KNApSAcK Metabolite C00035576
Metabolite
KNApSAcK Entry
| id | C00035576 |
|---|---|
| Name | di(2-Ethylhexyl) phthalate |
| CAS RN | 117-81-7 |
| Standard InChI | InChI=1S/C24H38O4/c1-5-9-13-19(7-3)17-27-23(25)21-15-11-12-16-22(21)24(26)28-18-20(8-4)14-10-6-2/h11-12,15-16,19-20H,5-10,13-14,17-18H2,1-4H3 |
| Standard InChI (Main Layer) | InChI=1S/C24H38O4/c1-5-9-13-19(7-3)17-27-23(25)21-15-11-12-16-22(21)24(26)28-18-20(8-4)14-10-6-2/h11-12,15-16,19-20H,5-10,13-14,17-18H2,1-4H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 6750 |
Link
ChEMBL
| By standard InChI | CHEMBL1242017 |
|---|---|
| By standard InChI Main Layer | CHEMBL402794 CHEMBL1242017 |
KEGG
| By LinkDB | C03690 |
|---|
CTD
| By CAS RN | D004051 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 1 |
Family
| family name | count |
|---|---|
| Euphorbiaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Alchornea cordifolia | 316697 | Euphorbiaceae | rosids | Viridiplantae |
Human Protein / Gene in interaction
100 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL402794 |
CHEMBL1909136
(2)
|
1 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | CHEMBL1242017 |
CHEMBL1738312
(1)
|
0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | CHEMBL402794 |
CHEMBL1909139
(2)
|
0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | CHEMBL402794 |
CHEMBL1909131
(2)
|
0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | CHEMBL402794 |
CHEMBL1909190
(2)
|
2 / 2 |
| P08246 | Neutrophil elastase | S1A | CHEMBL402794 |
CHEMBL1909195
(2)
|
2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | CHEMBL402794 |
CHEMBL1909215
(2)
|
0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | CHEMBL402794 |
CHEMBL1909201
(2)
|
0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | CHEMBL402794 |
CHEMBL1909176
(2)
|
0 / 0 |
| P29466 | Caspase-1 | C14 | CHEMBL402794 |
CHEMBL1909193
(2)
|
0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | CHEMBL402794 |
CHEMBL1909198
(2)
|
0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | CHEMBL402794 |
CHEMBL1909199
(2)
|
0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | CHEMBL402794 |
CHEMBL1909197
(2)
|
2 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | CHEMBL1242017 |
CHEMBL1794561
(1)
|
3 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | CHEMBL402794 |
CHEMBL1909123
(2)
|
1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | CHEMBL402794 |
CHEMBL1909092
(2)
|
0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | CHEMBL402794 |
CHEMBL1909169
(2)
|
1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | CHEMBL402794 |
CHEMBL1909157
(2)
|
0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | CHEMBL402794 |
CHEMBL1909156
(2)
|
0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | CHEMBL402794 |
CHEMBL1909143
(2)
|
1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | CHEMBL402794 |
CHEMBL1909174
(2)
|
0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | CHEMBL402794 |
CHEMBL1909090
(2)
|
0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | CHEMBL402794 |
CHEMBL1909093
(2)
|
0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | CHEMBL402794 |
CHEMBL1909127
(2)
|
0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | CHEMBL402794 |
CHEMBL1909204
(2)
|
0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | CHEMBL402794 |
CHEMBL1909202
(2)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL402794 |
CHEMBL1909135
(2)
|
0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | CHEMBL402794 |
CHEMBL1909203
(2)
|
1 / 11 |
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL1242017 |
CHEMBL1794339
(1)
|
2 / 3 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | CHEMBL402794 |
CHEMBL1909140
(2)
|
2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | CHEMBL402794 |
CHEMBL1909130
(2)
|
0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | CHEMBL402794 |
CHEMBL1909120
(2)
|
0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | CHEMBL402794 |
CHEMBL1909181
(2)
|
0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | CHEMBL402794 |
CHEMBL1909164
(2)
|
0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | CHEMBL402794 |
CHEMBL1909214
(2)
|
0 / 0 |
| P07858 | Cathepsin B | C1A | CHEMBL402794 |
CHEMBL950295
(1)
|
0 / 1 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | CHEMBL402794 |
CHEMBL1909175
(2)
|
0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | CHEMBL402794 |
CHEMBL1909096
(2)
|
1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | CHEMBL402794 |
CHEMBL1909118
(2)
|
0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | CHEMBL402794 |
CHEMBL1909166
(2)
|
1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL1242017 |
CHEMBL1614458
(1)
|
0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | CHEMBL402794 |
CHEMBL1909133
(2)
|
0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | CHEMBL402794 |
CHEMBL1909158
(2)
|
0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | CHEMBL402794 |
CHEMBL1909088
(2)
|
0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | CHEMBL402794 |
CHEMBL1909142
(2)
|
0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | CHEMBL402794 |
CHEMBL1909101
(2)
|
0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | CHEMBL402794 |
CHEMBL1909141
(2)
|
1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | CHEMBL402794 |
CHEMBL1909180
(2)
|
0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | CHEMBL402794 |
CHEMBL1909146
(2)
|
0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | CHEMBL402794 |
CHEMBL1909104
(2)
|
0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | CHEMBL402794 |
CHEMBL1909144
(2)
|
0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | CHEMBL402794 |
CHEMBL1909100
(2)
|
0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | CHEMBL1242017 |
CHEMBL2114835
(1)
|
0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | CHEMBL402794 |
CHEMBL1909167
(2)
|
1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | CHEMBL402794 |
CHEMBL1909129
(2)
|
0 / 0 |
| P08311 | Cathepsin G | S1A | CHEMBL402794 |
CHEMBL1909194
(2)
|
0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | CHEMBL402794 |
CHEMBL1909110
(2)
|
1 / 0 |
| P03956 | Interstitial collagenase | M10A | CHEMBL402794 |
CHEMBL1909196
(2)
|
0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | CHEMBL402794 |
CHEMBL1909119
(2)
|
0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL1242017 |
CHEMBL1794401
(1)
|
0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | CHEMBL402794 |
CHEMBL1909150
(2)
|
0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | CHEMBL402794 |
CHEMBL1909171
(2)
|
2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | CHEMBL402794 |
CHEMBL1909170
(2)
|
0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | CHEMBL402794 |
CHEMBL1909122
(2)
|
0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | CHEMBL402794 |
CHEMBL1909109
(2)
|
2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | CHEMBL402794 |
CHEMBL1909205
(2)
|
5 / 10 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | CHEMBL402794 |
CHEMBL1909172
(2)
|
1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | CHEMBL402794 |
CHEMBL1909114
(2)
|
0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | CHEMBL402794 |
CHEMBL1909125
(2)
|
0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | CHEMBL402794 |
CHEMBL1909126
(2)
|
3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | CHEMBL402794 |
CHEMBL1909108
(2)
|
0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | CHEMBL402794 |
CHEMBL1909124
(2)
|
1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL402794 |
CHEMBL1909200
(2)
|
0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | CHEMBL402794 |
CHEMBL1909207
(2)
|
2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL402794 |
CHEMBL1909132
(2)
|
0 / 0 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | CHEMBL1242017 |
CHEMBL2114842
(1)
|
0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | CHEMBL402794 |
CHEMBL1909186
(2)
|
0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | CHEMBL402794 |
CHEMBL1909145
(2)
|
1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | CHEMBL402794 |
CHEMBL1909091
(2)
|
1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | CHEMBL402794 |
CHEMBL1909212
(2)
|
1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | CHEMBL402794 |
CHEMBL1909211
(2)
|
0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | CHEMBL402794 |
CHEMBL1909105
(2)
|
0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | CHEMBL402794 |
CHEMBL1909182
(2)
|
0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | CHEMBL402794 |
CHEMBL1909173
(2)
|
0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | CHEMBL402794 |
CHEMBL1909113
(2)
|
0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | CHEMBL402794 |
CHEMBL1909187
(2)
|
0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | CHEMBL402794 |
CHEMBL1909168
(2)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL402794 |
CHEMBL1909134
(2)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL402794 CHEMBL1242017 |
CHEMBL1614108
(1)
CHEMBL1613886
(1)
CHEMBL1909138 (2) |
0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | CHEMBL402794 |
CHEMBL1909137
(2)
|
0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | CHEMBL1242017 |
CHEMBL1737991
(1)
|
0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL1242017 |
CHEMBL2114890
(1)
|
0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | CHEMBL402794 |
CHEMBL1909094
(2)
|
1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | CHEMBL402794 |
CHEMBL1909087
(2)
|
0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | CHEMBL402794 |
CHEMBL1909213
(2)
|
0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | CHEMBL402794 |
CHEMBL1909089
(2)
|
0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | CHEMBL402794 |
CHEMBL1909116
(2)
|
1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | CHEMBL402794 |
CHEMBL1909206
(2)
|
0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | CHEMBL402794 |
CHEMBL1909128
(2)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL1242017 |
CHEMBL1738442
(1)
|
0 / 0 |
CTD interaction (81)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D004051 | 5243 |
ABCB1
ABC20 CD243 CLCS GP170 MDR1 P-GP PGY1 |
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) | Diethylhexyl Phthalate promotes the reaction [NR1I2 protein results in increased expression of ABCB1 mRNA] |
increases expression
/ increases reaction |
mRNA |
17003290
|
| D004051 | 5243 |
ABCB1
ABC20 CD243 CLCS GP170 MDR1 P-GP PGY1 |
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) | Diethylhexyl Phthalate results in increased expression of ABCB1 mRNA |
increases expression
|
mRNA |
17003290
|
| D004051 | 34 |
ACADM
ACAD1 MCAD MCADH |
acyl-CoA dehydrogenase, C-4 to C-12 straight chain (EC:1.3.8.7) | Diethylhexyl Phthalate results in increased expression of ACADM mRNA |
increases expression
|
mRNA |
21354252
|
| D004051 | 37 |
ACADVL
ACAD6 LCACD VLCAD |
acyl-CoA dehydrogenase, very long chain (EC:1.3.8.9) | Diethylhexyl Phthalate results in increased expression of ACADVL mRNA |
increases expression
|
mRNA |
21354252
|
| D004051 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | Diethylhexyl Phthalate binds to and results in increased activity of AHR protein |
affects binding
/ increases activity |
protein |
23220035
|
| D004051 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of AKT1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
19956873
|
| D004051 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | Diethylhexyl Phthalate results in increased phosphorylation of AKT1 protein |
increases phosphorylation
|
protein |
19956873
|
| D004051 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of AKT1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
19956873
|
| D004051 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | Diethylhexyl Phthalate inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein] |
affects binding
/ decreases reaction / increases activity |
protein |
20943248
|
| D004051 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | Diethylhexyl Phthalate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] |
decreases reaction
/ increases activity |
protein |
19643168
|
| D004051 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | Diethylhexyl Phthalate metabolite inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein] |
affects binding
/ decreases reaction / increases activity |
protein |
20943248
|
| D004051 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | Diethylhexyl Phthalate results in increased activity of AR protein |
increases activity
|
protein |
19643168
|
| D004051 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | Flutamide inhibits the reaction [Diethylhexyl Phthalate results in increased activity of AR protein] |
decreases reaction
/ increases activity |
protein |
19643168
|
| D004051 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | Diethylhexyl Phthalate results in increased expression of BAX mRNA |
increases expression
|
mRNA |
22155658
|
| D004051 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | Diethylhexyl Phthalate results in decreased expression of BCL2 mRNA |
decreases expression
|
mRNA |
22155658
|
| D004051 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Diethylhexyl Phthalate results in increased activity of CASP3 protein |
increases activity
|
protein |
21864672
22155658 |
| D004051 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Diethylhexyl Phthalate results in increased expression of CASP3 protein alternative form |
increases expression
|
protein |
23220035
|
| D004051 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Diethylhexyl Phthalate results in increased activity of CASP7 protein |
increases activity
|
protein |
21864672
|
| D004051 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | Diethylhexyl Phthalate results in increased activity of CASP8 protein |
increases activity
|
protein |
22155658
|
| D004051 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | Diethylhexyl Phthalate results in increased activity of CASP9 protein |
increases activity
|
protein |
22155658
|
| D004051 | 1036 |
CDO1
|
cysteine dioxygenase type 1 (EC:1.13.11.20) | Diethylhexyl Phthalate results in decreased expression of CDO1 mRNA |
decreases expression
|
mRNA |
16223563
|
| D004051 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | CYP1A1 protein affects the susceptibility to Diethylhexyl Phthalate |
affects response to substance
|
protein |
8242868
|
| D004051 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | Diethylhexyl Phthalate metabolite results in increased expression of CYP1A1 |
increases expression
|
16954067
|
|
| D004051 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | Diethylhexyl Phthalate results in increased expression of and results in increased activity of CYP1B1 protein |
increases activity
/ increases expression |
protein |
16040568
|
| D004051 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | Diethylhexyl Phthalate results in increased expression of CYP1B1 mRNA |
increases expression
|
mRNA |
16040568
|
| D004051 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | [Dexamethasone co-treated with Diethylhexyl Phthalate] results in increased activity of CYP3A4 protein |
affects cotreatment
/ increases activity |
protein |
18332045
|
| D004051 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | [Dexamethasone co-treated with Diethylhexyl Phthalate] results in increased expression of CYP3A4 protein |
affects cotreatment
/ increases expression |
protein |
18332045
|
| D004051 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | Diethylhexyl Phthalate promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] |
affects binding
/ increases expression / increases reaction |
mRNA |
11581012
|
| D004051 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | Diethylhexyl Phthalate results in increased activity of CYP3A4 protein |
increases activity
|
protein |
21742782
|
| D004051 | 13117 | Diethylhexyl Phthalate results in increased expression of CYP4A10 mRNA |
increases expression
|
mRNA |
21354252
|
||
| D004051 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | Diethylhexyl Phthalate binds to and results in increased activity of ESR1 protein |
affects binding
/ increases activity |
protein |
15840436
|
| D004051 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | Diethylhexyl Phthalate inhibits the reaction [Estradiol binds to ESR1 protein] |
affects binding
/ decreases reaction |
protein |
20382090
|
| D004051 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | Diethylhexyl Phthalate results in increased activity of ESR1 protein |
increases activity
|
protein |
16756374
|
| D004051 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | Tamoxifen inhibits the reaction [Diethylhexyl Phthalate binds to and results in increased activity of ESR1 protein] |
affects binding
/ decreases reaction / increases activity |
protein |
15840436
|
| D004051 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | Diethylhexyl Phthalate binds to and results in decreased activity of ESR2 protein |
affects binding
/ decreases activity |
protein |
15840436
|
| D004051 | 3073 |
HEXA
TSD |
hexosaminidase A (alpha polypeptide) (EC:3.2.1.52) | Diethylhexyl Phthalate results in increased secretion of [HEXA protein binds to HEXB protein] |
affects binding
/ increases secretion |
protein |
20082445
|
| D004051 | 3073 |
HEXA
TSD |
hexosaminidase A (alpha polypeptide) (EC:3.2.1.52) | Plant Extracts inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of [HEXA protein binds to HEXB protein]] |
affects binding
/ decreases reaction / increases secretion |
protein |
20082445
|
| D004051 | 3074 |
HEXB
ENC-1AS |
hexosaminidase B (beta polypeptide) (EC:3.2.1.52) | Diethylhexyl Phthalate results in increased secretion of [HEXA protein binds to HEXB protein] |
affects binding
/ increases secretion |
protein |
20082445
|
| D004051 | 3074 |
HEXB
ENC-1AS |
hexosaminidase B (beta polypeptide) (EC:3.2.1.52) | Plant Extracts inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of [HEXA protein binds to HEXB protein]] |
affects binding
/ decreases reaction / increases secretion |
protein |
20082445
|
| D004051 | 3565 |
IL4
BCGF-1 BCGF1 BSF-1 BSF1 IL-4 |
interleukin 4 | Diethylhexyl Phthalate results in increased expression of IL4 mRNA |
increases expression
|
mRNA |
20082445
|
| D004051 | 3565 |
IL4
BCGF-1 BCGF1 BSF-1 BSF1 IL-4 |
interleukin 4 | Plant Extracts inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IL4 mRNA] |
decreases reaction
/ increases expression |
mRNA |
20082445
|
| D004051 | 27074 |
LAMP3
CD208 DC_LAMP DC-LAMP DCLAMP LAMP LAMP-3 TSC403 |
lysosomal-associated membrane protein 3 | Diethylhexyl Phthalate results in decreased expression of LAMP3 mRNA |
decreases expression
|
mRNA |
20678512
|
| D004051 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | Diethylhexyl Phthalate results in decreased expression of MAPK1 protein |
decreases expression
|
protein |
16455614
|
| D004051 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | Diethylhexyl Phthalate results in decreased expression of MAPK3 protein |
decreases expression
|
protein |
16455614
|
| D004051 | 4313 |
MMP2
CLG4 CLG4A MMP-II MONA TBE-1 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
19956873
|
| D004051 | 4313 |
MMP2
CLG4 CLG4A MMP-II MONA TBE-1 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP2 protein] |
decreases reaction
/ increases expression |
protein |
19956873
|
| D004051 | 4313 |
MMP2
CLG4 CLG4A MMP-II MONA TBE-1 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) | Diethylhexyl Phthalate results in increased expression of MMP2 mRNA |
increases expression
|
mRNA |
19956873
|
| D004051 | 4313 |
MMP2
CLG4 CLG4A MMP-II MONA TBE-1 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) | Diethylhexyl Phthalate results in increased expression of MMP2 protein |
increases expression
|
protein |
19956873
|
| D004051 | 4313 |
MMP2
CLG4 CLG4A MMP-II MONA TBE-1 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) | fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
19956873
|
| D004051 | 4313 |
MMP2
CLG4 CLG4A MMP-II MONA TBE-1 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) | fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP2 protein] |
decreases reaction
/ increases expression |
protein |
19956873
|
| D004051 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP9 mRNA] |
decreases reaction
/ increases expression |
mRNA |
19956873
|
| D004051 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP9 protein] |
decreases reaction
/ increases expression |
protein |
19956873
|
| D004051 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | Diethylhexyl Phthalate results in increased expression of MMP9 mRNA |
increases expression
|
mRNA |
19956873
|
| D004051 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | Diethylhexyl Phthalate results in increased expression of MMP9 protein |
increases expression
|
protein |
19956873
|
| D004051 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP9 mRNA] |
decreases reaction
/ increases expression |
mRNA |
19956873
|
| D004051 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP9 protein] |
decreases reaction
/ increases expression |
protein |
19956873
|
| D004051 | 4609 |
MYC
MRTL MYCC bHLHe39 c-Myc |
v-myc avian myelocytomatosis viral oncogene homolog | Diethylhexyl Phthalate results in decreased expression of MYC protein |
decreases expression
|
protein |
16455614
|
| D004051 | 8648 |
NCOA1
F-SRC-1 KAT13A RIP160 SRC1 bHLHe42 bHLHe74 |
nuclear receptor coactivator 1 (EC:2.3.1.48) | Diethylhexyl Phthalate promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] |
affects binding
/ increases expression / increases reaction |
protein |
11581012
|
| D004051 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | Diethylhexyl Phthalate binds to and results in increased activity of NR1I2 protein |
affects binding
/ increases activity |
protein |
16054614
21227907 |
| D004051 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | Diethylhexyl Phthalate promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] |
affects binding
/ increases expression / increases reaction |
protein |
11581012
|
| D004051 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | Diethylhexyl Phthalate promotes the reaction [NR1I2 protein results in increased expression of ABCB1 mRNA] |
increases expression
/ increases reaction |
protein |
17003290
|
| D004051 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | Diethylhexyl Phthalate results in increased activity of NR1I2 protein |
increases activity
|
protein |
22206814
|
| D004051 | 9970 |
NR1I3
CAR CAR1 MB67 |
nuclear receptor subfamily 1, group I, member 3 | Diethylhexyl Phthalate binds to and results in increased activity of NR1I3 protein alternative form |
affects binding
/ increases activity |
protein |
21227907
|
| D004051 | 9061 |
PAPSS1
ATPSK1 PAPSS SK1 |
3'-phosphoadenosine 5'-phosphosulfate synthase 1 (EC:2.7.1.25 2.7.7.4) | Diethylhexyl Phthalate results in decreased expression of PAPSS1 mRNA |
decreases expression
|
mRNA |
16223563
|
| D004051 | 9060 |
PAPSS2
ATPSK2 BCYM4 SK2 |
3'-phosphoadenosine 5'-phosphosulfate synthase 2 (EC:2.7.1.25 2.7.7.4) | Diethylhexyl Phthalate results in decreased expression of PAPSS2 mRNA |
decreases expression
|
mRNA |
16223563
|
| D004051 | 5465 |
PPARA
NR1C1 PPAR PPARalpha hPPAR |
peroxisome proliferator-activated receptor alpha | Diethylhexyl Phthalate metabolite results in increased activity of PPARA protein |
increases activity
|
protein |
10581215
|
| D004051 | 5465 |
PPARA
NR1C1 PPAR PPARalpha hPPAR |
peroxisome proliferator-activated receptor alpha | Diethylhexyl Phthalate results in decreased expression of PPARA protein |
decreases expression
|
protein |
16455614
|
| D004051 | 5465 |
PPARA
NR1C1 PPAR PPARalpha hPPAR |
peroxisome proliferator-activated receptor alpha | Diethylhexyl Phthalate results in increased expression of PPARA mRNA |
increases expression
|
mRNA |
21354252
|
| D004051 | 5465 |
PPARA
NR1C1 PPAR PPARalpha hPPAR |
peroxisome proliferator-activated receptor alpha | PPARA affects the susceptibility to Diethylhexyl Phthalate |
affects response to substance
|
21354252
|
|
| D004051 | 5465 |
PPARA
NR1C1 PPAR PPARalpha hPPAR |
peroxisome proliferator-activated receptor alpha | PPARA results in decreased susceptibility to Diethylhexyl Phthalate |
decreases response to substance
|
20123618
|
|
| D004051 | 5467 |
PPARD
FAAR NR1C2 NUC1 NUCI NUCII PPARB |
peroxisome proliferator-activated receptor delta | Diethylhexyl Phthalate results in increased expression of PPARD protein |
increases expression
|
protein |
16455614
|
| D004051 | 6821 |
SUOX
|
sulfite oxidase (EC:1.8.3.1) | Diethylhexyl Phthalate results in decreased expression of SUOX mRNA |
decreases expression
|
mRNA |
16223563
|
| D004051 | 7077 |
TIMP2
CSC-21K DDC8 |
TIMP metallopeptidase inhibitor 2 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
19956873
|
| D004051 | 7077 |
TIMP2
CSC-21K DDC8 |
TIMP metallopeptidase inhibitor 2 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 protein] |
decreases reaction
/ increases expression |
protein |
19956873
|
| D004051 | 7077 |
TIMP2
CSC-21K DDC8 |
TIMP metallopeptidase inhibitor 2 | Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA |
increases expression
|
mRNA |
19956873
|
| D004051 | 7077 |
TIMP2
CSC-21K DDC8 |
TIMP metallopeptidase inhibitor 2 | Diethylhexyl Phthalate results in increased expression of TIMP2 protein |
increases expression
|
protein |
19956873
|
| D004051 | 7077 |
TIMP2
CSC-21K DDC8 |
TIMP metallopeptidase inhibitor 2 | fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
19956873
|
| D004051 | 7077 |
TIMP2
CSC-21K DDC8 |
TIMP metallopeptidase inhibitor 2 | fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 protein] |
decreases reaction
/ increases expression |
protein |
19956873
|
| D004051 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | Diethylhexyl Phthalate results in increased expression of TNF mRNA |
increases expression
|
mRNA |
20082445
|
| D004051 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | Plant Extracts inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TNF mRNA] |
decreases reaction
/ increases expression |
mRNA |
20082445
|
| D004051 | 7422 |
VEGFA
MVCD1 VEGF VPF |
vascular endothelial growth factor A | Diethylhexyl Phthalate results in increased secretion of VEGFA protein |
increases secretion
|
protein |
18252963
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (41)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (36)
| KEGG | disease name | UniProt |
|---|---|---|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00932 | Tropical calcific pancreatitis |
P07858
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
Diseases related to CTD interactions
35 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D000014 | D004051 | Abnormalities, Drug-Induced |
marker/mechanism
|
6734493
20420898 |
|
| D000022 | D004051 | Abortion, Spontaneous |
marker/mechanism
|
22588786
|
|
| D000138 | D004051 | Acidosis |
marker/mechanism
|
22672789
|
|
| D000236 | D004051 | Adenoma |
marker/mechanism
|
3102426
|
|
| D000858 | D004051 | Anovulation |
marker/mechanism
|
19874833
|
|
| D006528 | D004051 | Carcinoma, Hepatocellular |
marker/mechanism
|
2399535
10478332 |
|
| D003876 | D004051 | Dermatitis, Atopic |
marker/mechanism
|
16882537
|
|
| D012734 | D004051 | Disorders of Sex Development |
marker/mechanism
|
17400582
20049201 |
|
| D005234 | D004051 | Fatty Liver |
marker/mechanism
therapeutic |
3378278
20307648 |
|
| D005327 | D004051 | Fetal Resorption |
marker/mechanism
|
21354252
|
|
| D005355 | D004051 | Fibrosis |
marker/mechanism
|
22677342
|
|
| D005832 | D004051 | Genital Diseases, Male |
marker/mechanism
|
20049201
|
|
| D005921 | D004051 | Glomerulonephritis |
marker/mechanism
|
22677342
|
|
| D006058 | D004051 | Gonadal Disorders |
marker/mechanism
|
19528224
|
|
| D006059 | D004051 | Gonadal Dysgenesis |
marker/mechanism
|
20335514
|
|
| D006529 | D004051 | Hepatomegaly |
marker/mechanism
|
20123618
22584684 |
|
| D006949 | D004051 | Hyperlipidemias |
therapeutic
|
3378278
|
|
| D006965 | D004051 | Hyperplasia |
marker/mechanism
|
3206528
9207284 21079920 |
|
| D006973 | D004051 | Hypertension |
marker/mechanism
|
22677342
|
|
| D007021 | D004051 | Hypospadias |
marker/mechanism
|
17400582
|
|
| D007674 | D004051 | Kidney Diseases |
marker/mechanism
|
3206528
23359474 |
|
| D007681 | D004051 | Kidney Papillary Necrosis |
marker/mechanism
|
3102426
|
|
| D008107 | D004051 | Liver Diseases |
marker/mechanism
|
3206528
9207284 |
|
| D008113 | D004051 | Liver Neoplasms |
marker/mechanism
|
6498799
11940454 20143881 |
|
| D008114 | D004051 | Liver Neoplasms, Experimental |
marker/mechanism
|
3102426
6872148 8167465 |
|
| D009336 | D004051 | Necrosis |
marker/mechanism
|
11836017
|
|
| D009765 | D004051 | Obesity |
therapeutic
|
20123618
|
|
| D010049 | D004051 | Ovarian Diseases |
marker/mechanism
|
23359474
|
|
| D011041 | D004051 | Poisoning |
marker/mechanism
|
23220035
|
|
| D011297 | D004051 | Prenatal Exposure Delayed Effects |
marker/mechanism
|
20335514
21354252 22588786 22677342 23359474 |
|
| D011469 | D004051 | Prostatic Diseases |
marker/mechanism
|
23359474
|
|
| D013733 | D004051 | Testicular Diseases |
marker/mechanism
|
11836017
17400582 20335514 21079920 23359474 |
|
| D014564 | D004051 | Urogenital Abnormalities |
marker/mechanism
|
20484383
|
|
| D015430 | D004051 | Weight Gain |
marker/mechanism
|
22588786
|
|
| D015431 | D004051 | Weight Loss |
therapeutic
|
3378278
|