KNApSAcK Metabolite C00033297
Metabolite
KNApSAcK Entry
| id | C00033297 |
|---|---|
| Name | Monodemethoxycurcumin / p-Hydroxycinnamoyl feruloyl methane |
| CAS RN | 24939-17-1 |
| Standard InChI | InChI=1S/C20H18O5/c1-25-20-12-15(6-11-19(20)24)5-10-18(23)13-17(22)9-4-14-2-7-16(21)8-3-14/h2-12,21,24H,13H2,1H3/b9-4+,10-5+ |
| Standard InChI (Main Layer) | InChI=1S/C20H18O5/c1-25-20-12-15(6-11-19(20)24)5-10-18(23)13-17(22)9-4-14-2-7-16(21)8-3-14/h2-12,21,24H,13H2,1H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 2164 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | C050229 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| Liliopsida | 1 |
Family
| family name | count |
|---|---|
| Zingiberaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Curcuma chuanyujin | 136212 | Zingiberaceae | Liliopsida | Viridiplantae |
Human Protein / Gene in interaction
CTD interaction (22)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C050229 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | demethoxycurcumin results in decreased activity of ABCC1 protein |
decreases activity
|
protein |
15885658
16021489 |
| C050229 | 1244 |
ABCC2
ABC30 CMOAT DJS MRP2 cMRP |
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | demethoxycurcumin results in decreased activity of ABCC2 protein |
decreases activity
|
protein |
15885658
|
| C050229 | 351 |
APP
AAA ABETA ABPP AD1 APPI CTFgamma CVAP PN-II PN2 |
amyloid beta (A4) precursor protein | demethoxycurcumin inhibits the reaction [APP protein binds to APP protein] |
affects binding
/ decreases reaction |
protein |
19715544
|
| C050229 | 351 |
APP
AAA ABETA ABPP AD1 APPI CTFgamma CVAP PN-II PN2 |
amyloid beta (A4) precursor protein | demethoxycurcumin results in decreased secretion of APP protein |
decreases secretion
|
protein |
19715544
|
| C050229 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | demethoxycurcumin inhibits the reaction [Peroxynitrous Acid results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
19188863
|
| C050229 | 2730 |
GCLM
GLCLR |
glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) | demethoxycurcumin results in increased expression of GCLM mRNA |
increases expression
|
mRNA |
19188863
|
| C050229 | 2730 |
GCLM
GLCLR |
glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) | demethoxycurcumin results in increased expression of GCLM protein |
increases expression
|
protein |
19188863
|
| C050229 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | demethoxycurcumin results in increased expression of HMOX1 mRNA |
increases expression
|
mRNA |
19188863
|
| C050229 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | demethoxycurcumin results in increased expression of HMOX1 protein |
increases expression
|
protein |
19188863
|
| C050229 | 3630 |
INS
IDDM2 ILPR IRDN MODY10 |
insulin | demethoxycurcumin results in increased secretion of INS protein |
increases secretion
|
protein |
19188863
|
| C050229 | 3791 |
KDR
CD309 FLK1 VEGFR VEGFR2 |
kinase insert domain receptor (a type III receptor tyrosine kinase) (EC:2.7.10.1) | demethoxycurcumin affects the expression of KDR mRNA |
affects expression
|
mRNA |
17960570
|
| C050229 | 4323 |
MMP14
MMP-14 MMP-X1 MT-MMP MT-MMP_1 MT1-MMP MT1MMP MTMMP1 WNCHRS |
matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80) | demethoxycurcumin results in decreased expression of MMP14 protein |
decreases expression
|
protein |
18495463
|
| C050229 | 4313 |
MMP2
CLG4 CLG4A MMP-II MONA TBE-1 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) | demethoxycurcumin results in decreased secretion of and results in decreased activity of MMP2 protein modified form |
decreases activity
/ decreases secretion |
protein |
18495463
|
| C050229 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | demethoxycurcumin results in decreased secretion of and results in decreased activity of MMP9 protein |
decreases activity
/ decreases secretion |
protein |
18495463
|
| C050229 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | demethoxycurcumin results in increased expression of NQO1 mRNA |
increases expression
|
mRNA |
19188863
|
| C050229 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | demethoxycurcumin results in increased expression of NQO1 protein |
increases expression
|
protein |
19188863
|
| C050229 | 5328 |
PLAU
ATF BDPLT5 QPD UPA URK u-PA |
plasminogen activator, urokinase (EC:3.4.21.73) | demethoxycurcumin results in decreased secretion of PLAU protein |
decreases secretion
|
protein |
18495463
|
| C050229 | 5468 |
PPARG
CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma |
peroxisome proliferator-activated receptor gamma | demethoxycurcumin binds to PPARG protein |
affects binding
|
protein |
15713005
|
| C050229 | 7077 |
TIMP2
CSC-21K DDC8 |
TIMP metallopeptidase inhibitor 2 | demethoxycurcumin results in decreased expression of TIMP2 protein |
decreases expression
|
protein |
18495463
|
| C050229 | 7422 |
VEGFA
MVCD1 VEGF VPF |
vascular endothelial growth factor A | demethoxycurcumin affects the expression of VEGFA mRNA |
affects expression
|
mRNA |
17960570
|
| C050229 | 7490 |
WT1
AWT1 EWS-WT1 GUD NPHS4 WAGR WIT-2 WT33 |
Wilms tumor 1 | demethoxycurcumin results in decreased expression of WT1 mRNA |
decreases expression
|
mRNA |
18034345
|
| C050229 | 7490 |
WT1
AWT1 EWS-WT1 GUD NPHS4 WAGR WIT-2 WT33 |
Wilms tumor 1 | demethoxycurcumin results in decreased expression of WT1 protein |
decreases expression
|
protein |
18034345
|