KCF-S cluster No. 3537 (3 metabolites)

Corresponding Phytochemical cluster No. 54

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (3)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	2
Spermatophyta	1

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Cumulative family count

class name	count
Meliaceae	2
Pinaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Androstane	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Androstane	C00280	C00003644

Metabolite list (3)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00003644	Androstenedione	CHEMBL274826 CHEMBL1596627 CHEMBL2140059 CHEMBL2311155	D000735	35 / 46 / 31	19 / 2
C00046996	6alpha-Hydroxyandrosta-1,4-diene-3,17-dione
C00047005	Androsta-1,4-diene-3,17-dione / (+)-Androsta-1,4-diene-3,17-dione	CHEMBL1078534 CHEMBL1554587	C006573	5 / 2 / 3

Human Protein / Gene in interactions

38 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00003644 C00047005	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00003644 C00047005	2 / 2
Q16637	Survival motor neuron protein	Unclassified protein	C00003644	4 / 1
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00003644	2 / 2
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00003644	0 / 0
O15245	Solute carrier family 22 member 1	Drug uniporter	C00003644	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00003644	11 / 10
P16473	Thyrotropin receptor	Glycohormone receptor	C00003644	3 / 2
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00003644	0 / 0
P31213	3-oxo-5-alpha-steroid 4-dehydrogenase 2	Oxidoreductase	C00003644	1 / 1
P54132	Bloom syndrome protein	Enzyme	C00003644	1 / 2
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00003644	1 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00003644	0 / 0
P04278	Sex hormone-binding globulin	Secreted protein	C00003644	0 / 0
P42330	Aldo-keto reductase family 1 member C3	Enzyme	C00003644	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00003644	2 / 0
O75496	Geminin	Unclassified protein	C00003644	0 / 0
P18405	3-oxo-5-alpha-steroid 4-dehydrogenase 1	Oxidoreductase	C00003644	0 / 0
P10145	Interleukin-8	Secreted protein	C00003644	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00003644	2 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00047005	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00003644	0 / 1
Q99700	Ataxin-2	Unclassified protein	C00003644	1 / 1
P37058	Testosterone 17-beta-dehydrogenase 3	Enzyme	C00003644	1 / 1
P28482	Mitogen-activated protein kinase 1	Erk	C00003644	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00003644	3 / 3
Q01453	Peripheral myelin protein 22	Unclassified protein	C00003644	5 / 2
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00003644	0 / 0
P03372	Estrogen receptor	NR3A1	C00003644	1 / 1
P08185	Corticosteroid-binding globulin	Secreted protein	C00003644	1 / 1
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00003644	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00047005	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00003644	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00003644	1 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003644	0 / 0
P10275	Androgen receptor	NR3C4	C00003644	3 / 4
P56937	3-keto-steroid reductase	Enzyme	C00047005	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00003644	1 / 1

19 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
64240	ABCG5, STSL	ATP-binding cassette, sub-family G (WHITE), member 5	C00003644
64241	ABCG8, GBD4, STSL	ATP-binding cassette, sub-family G (WHITE), member 8	C00003644
8644	AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS	aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357)	C00003644
367	AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM	androgen receptor	C00003644
1387	CREBBP, CBP, KAT3A, RSTS	CREB binding protein (EC:2.3.1.48)	C00003644
1586	CYP17A1, CPT7, CYP17, P450C17, S17AH	cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30)	C00003644
1588	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM	cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00003644
2938	GSTA1, GST2, GSTA1-1, GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	C00003644
2939	GSTA2, GST2, GSTA2-2, GTA2, GTH2	glutathione S-transferase alpha 2 (EC:2.5.1.18)	C00003644
2940	GSTA3, GSTA3-3, GTA3	glutathione S-transferase alpha 3 (EC:2.5.1.18)	C00003644
3294	HSD17B2, EDH17B2, HSD17, SDR9C2	hydroxysteroid (17-beta) dehydrogenase 2 (EC:1.1.1.62 1.1.1.239)	C00003644
3293	HSD17B3, EDH17B3, SDR12C2	hydroxysteroid (17-beta) dehydrogenase 3 (EC:1.1.1.64)	C00003644
3283	HSD3B1, 3BETAHSD, HSD3B, HSDB3, HSDB3A, I, SDR11E1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (EC:1.1.1.145 5.3.3.1)	C00003644
354	KLK3, APS, KLK2A1, PSA, hK3	kallikrein-related peptidase 3 (EC:3.4.21.77)	C00003644
3972	LHB, CGB4, LSH-B, hLHB	luteinizing hormone beta polypeptide	C00003644
2475	MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1	mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)	C00003644
10499	NCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75	nuclear receptor coactivator 2	C00003644
8202	NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP	nuclear receptor coactivator 3 (EC:2.3.1.48)	C00003644
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00003644

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions