TRMT13 mRNA	increases expression	mRNA	22846391
C007262	9958	USP15 UNPH-2 UNPH4	ubiquitin specific peptidase 15 (EC:3.4.19.12)	deoxynivalenol results in increased expression of USP15 mRNA	increases expression	mRNA	22846391
C007262	11091	WDR5 BIG-3 SWD3	WD repeat domain 5	deoxynivalenol results in increased expression of WDR5 mRNA	increases expression	mRNA	19438726

Related Disease

Diseases related to CTD interactions

9 disease from interactions of metabolites

MeSH disease	compound	disease name	evidence type	reference pmid
D000855	C007262	Anorexia	marker/mechanism	21873375 22903826
D005759	C007262	Gastroenteritis	marker/mechanism	22859312
D005767	C007262	Gastrointestinal Diseases	marker/mechanism	20633634
D005922	C007262	Glomerulonephritis, IGA	marker/mechanism	15173396 16524712
D007035	C007262	Hypothermia	marker/mechanism	21873375
D007249	C007262	Inflammation	marker/mechanism	22454431
D015651	C007262	Mycotoxicosis	marker/mechanism	21873375
D011041	C007262	Poisoning	marker/mechanism	22454431
D014839	C007262	Vomiting	marker/mechanism	22997060

KNApSAcK Metabolite C00003201

Index Metabolite Species Human Protein / Gene in interactions Related Diseases

Metabolite

KNApSAcK Entry

Cluster

Link

ChEMBL

KEGG

CTD

Species

Summary

Plant class

Family

List (2)

* NCBI

Human Protein / Gene in interaction

CTD interaction (242)

Related Disease

Diseases related to CTD interactions

9 disease from interactions of metabolites

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases