PCIDB

KNApSAcK Metabolite C00003478

Metabolite

KNApSAcK Entry

id C00003478
Name Resiniferatoxin
CAS RN 57444-62-9
Standard InChI InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-28(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-25(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)15-26-11-12-27(38)16-29(26)42-5/h6-14,16,23,28,30,33,38,41H,1,15,17-20H2,2-5H3/t23-,28+,30-,33-,34-,35-,36?,37-/m1/s1
Standard InChI (Main Layer) InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-28(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-25(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)15-26-11-12-27(38)16-29(26)42-5/h6-14,16,23,28,30,33,38,41H,1,15,17-20H2,2-5H3

Cluster

Phytochemical cluster No. 41
KCF-S cluster No. 4826

Link

ChEMBL

By standard InChI
By standard InChI Main Layer

KEGG

By LinkDB C09179

CTD

By CAS RN C024353

Species

Summary

Plant class

class name count
rosids 2

Family

family name count
Euphorbiaceae 2

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Euphorbia poisonii 3977 Euphorbiaceae rosids Viridiplantae
Euphorbia resinifera 457265 Euphorbiaceae rosids Viridiplantae

Human Protein / Gene in interaction

CTD interaction (8)

compound gene gene name gene description interaction interaction type form reference
pmid
C024353 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) resiniferatoxin results in increased activity of MAPK8 protein increases activity
protein 9580328
C024353 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) resiniferatoxin results in increased activity of MAPK9 protein increases activity
protein 9580328
C024353 7442 TRPV1
VR1
transient receptor potential cation channel, subfamily V, member 1 Cannabidiol inhibits the reaction [resiniferatoxin binds to TRPV1 protein] affects binding
/ decreases reaction
protein 11606325
C024353 7442 TRPV1
VR1
transient receptor potential cation channel, subfamily V, member 1 Cannabidiol inhibits the reaction [[resiniferatoxin binds to TRPV1 protein] which results in increased uptake of Calcium] affects binding
/ decreases reaction
/ increases uptake
protein 11606325
C024353 7442 TRPV1
VR1
transient receptor potential cation channel, subfamily V, member 1 resiniferatoxin binds to and results in increased activity of TRPV1 protein affects binding
/ increases activity
protein 16597917
C024353 7442 TRPV1
VR1
transient receptor potential cation channel, subfamily V, member 1 [resiniferatoxin binds to and results in increased activity of TRPV1 protein] which results in increased abundance of Calcium affects binding
/ increases abundance
/ increases activity
protein 16597917
C024353 7442 TRPV1
VR1
transient receptor potential cation channel, subfamily V, member 1 resiniferatoxin binds to TRPV1 protein affects binding
protein 11606325
C024353 7442 TRPV1
VR1
transient receptor potential cation channel, subfamily V, member 1 [resiniferatoxin binds to TRPV1 protein] which results in increased uptake of Calcium affects binding
/ increases uptake
protein 11606325

Related Disease

Diseases related to CTD interactions

11 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D058186 C024353 Acute Kidney Injury therapeutic
18460982
D003921 C024353 Diabetes Mellitus, Experimental marker/mechanism
17241282
D005119 C024353 Extravasation of Diagnostic and Therapeutic Materials marker/mechanism
17698245
D020078 C024353 Neurogenic Inflammation marker/mechanism
17698245
D010523 C024353 Peripheral Nervous System Diseases marker/mechanism
18219259
D015427 C024353 Reperfusion Injury therapeutic
18460982
19147859
D013276 C024353 Stomach Ulcer therapeutic
10674923
D001750 C024353 Urinary Bladder, Neurogenic marker/mechanism
17507042
D053201 C024353 Urinary Bladder, Overactive therapeutic
12700886
D016055 C024353 Urinary Retention marker/mechanism
17507042
D014839 C024353 Vomiting marker/mechanism
15680276