PCIDB

KNApSAcK Metabolite C00035814

Metabolite

KNApSAcK Entry

id C00035814
Name Butanol
CAS RN 71-36-3
Standard InChI InChI=1S/C4H10O/c1-2-3-4-5/h5H,2-4H2,1H3
Standard InChI (Main Layer) InChI=1S/C4H10O/c1-2-3-4-5/h5H,2-4H2,1H3

Cluster

Phytochemical cluster
KCF-S cluster No. 3722

Link

ChEMBL

By standard InChI CHEMBL14245
By standard InChI Main Layer CHEMBL14245

KEGG

By LinkDB C06142

CTD

By CAS RN D020001

Species

Summary

Plant class

class name count
asterids 1

Family

family name count
Solanaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Lycopersicon esculentum Mill. 4081 Solanaceae asterids Viridiplantae

Human Protein / Gene in interaction

2 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL14245 CHEMBL1614458 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL14245 CHEMBL1794456 (1)
0 / 1

CTD interaction (81)

compound gene gene name gene description interaction interaction type form reference
pmid
D020001 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 1-Butanol inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]] decreases reaction
/ increases export
protein 16118212
D020001 183 AGT
ANHU
SERPINA8
angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1-Butanol inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 12890486
D020001 183 AGT
ANHU
SERPINA8
angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1-Butanol inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 12890486
D020001 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) 1-Butanol inhibits the reaction [P2RY1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 16236484
D020001 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 15919668
D020001 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) 1-Butanol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] decreases reaction
/ increases activity
/ increases localization
protein 18218859
D020001 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) 1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein] decreases reaction
/ increases activity
/ increases localization
protein 18218859
D020001 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]] decreases reaction
/ increases activity
/ increases localization
protein 18218859
D020001 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]] decreases reaction
/ increases activity
/ increases localization
protein 18218859
D020001 382 ARF6
ADP-ribosylation factor 6 1-Butanol inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]] affects reaction
/ decreases reaction
/ increases abundance
protein 10931844
D020001 382 ARF6
ADP-ribosylation factor 6 1-Butanol inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]] decreases reaction
/ increases abundance
/ increases reaction
protein 10931844
D020001 727 C5
C5a
C5b
CPAMD4
complement component 5 1-Butanol inhibits the reaction [C5 protein results in increased activity of RELA protein] decreases reaction
/ increases activity
protein 19284563
D020001 727 C5
C5a
C5b
CPAMD4
complement component 5 1-Butanol inhibits the reaction [C5 protein results in increased activity of SPHK1 protein] decreases reaction
/ increases activity
protein 19284563
D020001 727 C5
C5a
C5b
CPAMD4
complement component 5 1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 19346296
D020001 727 C5
C5a
C5b
CPAMD4
complement component 5 1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 19346296
D020001 727 C5
C5a
C5b
CPAMD4
complement component 5 1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 19284563
D020001 727 C5
C5a
C5b
CPAMD4
complement component 5 1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 19284563
D020001 847 CAT
catalase (EC:1.11.1.6) CAT protein inhibits the reaction [1-Butanol results in increased susceptibility to Hydrogen Peroxide] decreases reaction
/ increases response to substance
protein 20417698
D020001 896 CCND3
cyclin D3 1-Butanol inhibits the reaction [PDGFB protein results in decreased expression of CCND3 protein] decreases expression
/ decreases reaction
protein 15919668
D020001 1135 CHRNA2
cholinergic receptor, nicotinic, alpha 2 (neuronal) 1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]] affects binding
/ affects reaction
/ increases reaction
/ increases transport
protein 11821649
D020001 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) 1-Butanol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ affects reaction
/ increases activity
protein 12604691
D020001 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) 1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] affects binding
/ increases activity
protein 12604691
D020001 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
/ increases activity
protein 12604691
D020001 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Mecamylamine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
/ increases activity
protein 12604691
D020001 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) 1-Butanol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ affects reaction
/ increases activity
protein 12604691
D020001 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) 1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] affects binding
/ increases activity
protein 12604691
D020001 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
/ increases activity
protein 12604691
D020001 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Mecamylamine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
/ increases activity
protein 12604691
D020001 1143 CHRNB4
cholinergic receptor, nicotinic, beta 4 (neuronal) 1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]] affects binding
/ affects reaction
/ increases reaction
/ increases transport
protein 11821649
D020001 2268 FGR
SRC2
c-fgr
c-src2
p55-Fgr
p55c-fgr
p58-Fgr
p58c-fgr
feline Gardner-Rasheed sarcoma viral oncogene homolog (EC:2.7.10.2) 1-Butanol inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with dihydrocytochalasin B] results in increased activity of FGR protein] affects cotreatment
/ decreases reaction
/ increases activity
protein 11078731
D020001 2554 GABRA1
ECA4
EJM
EJM5
gamma-aminobutyric acid (GABA) A receptor, alpha 1 1-Butanol affects the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein]] affects binding
/ affects reaction
/ increases activity
protein 11137757
D020001 2561 GABRB2
gamma-aminobutyric acid (GABA) A receptor, beta 2 1-Butanol affects the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein]] affects binding
/ affects reaction
/ increases activity
protein 11137757
D020001 2566 GABRG2
CAE2
ECA2
GEFSP3
gamma-aminobutyric acid (GABA) A receptor, gamma 2 1-Butanol affects the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein]] affects binding
/ affects reaction
/ increases activity
protein 11137757
D020001 2688 GH1
GH
GH-N
GHN
IGHD1B
hGH-N
growth hormone 1 1-Butanol affects the folding of GH1 protein affects folding
protein 11064379
D020001 2911 GRM1
GPRC1A
MGLU1
MGLUR1
SCAR13
glutamate receptor, metabotropic 1 1-Butanol affects the localization of GRM1 protein affects localization
protein 15470141
D020001 2911 GRM1
GPRC1A
MGLU1
MGLUR1
SCAR13
glutamate receptor, metabotropic 1 PLD2 protein affects the reaction [1-Butanol affects the localization of GRM1 protein] affects localization
/ affects reaction
protein 15470141
D020001 2915 GRM5
GPRC1E
MGLUR5
mGlu5
glutamate receptor, metabotropic 5 1-Butanol affects the localization of GRM5 protein affects localization
protein 15470141
D020001 2915 GRM5
GPRC1E
MGLUR5
mGlu5
glutamate receptor, metabotropic 5 PLD2 protein affects the reaction [1-Butanol affects the localization of GRM5 protein] affects localization
/ affects reaction
protein 15470141
D020001 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D020001 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D020001 9177 HTR3B
5-HT3B
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D020001 3484 IGFBP1
AFBP
IBP1
IGF-BP25
PP12
hIGFBP-1
insulin-like growth factor binding protein 1 1-Butanol inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA] decreases reaction
/ increases expression
mRNA 17065600
D020001 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta 1-Butanol inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone] decreases reaction
/ increases abundance
protein 11854442
D020001 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta 1-Butanol inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 11854442
D020001 3558 IL2
IL-2
TCGF
lymphokine
interleukin 2 1-Butanol inhibits the reaction [[4-O-methyl-12-O-tetradecanoylphorbol 13-acetate co-treated with Ionomycin] results in increased expression of IL2 protein] affects cotreatment
/ decreases reaction
/ increases expression
protein 18423386
D020001 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 1-Butanol inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 12039947
D020001 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 1-Butanol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 12039947
D020001 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 1-Butanol inhibits the reaction [[4-O-methyl-12-O-tetradecanoylphorbol 13-acetate co-treated with Ionomycin] results in increased phosphorylation of and results in increased activity of MAPK1 protein] affects cotreatment
/ decreases reaction
/ increases activity
/ increases phosphorylation
protein 18423386
D020001 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 1-Butanol inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 12890486
D020001 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 19346296
D020001 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 19284563
D020001 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 15919668
D020001 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 1-Butanol inhibits the reaction [VEGFA protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 14704231
D020001 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 1-Butanol inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 12890486
D020001 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 19346296
D020001 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 1-Butanol inhibits the reaction [C5 protein results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 19284563
D020001 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 15919668
D020001 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 1-Butanol inhibits the reaction [VEGFA protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 14704231
D020001 5028 P2RY1
P2Y1
purinergic receptor P2Y, G-protein coupled, 1 1-Butanol inhibits the reaction [P2RY1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 16236484
D020001 5155 PDGFB
IBGC5
PDGF-2
PDGF2
SIS
SSV
c-sis
platelet-derived growth factor beta polypeptide 1-Butanol inhibits the reaction [PDGFB protein results in decreased expression of CCND3 protein] decreases expression
/ decreases reaction
protein 15919668
D020001 5155 PDGFB
IBGC5
PDGF-2
PDGF2
SIS
SSV
c-sis
platelet-derived growth factor beta polypeptide 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 15919668
D020001 5155 PDGFB
IBGC5
PDGF-2
PDGF2
SIS
SSV
c-sis
platelet-derived growth factor beta polypeptide 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 15919668
D020001 5155 PDGFB
IBGC5
PDGF-2
PDGF2
SIS
SSV
c-sis
platelet-derived growth factor beta polypeptide 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 15919668
D020001 5155 PDGFB
IBGC5
PDGF-2
PDGF2
SIS
SSV
c-sis
platelet-derived growth factor beta polypeptide 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of RPS6KB1 protein] decreases reaction
/ increases phosphorylation
protein 15919668
D020001 5338 PLD2
phospholipase D2 (EC:3.1.4.4) 1-Butanol inhibits the reaction [ilimaquinone results in increased activity of PLD2 protein] decreases reaction
/ increases activity
protein 17897952
D020001 5338 PLD2
phospholipase D2 (EC:3.1.4.4) PLD2 protein affects the reaction [1-Butanol affects the localization of GRM1 protein] affects localization
/ affects reaction
protein 15470141
D020001 5338 PLD2
phospholipase D2 (EC:3.1.4.4) PLD2 protein affects the reaction [1-Butanol affects the localization of GRM5 protein] affects localization
/ affects reaction
protein 15470141
D020001 5579 PRKCB
PKC-beta
PKCB
PRKCB1
PRKCB2
protein kinase C, beta (EC:2.7.11.13) 1-Butanol affects the localization of PRKCB protein affects localization
protein 15067001
D020001 5590 PRKCZ
PKC-ZETA
PKC2
protein kinase C, zeta (EC:2.7.11.13) 1-Butanol inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PRKCZ protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15255942
D020001 5617 PRL
prolactin 1-Butanol inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PRL mRNA] decreases reaction
/ increases expression
mRNA 17065600
D020001 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) 1-Butanol inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 17640750
D020001 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) 1-Butanol inhibits the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 15210717
D020001 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) 1-Butanol inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 11854442
D020001 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A 1-Butanol inhibits the reaction [C5 protein results in increased activity of RELA protein] decreases reaction
/ increases activity
protein 19284563
D020001 6198 RPS6KB1
PS6K
S6K
S6K-beta-1
S6K1
STK14A
p70_S6KA
p70(S6K)-alpha
p70-S6K
p70-alpha
ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1) 1-Butanol inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15255942
D020001 6198 RPS6KB1
PS6K
S6K
S6K-beta-1
S6K1
STK14A
p70_S6KA
p70(S6K)-alpha
p70-S6K
p70-alpha
ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1) 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of RPS6KB1 protein] decreases reaction
/ increases phosphorylation
protein 15919668
D020001 6199 RPS6KB2
KLS
P70-beta
P70-beta-1
P70-beta-2
S6K-beta2
S6K2
SRK
STK14B
p70(S6K)-beta
p70S6Kb
ribosomal protein S6 kinase, 70kDa, polypeptide 2 (EC:2.7.11.1) 1-Butanol results in decreased activity of RPS6KB2 protein decreases activity
protein 12087098
D020001 8877 SPHK1
SPHK
sphingosine kinase 1 (EC:2.7.1.91) 1-Butanol inhibits the reaction [C5 protein results in increased activity of SPHK1 protein] decreases reaction
/ increases activity
protein 19284563
D020001 412 STS
ARSC
ARSC1
ASC
ES
SSDD
XLI
steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2) 1-Butanol inhibits the reaction [Tretinoin results in increased activity of STS protein] decreases reaction
/ increases activity
protein 16178010
D020001 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A 1-Butanol inhibits the reaction [VEGFA protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 14704231
D020001 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A 1-Butanol inhibits the reaction [VEGFA protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 14704231

Related Disease

Diseases related to proteins in ChEMBL interactions

KEGG DISEASE (1)

KEGG disease name UniProt
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001259 D020001 Ataxia marker/mechanism
7820390