KNApSAcK Metabolite C00033541
Metabolite
KNApSAcK Entry
| id | C00033541 |
|---|---|
| Name | 2,4-Dibromophenol |
| CAS RN | 615-58-7 |
| Standard InChI | InChI=1S/C6H4Br2O/c7-4-1-2-6(9)5(8)3-4/h1-3,9H |
| Standard InChI (Main Layer) | InChI=1S/C6H4Br2O/c7-4-1-2-6(9)5(8)3-4/h1-3,9H |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 2101 |
Link
ChEMBL
| By standard InChI | CHEMBL186858 |
|---|---|
| By standard InChI Main Layer | CHEMBL186858 |
KEGG
| By LinkDB | C14521 |
|---|
CTD
| By CAS RN | C013930 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Halymeniaceae | 1 |
| Rhodomelaceae | 1 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Grateloupia elliptica | 118371 | Halymeniaceae | Eukaryota | |
| Polysiphonia sphaerocarpa | 2804 | Rhodomelaceae | Eukaryota |
Human Protein / Gene in interaction
2 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | CHEMBL186858 |
CHEMBL833559
(1)
|
2 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | CHEMBL186858 |
CHEMBL831078
(1)
|
0 / 0 |
CTD interaction (10)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C013930 | 1583 |
CYP11A1
CYP11A CYPXIA1 P450SCC |
cytochrome P450, family 11, subfamily A, polypeptide 1 (EC:1.14.15.6) | 2,4-dibromophenol results in increased expression of CYP11A1 mRNA |
increases expression
|
mRNA |
17447562
|
| C013930 | 1585 |
CYP11B2
ALDOS CPN2 CYP11B CYP11BL CYPXIB2 P-450C18 P450C18 P450aldo |
cytochrome P450, family 11, subfamily B, polypeptide 2 (EC:1.14.15.4 1.14.15.5) | 2,4-dibromophenol results in increased expression of CYP11B2 mRNA |
increases expression
|
mRNA |
17447562
|
| C013930 | 1586 |
CYP17A1
CPT7 CYP17 P450C17 S17AH |
cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) | 2,4-dibromophenol results in increased expression of CYP17A1 mRNA |
increases expression
|
mRNA |
17447562
|
| C013930 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | 2,4-dibromophenol results in increased expression of CYP19A1 mRNA |
increases expression
|
mRNA |
17447562
|
| C013930 | 3156 |
HMGCR
LDLCQ3 |
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) | 2,4-dibromophenol results in increased expression of HMGCR mRNA |
increases expression
|
mRNA |
17447562
|
| C013930 | 3292 |
HSD17B1
EDH17B2 EDHB17 HSD17 SDR28C1 |
hydroxysteroid (17-beta) dehydrogenase 1 (EC:1.1.1.62) | 2,4-dibromophenol results in increased expression of HSD17B1 mRNA |
increases expression
|
mRNA |
17447562
|
| C013930 | 3295 |
HSD17B4
DBP MFE-2 MPF-2 PRLTS1 SDR8C1 |
hydroxysteroid (17-beta) dehydrogenase 4 (EC:4.2.1.107 4.2.1.119 1.1.1.n12) | 2,4-dibromophenol results in increased expression of HSD17B4 mRNA |
increases expression
|
mRNA |
17447562
|
| C013930 | 3284 |
HSD3B2
HSD3B HSDB SDR11E2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1) | 2,4-dibromophenol results in increased expression of HSD3B2 mRNA |
increases expression
|
mRNA |
17447562
|
| C013930 | 6770 |
STAR
STARD1 |
steroidogenic acute regulatory protein | 2,4-dibromophenol results in increased expression of STAR mRNA |
increases expression
|
mRNA |
17447562
|
| C013930 | 7276 |
TTR
CTS CTS1 HsT2651 PALB TBPA |
transthyretin | 2,4-dibromophenol binds to TTR protein |
affects binding
|
protein |
10869457
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (2)
| OMIM | preferred title | UniProt |
|---|---|---|
| #114500 | Colorectal cancer; crc |
P18054
|
| #133239 | Esophageal cancer |
P18054
|