KNApSAcK Metabolite C00033837
Metabolite
KNApSAcK Entry
| id | C00033837 |
|---|---|
| Name | Ethylparaben |
| CAS RN | 120-47-8 |
| Standard InChI | InChI=1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3 |
| Standard InChI (Main Layer) | InChI=1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 2169 |
Link
ChEMBL
| By standard InChI | CHEMBL15841 |
|---|---|
| By standard InChI Main Layer | CHEMBL15841 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | C012313 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| asterids | 1 |
Family
| family name | count |
|---|---|
| Gesneriaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Aeschynanthus bracteatus | 175969 | Gesneriaceae | asterids | Viridiplantae |
Human Protein / Gene in interaction
11 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P43166 | Carbonic anhydrase 7 | Lyase | CHEMBL15841 |
CHEMBL2340802
(1)
|
0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | CHEMBL15841 |
CHEMBL2340803
(1)
|
1 / 2 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | CHEMBL15841 |
CHEMBL2340799
(1)
|
0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | CHEMBL15841 |
CHEMBL2340800
(1)
|
1 / 2 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | CHEMBL15841 |
CHEMBL1908086
(1)
|
0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | CHEMBL15841 |
CHEMBL2340804
(1)
|
0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | CHEMBL15841 |
CHEMBL2340801
(1)
|
0 / 1 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | CHEMBL15841 |
CHEMBL1908080
(1)
|
5 / 1 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | CHEMBL15841 |
CHEMBL1908083
(1)
|
0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL15841 |
CHEMBL2114890
(1)
|
0 / 0 |
| P10275 | Androgen receptor | NR3C4 | CHEMBL15841 |
CHEMBL1794321
(1)
|
3 / 4 |
CTD interaction (4)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C012313 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | ethyl-p-hydroxybenzoate binds to ESR1 protein |
affects binding
|
protein |
11193391
|
| C012313 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | ethyl-p-hydroxybenzoate binds to ESR2 protein |
affects binding
|
protein |
11193391
|
| C012313 | 3952 |
LEP
LEPD OB OBS |
leptin | ethyl-p-hydroxybenzoate results in decreased expression of LEP mRNA |
decreases expression
|
mRNA |
22956630
|
| C012313 | 7299 |
TYR
ATN CMM8 OCA1 OCA1A OCAIA SHEP3 |
tyrosinase (EC:1.14.18.1) | TYR protein affects the susceptibility to ethyl-p-hydroxybenzoate |
affects response to substance
|
protein |
19944085
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (10)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
|
| #606785 | Crigler-najjar syndrome, type ii |
P22309
|
| #143500 | Gilbert syndrome |
P22309
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
KEGG DISEASE (9)
| KEGG | disease name | UniProt |
|---|---|---|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|