PCIDB

KNApSAcK Metabolite C00003782

Metabolite

KNApSAcK Entry

id C00003782
Name Norbixin / diapocarotene-6,6'-dioic acid
CAS RN 542-40-5
Standard InChI InChI=1S/C24H28O4/c1-19(11-7-13-21(3)15-17-23(25)26)9-5-6-10-20(2)12-8-14-22(4)16-18-24(27)28/h5-18H,1-4H3,(H,25,26)(H,27,28)/b6-5+,11-7+,12-8+,17-15+,18-16+,19-9+,20-10+,21-13+,22-14+
Standard InChI (Main Layer) InChI=1S/C24H28O4/c1-19(11-7-13-21(3)15-17-23(25)26)9-5-6-10-20(2)12-8-14-22(4)16-18-24(27)28/h5-18H,1-4H3,(H,25,26)(H,27,28)

Cluster

Phytochemical cluster No. 38
KCF-S cluster No. 2563

Link

ChEMBL

By standard InChI CHEMBL1602127
By standard InChI Main Layer CHEMBL1420783 CHEMBL1602127

KEGG

By LinkDB C08608

CTD

By CAS RN C099823

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Bixaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Bixa orellana 66672 Bixaceae rosids Viridiplantae

Human Protein / Gene in interaction

12 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1420783 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL1602127 CHEMBL1794561 (1)
3 / 1
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL1602127 CHEMBL1613800 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL1602127 CHEMBL1614458 (1)
0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL1602127 CHEMBL1794293 (1)
5 / 3
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1602127 CHEMBL1613910 (1)
3 / 3
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL1420783 CHEMBL1602127 CHEMBL2114842 (2)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL1602127 CHEMBL1614240 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL1420783 CHEMBL1602127 CHEMBL1614211 (2)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1602127 CHEMBL2114890 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL1602127 CHEMBL1613829 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL1602127 CHEMBL1614364 (1)
1 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (15)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#137800 Glioma susceptibility 1; glm1 P37231
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#601665 Obesity P37231
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (10)

KEGG disease name UniProt
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)