Lycopersicon esculentum Mill.
Species
KNApSAcK Entry
| Organism name | Lycopersicon esculentum Mill. |
|---|---|
| Genus | Lycopersicon |
| Family | Solanaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Solanum lycopersicum |
|---|---|
| Linked NCBI taxonomy ID | 4081 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Solanaceae |
|---|---|
| ID | 4070 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (71)
| Species | Activity |
|---|---|
| Lycopersicon esculentum Mill. | Acaricide |
| Lycopersicon esculentum Mill. | Allergenic |
| Lycopersicon esculentum Mill. | Allergenic |
| Lycopersicon esculentum Mill. | Analgesic |
| Lycopersicon esculentum Mill. | Analgesic |
| Lycopersicon esculentum Mill. | Antiaggregant |
| Lycopersicon esculentum Mill. | Antiartherosclerotic |
| Lycopersicon esculentum Mill. | Antiatherosclerotic |
| Lycopersicon esculentum Mill. | Antibacterial |
| Lycopersicon esculentum Mill. | Antiblister |
| Lycopersicon esculentum Mill. | Antiblister |
| Lycopersicon esculentum Mill. | Anticancer |
| Lycopersicon esculentum Mill. | Anticancer |
| Lycopersicon esculentum Mill. | Anticlastogenic |
| Lycopersicon esculentum Mill. | Antidermatitic |
| Lycopersicon esculentum Mill. | Antierythemic |
| Lycopersicon esculentum Mill. | Antiescherichia |
| Lycopersicon esculentum Mill. | Antihistaminic |
| Lycopersicon esculentum Mill. | Antiinflammatory |
| Lycopersicon esculentum Mill. | Antileukemic |
| Lycopersicon esculentum Mill. | Antimaculitic |
| Lycopersicon esculentum Mill. | Antimutagenic |
| Lycopersicon esculentum Mill. | Antinitrosaminic |
| Lycopersicon esculentum Mill. | Antinitrosaminic |
| Lycopersicon esculentum Mill. | Antiobesity |
| Lycopersicon esculentum Mill. | Antioxidant |
| Lycopersicon esculentum Mill. | Antioxidant |
| Lycopersicon esculentum Mill. | Antiplatelet |
| Lycopersicon esculentum Mill. | Antiproliferant |
| Lycopersicon esculentum Mill. | Antiprostatitic |
| Lycopersicon esculentum Mill. | Antiprostatitic |
| Lycopersicon esculentum Mill. | Antiradicular |
| Lycopersicon esculentum Mill. | Antiseptic |
| Lycopersicon esculentum Mill. | Antiseptic |
| Lycopersicon esculentum Mill. | Antistaphylococcic |
| Lycopersicon esculentum Mill. | Antithrombic |
| Lycopersicon esculentum Mill. | Antitumor |
| Lycopersicon esculentum Mill. | Aperient |
| Lycopersicon esculentum Mill. | Aperient |
| Lycopersicon esculentum Mill. | Aperitif |
| Lycopersicon esculentum Mill. | Bactericide |
| Lycopersicon esculentum Mill. | Cardioprotective |
| Lycopersicon esculentum Mill. | Cardiotonic |
| Lycopersicon esculentum Mill. | Chemopreventive |
| Lycopersicon esculentum Mill. | Chemopreventive |
| Lycopersicon esculentum Mill. | Depurative |
| Lycopersicon esculentum Mill. | Depurative |
| Lycopersicon esculentum Mill. | Digestive |
| Lycopersicon esculentum Mill. | Digestive |
| Lycopersicon esculentum Mill. | Diuretic |
| Lycopersicon esculentum Mill. | Diuretic |
| Lycopersicon esculentum Mill. | Fungicide |
| Lycopersicon esculentum Mill. | Fungicide |
| Lycopersicon esculentum Mill. | Hemolytic |
| Lycopersicon esculentum Mill. | Herbicide |
| Lycopersicon esculentum Mill. | Herbicide |
| Lycopersicon esculentum Mill. | Hyotensive |
| Lycopersicon esculentum Mill. | Hypocholesterolemic |
| Lycopersicon esculentum Mill. | Hypocholesterolemic |
| Lycopersicon esculentum Mill. | Hypotensive |
| Lycopersicon esculentum Mill. | Insecticide |
| Lycopersicon esculentum Mill. | Keratolytic |
| Lycopersicon esculentum Mill. | Larvicide |
| Lycopersicon esculentum Mill. | Larvicide |
| Lycopersicon esculentum Mill. | Orexigenic |
| Lycopersicon esculentum Mill. | Pectoral |
| Lycopersicon esculentum Mill. | Pectoral |
| Lycopersicon esculentum Mill. | Photoprotective |
| Lycopersicon esculentum Mill. | Poison |
| Lycopersicon esculentum Mill. | Poison |
| Lycopersicon esculentum Mill. | Vermifuge |
Metabolite list (23)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00031991
|
Lycoperoside F
|
CHEMBL1269162
|
No. 21 | No. 11 |
|
|||
|
C00031901
|
Isoesculeogenin A
|
CHEMBL1269939
|
2 / 0 / 0 | No. 171 | No. 11 |
|
||
|
C00035879
|
Tetradecane
|
CHEMBL135488
|
C024713
|
3 / 2 | No. 877 |
|
||
|
C00001248
|
Dodecane
|
CHEMBL30959
|
C007548
|
1 / 0 / 0 | 3 / 2 | No. 877 |
|
|
|
C00000356
|
cis-3-Hexen-1-ol
|
C051918
|
0 / 1 | No. 1746 |
|
|||
|
C00035857
|
Octane
/ n-Octane |
CHEMBL134886
|
C026728
|
No. 1749 |
|
|||
|
C00034882
|
Nonane
/ n-Nonane |
CHEMBL335900
|
C017573
|
1 / 3 / 2 | 3 / 2 | No. 1749 |
|
|
|
C00030828
|
Nonanal
/ n-Nonanal |
C008664
|
1 / 1 | No. 1993 |
|
|||
|
C00030099
|
Decanal
/ Capraldehyde |
C021170
|
2 / 0 | No. 1993 |
|
|||
|
C00000351
|
trans-2-Hexenal
|
No. 2883 |
|
|||||
|
C00034763
|
2-Amylfuran
/ 2-Pentylfuran |
No. 3145 |
|
|||||
|
C00030880
|
Octanal
/ n-Octanal |
CHEMBL18407
|
C031639
|
2 / 0 | No. 3593 |
|
||
|
C00000357
|
Hexanal
|
CHEMBL280331
|
C010463
|
7 / 0 | No. 3593 |
|
||
|
C00035814
|
Butanol
|
CHEMBL14245
|
D020001
|
2 / 0 / 1 | 40 / 1 | No. 3722 |
|
|
|
C00035784
|
1-Pentanol
/ n-Pentanol |
CHEMBL14568
|
C024999
|
2 / 7 / 5 | 2 / 0 | No. 3722 |
|
|
|
C00035797
|
6-Methyl-1-heptene
|
No. 4594 |
|
|||||
|
C00035853
|
Methylcyclohexane
|
No. 5911 |
|
|||||
|
C00034452
|
Benzaldehyde
|
CHEMBL15972
|
C032175
|
8 / 7 / 3 | 3 / 1 | No. 6311 |
|
|
|
C00035778
|
1,3-Dimethylbenzene
|
CHEMBL286727
|
C031285
|
5 / 7 / 5 | 7 / 5 | No. 6896 |
|
|
|
C00035779
|
1,5-Heptadien-3-yne
|
No. 6991 |
|
|||||
|
C00035792
|
3-Methylbutanol
|
No. 7125 |
|
|||||
|
C00035881
|
trans-2,4-hexadienal
|
No. 8278 |
|
|||||
|
C00035785
|
1-Penten-3-one
|
CHEMBL1506228
|
C057461
|
4 / 6 / 6 | No. 8912 |
|
Human Protein / Gene in interactions
19 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00034452 C00035785 C00035814 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00035778 C00035785 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00035784 C00035785 | 3 / 4 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00035778 C00035814 | 0 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00034882 C00035785 | 3 / 2 |
| P10145 | Interleukin-8 | Secreted protein | C00034452 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00034452 | 0 / 0 |
| P14902 | Indoleamine 2,3-dioxygenase 1 | Enzyme | C00034452 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00034452 | 2 / 0 |
| P35610 | Sterol O-acyltransferase 1 | Enzyme | C00031901 | 0 / 0 |
| O75908 | Sterol O-acyltransferase 2 | Enzyme | C00031901 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00034452 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00034452 | 4 / 2 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00035778 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00034452 | 1 / 1 |
| P22303 | Acetylcholinesterase | Hydrolase | C00035778 | 1 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00035778 | 6 / 4 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00035784 | 4 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001248 | 0 / 0 |
56 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001248
C00034882
C00035778
C00035814
C00035879 |
| 231 | AKR1B1, ADR, ALDR1, ALR2, AR | aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) |
C00000357
C00030099
C00030828
C00030880
|
| 217 | ALDH2, ALDH-E2, ALDHI, ALDM | aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) |
C00000357
C00030099
C00034452
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00001248
C00034882
C00035879
|
| 221 | ALDH3B1, ALDH4, ALDH7 | aldehyde dehydrogenase 3 family, member B1 (EC:1.2.1.5) |
C00000357
C00030880
C00034452
|
| 3552 | IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 | interleukin 1, alpha |
C00001248
C00035879
|
| 218 | ALDH3A1, ALDH3, ALDHIII | aldehyde dehydrogenase 3 family, member A1 (EC:1.2.1.5) |
C00000357
C00034452
|
| 1143 | CHRNB4 | cholinergic receptor, nicotinic, beta 4 (neuronal) |
C00035784
C00035814
|
| 1135 | CHRNA2 | cholinergic receptor, nicotinic, alpha 2 (neuronal) |
C00035784
C00035814
|
| 1141 | CHRNB2, EFNL3, nAChRB2 | cholinergic receptor, nicotinic, beta 2 (neuronal) |
C00035814
|
| 5241 | PGR, NR3C3, PR | progesterone receptor |
C00034882
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00000357
|
| 501 | ALDH7A1, ATQ1, EPD, PDE | aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31) |
C00000357
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00035778
|
| 57053 | CHRNA10 | cholinergic receptor, nicotinic, alpha 10 (neuronal) |
C00035778
|
| 55584 | CHRNA9, HSA243342, NACHRA9 | cholinergic receptor, nicotinic, alpha 9 (neuronal) |
C00035778
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00035778
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00035778
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00035778
|
| 19 | ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD | ATP-binding cassette, sub-family A (ABC1), member 1 |
C00035814
|
| 183 | AGT, ANHU, SERPINA8 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
C00035814
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00035814
|
| 240 | ALOX5, 5-LO, 5-LOX, 5LPG, LOG5 | arachidonate 5-lipoxygenase (EC:1.13.11.34) |
C00035814
|
| 382 | ARF6 | ADP-ribosylation factor 6 |
C00035814
|
| 727 | C5, C5a, C5b, CPAMD4 | complement component 5 |
C00035814
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00035814
|
| 896 | CCND3 | cyclin D3 |
C00035814
|
| 1137 | CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 | cholinergic receptor, nicotinic, alpha 4 (neuronal) |
C00035814
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00000357
|
| 2268 | FGR, SRC2, c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr | feline Gardner-Rasheed sarcoma viral oncogene homolog (EC:2.7.10.2) |
C00035814
|
| 2554 | GABRA1, ECA4, EJM, EJM5 | gamma-aminobutyric acid (GABA) A receptor, alpha 1 |
C00035814
|
| 2561 | GABRB2 | gamma-aminobutyric acid (GABA) A receptor, beta 2 |
C00035814
|
| 2566 | GABRG2, CAE2, ECA2, GEFSP3 | gamma-aminobutyric acid (GABA) A receptor, gamma 2 |
C00035814
|
| 2688 | GH1, GH, GH-N, GHN, IGHD1B, hGH-N | growth hormone 1 |
C00035814
|
| 2911 | GRM1, GPRC1A, MGLU1, MGLUR1, SCAR13 | glutamate receptor, metabotropic 1 |
C00035814
|
| 2915 | GRM5, GPRC1E, MGLUR5, mGlu5 | glutamate receptor, metabotropic 5 |
C00035814
|
| 3359 | HTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3 | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic |
C00035814
|
| 9177 | HTR3B, 5-HT3B | 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic |
C00035814
|
| 3484 | IGFBP1, AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1 | insulin-like growth factor binding protein 1 |
C00035814
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00035814
|
| 3558 | IL2, IL-2, TCGF, lymphokine | interleukin 2 |
C00035814
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00035814
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00035814
|
| 5028 | P2RY1, P2Y1 | purinergic receptor P2Y, G-protein coupled, 1 |
C00035814
|
| 5155 | PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis | platelet-derived growth factor beta polypeptide |
C00035814
|
| 5338 | PLD2 | phospholipase D2 (EC:3.1.4.4) |
C00035814
|
| 5579 | PRKCB, PKC-beta, PKCB, PRKCB1, PRKCB2 | protein kinase C, beta (EC:2.7.11.13) |
C00035814
|
| 5590 | PRKCZ, PKC-ZETA, PKC2 | protein kinase C, zeta (EC:2.7.11.13) |
C00035814
|
| 5617 | PRL | prolactin |
C00035814
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00035814
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00035814
|
| 6198 | RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70_S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha | ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1) |
C00035814
|
| 6199 | RPS6KB2, KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B, p70(S6K)-beta, p70S6Kb | ribosomal protein S6 kinase, 70kDa, polypeptide 2 (EC:2.7.11.1) |
C00035814
|
| 8877 | SPHK1, SPHK | sphingosine kinase 1 (EC:2.7.1.91) |
C00035814
|
| 412 | STS, ARSC, ARSC1, ASC, ES, SSDD, XLI | steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2) |
C00035814
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00035814
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (24)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (15)
| KEGG | name | UniProt |
|---|---|---|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
Diseases related to CTD interactions
10 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D017453 | Dermatitis, Irritant |
C00001248
C00034882 C00035879 |
| D004890 | Erythema |
C00001248
C00034882 C00035879 |
| D012640 | Seizures |
C00035778
C00034452 |
| D005119 | Extravasation of Diagnostic and Therapeutic Materials |
C00035778
|
| D003872 | Dermatitis |
C00035778
|
| D055371 | Acute Lung Injury |
C00035778
|
| D020258 | Neurotoxicity Syndromes |
C00035778
|
| D009336 | Necrosis |
C00030828
|
| D001008 | Anxiety Disorders |
C00000356
|
| D001259 | Ataxia |
C00035814
|