KNApSAcK Metabolite C00003644
Metabolite
KNApSAcK Entry
| id | C00003644 |
|---|---|
| Name | Androstenedione |
| CAS RN | 63-05-8 |
| Standard InChI | InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3 |
Cluster
| Phytochemical cluster | No. 54 |
|---|---|
| KCF-S cluster | No. 3537 |
Link
ChEMBL
| By standard InChI | CHEMBL274826 |
|---|---|
| By standard InChI Main Layer | CHEMBL274826 CHEMBL1596627 CHEMBL2140059 CHEMBL2311155 |
KEGG
| By LinkDB | C00280 |
|---|
CTD
| By CAS RN | D000735 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| Spermatophyta | 1 |
Family
| family name | count |
|---|---|
| Pinaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Pinus sylvestris | 3349 | Pinaceae | Spermatophyta | Viridiplantae |
Human Protein / Gene in interaction
35 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q16637 | Survival motor neuron protein | Unclassified protein | CHEMBL274826 |
CHEMBL1613842
(2)
|
4 / 2 |
| Q99700 | Ataxin-2 | Unclassified protein | CHEMBL2140059 |
CHEMBL2114784
(1)
|
1 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | CHEMBL274826 |
CHEMBL1794499
(1)
|
2 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | CHEMBL274826 |
CHEMBL1794573
(1)
|
2 / 2 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | CHEMBL274826 |
CHEMBL1794524
(2)
CHEMBL1794552
(1)
|
0 / 0 |
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | CHEMBL274826 |
CHEMBL993349
(1)
|
0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL274826 |
CHEMBL1614544
(1)
|
11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | CHEMBL1596627 |
CHEMBL1614281
(1)
CHEMBL1614361
(1)
|
3 / 2 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | CHEMBL274826 |
CHEMBL1794371
(2)
|
0 / 0 |
| P31213 | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | Oxidoreductase | CHEMBL2311155 |
CHEMBL805431
(1)
|
1 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | CHEMBL274826 |
CHEMBL1614522
(1)
CHEMBL1614067
(1)
|
1 / 2 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | CHEMBL274826 |
CHEMBL1614166
(1)
|
1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL274826 |
CHEMBL1614458
(1)
|
0 / 0 |
| P04278 | Sex hormone-binding globulin | Secreted protein | CHEMBL274826 |
CHEMBL812631
(1)
CHEMBL858260
(1)
CHEMBL809266 (1) CHEMBL809276 (1) CHEMBL858262 (1) CHEMBL922711 (1) |
0 / 0 |
| P42330 | Aldo-keto reductase family 1 member C3 | Enzyme | CHEMBL274826 |
CHEMBL962456
(1)
CHEMBL962457
(1)
|
0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | CHEMBL274826 |
CHEMBL1794584
(1)
|
2 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL274826 |
CHEMBL2114843
(2)
|
0 / 0 |
| P18405 | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Oxidoreductase | CHEMBL2311155 |
CHEMBL804515
(1)
|
0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | CHEMBL274826 |
CHEMBL2114835
(1)
|
0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | CHEMBL2140059 |
CHEMBL2114788
(1)
|
0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | CHEMBL274826 |
CHEMBL1794382
(1)
CHEMBL1794456
(1)
|
0 / 1 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | CHEMBL274826 |
CHEMBL663242
(1)
CHEMBL662246
(1)
CHEMBL662257 (1) CHEMBL662259 (1) CHEMBL765531 (1) CHEMBL765534 (1) CHEMBL783021 (2) CHEMBL883669 (1) CHEMBL2014374 (1) |
2 / 2 |
| P37058 | Testosterone 17-beta-dehydrogenase 3 | Enzyme | CHEMBL274826 |
CHEMBL818799
(1)
CHEMBL820660
(1)
CHEMBL820661 (1) CHEMBL871638 (1) CHEMBL820667 (1) CHEMBL820668 (1) CHEMBL828612 (1) CHEMBL835415 (1) CHEMBL835420 (1) |
1 / 1 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL274826 |
CHEMBL1613808
(1)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL274826 |
CHEMBL1614227
(1)
|
3 / 3 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | CHEMBL274826 |
CHEMBL1614171
(1)
|
5 / 2 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | CHEMBL274826 |
CHEMBL2114842
(2)
|
0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | CHEMBL274826 |
CHEMBL1794364
(2)
|
1 / 1 |
| P08185 | Corticosteroid-binding globulin | Secreted protein | CHEMBL274826 |
CHEMBL665988
(1)
CHEMBL665989
(1)
CHEMBL665992 (1) CHEMBL665994 (1) CHEMBL665995 (1) CHEMBL840929 (1) CHEMBL665996 (1) CHEMBL665997 (1) CHEMBL858261 (1) |
1 / 1 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | CHEMBL274826 |
CHEMBL2114853
(1)
|
0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | CHEMBL274826 |
CHEMBL1794483
(1)
|
0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | CHEMBL274826 |
CHEMBL1614052
(1)
|
1 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL274826 |
CHEMBL2114890
(1)
|
0 / 0 |
| P10275 | Androgen receptor | NR3C4 | CHEMBL274826 |
CHEMBL1794321
(2)
|
3 / 4 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | CHEMBL274826 CHEMBL2140059 |
CHEMBL2354287
(2)
|
1 / 1 |
CTD interaction (48)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D000735 | 64240 |
ABCG5
STSL |
ATP-binding cassette, sub-family G (WHITE), member 5 | Androstenedione results in increased activity of [ABCG5 protein binds to ABCG8 protein] |
affects binding
/ increases activity |
protein |
17055487
|
| D000735 | 64241 |
ABCG8
GBD4 STSL |
ATP-binding cassette, sub-family G (WHITE), member 8 | Androstenedione results in increased activity of [ABCG5 protein binds to ABCG8 protein] |
affects binding
/ increases activity |
protein |
17055487
|
| D000735 | 8644 |
AKR1C3
DD3 DDX HA1753 HAKRB HAKRe HSD17B5 PGFS hluPGFS |
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) | AKR1C3 protein results in increased metabolism of Androstenedione |
increases metabolic processing
|
protein |
19010312
|
| D000735 | 8644 |
AKR1C3
DD3 DDX HA1753 HAKRB HAKRe HSD17B5 PGFS hluPGFS |
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) | [AKR1C3 protein results in increased metabolism of Androstenedione] which results in increased chemical synthesis of Dihydrotestosterone |
increases chemical synthesis
/ increases metabolic processing |
protein |
19010312
|
| D000735 | 8644 |
AKR1C3
DD3 DDX HA1753 HAKRB HAKRe HSD17B5 PGFS hluPGFS |
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) | [AKR1C3 protein results in increased metabolism of Androstenedione] which results in increased chemical synthesis of Testosterone |
increases chemical synthesis
/ increases metabolic processing |
protein |
19010312
|
| D000735 | 8644 |
AKR1C3
DD3 DDX HA1753 HAKRB HAKRe HSD17B5 PGFS hluPGFS |
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) | AKR1C3 protein results in increased reduction of Androstenedione |
increases reduction
|
protein |
17950253
20036328 |
| D000735 | 8644 |
AKR1C3
DD3 DDX HA1753 HAKRB HAKRe HSD17B5 PGFS hluPGFS |
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) | [AKR1C3 protein results in increased reduction of Androstenedione] which results in increased chemical synthesis of Testosterone |
increases chemical synthesis
/ increases reduction |
protein |
20036328
|
| D000735 | 8644 |
AKR1C3
DD3 DDX HA1753 HAKRB HAKRe HSD17B5 PGFS hluPGFS |
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) | Indomethacin analog inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione] |
decreases reaction
/ increases reduction |
protein |
17950253
|
| D000735 | 8644 |
AKR1C3
DD3 DDX HA1753 HAKRB HAKRe HSD17B5 PGFS hluPGFS |
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) | Indomethacin inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione] |
decreases reaction
/ increases reduction |
protein |
17950253
|
| D000735 | 8644 |
AKR1C3
DD3 DDX HA1753 HAKRB HAKRe HSD17B5 PGFS hluPGFS |
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) | N-(4-chlorobenzoyl)melatonin inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione] |
decreases reaction
/ increases reduction |
protein |
17950253
|
| D000735 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | Androstenedione binds to and results in increased activity of AR protein |
affects binding
/ increases activity |
protein |
12730620
15336702 17804755 |
| D000735 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | Androstenedione inhibits the reaction [[Dihydrotestosterone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein] |
affects binding
/ decreases reaction / increases activity / increases expression |
protein |
15336702
|
| D000735 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | NCOA2 protein promotes the reaction [Androstenedione binds to and results in increased activity of AR protein] |
affects binding
/ increases activity / increases reaction |
protein |
15336702
|
| D000735 | 1387 |
CREBBP
CBP KAT3A RSTS |
CREB binding protein (EC:2.3.1.48) | Androstenedione results in increased activity of CREBBP protein |
increases activity
|
protein |
16467117
|
| D000735 | 1586 |
CYP17A1
CPT7 CYP17 P450C17 S17AH |
cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) | Androstenedione results in decreased expression of CYP17A1 mRNA |
decreases expression
|
mRNA |
15625562
|
| D000735 | 1586 |
CYP17A1
CPT7 CYP17 P450C17 S17AH |
cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) | CYP17A1 protein affects the abundance of Androstenedione |
affects abundance
|
protein |
21427057
|
| D000735 | 1586 |
CYP17A1
CPT7 CYP17 P450C17 S17AH |
cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) | CYP17A1 protein affects the chemical synthesis of Androstenedione |
affects chemical synthesis
|
protein |
14522586
15562394 16030167 |
| D000735 | 1586 |
CYP17A1
CPT7 CYP17 P450C17 S17AH |
cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) | TNF protein inhibits the reaction [CYP17A1 protein affects the chemical synthesis of Androstenedione] |
affects chemical synthesis
/ decreases reaction |
protein |
16030167
|
| D000735 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [CYP19A1 protein results in increased metabolism of Androstenedione] |
decreases reaction
/ increases metabolic processing |
protein |
22120136
|
| D000735 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | Atrazine promotes the reaction [CYP19A1 protein results in increased metabolism of Androstenedione] |
increases metabolic processing
/ increases reaction |
protein |
22120136
|
| D000735 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | bisphenol A affects the reaction [CYP19A1 protein results in increased metabolism of Androstenedione] |
affects reaction
/ increases metabolic processing |
protein |
22120136
|
| D000735 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | CYP19A1 protein affects the metabolism of Androstenedione |
affects metabolic processing
|
protein |
12628686
16030167 16033851 16054388 |
| D000735 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | CYP19A1 protein binds to and results in increased metabolism of Androstenedione |
affects binding
/ increases metabolic processing |
protein |
11522339
|
| D000735 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | CYP19A1 protein results in increased metabolism of Androstenedione |
increases metabolic processing
|
protein |
22120136
|
| D000735 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | Methoxychlor affects the reaction [CYP19A1 protein results in increased metabolism of Androstenedione] |
affects reaction
/ increases metabolic processing |
protein |
22120136
|
| D000735 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | Methyltestosterone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione] |
affects metabolic processing
/ decreases reaction |
protein |
12628686
|
| D000735 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | Nandrolone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione] |
affects metabolic processing
/ decreases reaction |
protein |
12628686
|
| D000735 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | Testosterone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione] |
affects metabolic processing
/ decreases reaction |
protein |
12628686
|
| D000735 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | TNF protein promotes the reaction [CYP19A1 protein affects the metabolism of Androstenedione] |
affects metabolic processing
/ increases reaction |
protein |
16030167
|
| D000735 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | trestolone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione] |
affects metabolic processing
/ decreases reaction |
protein |
12628686
|
| D000735 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | tributyltin inhibits the reaction [CYP19A1 protein binds to and results in increased metabolism of Androstenedione] |
affects binding
/ decreases reaction / increases metabolic processing |
protein |
11522339
|
| D000735 | 2938 |
GSTA1
GST2 GSTA1-1 GTH1 |
glutathione S-transferase alpha 1 (EC:2.5.1.18) | GSTA1 protein results in increased chemical synthesis of Androstenedione |
increases chemical synthesis
|
protein |
23650189
|
| D000735 | 2939 |
GSTA2
GST2 GSTA2-2 GTA2 GTH2 |
glutathione S-transferase alpha 2 (EC:2.5.1.18) | GSTA2 protein polymorphism results in decreased metabolism of Androstenedione |
decreases metabolic processing
|
protein |
15077012
|
| D000735 | 2940 |
GSTA3
GSTA3-3 GTA3 |
glutathione S-transferase alpha 3 (EC:2.5.1.18) | [GSTA3 protein affects the metabolism of 5-androstene-3,17-dione] which affects the chemical synthesis of Androstenedione |
affects chemical synthesis
/ affects metabolic processing |
protein |
18426392
|
| D000735 | 2940 |
GSTA3
GSTA3-3 GTA3 |
glutathione S-transferase alpha 3 (EC:2.5.1.18) | GSTA3 protein results in increased chemical synthesis of Androstenedione |
increases chemical synthesis
|
protein |
23650189
|
| D000735 | 3294 |
HSD17B2
EDH17B2 HSD17 SDR9C2 |
hydroxysteroid (17-beta) dehydrogenase 2 (EC:1.1.1.62 1.1.1.239) | HSD17B2 protein results in increased chemical synthesis of Androstenedione |
increases chemical synthesis
|
protein |
16054388
|
| D000735 | 3293 |
HSD17B3
EDH17B3 SDR12C2 |
hydroxysteroid (17-beta) dehydrogenase 3 (EC:1.1.1.64) | HSD17B3 protein results in increased metabolism of Androstenedione |
increases metabolic processing
|
protein |
17071532
|
| D000735 | 3283 |
HSD3B1
3BETAHSD HSD3B HSDB3 HSDB3A I SDR11E1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (EC:1.1.1.145 5.3.3.1) | HSD3B1 protein results in increased chemical synthesis of Androstenedione |
increases chemical synthesis
|
protein |
16054388
|
| D000735 | 354 |
KLK3
APS KLK2A1 PSA hK3 |
kallikrein-related peptidase 3 (EC:3.4.21.77) | Androstenedione inhibits the reaction [[Dihydrotestosterone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein] |
affects binding
/ decreases reaction / increases activity / increases expression |
protein |
15336702
|
| D000735 | 3972 |
LHB
CGB4 LSH-B hLHB |
luteinizing hormone beta polypeptide | LHB protein results in increased abundance of Androstenedione |
increases abundance
|
protein |
23433069
|
| D000735 | 2475 |
MTOR
FRAP FRAP1 FRAP2 RAFT1 RAPT1 |
mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) | Androstenedione affects the activity of MTOR protein |
affects activity
|
protein |
16033851
|
| D000735 | 2475 |
MTOR
FRAP FRAP1 FRAP2 RAFT1 RAPT1 |
mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) | everolimus inhibits the reaction [Androstenedione affects the activity of MTOR protein] |
affects activity
/ decreases reaction |
protein |
16033851
|
| D000735 | 2475 |
MTOR
FRAP FRAP1 FRAP2 RAFT1 RAPT1 |
mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) | [letrozole co-treated with everolimus] inhibits the reaction [Androstenedione affects the activity of MTOR protein] |
affects activity
/ affects cotreatment / decreases reaction |
protein |
16033851
|
| D000735 | 2475 |
MTOR
FRAP FRAP1 FRAP2 RAFT1 RAPT1 |
mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) | letrozole inhibits the reaction [Androstenedione affects the activity of MTOR protein] |
affects activity
/ decreases reaction |
protein |
16033851
|
| D000735 | 10499 |
NCOA2
GRIP1 KAT13C NCoA-2 SRC2 TIF2 bHLHe75 |
nuclear receptor coactivator 2 | NCOA2 protein promotes the reaction [Androstenedione binds to and results in increased activity of AR protein] |
affects binding
/ increases activity / increases reaction |
protein |
15336702
|
| D000735 | 8202 |
NCOA3
ACTR AIB-1 AIB1 CAGH16 CTG26 KAT13B RAC3 SRC-3 SRC3 TNRC14 TNRC16 TRAM-1 bHLHe42 pCIP |
nuclear receptor coactivator 3 (EC:2.3.1.48) | Androstenedione results in increased activity of NCOA3 protein |
increases activity
|
protein |
16467117
|
| D000735 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | TNF protein inhibits the reaction [CYP17A1 protein affects the chemical synthesis of Androstenedione] |
affects chemical synthesis
/ decreases reaction |
protein |
16030167
|
| D000735 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | TNF protein promotes the reaction [CYP19A1 protein affects the metabolism of Androstenedione] |
affects metabolic processing
/ increases reaction |
protein |
16030167
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (46)
| OMIM | preferred title | UniProt |
|---|---|---|
| #264300 | 17-beta hydroxysteroid dehydrogenase iii deficiency |
P37058
|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #611489 | Corticosteroid-binding globulin deficiency |
P08185
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #264600 | Pseudovaginal perineoscrotal hypospadias; ppsh |
P31213
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
KEGG DISEASE (31)
| KEGG | disease name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H01163 | Corticosteroid-binding globulin (CBG) deficiency |
P08185
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
P31213 (related) P37058 (related) |
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
Q16637 (related) |
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|