Fusarium roseum
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00012643
|
4-Deacetylanguidin
/ 15-Acetoxyscirpenol / 15-Acetylscirpenetriol / 15-O-Acetylscirpenetriol / 15-Mono-O-acetylscirpenol / 15-Acetoxyscirpen-3,4-diol |
CHEMBL1080609
|
C016945
|
No. 1091 |
|
|||
|
C00012642
|
Anguidol
/ Scirpenol / Scirpentriol / Scirpenetriol / 12,13-Epoxy-trichothec-9-ene-3alpha,4beta,15-triol |
CHEMBL154310
CHEMBL1985609 |
C038854
|
No. 1091 |
|
|||
|
C00012645
|
Isotrichodermin
|
C063750
|
No. 1091 |
|
||||
|
C00003201
|
Vomitoxin
|
CHEMBL513300
|
C007262
|
98 / 9 | No. 4211 |
|
||
|
C00012654
|
Trichothecolon
/ 12,13-Epoxy-4b-hydroxytrichothec-9-en-8-one |
CHEMBL481642
|
C048128
|
No. 4211 |
|
Human Protein / Gene in interactions
98 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 248 | ALPI, IAP | alkaline phosphatase, intestinal (EC:3.1.3.1) |
C00003201
|
| 430 | ASCL2, ASH2, HASH2, MASH2, bHLHa45 | achaete-scute family bHLH transcription factor 2 |
C00003201
|
| 466 | ATF1, EWS-ATF1, FUS/ATF-1, TREB36 | activating transcription factor 1 |
C00003201
|
| 1386 | ATF2, CRE-BP1, CREB2, HB16, TREB7 | activating transcription factor 2 (EC:2.3.1.48) |
C00003201
|
| 467 | ATF3 | activating transcription factor 3 |
C00003201
|
| 22926 | ATF6, ATF6A | activating transcription factor 6 |
C00003201
|
| 9531 | BAG3, BAG-3, BIS, CAIR-1, MFM6 | BCL2-associated athanogene 3 |
C00003201
|
| 578 | BAK1, BAK, BAK-LIKE, BCL2L7, CDN1 | BCL2-antagonist/killer 1 |
C00003201
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00003201
|
| 27113 | BBC3, JFY-1, JFY1, PUMA | BCL2 binding component 3 |
C00003201
|
| 8915 | BCL10, CARMEN, CIPER, CLAP, c-E10, mE10 | B-cell CLL/lymphoma 10 |
C00003201
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00003201
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00003201
|
| 23786 | BCL2L13, BCL-RAMBO, Bcl2-L-13, MIL1 | BCL2-like 13 (apoptosis facilitator) |
C00003201
|
| 9774 | BCLAF1, BTF, bK211L9.1 | BCL2-associated transcription factor 1 |
C00003201
|
| 637 | BID, FP497 | BH3 interacting domain death agonist |
C00003201
|
| 662 | BNIP1, NIP1, SEC20, TRG-8 | BCL2/adenovirus E1B 19kDa interacting protein 1 |
C00003201
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00003201
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00003201
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00003201
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00003201
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00003201
|
| 6348 | CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 | chemokine (C-C motif) ligand 3 |
C00003201
|
| 6351 | CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 | chemokine (C-C motif) ligand 4 |
C00003201
|
| 929 | CD14 | CD14 molecule |
C00003201
|
| 1604 | CD55, CR, CROM, DAF, TC | CD55 molecule, decay accelerating factor for complement (Cromer blood group) |
C00003201
|
| 969 | CD69, AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3 | CD69 molecule |
C00003201
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00003201
|
| 1147 | CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 | conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) |
C00003201
|
| 1364 | CLDN4, CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R | claudin 4 |
C00003201
|
| 6376 | CX3CL1, ABCD-3, C3Xkine, CXC3, CXC3C, NTN, NTT, SCYD1, fractalkine, neurotactin | chemokine (C-X3-C motif) ligand 1 |
C00003201
|
| 2919 | CXCL1, FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
C00003201
|
| 7852 | CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM | chemokine (C-X-C motif) receptor 4 |
C00003201
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00003201
|
| 1584 | CYP11B1, CPN1, CYP11B, FHI, P450C11 | cytochrome P450, family 11, subfamily B, polypeptide 1 (EC:1.14.15.4) |
C00003201
|
| 1585 | CYP11B2, ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P-450C18, P450C18, P450aldo | cytochrome P450, family 11, subfamily B, polypeptide 2 (EC:1.14.15.4 1.14.15.5) |
C00003201
|
| 1586 | CYP17A1, CPT7, CYP17, P450C17, S17AH | cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) |
C00003201
|
| 1588 | CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM | cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00003201
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00003201
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00003201
|
| 1589 | CYP21A2, CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B | cytochrome P450, family 21, subfamily A, polypeptide 2 (EC:1.14.99.10) |
C00003201
|
| 1649 | DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 | DNA-damage-inducible transcript 3 |
C00003201
|
| 1843 | DUSP1, CL100, HVH1, MKP-1, MKP1, PTPN10 | dual specificity phosphatase 1 (EC:3.1.3.16 3.1.3.48) |
C00003201
|
| 1958 | EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 | early growth response 1 |
C00003201
|
| 83939 | EIF2A, EIF-2A, MST089, MSTP004, MSTP089 | eukaryotic translation initiation factor 2A, 65kDa |
C00003201
|
| 5610 | EIF2AK2, EIF2AK1, PKR, PRKR | eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1 2.7.10.2) |
C00003201
|
| 1994 | ELAVL1, ELAV1, HUR, Hua, MelG | ELAV like RNA binding protein 1 |
C00003201
|
| 2081 | ERN1, IRE1, IRE1P, IRE1a, hIRE1p | endoplasmic reticulum to nucleus signaling 1 (EC:2.7.11.1) |
C00003201
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00003201
|
| 3055 | HCK, JTK9, p59Hck, p61Hck | hemopoietic cell kinase (EC:2.7.10.2) |
C00003201
|
| 3156 | HMGCR, LDLCQ3 | 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) |
C00003201
|
| 3204 | HOXA7, ANTP, HOX1, HOX1.1, HOX1A | homeobox A7 |
C00003201
|
| 3284 | HSD3B2, HSD3B, HSDB, SDR11E2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1) |
C00003201
|
| 3309 | HSPA5, BIP, GRP78, MIF2 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
C00003201
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00003201
|
| 3458 | IFNG, IFG, IFI | interferon, gamma |
C00003201
|
| 3459 | IFNGR1, CD119, IFNGR | interferon gamma receptor 1 |
C00003201
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00003201
|
| 3558 | IL2, IL-2, TCGF, lymphokine | interleukin 2 |
C00003201
|
| 3565 | IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 | interleukin 4 |
C00003201
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00003201
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00003201
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00003201
|
| 3727 | JUND, AP-1 | jun D proto-oncogene |
C00003201
|
| 4297 | KMT2A, ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1A, TET1-MLL, TRX1, WDSTS | lysine (K)-specific methyltransferase 2A (EC:2.1.1.43) |
C00003201
|
| 5608 | MAP2K6, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3 | mitogen-activated protein kinase kinase 6 (EC:2.7.12.2) |
C00003201
|
| 4217 | MAP3K5, ASK1, MAPKKK5, MEKK5 | mitogen-activated protein kinase kinase kinase 5 (EC:2.7.11.25) |
C00003201
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00003201
|
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) |
C00003201
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00003201
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00003201
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00003201
|
| 4194 | MDM4, HDMX, MDMX, MRP1 | Mdm4 p53 binding protein homolog (mouse) |
C00003201
|
| 4772 | NFATC1, NF-ATC, NFAT2, NFATc | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 |
C00003201
|
| 4791 | NFKB2, H2TF1, LYT-10, LYT10, NF-kB2, p105, p52 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
C00003201
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00003201
|
| 4793 | NFKBIB, IKBB, TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
C00003201
|
| 64127 | NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1 | nucleotide-binding oligomerization domain containing 2 |
C00003201
|
| 9572 | NR1D1, EAR1, THRA1, THRAL, ear-1, hRev | nuclear receptor subfamily 1, group D, member 1 |
C00003201
|
| 2516 | NR5A1, AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3 | nuclear receptor subfamily 5, group A, member 1 |
C00003201
|
| 100506658 | OCLN, BLCPMG | occludin (EC:2.1.1.67) |
C00003201
|
| 5366 | PMAIP1, APR, NOXA | phorbol-12-myristate-13-acetate-induced protein 1 |
C00003201
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00003201
|
| 5728 | PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 | phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) |
C00003201
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00003201
|
| 5929 | RBBP5, RBQ3, SWD1 | retinoblastoma binding protein 5 |
C00003201
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00003201
|
| 5971 | RELB, I-REL, IREL, REL-B | v-rel avian reticuloendotheliosis viral oncogene homolog B |
C00003201
|
| 6648 | SOD2, IPOB, MNSOD, MVCD6 | superoxide dismutase 2, mitochondrial (EC:1.15.1.1) |
C00003201
|
| 6659 | SOX4, EVI16 | SRY (sex determining region Y)-box 4 |
C00003201
|
| 6667 | SP1 | Sp1 transcription factor |
C00003201
|
| 6890 | TAP1, ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
C00003201
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00003201
|
| 7185 | TRAF1, EBI6, MGC:10353 | TNF receptor-associated factor 1 |
C00003201
|
| 7189 | TRAF6, MGC:3310, RNF85 | TNF receptor-associated factor 6, E3 ubiquitin protein ligase |
C00003201
|
| 54482 | TRMT13, CCDC76 | tRNA methyltransferase 13 homolog (S. cerevisiae) (EC:2.1.1.225) |
C00003201
|
| 9958 | USP15, UNPH-2, UNPH4 | ubiquitin specific peptidase 15 (EC:3.4.19.12) |
C00003201
|
| 11091 | WDR5, BIG-3, SWD3 | WD repeat domain 5 |
C00003201
|
Related Diseases
Diseases related to CTD interactions
9 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000855 | Anorexia |
C00003201
|
| D005759 | Gastroenteritis |
C00003201
|
| D005767 | Gastrointestinal Diseases |
C00003201
|
| D005922 | Glomerulonephritis, IGA |
C00003201
|
| D007035 | Hypothermia |
C00003201
|
| D007249 | Inflammation |
C00003201
|
| D015651 | Mycotoxicosis |
C00003201
|
| D011041 | Poisoning |
C00003201
|
| D014839 | Vomiting |
C00003201
|