Euphorbia resinifera
Species
KNApSAcK Entry
| Organism name | Euphorbia resinifera |
|---|---|
| Genus | Euphorbia |
| Family | Euphorbiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Euphorbia resinifera |
|---|---|
| Linked NCBI taxonomy ID | 457265 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Euphorbiaceae |
|---|---|
| ID | 3977 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (10)
| Species | Activity |
|---|---|
| Euphorbia resinifera O. Berg & C.F. Schmidt | Abortifacient |
| Euphorbia resinifera O. Berg & C.F. Schmidt | Carcinogenic |
| Euphorbia resinifera O. Berg & C.F. Schmidt | Emetic |
| Euphorbia resinifera O. Berg & C.F. Schmidt | Immunostimulant |
| Euphorbia resinifera O. Berg & C.F. Schmidt | Irritant |
| Euphorbia resinifera O. Berg & C.F. Schmidt | Laxative |
| Euphorbia resinifera O. Berg & C.F. Schmidt | Rubefacient |
| Euphorbia resinifera O. Berg & C.F. Schmidt | Sialagogue |
| Euphorbia resinifera O. Berg & C.F. Schmidt | toxic |
| Euphorbia resinifera O. Berg & C.F. Schmidt | Vesicant |
Metabolite list (3)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003745
|
Euphol
/ alpha-Euphol / (+)-alpha-Euphol |
CHEMBL225111
CHEMBL465181 CHEMBL1397369 |
C062557
|
10 / 17 / 17 | No. 218 | No. 51 |
|
|
|
C00003478
|
Resiniferatoxin
|
C024353
|
3 / 11 | No. 4826 | No. 41 |
|
||
|
C00003477
|
Resiniferonol
|
CHEMBL521374
|
C035114
|
No. 4995 | No. 41 |
|
Human Protein / Gene in interactions
10 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003745 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003745 | 11 / 10 |
| Q16850 | Lanosterol 14-alpha demethylase | Cytochrome P450 51A1 | C00003745 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003745 | 2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003745 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003745 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00003745 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003745 | 0 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003745 | 4 / 3 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00003745 | 0 / 0 |
3 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00003478
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00003478
|
| 7442 | TRPV1, VR1 | transient receptor potential cation channel, subfamily V, member 1 |
C00003478
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (17)
| OMIM | preferred title | UniProt |
|---|---|---|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (17)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
Diseases related to CTD interactions
11 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D058186 | Acute Kidney Injury |
C00003478
|
| D003921 | Diabetes Mellitus, Experimental |
C00003478
|
| D005119 | Extravasation of Diagnostic and Therapeutic Materials |
C00003478
|
| D020078 | Neurogenic Inflammation |
C00003478
|
| D010523 | Peripheral Nervous System Diseases |
C00003478
|
| D015427 | Reperfusion Injury |
C00003478
|
| D013276 | Stomach Ulcer |
C00003478
|
| D001750 | Urinary Bladder, Neurogenic |
C00003478
|
| D053201 | Urinary Bladder, Overactive |
C00003478
|
| D016055 | Urinary Retention |
C00003478
|
| D014839 | Vomiting |
C00003478
|