PCIDB

KNApSAcK Metabolite C00000388

Metabolite

KNApSAcK Entry

id C00000388
Name AA / Arachidonic acid
CAS RN 506-32-1
Standard InChI InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-15-
Standard InChI (Main Layer) InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)

Cluster

Phytochemical cluster No. 50
KCF-S cluster No. 2002

Link

ChEMBL

By standard InChI CHEMBL15594
By standard InChI Main Layer CHEMBL7594 CHEMBL15594

KEGG

By LinkDB C00219

CTD

By CAS RN D016718

Species

Summary

Plant class

class name count

Family

family name count
Mortierellaceae 1
Ceramiaceae 1

List (4)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Mnium spp.
Mortierella alpina 64518 Mortierellaceae Fungi
Ptilota filicina 153248 Ceramiaceae Eukaryota
Scolopendrium vulgare

Human Protein / Gene in interaction

34 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL15594 CHEMBL1613992 (1)
7 / 44
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL15594 CHEMBL1014035 (1)
0 / 3
P15090 Fatty acid-binding protein, adipocyte Other cytosolic protein CHEMBL15594 CHEMBL641280 (1)
0 / 0
P29466 Caspase-1 C14 CHEMBL15594 CHEMBL1614158 (1)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL15594 CHEMBL1614331 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL15594 CHEMBL1614544 (1)
11 / 10
Q9UP65 Cytosolic phospholipase A2 gamma Enzyme CHEMBL15594 CHEMBL665920 (1)
0 / 0
Q16850 Lanosterol 14-alpha demethylase Cytochrome P450 51A1 CHEMBL15594 CHEMBL934981 (1)
0 / 0
P54132 Bloom syndrome protein Enzyme CHEMBL15594 CHEMBL1614067 (1)
1 / 2
P11473 Vitamin D3 receptor NR1I1 CHEMBL15594 CHEMBL1794311 (2)
2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL15594 CHEMBL1613800 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL15594 CHEMBL1614458 (2)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL15594 CHEMBL1738606 (2)
0 / 0
O00519 Fatty-acid amide hydrolase 1 Enzyme CHEMBL15594 CHEMBL938648 (1)
0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL15594 CHEMBL1614280 (1)
0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL15594 CHEMBL1794342 (1)
0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL15594 CHEMBL1963893 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL15594 CHEMBL1794467 (2)
0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 CHEMBL15594 CHEMBL976708 (1) CHEMBL976710 (1)
CHEMBL976711 (1)
2 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL7594 CHEMBL760387 (1)
5 / 3
P13726 Tissue factor Membrane receptor CHEMBL15594 CHEMBL995691 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL15594 CHEMBL1613910 (2)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL15594 CHEMBL1614038 (2)
2 / 2
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL15594 CHEMBL1614240 (2)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL15594 CHEMBL1614108 (2) CHEMBL1613886 (2)
0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL15594 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL15594 CHEMBL1614250 (2) CHEMBL1614421 (2)
CHEMBL1614502 (1)
4 / 3
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL15594 CHEMBL1794536 (2)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL15594 CHEMBL1613914 (2)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL15594 CHEMBL1613829 (2)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL15594 CHEMBL1738442 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL15594 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL15594 CHEMBL1614531 (2)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL15594 CHEMBL1614531 (2)
1 / 3

CTD interaction (337)

compound gene gene name gene description interaction interaction type form reference
pmid
D016718 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D016718 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D016718 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 Arachidonic Acid results in increased degradation of ABCA1 protein increases degradation
protein 16118212
D016718 8647 ABCB11
ABC16
BRIC2
BSEP
PFIC-2
PFIC2
PGY4
SPGP
ATP-binding cassette, sub-family B (MDR/TAP), member 11 Arachidonic Acid promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA] increases expression
/ increases reaction
mRNA 15307955
D016718 5825 ABCD3
ABC43
PMP70
PXMP1
ZWS2
ATP-binding cassette, sub-family D (ALD), member 3 Arachidonic Acid results in decreased expression of ABCD3 mRNA decreases expression
mRNA 16704987
D016718 9619 ABCG1
ABC8
WHITE1
ATP-binding cassette, sub-family G (WHITE), member 1 Arachidonic Acid results in decreased expression of ABCG1 mRNA decreases expression
mRNA 16730733
D016718 104 ADARB1
ADAR2
DRABA2
DRADA2
RED1
adenosine deaminase, RNA-specific, B1 (EC:3.5.4.37) Arachidonic Acid results in decreased expression of ADARB1 mRNA decreases expression
mRNA 16704987
D016718 196 AHR
bHLHe76
aryl hydrocarbon receptor AHR affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [PLA2G4A protein results in increased secretion of Arachidonic Acid]] affects reaction
/ increases reaction
/ increases secretion
19162293
D016718 239 ALOX12
12-LOX
12S-LOX
LOG12
arachidonate 12-lipoxygenase (EC:1.13.11.31) ALOX12 protein results in increased metabolism of Arachidonic Acid increases metabolic processing
protein 17027136
D016718 246 ALOX15
12-LOX
15-LOX-1
15LOX-1
arachidonate 15-lipoxygenase (EC:1.13.11.31 1.13.11.33) ALOX15 protein affects the metabolism of Arachidonic Acid affects metabolic processing
protein 8305483
D016718 246 ALOX15
12-LOX
15-LOX-1
15LOX-1
arachidonate 15-lipoxygenase (EC:1.13.11.31 1.13.11.33) [IL4 protein co-treated with Arachidonic Acid] results in increased activity of ALOX15 protein affects cotreatment
/ increases activity
protein 11861792
D016718 246 ALOX15
12-LOX
15-LOX-1
15LOX-1
arachidonate 15-lipoxygenase (EC:1.13.11.31 1.13.11.33) [IL4 protein co-treated with Arachidonic Acid] results in increased expression of ALOX15 mRNA affects cotreatment
/ increases expression
mRNA 11861792
D016718 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) ALOX5 protein results in increased metabolism of Arachidonic Acid increases metabolic processing
protein 18295198
D016718 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) Arachidonic Acid inhibits the reaction [L 708714 binds to ALOX5 protein] affects binding
/ decreases reaction
protein 7577949
D016718 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) CJ 13610 inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid] decreases reaction
/ increases metabolic processing
protein 18295198
D016718 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) zileuton inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid] decreases reaction
/ increases metabolic processing
protein 18295198
D016718 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) [zileuton results in decreased activity of ALOX5 protein] which affects the abundance of Arachidonic Acid affects abundance
/ decreases activity
protein 9495842
D016718 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) [zileuton results in decreased activity of ALOX5 protein] which results in decreased susceptibility to Arachidonic Acid decreases activity
/ decreases response to substance
protein 7592874
D016718 335 APOA1
apolipoprotein A-I Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D016718 335 APOA1
apolipoprotein A-I Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D016718 335 APOA1
apolipoprotein A-I Arachidonic Acid results in decreased expression of APOA1 mRNA decreases expression
mRNA 7983038
D016718 348 APOE
AD2
LDLCQ5
LPG
apolipoprotein E APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2] increases abundance
/ increases reaction
gene 20530721
D016718 348 APOE
AD2
LDLCQ5
LPG
apolipoprotein E Aspirin inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] decreases reaction
/ increases abundance
/ increases reaction
gene 20530721
D016718 348 APOE
AD2
LDLCQ5
LPG
apolipoprotein E dazoxiben inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] decreases reaction
/ increases abundance
/ increases reaction
gene 20530721
D016718 348 APOE
AD2
LDLCQ5
LPG
apolipoprotein E tempol inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] decreases reaction
/ increases abundance
/ increases reaction
gene 20530721
D016718 360 AQP3
AQP-3
GIL
aquaporin 3 (Gill blood group) Arachidonic Acid results in decreased expression of AQP3 mRNA decreases expression
mRNA 16704987
D016718 396 ARHGDIA
GDIA1
NPHS8
RHOGDI
RHOGDI-1
Rho GDP dissociation inhibitor (GDI) alpha Arachidonic Acid results in increased expression of ARHGDIA mRNA increases expression
mRNA 16704987
D016718 1386 ATF2
CRE-BP1
CREB2
HB16
TREB7
activating transcription factor 2 (EC:2.3.1.48) 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in increased phosphorylation of ATF2 protein] decreases reaction
/ increases phosphorylation
protein 19720122
D016718 1386 ATF2
CRE-BP1
CREB2
HB16
TREB7
activating transcription factor 2 (EC:2.3.1.48) Arachidonic Acid results in increased phosphorylation of ATF2 protein increases phosphorylation
protein 19720122
D016718 467 ATF3
activating transcription factor 3 Arachidonic Acid results in increased expression of ATF3 mRNA increases expression
mRNA 16704987
D016718 581 BAX
BCL2L4
BCL2-associated X protein 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid affects the localization of BAX protein] affects localization
/ decreases reaction
protein 19540902
D016718 581 BAX
BCL2L4
BCL2-associated X protein 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid affects the localization of BAX protein] affects localization
/ decreases reaction
protein 19540902
D016718 581 BAX
BCL2L4
BCL2-associated X protein anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Arachidonic Acid affects the localization of BAX protein] affects localization
/ decreases reaction
protein 19540902
D016718 581 BAX
BCL2L4
BCL2-associated X protein Arachidonic Acid affects the localization of BAX protein affects localization
protein 19540902
19720122
D016718 581 BAX
BCL2L4
BCL2-associated X protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arachidonic Acid affects the localization of BAX protein] affects localization
/ decreases reaction
protein 19540902
D016718 581 BAX
BCL2L4
BCL2-associated X protein MAPK14 mutant form inhibits the reaction [Arachidonic Acid affects the localization of BAX protein] affects localization
/ decreases reaction
protein 19540902
D016718 581 BAX
BCL2L4
BCL2-associated X protein MAPK8 mutant form inhibits the reaction [Arachidonic Acid affects the localization of BAX protein] affects localization
/ decreases reaction
protein 19540902
D016718 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
protein 19540902
D016718 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
protein 19540902
D016718 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
protein 19540902
D016718 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 [Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2 protein affects cotreatment
/ decreases expression
protein 19620254
D016718 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Arachidonic Acid results in decreased expression of BCL2 protein decreases expression
protein 19540902
19720122
D016718 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
protein 19540902
D016718 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 MAPK14 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
protein 19540902
D016718 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 MAPK8 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
protein 19540902
D016718 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 resveratrol inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2 protein] affects cotreatment
/ decreases expression
/ decreases reaction
protein 19620254
D016718 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein] decreases expression
/ decreases reaction
protein 19540902
D016718 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein] decreases expression
/ decreases reaction
protein 19540902
D016718 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein] decreases expression
/ decreases reaction
protein 19540902
D016718 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 [Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein affects cotreatment
/ decreases expression
protein 19620254
D016718 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 Arachidonic Acid results in decreased expression of BCL2L1 protein decreases expression
protein 19540902
19720122
D016718 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein] decreases expression
/ decreases reaction
protein 19540902
D016718 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 MAPK14 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein] decreases expression
/ decreases reaction
protein 19540902
D016718 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 MAPK8 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein] decreases expression
/ decreases reaction
protein 19540902
D016718 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 resveratrol inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein] affects cotreatment
/ decreases expression
/ decreases reaction
protein 19620254
D016718 627 BDNF
ANON2
BULN2
brain-derived neurotrophic factor Arachidonic Acid results in decreased expression of BDNF mRNA decreases expression
mRNA 16704987
D016718 637 BID
FP497
BH3 interacting domain death agonist Arachidonic Acid results in increased cleavage of BID protein increases cleavage
protein 19720122
D016718 637 BID
FP497
BH3 interacting domain death agonist FADD protein promotes the reaction [Arachidonic Acid results in increased cleavage of BID protein] increases cleavage
/ increases reaction
protein 19720122
D016718 11161 C14orf1
ERG28
NET51
chromosome 14 open reading frame 1 Arachidonic Acid results in decreased expression of C14ORF1 mRNA decreases expression
mRNA 16704987
D016718 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in increased degradation of CASP3 protein alternative form] decreases reaction
/ increases degradation
protein 19540902
D016718 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) [Arachidonic Acid co-treated with Iron] results in decreased expression of CASP3 protein affects cotreatment
/ decreases expression
protein 19620254
D016718 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Arachidonic Acid results in increased activity of CASP3 protein increases activity
protein 16704987
19720122
D016718 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Arachidonic Acid results in increased degradation of CASP3 protein alternative form increases degradation
protein 19540902
D016718 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) FADD protein promotes the reaction [Arachidonic Acid results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 19720122
D016718 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) resveratrol inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of CASP3 protein] affects cotreatment
/ decreases expression
/ decreases reaction
protein 19620254
D016718 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) Arachidonic Acid results in increased activity of CASP8 protein increases activity
protein 19720122
D016718 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) FADD protein promotes the reaction [Arachidonic Acid results in increased activity of CASP8 protein] increases activity
/ increases reaction
protein 19720122
D016718 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Arachidonic Acid results in increased activity of CASP9 protein increases activity
protein 19540902
19720122
D016718 958 CD40
Bp50
CDW40
TNFRSF5
p50
CD40 molecule, TNF receptor superfamily member 5 Arachidonic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA] decreases reaction
/ increases expression
mRNA 15684433
D016718 1066 CES1
ACAT
CE-1
CEH
CES2
HMSE
HMSE1
PCE-1
REH
SES1
TGH
hCE-1
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) Arachidonic Acid results in decreased activity of CES1 protein decreases activity
protein 19761868
D016718 1066 CES1
ACAT
CE-1
CEH
CES2
HMSE
HMSE1
PCE-1
REH
SES1
TGH
hCE-1
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) [CES1 protein results in increased hydrolysis of 2-arachidonylglycerol] which results in increased chemical synthesis of Arachidonic Acid increases chemical synthesis
/ increases hydrolysis
protein 21049984
D016718 8824 CES2
CE-2
CES2A1
PCE-2
iCE
carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) [CES2 protein results in increased hydrolysis of 2-arachidonylglycerol] which results in increased chemical synthesis of Arachidonic Acid increases chemical synthesis
/ increases hydrolysis
protein 21049984
D016718 1269 CNR2
CB-2
CB2
CX5
cannabinoid receptor 2 (macrophage) CNR2 protein affects the reaction [Arachidonic Acid results in increased expression of IL8 protein] affects reaction
/ increases expression
protein 15115777
D016718 80781 COL18A1
KNO
KNO1
KS
collagen, type XVIII, alpha 1 Arachidonic Acid results in decreased expression of COL18A1 mRNA decreases expression
mRNA 16704987
D016718 1374 CPT1A
CPT1
CPT1-L
L-CPT1
carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) Arachidonic Acid results in increased expression of CPT1A mRNA increases expression
mRNA 15307955
D016718 1445 CSK
c-src tyrosine kinase (EC:2.7.10.2) Arachidonic Acid affects the localization of CSK protein affects localization
protein 18388244
D016718 1445 CSK
c-src tyrosine kinase (EC:2.7.10.2) Arachidonic Acid results in increased activity of CSK protein increases activity
protein 18388244
D016718 10217 CTDSPL
C3orf8
HYA22
PSR1
RBSP3
SCP3
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like (EC:3.1.3.16) Arachidonic Acid results in decreased expression of CTDSPL mRNA decreases expression
mRNA 16704987
D016718 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic Arachidonic Acid affects the localization of CYCS protein affects localization
protein 19720122
D016718 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) CYP1A1 protein affects the metabolism of Arachidonic Acid affects metabolic processing
protein 15258110
D016718 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) Arachidonic Acid results in decreased activity of CYP1A2 protein decreases activity
protein 16978661
D016718 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) CYP1B1 protein affects the metabolism of Arachidonic Acid affects metabolic processing
protein 15258110
D016718 1557 CYP2C19
CPCJ
CYP2C
P450C2C
P450IIC19
cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) Arachidonic Acid results in decreased activity of CYP2C19 protein decreases activity
protein 16978661
D016718 1557 CYP2C19
CPCJ
CYP2C
P450C2C
P450IIC19
cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) CYP2C19 gene SNP affects the susceptibility to [Adenosine Diphosphate co-treated with Arachidonic Acid] affects cotreatment
/ affects response to substance
gene 18004210
D016718 1557 CYP2C19
CPCJ
CYP2C
P450C2C
P450IIC19
cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) CYP2C19 protein results in increased metabolism of [Arachidonic Acid co-treated with NADP] affects cotreatment
/ increases metabolic processing
protein 16978661
D016718 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) Arachidonic Acid results in decreased activity of CYP2C9 protein decreases activity
protein 16978661
D016718 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) CYP2C9 protein results in increased metabolism of [Arachidonic Acid co-treated with NADP] affects cotreatment
/ increases metabolic processing
protein 16978661
D016718 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) allyl sulfide inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]] affects cotreatment
/ decreases reaction
/ increases response to substance
protein 12086689
D016718 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) [Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein affects cotreatment
/ increases expression
protein 17034788
D016718 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein affects cotreatment
/ increases expression
protein 17034788
D016718 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein affects cotreatment
/ increases expression
protein 17034788
D016718 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Arachidonic Acid results in decreased activity of CYP2E1 protein decreases activity
protein 16978661
D016718 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Cadmium Chloride affects the reaction [CYP2E1 protein results in increased susceptibility to Arachidonic Acid] affects reaction
/ increases response to substance
protein 12566070
D016718 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid] affects cotreatment
/ increases response to substance
protein 12086689
D016718 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) CYP2E1 results in increased susceptibility to Arachidonic Acid increases response to substance
12566070
D016718 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) CYP2E1 results in increased susceptibility to [Arachidonic Acid co-treated with Zinc Sulfate] affects cotreatment
/ increases response to substance
12566070
D016718 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Ditiocarb inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]] affects cotreatment
/ decreases reaction
/ increases response to substance
protein 12086689
D016718 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]] affects cotreatment
/ decreases reaction
/ increases response to substance
protein 12086689
D016718 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Zinc Sulfate inhibits the reaction [CYP2E1 results in increased susceptibility to Arachidonic Acid] decreases reaction
/ increases response to substance
12566070
D016718 1573 CYP2J2
CPJ2
cytochrome P450, family 2, subfamily J, polypeptide 2 (EC:1.14.14.1) Arachidonic Acid inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole] decreases methylation
/ decreases reaction
protein 12386130
D016718 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) Arachidonic Acid results in decreased activity of CYP3A4 protein decreases activity
protein 16978661
D016718 54541 DDIT4
Dig2
REDD-1
REDD1
DNA-damage-inducible transcript 4 Arachidonic Acid results in increased expression of DDIT4 mRNA increases expression
mRNA 16704987
D016718 57062 DDX24
DEAD (Asp-Glu-Ala-Asp) box helicase 24 (EC:3.6.4.13) Arachidonic Acid results in decreased expression of DDX24 mRNA decreases expression
mRNA 16704987
D016718 1717 DHCR7
SLOS
7-dehydrocholesterol reductase (EC:1.3.1.21) Arachidonic Acid results in decreased expression of DHCR7 mRNA decreases expression
mRNA 16704987
D016718 10682 EBP
CDPX2
CHO2
CPX
CPXD
emopamil binding protein (sterol isomerase) (EC:5.3.3.5) Arachidonic Acid results in decreased expression of EBP mRNA decreases expression
mRNA 16704987
D016718 1958 EGR1
AT225
G0S30
KROX-24
NGFI-A
TIS8
ZIF-268
ZNF225
early growth response 1 Arachidonic Acid results in increased expression of EGR1 mRNA increases expression
mRNA 16704987
D016718 8772 FADD
MORT1
Fas (TNFRSF6)-associated via death domain FADD protein promotes the reaction [Arachidonic Acid results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 19720122
D016718 8772 FADD
MORT1
Fas (TNFRSF6)-associated via death domain FADD protein promotes the reaction [Arachidonic Acid results in increased activity of CASP8 protein] increases activity
/ increases reaction
protein 19720122
D016718 8772 FADD
MORT1
Fas (TNFRSF6)-associated via death domain FADD protein promotes the reaction [Arachidonic Acid results in increased cleavage of BID protein] increases cleavage
/ increases reaction
protein 19720122
D016718 9415 FADS2
D6D
DES6
FADSD6
LLCDL2
SLL0262
TU13
fatty acid desaturase 2 (EC:1.14.19.-) Arachidonic Acid results in decreased expression of FADS2 mRNA decreases expression
mRNA 21457203
D016718 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein] decreases reaction
/ increases expression
protein 19720122
D016718 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein] decreases reaction
/ increases expression
protein 19720122
D016718 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein] decreases reaction
/ increases expression
protein 19720122
D016718 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor Arachidonic Acid results in increased expression of FAS mRNA increases expression
mRNA 19720122
D016718 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor Arachidonic Acid results in increased expression of FAS protein increases expression
protein 19720122
D016718 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]] affects reaction
/ decreases reaction
/ increases expression
protein 19720122
D016718 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor JUN protein affects the reaction [Arachidonic Acid results in increased expression of FAS protein] affects reaction
/ increases expression
protein 19720122
D016718 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein] decreases reaction
/ increases expression
protein 19720122
D016718 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein] decreases reaction
/ increases expression
protein 19720122
D016718 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein] decreases reaction
/ increases expression
protein 19720122
D016718 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein] decreases reaction
/ increases expression
protein 19720122
D016718 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) Arachidonic Acid results in increased expression of FASLG mRNA increases expression
mRNA 19720122
D016718 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) Arachidonic Acid results in increased expression of FASLG protein increases expression
protein 19720122
D016718 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]] affects reaction
/ decreases reaction
/ increases expression
protein 19720122
D016718 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) JUN protein affects the reaction [Arachidonic Acid results in increased expression of FASLG protein] affects reaction
/ increases expression
protein 19720122
D016718 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein] decreases reaction
/ increases expression
protein 19720122
D016718 2261 FGFR3
ACH
CD333
CEK2
HSFGFR3EX
JTK4
fibroblast growth factor receptor 3 (EC:2.7.10.1) Arachidonic Acid results in decreased expression of FGFR3 mRNA decreases expression
mRNA 16704987
D016718 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Arachidonic Acid results in decreased phosphorylation of FOS protein decreases phosphorylation
protein 19720122
D016718 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Arachidonic Acid results in increased expression of FOS mRNA increases expression
mRNA 10864209
15878913
16704987
D016718 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of FOS mRNA] decreases reaction
/ increases expression
mRNA 10864209
D016718 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]] affects reaction
/ decreases reaction
/ increases expression
protein 19720122
D016718 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]] affects reaction
/ decreases reaction
/ increases expression
protein 19720122
D016718 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Arachidonic Acid results in increased expression of FOS mRNA] decreases reaction
/ increases expression
mRNA 10864209
D016718 8061 FOSL1
FRA
FRA1
fra-1
FOS-like antigen 1 Arachidonic Acid results in increased expression of FOSL1 mRNA increases expression
mRNA 16704987
D016718 2729 GCLC
GCL
GCS
GLCL
GLCLC
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) Arachidonic Acid results in increased activity of GCLC protein increases activity
protein 17092368
D016718 2729 GCLC
GCL
GCS
GLCL
GLCLC
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) Arachidonic Acid results in increased expression of GCLC mRNA increases expression
mRNA 16704987
17092368
D016718 2730 GCLM
GLCLR
glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) Arachidonic Acid results in increased expression of GCLM mRNA increases expression
mRNA 16704987
D016718 10007 GNPDA1
GNP1
GNPDA
GNPI
GPI
HLN
glucosamine-6-phosphate deaminase 1 (EC:3.5.99.6) Arachidonic Acid results in decreased expression of GNPDA1 mRNA decreases expression
mRNA 16704987
D016718 2876 GPX1
GPXD
GSHPX1
glutathione peroxidase 1 (EC:1.11.1.9) [Iodoacetates results in decreased activity of GPX1 protein] which affects the metabolism of Arachidonic Acid affects metabolic processing
/ decreases activity
protein 11115402
D016718 2879 GPX4
GPx-4
GSHPx-4
MCSP
PHGPx
snGPx
snPHGPx
glutathione peroxidase 4 (EC:1.11.1.12) Arachidonic Acid promotes the reaction [Sodium Selenite results in increased expression of and results in increased activity of GPX4 protein] increases activity
/ increases expression
/ increases reaction
protein 14642406
D016718 2879 GPX4
GPx-4
GSHPx-4
MCSP
PHGPx
snGPx
snPHGPx
glutathione peroxidase 4 (EC:1.11.1.12) [Iodoacetates results in decreased activity of GPX4 protein] which affects the metabolism of Arachidonic Acid affects metabolic processing
/ decreases activity
protein 11115402
D016718 2932 GSK3B
glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) [SB 216763 results in decreased activity of GSK3B protein] results in decreased susceptibility to [Arachidonic Acid co-treated with Iron] affects cotreatment
/ decreases activity
/ decreases response to substance
protein 19620254
D016718 3156 HMGCR
LDLCQ3
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) Arachidonic Acid results in decreased expression of HMGCR mRNA decreases expression
mRNA 16704987
D016718 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) Arachidonic Acid results in increased expression of HMOX1 mRNA increases expression
mRNA 16704987
17092368
D016718 9653 HS2ST1
dJ604K5.2
heparan sulfate 2-O-sulfotransferase 1 (EC:2.8.2.-) Arachidonic Acid results in decreased expression of HS2ST1 mRNA decreases expression
mRNA 16704987
D016718 51668 HSPB11
C1orf41
HSPCO34
IFT25
PP25
heat shock protein family B (small), member 11 Arachidonic Acid results in decreased expression of HSPB11 mRNA decreases expression
mRNA 16704987
D016718 3350 HTR1A
5-HT-1A
5-HT1A
5HT1a
ADRB2RL1
ADRBRL1
G-21
PFMCD
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Arachidonic Acid metabolite inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] decreases reaction
/ increases abundance
protein 11356925
D016718 3399 ID3
HEIR-1
bHLHb25
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein Arachidonic Acid results in decreased expression of ID3 mRNA decreases expression
mRNA 16704987
D016718 3422 IDI1
IPP1
IPPI1
isopentenyl-diphosphate delta isomerase 1 (EC:5.3.3.2) Arachidonic Acid results in decreased expression of IDI1 mRNA decreases expression
mRNA 16704987
D016718 3490 IGFBP7
AGM
FSTL2
IBP-7
IGFBP-7
IGFBP-7v
IGFBPRP1
MAC25
PSF
RAMSVPS
TAF
insulin-like growth factor binding protein 7 Arachidonic Acid results in decreased expression of IGFBP7 mRNA decreases expression
mRNA 16704987
D016718 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) Arachidonic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] decreases reaction
/ increases expression
mRNA 15684433
D016718 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta [Arachidonic Acid results in increased abundance of Dinoprostone] promotes the reaction [IL1B protein results in increased expression of PTGS2 protein] increases abundance
/ increases expression
/ increases reaction
protein 11112151
D016718 3565 IL4
BCGF-1
BCGF1
BSF-1
BSF1
IL-4
interleukin 4 [IL4 protein co-treated with Arachidonic Acid] results in increased activity of ALOX15 protein affects cotreatment
/ increases activity
protein 11861792
D016718 3565 IL4
BCGF-1
BCGF1
BSF-1
BSF1
IL-4
interleukin 4 [IL4 protein co-treated with Arachidonic Acid] results in increased expression of ALOX15 mRNA affects cotreatment
/ increases expression
protein 11861792
D016718 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Arachidonic Acid results in increased secretion of IL6 protein increases secretion
protein 20436887
21457203
D016718 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Arachidonic Acid results in increased secretion of IL8 protein increases secretion
protein 21457203
D016718 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 CNR2 protein affects the reaction [Arachidonic Acid results in increased expression of IL8 protein] affects reaction
/ increases expression
protein 15115777
D016718 10994 ILVBL
209L8
AHAS
ILV2H
ilvB (bacterial acetolactate synthase)-like (EC:2.2.1.-) Arachidonic Acid results in decreased expression of ILVBL mRNA decreases expression
mRNA 16704987
D016718 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin Arachidonic Acid promotes the reaction [Glucose results in increased secretion of INS protein] increases reaction
/ increases secretion
protein 17192482
D016718 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin Arachidonic Acid results in increased secretion of INS protein increases secretion
protein 17192482
D016718 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Arachidonic Acid results in increased secretion of INS protein] increases reaction
/ increases secretion
protein 17192482
D016718 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin phenidone promotes the reaction [Arachidonic Acid results in increased secretion of INS protein] increases reaction
/ increases secretion
protein 17192482
D016718 3670 ISL1
ISLET1
Isl-1
ISL LIM homeobox 1 Arachidonic Acid results in decreased expression of ISL1 mRNA decreases expression
mRNA 16704987
D016718 3674 ITGA2B
BDPLT16
BDPLT2
CD41
CD41B
GP2B
GPIIb
GT
GTA
HPA3
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) Arachidonic Acid results in increased expression of ITGA2B protein increases expression
protein 18413191
D016718 3674 ITGA2B
BDPLT16
BDPLT2
CD41
CD41B
GP2B
GPIIb
GT
GTA
HPA3
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein] decreases reaction
/ increases expression
protein 18413191
D016718 3674 ITGA2B
BDPLT16
BDPLT2
CD41
CD41B
GP2B
GPIIb
GT
GTA
HPA3
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]] decreases reaction
/ increases expression
protein 18413191
D016718 3655 ITGA6
CD49f
ITGA6B
VLA-6
integrin, alpha 6 Arachidonic Acid results in increased expression of ITGA6 mRNA increases expression
mRNA 16704987
D016718 3690 ITGB3
BDPLT16
BDPLT2
CD61
GP3A
GPIIIa
GT
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Arachidonic Acid results in increased expression of ITGB3 protein increases expression
protein 18413191
D016718 3690 ITGB3
BDPLT16
BDPLT2
CD61
GP3A
GPIIIa
GT
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein] decreases reaction
/ increases expression
protein 18413191
D016718 3690 ITGB3
BDPLT16
BDPLT2
CD61
GP3A
GPIIIa
GT
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]] decreases reaction
/ increases expression
protein 18413191
D016718 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Arachidonic Acid results in increased expression of and results in increased phosphorylation of JUN protein increases expression
/ increases phosphorylation
protein 16704987
D016718 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Arachidonic Acid results in increased expression of JUN mRNA increases expression
mRNA 16704987
D016718 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene JUN protein affects the reaction [Arachidonic Acid results in increased expression of FASLG protein] affects reaction
/ increases expression
protein 19720122
D016718 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene JUN protein affects the reaction [Arachidonic Acid results in increased expression of FAS protein] affects reaction
/ increases expression
protein 19720122
D016718 54207 KCNK10
K2p10.1
TREK-2
TREK2
potassium channel, subfamily K, member 10 Arachidonic Acid promotes the reaction [KCNK10 protein results in increased transport of Potassium] increases reaction
/ increases transport
protein 16075240
D016718 3776 KCNK2
K2p2.1
TPKC1
TREK
TREK-1
TREK1
hTREK-1c
hTREK-1e
potassium channel, subfamily K, member 2 Arachidonic Acid promotes the reaction [KCNK2 protein results in increased transport of Potassium] increases reaction
/ increases transport
protein 16075240
D016718 50801 KCNK4
K2p4.1
TRAAK
TRAAK1
potassium channel, subfamily K, member 4 Arachidonic Acid promotes the reaction [KCNK4 protein results in increased transport of Potassium] increases reaction
/ increases transport
protein 10767409
16075240
D016718 688 KLF5
BTEB2
CKLF
IKLF
Kruppel-like factor 5 (intestinal) Arachidonic Acid results in increased expression of KLF5 mRNA increases expression
mRNA 16704987
D016718 3827 KNG1
BDK
BK
KNG
kininogen 1 Arachidonic Acid inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA] decreases reaction
/ increases expression
mRNA 15307955
D016718 3875 KRT18
CYK18
K18
keratin 18 [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein affects cotreatment
/ increases expression
protein 17034788
D016718 3856 KRT8
CARD2
CK-8
CK8
CYK8
K2C8
K8
KO
keratin 8 [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein affects cotreatment
/ increases expression
protein 17034788
D016718 3949 LDLR
FH
FHC
LDLCQ2
low density lipoprotein receptor Aspirin inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] decreases reaction
/ increases abundance
/ increases reaction
gene 20530721
D016718 3949 LDLR
FH
FHC
LDLCQ2
low density lipoprotein receptor dazoxiben inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] decreases reaction
/ increases abundance
/ increases reaction
gene 20530721
D016718 3949 LDLR
FH
FHC
LDLCQ2
low density lipoprotein receptor LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2] increases abundance
/ increases reaction
gene 20530721
D016718 3949 LDLR
FH
FHC
LDLCQ2
low density lipoprotein receptor tempol inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] decreases reaction
/ increases abundance
/ increases reaction
gene 20530721
D016718 4047 LSS
OSC
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) (EC:5.4.99.7) Arachidonic Acid results in decreased expression of LSS mRNA decreases expression
mRNA 16704987
D016718 51747 LUC7L3
CRA
CREAP-1
CROP
LUC7A
OA48-18
hLuc7A
LUC7-like 3 (S. cerevisiae) Arachidonic Acid results in decreased expression of LUC7L3 mRNA decreases expression
mRNA 16704987
D016718 23764 MAFF
U-MAF
hMafF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F Arachidonic Acid results in increased expression of MAFF mRNA increases expression
mRNA 16704987
D016718 5604 MAP2K1
CFC3
MAPKK1
MEK1
MKK1
PRKMK1
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]] affects reaction
/ decreases reaction
/ increases expression
protein 19720122
D016718 5604 MAP2K1
CFC3
MAPKK1
MEK1
MKK1
PRKMK1
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]] affects reaction
/ decreases reaction
/ increases expression
protein 19720122
D016718 5604 MAP2K1
CFC3
MAPKK1
MEK1
MKK1
PRKMK1
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein] decreases reaction
/ increases expression
protein 19720122
D016718 5604 MAP2K1
CFC3
MAPKK1
MEK1
MKK1
PRKMK1
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein] decreases reaction
/ increases expression
protein 19720122
D016718 1432 MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
mitogen-activated protein kinase 14 (EC:2.7.11.24) MAPK14 mutant form inhibits the reaction [Arachidonic Acid affects the localization of BAX protein] affects localization
/ decreases reaction
mutant form 19540902
D016718 1432 MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
mitogen-activated protein kinase 14 (EC:2.7.11.24) MAPK14 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein] decreases expression
/ decreases reaction
mutant form 19540902
D016718 1432 MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
mitogen-activated protein kinase 14 (EC:2.7.11.24) MAPK14 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
mutant form 19540902
D016718 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) MAPK8 mutant form inhibits the reaction [Arachidonic Acid affects the localization of BAX protein] affects localization
/ decreases reaction
mutant form 19540902
D016718 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) MAPK8 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein] decreases expression
/ decreases reaction
mutant form 19540902
D016718 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) MAPK8 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
mutant form 19540902
D016718 4137 MAPT
DDPAC
FTDP-17
MAPTL
MSTD
MTBT1
MTBT2
PPND
TAU
microtubule-associated protein tau Arachidonic Acid results in increased phosphorylation of MAPT protein increases phosphorylation
protein 12605413
D016718 4137 MAPT
DDPAC
FTDP-17
MAPTL
MSTD
MTBT1
MTBT2
PPND
TAU
microtubule-associated protein tau Ro 31-8220 inhibits the reaction [Arachidonic Acid results in increased phosphorylation of MAPT protein] decreases reaction
/ increases phosphorylation
protein 12605413
D016718 4322 MMP13
CLG3
MANDP1
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) Arachidonic Acid results in increased expression of MMP13 mRNA increases expression
mRNA 16185265
D016718 4322 MMP13
CLG3
MANDP1
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) Arachidonic Acid results in increased secretion of MMP13 protein increases secretion
protein 16185265
D016718 4322 MMP13
CLG3
MANDP1
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) Isotretinoin inhibits the reaction [Arachidonic Acid results in increased expression of MMP13 mRNA] decreases reaction
/ increases expression
mRNA 16185265
D016718 4322 MMP13
CLG3
MANDP1
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) Isotretinoin inhibits the reaction [Arachidonic Acid results in increased secretion of MMP13 protein] decreases reaction
/ increases secretion
protein 16185265
D016718 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Arachidonic Acid results in increased expression of MMP2 mRNA increases expression
mRNA 16185265
D016718 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Arachidonic Acid results in increased secretion of MMP2 protein increases secretion
protein 16185265
D016718 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Isotretinoin inhibits the reaction [Arachidonic Acid results in increased expression of MMP2 mRNA] decreases reaction
/ increases expression
mRNA 16185265
D016718 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Isotretinoin inhibits the reaction [Arachidonic Acid results in increased secretion of MMP2 protein] decreases reaction
/ increases secretion
protein 16185265
D016718 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Arachidonic Acid results in increased expression of MMP9 mRNA increases expression
mRNA 16185265
D016718 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Arachidonic Acid results in increased secretion of MMP9 protein increases secretion
protein 16185265
D016718 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Isotretinoin inhibits the reaction [Arachidonic Acid results in increased expression of MMP9 mRNA] decreases reaction
/ increases expression
mRNA 16185265
D016718 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Isotretinoin inhibits the reaction [Arachidonic Acid results in increased secretion of MMP9 protein] decreases reaction
/ increases secretion
protein 16185265
D016718 4353 MPO
myeloperoxidase (EC:1.11.2.2) Arachidonic Acid results in increased secretion of MPO protein increases secretion
protein 3111576
D016718 4502 MT2A
MT2
metallothionein 2A Arachidonic Acid promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA] increases expression
/ increases reaction
mRNA 12566070
D016718 653361 NCF1
NCF1A
NOXO2
SH3PXD1A
p47phox
neutrophil cytosolic factor 1 Adiponectin inhibits the reaction [Arachidonic Acid results in increased localization of NCF1 protein] decreases reaction
/ increases localization
protein 20832062
D016718 653361 NCF1
NCF1A
NOXO2
SH3PXD1A
p47phox
neutrophil cytosolic factor 1 Arachidonic Acid affects the reaction [Zymosan analog affects the localization of NCF1 protein] affects localization
/ affects reaction
protein 12101222
D016718 653361 NCF1
NCF1A
NOXO2
SH3PXD1A
p47phox
neutrophil cytosolic factor 1 Arachidonic Acid results in increased localization of NCF1 protein increases localization
protein 20832062
D016718 4688 NCF2
NCF-2
NOXA2
P67-PHOX
P67PHOX
neutrophil cytosolic factor 2 Arachidonic Acid affects the reaction [Zymosan analog affects the localization of NCF2 protein] affects localization
/ affects reaction
protein 12101222
D016718 27035 NOX1
GP91-2
MOX1
NOH-1
NOH1
NADPH oxidase 1 Arachidonic Acid results in increased cleavage of and results in increased secretion of NOX1 protein increases cleavage
/ increases secretion
protein 20832062
D016718 27035 NOX1
GP91-2
MOX1
NOH-1
NOH1
NADPH oxidase 1 Cholesterol, LDL affects the reaction [Adiponectin inhibits the reaction [Arachidonic Acid results in increased cleavage of NOX1 protein]] affects reaction
/ decreases reaction
/ increases cleavage
protein 20832062
D016718 9971 NR1H4
BAR
FXR
HRR-1
HRR1
RIP14
nuclear receptor subfamily 1, group H, member 4 Arachidonic Acid binds to NR1H4 protein affects binding
protein 15307955
D016718 9971 NR1H4
BAR
FXR
HRR-1
HRR1
RIP14
nuclear receptor subfamily 1, group H, member 4 Arachidonic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] decreases reaction
/ increases activity
protein 15307955
D016718 7025 NR2F1
COUP-TFI
EAR-3
EAR3
ERBAL3
NR2F2
SVP44
TCFCOUP1
TFCOUP1
nuclear receptor subfamily 2, group F, member 1 Arachidonic Acid results in decreased expression of NR2F1 mRNA decreases expression
mRNA 16704987
D016718 4929 NR4A2
HZF-3
NOT
NURR1
RNR1
TINUR
nuclear receptor subfamily 4, group A, member 2 Arachidonic Acid results in decreased expression of NR4A2 mRNA decreases expression
mRNA 16704987
D016718 4902 NRTN
NTN
neurturin Arachidonic Acid results in decreased expression of NRTN mRNA decreases expression
mRNA 16704987
D016718 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in increased cleavage of PARP1 protein] decreases reaction
/ increases cleavage
protein 19540902
D016718 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Arachidonic Acid results in increased cleavage of PARP1 protein increases cleavage
protein 19540902
21132278
D016718 9659 PDE4DIP
CMYA2
MMGL
phosphodiesterase 4D interacting protein Arachidonic Acid results in decreased expression of PDE4DIP mRNA decreases expression
mRNA 16704987
D016718 57107 PDSS2
C6orf210
COQ10D3
DLP1
bA59I9.3
hDLP1
prenyl (decaprenyl) diphosphate synthase, subunit 2 (EC:2.5.1.91) Arachidonic Acid results in decreased expression of PDSS2 mRNA decreases expression
mRNA 16704987
D016718 22822 PHLDA1
DT1P1B11
PHRIP
TDAG51
pleckstrin homology-like domain, family A, member 1 Arachidonic Acid results in increased expression of PHLDA1 mRNA increases expression
mRNA 16704987
D016718 5321 PLA2G4A
PLA2G4
cPLA2-alpha
phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) AHR affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [PLA2G4A protein results in increased secretion of Arachidonic Acid]] affects reaction
/ increases reaction
/ increases secretion
protein 19162293
D016718 5321 PLA2G4A
PLA2G4
cPLA2-alpha
phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) Arachidonic Acid results in increased expression of PLA2G4A mRNA increases expression
mRNA 15878913
D016718 5321 PLA2G4A
PLA2G4
cPLA2-alpha
phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) Arachidonic Acid results in increased expression of PLA2G4A protein increases expression
protein 15878913
D016718 5321 PLA2G4A
PLA2G4
cPLA2-alpha
phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) Dinoprostone promotes the reaction [Arachidonic Acid results in increased expression of PLA2G4A mRNA] increases expression
/ increases reaction
mRNA 15878913
D016718 5321 PLA2G4A
PLA2G4
cPLA2-alpha
phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PLA2G4A mRNA] decreases reaction
/ increases expression
mRNA 15878913
D016718 5322 PLA2G5
FRFB
GV-PLA2
PLA2-10
hVPLA(2)
phospholipase A2, group V (EC:3.1.1.4) PLA2G5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Arachidonic Acid] increases abundance
/ increases reaction
protein 9495842
D016718 5366 PMAIP1
APR
NOXA
phorbol-12-myristate-13-acetate-induced protein 1 Arachidonic Acid results in increased expression of PMAIP1 mRNA increases expression
mRNA 16704987
D016718 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) Arachidonic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] decreases reaction
/ increases hydrolysis
protein 15375178
D016718 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) Arachidonic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] decreases reaction
/ increases hydrolysis
protein 15375178
D016718 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) Arachidonic Acid results in decreased activity of PON1 protein decreases activity
protein 15375178
D016718 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha Arachidonic Acid binds to and results in increased activity of PPARA protein affects binding
/ increases activity
protein 10403814
15491415
D016718 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha Arachidonic Acid results in increased expression of PPARA mRNA increases expression
mRNA 11172467
D016718 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha Arachidonic Acid results in increased expression of PPARA protein increases expression
protein 11172467
D016718 5467 PPARD
FAAR
NR1C2
NUC1
NUCI
NUCII
PPARB
peroxisome proliferator-activated receptor delta Arachidonic Acid results in increased expression of PPARD mRNA increases expression
mRNA 11172467
D016718 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Arachidonic Acid results in decreased expression of PPARG mRNA decreases expression
mRNA 11172467
D016718 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Arachidonic Acid results in decreased expression of PPARG protein decreases expression
protein 11172467
D016718 100194835 Arachidonic Acid results in decreased expression of PRP4 mRNA decreases expression
mRNA 16704987
D016718 29968 PSAT1
EPIP
PSA
PSAT
phosphoserine aminotransferase 1 (EC:2.6.1.52) Arachidonic Acid results in increased expression of PSAT1 mRNA increases expression
mRNA 16704987
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Arachidonic Acid results in increased activity of PTGS1 protein increases activity
protein 19751497
21163909
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine increases activity
/ increases response to substance
protein 21163909
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine increases abundance
/ increases activity
/ increases response to substance
protein 21163909
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine increases activity
/ increases response to substance
protein 21163909
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine increases abundance
/ increases activity
/ increases response to substance
protein 21163909
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) arzanol inhibits the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid] decreases reaction
/ increases chemical synthesis
/ increases metabolic processing
protein 20933508
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) arzanol inhibits the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2] decreases reaction
/ increases chemical synthesis
/ increases metabolic processing
protein 20933508
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Aspirin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein] decreases reaction
/ increases activity
protein 21163909
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine] decreases reaction
/ increases activity
/ increases response to substance
protein 21163909
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) DuP 697 inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein] decreases reaction
/ increases activity
protein 21163909
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) PTGS1 protein alternative form results in increased metabolism of Arachidonic Acid increases metabolic processing
protein 16141368
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) PTGS1 protein results in increased metabolism of Arachidonic Acid increases metabolic processing
protein 16141368
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid increases chemical synthesis
/ increases metabolic processing
protein 20933508
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2 increases chemical synthesis
/ increases metabolic processing
protein 20933508
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) resveratrol inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein] decreases reaction
/ increases activity
protein 19751497
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) SC 560 inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein] decreases reaction
/ increases activity
protein 19751497
21163909
D016718 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) valerylsalicylate inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein] decreases reaction
/ increases activity
protein 19751497
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [ajulemic acid results in increased expression of PTGS2 mRNA] which results in increased secretion of Arachidonic Acid increases expression
/ increases secretion
mRNA 18840450
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Arachidonic Acid inhibits the reaction [5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone binds to and results in decreased activity of PTGS2 protein] affects binding
/ decreases activity
/ decreases reaction
protein 9146894
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Arachidonic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] decreases reaction
/ increases expression
mRNA 15684433
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [Arachidonic Acid results in increased abundance of Dinoprostone] promotes the reaction [IL1B protein results in increased expression of PTGS2 protein] increases abundance
/ increases expression
/ increases reaction
protein 11112151
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Arachidonic Acid results in increased activity of PTGS2 protein increases activity
protein 21163909
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine increases activity
/ increases response to substance
protein 21163909
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine increases abundance
/ increases activity
/ increases response to substance
protein 21163909
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine increases activity
/ increases response to substance
protein 21163909
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine increases abundance
/ increases activity
/ increases response to substance
protein 21163909
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Arachidonic Acid results in increased expression of PTGS2 mRNA increases expression
mRNA 15878913
17092368
18388244
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Arachidonic Acid results in increased expression of PTGS2 protein increases expression
protein 15878913
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Aspirin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS2 protein] decreases reaction
/ increases activity
protein 21163909
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine] decreases reaction
/ increases activity
/ increases response to substance
protein 21163909
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Dinoprostone promotes the reaction [Arachidonic Acid results in increased expression of PTGS2 mRNA] increases expression
/ increases reaction
mRNA 15878913
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PTGS2 mRNA] decreases reaction
/ increases expression
mRNA 15878913
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Ibuprofen inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid] decreases reaction
/ increases metabolic processing
protein 18297109
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) nimesulide inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid] decreases reaction
/ increases metabolic processing
protein 18297109
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [PTGS2 co-treated with Arachidonic Acid] results in increased expression of VEGFA affects cotreatment
/ increases expression
12821125
D016718 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) PTGS2 protein results in increased metabolism of Arachidonic Acid increases metabolic processing
protein 18297109
D016718 7803 PTP4A1
HH72
PRL-1
PRL1
PTP(CAAX1)
PTPCAAX1
protein tyrosine phosphatase type IVA, member 1 (EC:3.1.3.48) Arachidonic Acid results in increased expression of PTP4A1 mRNA increases expression
mRNA 16704987
D016718 9693 RAPGEF2
CNrasGEF
NRAPGEP
PDZ-GEF1
PDZGEF1
RA-GEF
RA-GEF-1
Rap-GEP
nRap_GEP
Rap guanine nucleotide exchange factor (GEF) 2 Arachidonic Acid results in increased expression of RAPGEF2 mRNA increases expression
mRNA 16704987
D016718 56729 RETN
ADSF
FIZZ3
RETN1
RSTN
XCP1
resistin Arachidonic Acid results in decreased expression of RETN mRNA decreases expression
mRNA 15949695
D016718 6319 SCD
FADS5
MSTP008
SCD1
SCDOS
stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) Arachidonic Acid results in increased expression of SCD mRNA increases expression
mRNA 21457203
D016718 6403 SELP
CD62
CD62P
GMP140
GRMP
LECAM3
PADGEM
PSEL
selectin P (granule membrane protein 140kDa, antigen CD62) Arachidonic Acid results in increased expression of SELP protein increases expression
protein 18413191
D016718 6403 SELP
CD62
CD62P
GMP140
GRMP
LECAM3
PADGEM
PSEL
selectin P (granule membrane protein 140kDa, antigen CD62) Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein] decreases reaction
/ increases expression
protein 17543677
18413191
D016718 6403 SELP
CD62
CD62P
GMP140
GRMP
LECAM3
PADGEM
PSEL
selectin P (granule membrane protein 140kDa, antigen CD62) Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]] decreases reaction
/ increases expression
protein 18413191
D016718 5055 SERPINB2
HsT1201
PAI
PAI-2
PAI2
PLANH2
serpin peptidase inhibitor, clade B (ovalbumin), member 2 Arachidonic Acid results in increased expression of SERPINB2 mRNA increases expression
mRNA 18388244
D016718 6502 SKP2
FBL1
FBXL1
FLB1
p45
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase Arachidonic Acid results in decreased expression of SKP2 mRNA decreases expression
mRNA 16704987
D016718 23657 SLC7A11
CCBR1
xCT
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 Arachidonic Acid results in increased expression of SLC7A11 mRNA increases expression
mRNA 16704987
D016718 6591 SNAI2
SLUG
SLUGH1
SNAIL2
WS2D
snail family zinc finger 2 Arachidonic Acid results in increased expression of SNAI2 mRNA increases expression
mRNA 16704987
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA] decreases reaction
/ increases expression
mRNA 12031898
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein] decreases reaction
/ increases expression
protein 12031898
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) [Arachidonic Acid results in increased abundance of Reactive Oxygen Species] which results in increased expression of SOD2 increases abundance
/ increases expression
12031898
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Arachidonic Acid results in increased expression of and results in increased activity of SOD2 protein increases activity
/ increases expression
protein 12031898
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Arachidonic Acid results in increased expression of SOD2 mRNA increases expression
mRNA 12031898
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) calphostin C inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA] decreases reaction
/ increases expression
mRNA 12031898
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) calphostin C inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein] decreases reaction
/ increases expression
protein 12031898
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Dactinomycin inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA] decreases reaction
/ increases expression
mRNA 12031898
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Indomethacin inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA] decreases reaction
/ increases expression
mRNA 12031898
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Indomethacin inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein] decreases reaction
/ increases expression
protein 12031898
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Masoprocol inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA] decreases reaction
/ increases expression
mRNA 12031898
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Masoprocol inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein] decreases reaction
/ increases expression
protein 12031898
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA] decreases reaction
/ increases expression
mRNA 12031898
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein] decreases reaction
/ increases expression
protein 12031898
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Phenols inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA] decreases reaction
/ increases expression
mRNA 12031898
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) pyrrolidine dithiocarbamic acid inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA] decreases reaction
/ increases expression
mRNA 12031898
D016718 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) pyrrolidine dithiocarbamic acid inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein] decreases reaction
/ increases expression
protein 12031898
D016718 6662 SOX9
CMD1
CMPD1
SRA1
SRY (sex determining region Y)-box 9 Arachidonic Acid results in decreased expression of SOX9 mRNA decreases expression
mRNA 16704987
D016718 6678 SPARC
ON
secreted protein, acidic, cysteine-rich (osteonectin) Arachidonic Acid results in decreased expression of SPARC mRNA decreases expression
mRNA 16704987
D016718 6683 SPAST
ADPSP
FSP2
SPG4
spastin (EC:3.6.4.3) Arachidonic Acid results in decreased expression of SPAST mRNA decreases expression
mRNA 16704987
D016718 8878 SQSTM1
A170
OSIL
PDB3
ZIP3
p60
p62
p62B
sequestosome 1 Arachidonic Acid results in increased expression of SQSTM1 mRNA increases expression
mRNA 16704987
D016718 23380 SRGAP2
ARHGAP34
FNBP2
SRGAP2A
SRGAP3
SLIT-ROBO Rho GTPase activating protein 2 Arachidonic Acid results in decreased expression of SRGAP2 mRNA decreases expression
mRNA 16704987
D016718 8614 STC2
STC-2
STCRP
stanniocalcin 2 Arachidonic Acid results in increased expression of STC2 mRNA increases expression
mRNA 16704987
D016718 6794 STK11
LKB1
PJS
hLKB1
serine/threonine kinase 11 (EC:2.7.11.1) STK11 protein affects the reaction [resveratrol results in decreased susceptibility to [Arachidonic Acid co-treated with Iron]] affects cotreatment
/ affects reaction
/ decreases response to substance
protein 19620254
D016718 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Arachidonic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] decreases reaction
/ increases expression
mRNA 15684433
D016718 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased secretion of Arachidonic Acid] decreases reaction
/ increases secretion
protein 1515551
D016718 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor TNF protein results in increased secretion of Arachidonic Acid increases secretion
protein 1515551
D016718 51330 TNFRSF12A
CD266
FN14
TWEAKR
tumor necrosis factor receptor superfamily, member 12A Arachidonic Acid results in increased expression of TNFRSF12A mRNA increases expression
mRNA 16704987
D016718 64759 TNS3
TEM6
TENS1
tensin 3 Arachidonic Acid results in decreased expression of TNS3 mRNA decreases expression
mRNA 16704987
D016718 7153 TOP2A
TOP2
TP2A
topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) Arachidonic Acid results in decreased expression of TOP2A mRNA decreases expression
mRNA 16704987
D016718 7223 TRPC4
HTRP-4
HTRP4
TRP4
transient receptor potential cation channel, subfamily C, member 4 TRPC4 protein affects the reaction [Arachidonic Acid results in increased transport of Calcium] affects reaction
/ increases transport
protein 11830588
D016718 59341 TRPV4
CMT2C
HMSN2C
OTRPC4
SMAL
SPSMA
SSQTL1
TRP12
VRL2
VROAC
transient receptor potential cation channel, subfamily V, member 4 Arachidonic Acid results in increased activity of TRPV4 protein increases activity
protein 20956320
D016718 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) UGT1A1 protein results in increased glucuronidation of Arachidonic Acid increases glucuronidation
protein 15231852
D016718 54575 UGT1A10
UDPGT
UGT-1J
UGT1-10
UGT1.10
UGT1J
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) UGT1A10 protein results in increased glucuronidation of Arachidonic Acid increases glucuronidation
protein 15231852
D016718 54659 UGT1A3
UDPGT
UDPGT_1-3
UGT-1C
UGT1-03
UGT1.3
UGT1C
UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) UGT1A3 protein results in increased glucuronidation of Arachidonic Acid increases glucuronidation
protein 15231852
D016718 54657 UGT1A4
HUG-BR2
UDPGT
UDPGT_1-4
UGT-1D
UGT1-04
UGT1.4
UGT1D
UDP glucuronosyltransferase 1 family, polypeptide A4 (EC:2.4.1.17) UGT1A4 protein results in increased glucuronidation of Arachidonic Acid increases glucuronidation
protein 15231852
D016718 54600 UGT1A9
HLUGP4
LUGP4
UDPGT
UDPGT_1-9
UGT-1I
UGT1-09
UGT1-9
UGT1.9
UGT1AI
UGT1I
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) UGT1A9 protein results in increased glucuronidation of Arachidonic Acid increases glucuronidation
protein 15231852
D016718 7364 UGT2B7
UDPGT_2B9
UDPGT2B7
UDPGTH2
UGT2B9
UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) UGT2B7 protein results in increased glucuronidation of Arachidonic Acid increases glucuronidation
protein 15231852
D016718 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Arachidonic Acid results in increased expression of VEGFA mRNA increases expression
mRNA 18388244
D016718 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A [PTGS2 co-treated with Arachidonic Acid] results in increased expression of VEGFA affects cotreatment
/ increases expression
12821125
D016718 7534 YWHAZ
14-3-3-zeta
KCIP-1
YWHAD
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide Arachidonic Acid results in increased expression of YWHAZ mRNA increases expression
mRNA 16704987
D016718 79413 ZBED2
zinc finger, BED-type containing 2 Arachidonic Acid results in decreased expression of ZBED2 mRNA decreases expression
mRNA 16704987

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (41)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#119900 Digital clubbing, isolated congenital P15428
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#601665 Obesity P37231
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (70)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

21 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000014 D016718 Abnormalities, Drug-Induced therapeutic
3141453
D000015 D016718 Abnormalities, Multiple marker/mechanism
20801906
D001321 D016718 Autistic Disorder marker/mechanism
18582451
D001919 D016718 Bradycardia marker/mechanism
6804092
D002318 D016718 Cardiovascular Diseases marker/mechanism
2730548
D019970 D016718 Cocaine-Related Disorders marker/mechanism
14500111
D019465 D016718 Craniofacial Abnormalities therapeutic
3141453
D004487 D016718 Edema marker/mechanism
7508328
7990266
9599246
9831321
11291777
11698051
15177302
16716910
20054000
21138055
21731166
D005334 D016718 Fever marker/mechanism
11852909
D005483 D016718 Flushing marker/mechanism
20417059
D006330 D016718 Heart Defects, Congenital marker/mechanism
20801906
D006470 D016718 Hemorrhage marker/mechanism
20801906
D006930 D016718 Hyperalgesia marker/mechanism
2128375
D007022 D016718 Hypotension marker/mechanism
1908582
6804092
D007249 D016718 Inflammation marker/mechanism
9831321
15177302
17371808
D009336 D016718 Necrosis marker/mechanism
12086689
12566070
D009436 D016718 Neural Tube Defects therapeutic
3141453
D010490 D016718 Pericardial Effusion marker/mechanism
20801906
D013923 D016718 Thromboembolism marker/mechanism
3114525
D013927 D016718 Thrombosis therapeutic
15990700
D014012 D016718 Tinnitus marker/mechanism
18632935