PCIDB

KNApSAcK Metabolite C00003618

Metabolite

KNApSAcK Entry

id C00003618
Name Digoxin
CAS RN 20830-75-5
Standard InChI InChI=1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19?,20?,21?,23-,24+,25-,26-,27+,28+,29-,30+,31-,33+,34-,35-,36?,37-,38?,39+,40+,41+/m1/s1
Standard InChI (Main Layer) InChI=1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3

Cluster

Phytochemical cluster No. 56
KCF-S cluster No. 272

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL1751 CHEMBL1477182 CHEMBL1512361

KEGG

By LinkDB C06956

CTD

By CAS RN D004077

Species

Summary

Plant class

class name count
asterids 2

Family

family name count
Plantaginaceae 2

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Digitalis lanata 49450 Plantaginaceae asterids Viridiplantae
Digitalis orientalis 4163 Plantaginaceae asterids Viridiplantae

Human Protein / Gene in interaction

139 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1751 CHEMBL1477182 CHEMBL1741321 (1) CHEMBL1909136 (2)
CHEMBL2071965 (1)
1 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL1751 CHEMBL1477182 CHEMBL1613992 (2) CHEMBL1613995 (2)
CHEMBL2114895 (1)
7 / 44
Q16637 Survival motor neuron protein Unclassified protein CHEMBL1477182 CHEMBL1512361 CHEMBL1613842 (2)
4 / 2
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter CHEMBL1751 CHEMBL2169429 (1)
1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL1751 CHEMBL2169431 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL1477182 CHEMBL2114784 (1)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL1751 CHEMBL1794499 (1)
2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL1751 CHEMBL1909139 (2)
0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase CHEMBL1751 CHEMBL965575 (1)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL1751 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL1751 CHEMBL1909190 (2)
2 / 2
P01375 Tumor necrosis factor Secreted protein CHEMBL1751 CHEMBL2114889 (1)
3 / 6
P08246 Neutrophil elastase S1A CHEMBL1751 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL1751 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL1751 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL1751 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL1751 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL1751 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL1751 CHEMBL1909199 (2)
0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL1751 CHEMBL1794524 (2) CHEMBL1794552 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL1751 CHEMBL1909197 (2)
2 / 2
O15245 Solute carrier family 22 member 1 Drug uniporter CHEMBL1751 CHEMBL993349 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL1751 CHEMBL1477182 CHEMBL1614544 (3)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1477182 CHEMBL1614361 (1)
3 / 2
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL1751 CHEMBL1794399 (2) CHEMBL1794561 (1)
3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 CHEMBL1751 CHEMBL1794371 (2) CHEMBL1794471 (2)
0 / 0
P00918 Carbonic anhydrase 2 Lyase CHEMBL1751 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL1751 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL1751 CHEMBL965569 (1) CHEMBL965573 (1)
CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL1751 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL1751 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL1751 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL1751 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL1751 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL1751 CHEMBL1909093 (2)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL1751 CHEMBL755826 (1) CHEMBL755827 (1)
CHEMBL754160 (1) CHEMBL754161 (1)
CHEMBL1743157 (1) CHEMBL2077111 (1)
CHEMBL2077420 (1) CHEMBL2077421 (1)
CHEMBL2076098 (1) CHEMBL2076099 (1)
CHEMBL2076268 (1) CHEMBL2076278 (1)
CHEMBL2076683 (1) CHEMBL2076703 (1)
CHEMBL2076852 (1) CHEMBL2077017 (1)
CHEMBL2077347 (1) CHEMBL2075195 (1)
CHEMBL2075438 (1) CHEMBL2076207 (1)
CHEMBL2076209 (1) CHEMBL2076241 (1)
CHEMBL2076251 (1) CHEMBL2076044 (1)
1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL1751 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL1751 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL1751 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1751 CHEMBL1477182 CHEMBL1741325 (1) CHEMBL1909135 (2)
CHEMBL2071963 (1)
0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL1751 CHEMBL1909203 (2)
1 / 11
P11473 Vitamin D3 receptor NR1I1 CHEMBL1751 CHEMBL1794376 (2)
2 / 3
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL1751 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL1751 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL1751 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL1751 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL1751 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL1751 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL1751 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL1751 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL1751 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL1751 CHEMBL1909166 (2)
1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL1751 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL1477182 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL1751 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL1751 CHEMBL2114843 (3) CHEMBL2114780 (3)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL1751 CHEMBL1613838 (2)
0 / 0
P46721 Solute carrier organic anion transporter family member 1A2 Unclassified protein CHEMBL1751 CHEMBL1743150 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL1751 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL1751 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL1751 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL1751 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL1751 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL1751 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL1751 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL1751 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL1751 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL1751 CHEMBL1909100 (2)
0 / 0
P10145 Interleukin-8 Secreted protein CHEMBL1751 CHEMBL2114835 (1)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL1751 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL1751 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL1751 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL1751 CHEMBL1909110 (2)
1 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor CHEMBL1751 CHEMBL1614133 (1)
1 / 2
P03956 Interstitial collagenase M10A CHEMBL1751 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL1751 CHEMBL1909119 (2)
0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter CHEMBL1751 CHEMBL1743146 (1) CHEMBL2076238 (1)
CHEMBL2169430 (1)
1 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL1751 CHEMBL1794382 (2) CHEMBL1794456 (1)
CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL1751 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL1751 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL1751 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL1751 CHEMBL1909109 (2)
2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL1751 CHEMBL1794293 (2) CHEMBL1794510 (2)
5 / 3
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL1751 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL1751 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL1751 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL1751 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL1751 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL1751 CHEMBL1909108 (2)
0 / 0
P06280 Alpha-galactosidase A Enzyme CHEMBL1751 CHEMBL1614217 (1)
1 / 1
Q96RI1 Bile acid receptor NR1H4 CHEMBL1751 CHEMBL1794415 (1) CHEMBL1794437 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL1751 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL1751 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL1751 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1751 CHEMBL1477182 CHEMBL1741322 (1) CHEMBL1909132 (2)
CHEMBL2071962 (1)
0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL1751 CHEMBL1006005 (1)
1 / 1
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL1751 CHEMBL1614342 (2)
1 / 1
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL1751 CHEMBL2114842 (1) CHEMBL2327511 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1751 CHEMBL1738588 (2)
0 / 0
P21439 Multidrug resistance protein 3 Enzyme CHEMBL1751 CHEMBL1743163 (1)
3 / 2
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL1751 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL1751 CHEMBL1794364 (2) CHEMBL1794542 (1)
CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL1751 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL1751 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL1751 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL1751 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL1751 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL1751 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL1751 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL1751 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL1751 CHEMBL1909168 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1751 CHEMBL1477182 CHEMBL1741323 (1) CHEMBL1909134 (2)
CHEMBL2071964 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1751 CHEMBL1477182 CHEMBL664809 (1) CHEMBL1741324 (1)
CHEMBL1909138 (2) CHEMBL2071966 (1)
CHEMBL2071967 (1)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL1751 CHEMBL1909137 (2)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL1751 CHEMBL1614211 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1751 CHEMBL1738184 (1) CHEMBL2114890 (2)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL1751 CHEMBL1794321 (2) CHEMBL1794560 (1)
3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL1751 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL1751 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL1751 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL1751 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL1751 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL1751 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL1751 CHEMBL1909128 (2)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL1751 CHEMBL1613829 (1)
0 / 0
P42224 Signal transducer and activator of transcription 1-alpha/beta Unclassified protein CHEMBL1751 CHEMBL1614313 (1)
3 / 3
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL1751 CHEMBL2354311 (1)
1 / 0
Q6ZQN7 Solute carrier organic anion transporter family member 4C1 Unclassified protein CHEMBL1751 CHEMBL2076885 (1) CHEMBL2075763 (1)
0 / 0
Q9NYB5 Solute carrier organic anion transporter family member 1C1 Unclassified protein CHEMBL1751 CHEMBL2076222 (1)
0 / 0
Q86UW1 Organic solute transporter subunit alpha Unclassified protein CHEMBL1751 CHEMBL2078563 (1)
0 / 0
P05023 Sodium/potassium-transporting ATPase subunit alpha-1 Hydrolase CHEMBL1751 CHEMBL751509 (1)
0 / 0
P14415 Sodium/potassium-transporting ATPase subunit beta-2 potassium_sodium CHEMBL1751 CHEMBL751509 (1)
0 / 0
P13637 Sodium/potassium-transporting ATPase subunit alpha-3 Hydrolase CHEMBL1751 CHEMBL751509 (1)
2 / 1
Q13733 Sodium/potassium-transporting ATPase subunit alpha-4 Hydrolase CHEMBL1751 CHEMBL751509 (1)
0 / 0
P54710 Sodium/potassium-transporting ATPase subunit gamma potassium_sodium CHEMBL1751 CHEMBL751509 (1)
1 / 1
P54709 Sodium/potassium-transporting ATPase subunit beta-3 potassium_sodium CHEMBL1751 CHEMBL751509 (1)
0 / 0
P50993 Sodium/potassium-transporting ATPase subunit alpha-2 Hydrolase CHEMBL1751 CHEMBL751509 (1)
2 / 2
P05026 Sodium/potassium-transporting ATPase subunit beta-1 potassium_sodium CHEMBL1751 CHEMBL751509 (1)
0 / 0
Q06710 Paired box protein Pax-8 Unclassified protein CHEMBL1751 CHEMBL2354301 (1)
1 / 2

CTD interaction (63)

compound gene gene name gene description interaction interaction type form reference
pmid
D004077 10351 ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8 Digoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] decreases reaction
/ increases uptake
protein 12379217
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin results in increased expression of ABCB1 protein] decreases reaction
/ increases expression
protein 19647009
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin results in increased expression of ABCB1 mRNA] decreases reaction
/ increases expression
mRNA 19647009
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin results in increased expression of ABCB1 protein] decreases reaction
/ increases expression
protein 19647009
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 gene SNP affects the abundance of Digoxin affects abundance
gene 21311904
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 protein affects the transport of Digoxin affects transport
protein 15969931
19505989
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 protein binds to and affects the metabolism of Digoxin affects binding
/ affects metabolic processing
protein 15856409
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 protein results in decreased uptake of Digoxin decreases uptake
protein 10617675
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 protein results in increased export of Digoxin increases export
protein 16674925
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 protein results in increased transport of Digoxin increases transport
protein 10527640
11231118
11895100
16221533
16671962
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Amiodarone inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 11231118
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) azelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 11231118
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) benidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 11895100
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Bepridil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 11895100
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Bisoprolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 16671962
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Capsaicin affects the reaction [ABCB1 protein results in increased export of Digoxin] affects reaction
/ increases export
protein 16674925
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 11895100
16671962
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) desethylamiodarone inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 11231118
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) desmethylazelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 11231118
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Diazinon affects the reaction [ABCB1 protein results in increased transport of Digoxin] affects reaction
/ increases transport
protein 16221533
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Digoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium] decreases reaction
/ increases transport
protein 23104431
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Digoxin results in increased expression of ABCB1 mRNA increases expression
mRNA 19647009
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Digoxin results in increased expression of ABCB1 protein increases expression
protein 19647009
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) [Digoxin results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin decreases response to substance
/ increases expression
19647009
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Diltiazem inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 11895100
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Doxazosin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 11895100
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) efonidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 11895100
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Itraconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin] affects transport
/ decreases reaction
protein 15969931
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Ketoconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin] affects transport
/ decreases reaction
protein 15969931
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) KN 93 inhibits the reaction [Digoxin results in increased expression of ABCB1 protein] decreases reaction
/ increases expression
protein 19647009
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) manidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 11895100
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) mepirodipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 11895100
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Nicardipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 11895100
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) nilvadipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 11895100
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Nisoldipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 11895100
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Propranolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 16671962
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) valspodar inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 16671962
D004077 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] decreases reaction
/ increases transport
protein 10527640
11895100
D004077 9429 ABCG2
ABC15
ABCP
BCRP
BCRP1
BMDP
CD338
CDw338
EST157481
GOUT1
MRX
MXR
MXR1
UAQTL1
ATP-binding cassette, sub-family G (WHITE), member 2 Digoxin results in decreased activity of ABCG2 protein decreases activity
protein 15365089
D004077 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Digoxin results in decreased expression of CCL2 protein decreases expression
protein 20116850
D004077 6351 CCL4
ACT2
AT744.1
G-26
HC21
LAG-1
LAG1
MIP-1-beta
MIP1B
MIP1B1
SCYA2
SCYA4
chemokine (C-C motif) ligand 4 Digoxin results in decreased expression of CCL4 protein decreases expression
protein 20116850
D004077 6352 CCL5
D17S136E
RANTES
SCYA5
SIS-delta
SISd
TCP228
eoCP
chemokine (C-C motif) ligand 5 Digoxin results in decreased expression of CCL5 protein decreases expression
protein 20116850
D004077 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin affects the localization of HIF1A protein] affects localization
/ decreases reaction
protein 19647009
D004077 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein] decreases reaction
/ increases phosphorylation
protein 19647009
D004077 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin affects the localization of HIF1A protein] affects localization
/ decreases reaction
protein 19647009
D004077 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Digoxin affects the localization of HIF1A protein affects localization
protein 19647009
D004077 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Digoxin results in increased activity of HIF1A protein increases activity
protein 19647009
D004077 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Digoxin results in increased phosphorylation of and results in increased expression of HIF1A protein increases expression
/ increases phosphorylation
protein 19647009
D004077 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) KN 93 inhibits the reaction [Digoxin affects the localization of HIF1A protein] affects localization
/ decreases reaction
protein 19647009
D004077 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) KN 93 inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein] decreases reaction
/ increases phosphorylation
protein 19647009
D004077 3570 IL6R
CD126
IL-6R-1
IL-6RA
IL6Q
IL6RA
IL6RQ
gp80
interleukin 6 receptor Digoxin results in decreased expression of IL6R protein modified form decreases expression
protein 20116850
D004077 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Digoxin results in decreased expression of IL8 protein decreases expression
protein 20116850
D004077 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin INS protein results in decreased susceptibility to Digoxin decreases response to substance
protein 22562035
D004077 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein] decreases activity
/ decreases reaction
protein 19139152
D004077 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 Astemizole inhibits the reaction [Digoxin results in decreased metabolism of KCNH2 protein modified form] decreases metabolic processing
/ decreases reaction
protein 19139152
D004077 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 Digoxin results in decreased activity of KCNH2 protein decreases activity
protein 19139152
D004077 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 Digoxin results in decreased expression of KCNH2 protein modified form decreases expression
protein 19139152
D004077 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 KCNH2 gene affects the susceptibility to Digoxin affects response to substance
gene 19139152
D004077 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 Sodium deficiency inhibits the reaction [Digoxin results in decreased expression of KCNH2 protein] decreases expression
/ decreases reaction
protein 19139152
D004077 4879 NPPB
BNP
natriuretic peptide B Digoxin results in increased expression of NPPB protein increases expression
protein 16032632
D004077 6580 SLC22A1
HOCT1
OCT1
oct1_cds
solute carrier family 22 (organic cation transporter), member 1 Digoxin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] decreases reaction
/ increases uptake
protein 21641380
D004077 6581 SLC22A3
EMT
EMTH
OCT3
solute carrier family 22 (organic cation transporter), member 3 Digoxin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] decreases reaction
/ increases uptake
protein 21641380
D004077 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Digoxin results in decreased expression of VEGFA protein decreases expression
protein 20116850

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (97)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
#104290 Alternating hemiplegia of childhood 1; ahc1 P50993
#614820 Alternating hemiplegia of childhood 2; ahc2 P13637
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#209950 Atypical mycobacteriosis, familial P42224
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#614162 Candidiasis, familial, 7; candf7 P42224
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#614972 Cholestasis, intrahepatic, of pregnancy 3; icp3 P21439
#602347 Cholestasis, progressive familial intrahepatic, 3; pfic3 P21439
#114500 Colorectal cancer; crc P84022
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#128235 Dystonia 12; dyt12 P13637
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600803 Gallbladder disease 1; gbd1 P21439
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
P37231
#610140 Heart-hand syndrome, slovenian type P02545
#610424 Hepatitis b virus, susceptibility to P01375
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#154020 Hypomagnesemia 2, renal; homg2 P54710
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#218700 Hypothyroidism, congenital, nongoitrous, 2; chng2 Q06710
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#611162 Malaria, susceptibility to P01375
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#602481 Migraine, familial hemiplegic, 2; fhm2 P50993
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#613796 Mycobacterial and viral infections, susceptibility to, autosomal recessive P42224
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607507 Psoriatic arthritis, susceptibility to P01375
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (93)

KEGG disease name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
P40763 (related)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00079 Asthma P01375 (related)
P07550 (related)
H00080 Systemic lupus erythematosus P01375 (related)
P01375 (marker)
H00083 Allograft rejection P01375 (related)
H00084 Graft-versus-host disease P01375 (related)
P01375 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
Q06710 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00831 Primary dystonia P13637 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
Q06710 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00624 Familial cholestasis P21439 (related)
H01213 Gallbladder disease P21439 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00089 IFN-gamma/IL-12 axis P42224 (related)
H00363 Candidiasis P42224 (related)
H01109 Chronic mucocutaneous candidiasis (CMC) P42224 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00775 Familial or sporadic hemiplegic migraine P50993 (related)
H00998 Alternating hemiplegia of childhood P50993 (related)
H01210 Hypomagnesemia P54710 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

106 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D015746 D004077 Abdominal Pain marker/mechanism
7427472
D058186 D004077 Acute Kidney Injury marker/mechanism
12243603
D000370 D004077 Ageusia marker/mechanism
16730151
D000743 D004077 Anemia, Hemolytic marker/mechanism
4124995
D000787 D004077 Angina Pectoris therapeutic
2912410
D000855 D004077 Anorexia marker/mechanism
3588469
4521669
11496033
D001145 D004077 Arrhythmias, Cardiac marker/mechanism
therapeutic
3420
618505
758230
1166019
1259829
1413169
1449452
1696671
1958605
2535056
3498356
5009479
6173523
7070893
7193016
7319536
11794432
12361690
12365708
12804730
12939524
D001259 D004077 Ataxia marker/mechanism
5440585
D001281 D004077 Atrial Fibrillation marker/mechanism
therapeutic
402273
1307536
1449452
1771805
1898998
2039889
2495120
2633456
3709557
4255107
4810020
6726272
6824397
6847447
7484490
7653451
7714233
7937281
8122604
8161643
9023092
10689846
11678058
11761419
15138971
15160669
15334025
17434635
19098677
19282313
D001282 D004077 Atrial Flutter marker/mechanism
therapeutic
5020716
7937281
8407013
8957602
20093999
D018880 D004077 Atrial Premature Complexes marker/mechanism
66122
D054537 D004077 Atrioventricular Block marker/mechanism
66122
319642
4255107
5020716
5030650
5031735
7226934
9505930
15334025
19028199
D001321 D004077 Autistic Disorder marker/mechanism
14585753
D001327 D004077 Autoimmune Diseases therapeutic
21441909
C535438 D004077 Bidirectional tachycardia marker/mechanism
4781244
6831957
7082511
7451788
7782630
9023092
9548072
D001919 D004077 Bradycardia marker/mechanism
82842
1997018
2495120
2715933
3334799
7070893
7226934
7346740
8161643
9429088
9674488
15334025
16032632
D001927 D004077 Brain Diseases marker/mechanism
7714233
D002037 D004077 Bundle-Branch Block marker/mechanism
97948
2495120
3729077
16032632
D006332 D004077 Cardiomegaly marker/mechanism
19687166
D009202 D004077 Cardiomyopathies therapeutic
589261
7103641
7573102
D002311 D004077 Cardiomyopathy, Dilated therapeutic
2722306
9838955
D002318 D004077 Cardiovascular Diseases therapeutic
9846537
D002526 D004077 Cerebellar Diseases marker/mechanism
5440585
D002598 D004077 Chagas Cardiomyopathy therapeutic
16764726
D002639 D004077 Cheyne-Stokes Respiration marker/mechanism
5440585
D002819 D004077 Chorea marker/mechanism
3382897
6726272
10495059
D003072 D004077 Cognition Disorders marker/mechanism
8134536
17078259
D003117 D004077 Color Vision Defects marker/mechanism
1771077
6654298
6973045
7283806
7816418
12386084
D003128 D004077 COMA marker/mechanism
5440585
D003221 D004077 Confusion marker/mechanism
1965965
6847447
D003324 D004077 Coronary Artery Disease therapeutic
758516
D003329 D004077 Coronary Vasospasm marker/mechanism
7810184
D003645 D004077 Death, Sudden marker/mechanism
10437870
D003680 D004077 Deglutition Disorders marker/mechanism
2039889
3742345
D003693 D004077 Delirium marker/mechanism
618505
8134536
D003704 D004077 Dementia marker/mechanism
17326274
D003866 D004077 Depressive Disorder marker/mechanism
6719535
7714233
8077083
D003967 D004077 Diarrhea marker/mechanism
9220047
20466255
D004244 D004077 Dizziness marker/mechanism
11678058
D056486 D004077 Drug-Induced Liver Injury marker/mechanism
1479182
22331495
D062787 D004077 Drug Overdose marker/mechanism
9667338
D064420 D004077 Drug-Related Side Effects and Adverse Reactions marker/mechanism
11808
140932
533394
702246
3334799
3976714
4003251
4255107
4418514
4668629
4781244
5020716
5030650
5071802
6409240
7110822
7226934
7283806
7320392
7837314
8113441
8338474
8993214
9220047
9357092
9548072
9727817
12701389
16594604
20466255
D004374 D004077 Ductus Arteriosus, Patent therapeutic
6880719
7070893
D055154 D004077 Dysphonia marker/mechanism
2039889
D004417 D004077 Dyspnea marker/mechanism
12078937
16032632
D001068 D004077 Eating Disorders marker/mechanism
618505
D004437 D004077 Ebstein Anomaly therapeutic
4819255
D004487 D004077 Edema marker/mechanism
16032632
D007172 D004077 Erectile Dysfunction marker/mechanism
9554348
D058447 D004077 Eye Pain marker/mechanism
1532600
D005221 D004077 Fatigue marker/mechanism
11496033
D005315 D004077 Fetal Diseases therapeutic
14745562
D006212 D004077 Hallucinations marker/mechanism
517886
6847447
D006323 D004077 Heart Arrest marker/mechanism
1958605
2912410
3179159
3544756
3663292
4251179
5764970
6992826
9667338
12921933
D006327 D004077 Heart Block marker/mechanism
1997018
5009479
5031735
5440585
5823016
6831957
7082511
7346740
7398422
9493887
12181225
D006331 D004077 Heart Diseases marker/mechanism
therapeutic
588806
6695683
D006333 D004077 Heart Failure marker/mechanism
therapeutic
517886
642984
1632402
1696671
2277481
3004211
3075397
3813644
4255107
6630284
6704950
6798885
6847447
7202043
7359592
7398145
7560247
7714233
7728813
8161643
8409069
8561216
8614419
9123633
9818470
11477829
11496033
12365708
12723015
16764726
19282313
21516734
D006505 D004077 Hepatitis marker/mechanism
12243603
D006947 D004077 Hyperkalemia marker/mechanism
1997018
16032632
D006973 D004077 Hypertension therapeutic
9772400
11016824
D007008 D004077 Hypokalemia marker/mechanism
1259829
2311237
6603084
D007022 D004077 Hypotension marker/mechanism
9429088
11016824
D007232 D004077 Infant, Newborn, Diseases marker/mechanism
7070893
D007235 D004077 Infant, Premature, Diseases therapeutic
6880719
D007859 D004077 Learning Disorders marker/mechanism
6415737
D053609 D004077 Lethargy marker/mechanism
3588469
D008133 D004077 Long QT Syndrome marker/mechanism
3271390
D008173 D004077 Lung Diseases, Obstructive therapeutic
11150940
D008275 D004077 Magnesium Deficiency marker/mechanism
2311237
D008569 D004077 Memory Disorders marker/mechanism
618505
6415737
D001523 D004077 Mental Disorders marker/mechanism
1735661
3565623
D008944 D004077 Mitral Valve Insufficiency therapeutic
5440585
6847447
9838955
D019964 D004077 Mood Disorders marker/mechanism
618505
D009325 D004077 Nausea marker/mechanism
2495120
3709557
6726272
9220047
11496033
11678058
16032632
20466255
D009369 D004077 Neoplasms therapeutic
18701493
D009410 D004077 Nerve Degeneration marker/mechanism
12562015
D009759 D004077 Nystagmus, Pathologic marker/mechanism
5440585
D000857 D004077 Olfaction Disorders marker/mechanism
16730151
D009901 D004077 Optic Nerve Diseases marker/mechanism
12365708
D010146 D004077 Pain marker/mechanism
4687265
D010259 D004077 Paranoid Disorders marker/mechanism
3588469
D010554 D004077 Personality Disorders marker/mechanism
7714233
D011596 D004077 Psychomotor Disorders marker/mechanism
11496033
D011654 D004077 Pulmonary Edema therapeutic
6374055
D051437 D004077 Renal Insufficiency marker/mechanism
9155634
D012206 D004077 Rhabdomyolysis marker/mechanism
11149552
12243603
D012640 D004077 Seizures marker/mechanism
1665475
1958605
6405441
6426855
D020018 D004077 Sexual Dysfunctions, Psychological marker/mechanism
2952803
7416947
D012804 D004077 Sick Sinus Syndrome marker/mechanism
1132120
6409240
7206114
D012848 D004077 Sinoatrial Block marker/mechanism
7405294
D013375 D004077 Substance Withdrawal Syndrome marker/mechanism
9207619
D013610 D004077 Tachycardia marker/mechanism
therapeutic
1997018
2429280
3859260
6842789
16128378
D013612 D004077 Tachycardia, Ectopic Atrial marker/mechanism
3138054
D013613 D004077 Tachycardia, Ectopic Junctional marker/mechanism
7226934
9493887
12181225
D013614 D004077 Tachycardia, Paroxysmal marker/mechanism
5823016
7226934
7346740
D013617 D004077 Tachycardia, Supraventricular marker/mechanism
therapeutic
66122
2189795
3709557
3776866
3982906
4255107
5764970
6831957
6859944
7082511
7226934
7346740
7398422
7451788
14745562
20093999
D017180 D004077 Tachycardia, Ventricular marker/mechanism
61518
1013176
2446278
3138054
4255107
4711856
4810020
4954152
4965975
5764970
6173530
7226934
7398422
7837314
8444004
9220047
11761419
15138971
D016171 D004077 Torsades de Pointes marker/mechanism
1743800
6695683
D014277 D004077 Trigeminal Neuralgia marker/mechanism
758516
D018754 D004077 Ventricular Dysfunction therapeutic
3946163
D018487 D004077 Ventricular Dysfunction, Left therapeutic
7728813
9207619
D014693 D004077 Ventricular Fibrillation marker/mechanism
4088942
5041936
5676466
5764970
7110822
7202043
7295427
8532572
9667338
D018879 D004077 Ventricular Premature Complexes marker/mechanism
66122
4015280
4255107
4711856
4810020
5676466
5764970
7226934
11761419
D014786 D004077 Vision Disorders marker/mechanism
618505
1771077
8113441
9512168
11151114
12365708
16730151
20466255
D014839 D004077 Vomiting marker/mechanism
2495120
6726272
9220047
11678058
D015431 D004077 Weight Loss marker/mechanism
4521669
6847447