KCF-S cluster No. 2002 (5 metabolites)

Corresponding Phytochemical cluster No. 50


Plant Species


Cumulative plant class count

class name count
Viridiplantae 1

Cumulative family count

class name count
Ceramiaceae 3
Palmariaceae 1
Rhodomelaceae 1
Mortierellaceae 1
Gigartinaceae 1
Dumontiaceae 1

KEGG BRITE br08003 External link 512


Categories (1)

br08003 Category # of metabolite
Liner triterpenes 1

metabolites link (2)

br08003 Category KEGG ID KNApSAcK ID
Liner triterpenes C06428 C00000408
Liner triterpenes C06428 C00001215

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00000388 External link 512 AA
/ Arachidonic acid
CHEMBL7594
CHEMBL15594
D016718
34 / 41 / 70 153 / 21
C00000405 External link 512 Stearidonate
CHEMBL484430
C00000408 External link 512 EPA
/ Eicosapentaenoic acid
CHEMBL460026
12 / 12 / 10
C00000483 External link 512 Hexadeca-4,7,10,13-tetraenoic acid
/ 4,7,10,13-cis-Hexadecatetraenoic acid
C00001215 External link 512 (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoic acid
CHEMBL460026
D015118
12 / 12 / 10 36 / 17

Human Protein / Gene in interactions

37 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P00352 Retinal dehydrogenase 1 Enzyme C00000388 C00000408 C00001215 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000388 C00000408 C00001215 2 / 3
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000388 C00000408 C00001215 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00000388 C00000408 C00001215 0 / 0
P13726 Tissue factor Membrane receptor C00000388 C00000408 C00001215 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00000388 C00000408 C00001215 5 / 3
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000388 C00000408 C00001215 1 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000388 C00000408 C00001215 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00000388 C00000408 C00001215 2 / 2
Q9UGP5 DNA polymerase lambda Enzyme C00000408 C00001215 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00000408 C00001215 2 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00000408 C00001215 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00000388 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00000388 0 / 0
O00519 Fatty-acid amide hydrolase 1 Enzyme C00000388 0 / 0
P54132 Bloom syndrome protein Enzyme C00000388 1 / 2
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00000388 0 / 0
Q16850 Lanosterol 14-alpha demethylase Cytochrome P450 51A1 C00000388 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00000388 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00000388 0 / 0
Q9UP65 Cytosolic phospholipase A2 gamma Enzyme C00000388 0 / 0
P02545 Prelamin-A/C Unclassified protein C00000388 11 / 10
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00000388 0 / 0
P29466 Caspase-1 C14 C00000388 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000388 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000388 2 / 2
P16050 Arachidonate 15-lipoxygenase Enzyme C00000388 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000388 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000388 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000388 4 / 3
P15090 Fatty acid-binding protein, adipocyte Other cytosolic protein C00000388 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000388 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000388 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000388 0 / 3
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000388 1 / 1
O00255 Menin Unclassified protein C00000388 2 / 5
P04637 Cellular tumor antigen p53 Transcription Factor C00000388 7 / 37

168 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
19 ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD ATP-binding cassette, sub-family A (ABC1), member 1 C00000388 C00001215
9619 ABCG1, ABC8, WHITE1 ATP-binding cassette, sub-family G (WHITE), member 1 C00000388 C00001215
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000388 C00001215
56729 RETN, ADSF, FIZZ3, RETN1, RSTN, XCP1 resistin C00000388 C00001215
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000388 C00001215
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000388 C00001215
958 CD40, Bp50, CDW40, TNFRSF5, p50 CD40 molecule, TNF receptor superfamily member 5 C00000388 C00001215
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00000388 C00001215
5467 PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB peroxisome proliferator-activated receptor delta C00000388 C00001215
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000388 C00001215
1557 CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00000388 C00001215
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00000388 C00001215
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00000388 C00001215
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00000388 C00001215
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00000388 C00001215
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00000388 C00001215
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00000388 C00001215
3593 IL12B, CLMF, CLMF2, IL-12B, NKSF, NKSF2 interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) C00000388 C00001215
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00000388 C00001215
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00000388 C00001215
3565 IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 interleukin 4 C00000388 C00001215
4902 NRTN, NTN neurturin C00000388
3952 LEP, LEPD, OB, OBS leptin C00001215
778733 C00001215
117159 DCD, AIDD, DCD-1, DSEP, HCAP, PIF dermcidin C00001215
1535 CYBA, p22-PHOX cytochrome b-245, alpha polypeptide C00001215
1401 CRP, PTX1 C-reactive protein, pentraxin-related C00001215
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00001215
5683 PSMA2, HC3, MU, PMSA2, PSC2 proteasome (prosome, macropain) subunit, alpha type, 2 (EC:3.4.25.1) C00001215
5693 PSMB5, LMPX, MB1, X proteasome (prosome, macropain) subunit, beta type, 5 (EC:3.4.25.1) C00001215
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00001215
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00001215
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00001215
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00001215
6720 SREBF1, SREBP-1c, SREBP1, bHLHd1 sterol regulatory element binding transcription factor 1 C00001215
9370 ADIPOQ, ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28 adiponectin, C1Q and collagen domain containing C00001215
8647 ABCB11, ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP ATP-binding cassette, sub-family B (MDR/TAP), member 11 C00000388
5825 ABCD3, ABC43, PMP70, PXMP1, ZWS2 ATP-binding cassette, sub-family D (ALD), member 3 C00000388
104 ADARB1, ADAR2, DRABA2, DRADA2, RED1 adenosine deaminase, RNA-specific, B1 (EC:3.5.4.37) C00000388
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000388
239 ALOX12, 12-LOX, 12S-LOX, LOG12 arachidonate 12-lipoxygenase (EC:1.13.11.31) C00000388
246 ALOX15, 12-LOX, 15-LOX-1, 15LOX-1 arachidonate 15-lipoxygenase (EC:1.13.11.31 1.13.11.33) C00000388
240 ALOX5, 5-LO, 5-LOX, 5LPG, LOG5 arachidonate 5-lipoxygenase (EC:1.13.11.34) C00000388
335 APOA1 apolipoprotein A-I C00000388
348 APOE, AD2, LDLCQ5, LPG apolipoprotein E C00000388
360 AQP3, AQP-3, GIL aquaporin 3 (Gill blood group) C00000388
396 ARHGDIA, GDIA1, NPHS8, RHOGDI, RHOGDI-1 Rho GDP dissociation inhibitor (GDI) alpha C00000388
1386 ATF2, CRE-BP1, CREB2, HB16, TREB7 activating transcription factor 2 (EC:2.3.1.48) C00000388
467 ATF3 activating transcription factor 3 C00000388
581 BAX, BCL2L4 BCL2-associated X protein C00000388
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000388
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00000388
627 BDNF, ANON2, BULN2 brain-derived neurotrophic factor C00000388
637 BID, FP497 BH3 interacting domain death agonist C00000388
11161 C14orf1, ERG28, NET51 chromosome 14 open reading frame 1 C00000388
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00000388
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000388
1066 CES1, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1 carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) C00000388
8824 CES2, CE-2, CES2A1, PCE-2, iCE carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) C00000388
1269 CNR2, CB-2, CB2, CX5 cannabinoid receptor 2 (macrophage) C00000388
80781 COL18A1, KNO, KNO1, KS collagen, type XVIII, alpha 1 C00000388
1374 CPT1A, CPT1, CPT1-L, L-CPT1 carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) C00000388
1445 CSK c-src tyrosine kinase (EC:2.7.10.2) C00000388
10217 CTDSPL, C3orf8, HYA22, PSR1, RBSP3, SCP3 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like (EC:3.1.3.16) C00000388
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00000388
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000388
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00000388
1573 CYP2J2, CPJ2 cytochrome P450, family 2, subfamily J, polypeptide 2 (EC:1.14.14.1) C00000388
54541 DDIT4, Dig2, REDD-1, REDD1 DNA-damage-inducible transcript 4 C00000388
57062 DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 (EC:3.6.4.13) C00000388
1717 DHCR7, SLOS 7-dehydrocholesterol reductase (EC:1.3.1.21) C00000388
10682 EBP, CDPX2, CHO2, CPX, CPXD emopamil binding protein (sterol isomerase) (EC:5.3.3.5) C00000388
1958 EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 early growth response 1 C00000388
8772 FADD, MORT1 Fas (TNFRSF6)-associated via death domain C00000388
9415 FADS2, D6D, DES6, FADSD6, LLCDL2, SLL0262, TU13 fatty acid desaturase 2 (EC:1.14.19.-) C00000388
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00000388
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00000388
2261 FGFR3, ACH, CD333, CEK2, HSFGFR3EX, JTK4 fibroblast growth factor receptor 3 (EC:2.7.10.1) C00000388
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00000388
8061 FOSL1, FRA, FRA1, fra-1 FOS-like antigen 1 C00000388
2730 GCLM, GLCLR glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) C00000388
10007 GNPDA1, GNP1, GNPDA, GNPI, GPI, HLN glucosamine-6-phosphate deaminase 1 (EC:3.5.99.6) C00000388
2876 GPX1, GPXD, GSHPX1 glutathione peroxidase 1 (EC:1.11.1.9) C00000388
2879 GPX4, GPx-4, GSHPx-4, MCSP, PHGPx, snGPx, snPHGPx glutathione peroxidase 4 (EC:1.11.1.12) C00000388
2932 GSK3B glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) C00000388
3156 HMGCR, LDLCQ3 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) C00000388
9653 HS2ST1, dJ604K5.2 heparan sulfate 2-O-sulfotransferase 1 (EC:2.8.2.-) C00000388
51668 HSPB11, C1orf41, HSPCO34, IFT25, PP25 heat shock protein family B (small), member 11 C00000388
3350 HTR1A, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled C00000388
3399 ID3, HEIR-1, bHLHb25 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein C00000388
3422 IDI1, IPP1, IPPI1 isopentenyl-diphosphate delta isomerase 1 (EC:5.3.3.2) C00000388
3490 IGFBP7, AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF insulin-like growth factor binding protein 7 C00000388
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00000388
10994 ILVBL, 209L8, AHAS, ILV2H ilvB (bacterial acetolactate synthase)-like (EC:2.2.1.-) C00000388
3630 INS, IDDM2, ILPR, IRDN, MODY10 insulin C00000388
3670 ISL1, ISLET1, Isl-1 ISL LIM homeobox 1 C00000388
3674 ITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3 integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) C00000388
3655 ITGA6, CD49f, ITGA6B, VLA-6 integrin, alpha 6 C00000388
3690 ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) C00000388
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00000388
54207 KCNK10, K2p10.1, TREK-2, TREK2 potassium channel, subfamily K, member 10 C00000388
3776 KCNK2, K2p2.1, TPKC1, TREK, TREK-1, TREK1, hTREK-1c, hTREK-1e potassium channel, subfamily K, member 2 C00000388
50801 KCNK4, K2p4.1, TRAAK, TRAAK1 potassium channel, subfamily K, member 4 C00000388
688 KLF5, BTEB2, CKLF, IKLF Kruppel-like factor 5 (intestinal) C00000388
3827 KNG1, BDK, BK, KNG kininogen 1 C00000388
3875 KRT18, CYK18, K18 keratin 18 C00000388
3856 KRT8, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO keratin 8 C00000388
3949 LDLR, FH, FHC, LDLCQ2 low density lipoprotein receptor C00000388
4047 LSS, OSC lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) (EC:5.4.99.7) C00000388
51747 LUC7L3, CRA, CREAP-1, CROP, LUC7A, OA48-18, hLuc7A LUC7-like 3 (S. cerevisiae) C00000388
23764 MAFF, U-MAF, hMafF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F C00000388
5604 MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) C00000388
1432 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA mitogen-activated protein kinase 14 (EC:2.7.11.24) C00000388
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00000388
4137 MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU microtubule-associated protein tau C00000388
4322 MMP13, CLG3, MANDP1 matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) C00000388
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00000388
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00000388
4353 MPO myeloperoxidase (EC:1.11.2.2) C00000388
4502 MT2A, MT2 metallothionein 2A C00000388
653361 NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox neutrophil cytosolic factor 1 C00000388
4688 NCF2, NCF-2, NOXA2, P67-PHOX, P67PHOX neutrophil cytosolic factor 2 C00000388
27035 NOX1, GP91-2, MOX1, NOH-1, NOH1 NADPH oxidase 1 C00000388
9971 NR1H4, BAR, FXR, HRR-1, HRR1, RIP14 nuclear receptor subfamily 1, group H, member 4 C00000388
7025 NR2F1, COUP-TFI, EAR-3, EAR3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1 nuclear receptor subfamily 2, group F, member 1 C00000388
4929 NR4A2, HZF-3, NOT, NURR1, RNR1, TINUR nuclear receptor subfamily 4, group A, member 2 C00000388
3558 IL2, IL-2, TCGF, lymphokine interleukin 2 C00001215
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00000388
9659 PDE4DIP, CMYA2, MMGL phosphodiesterase 4D interacting protein C00000388
57107 PDSS2, C6orf210, COQ10D3, DLP1, bA59I9.3, hDLP1 prenyl (decaprenyl) diphosphate synthase, subunit 2 (EC:2.5.1.91) C00000388
22822 PHLDA1, DT1P1B11, PHRIP, TDAG51 pleckstrin homology-like domain, family A, member 1 C00000388
5321 PLA2G4A, PLA2G4, cPLA2-alpha phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) C00000388
5322 PLA2G5, FRFB, GV-PLA2, PLA2-10, hVPLA(2) phospholipase A2, group V (EC:3.1.1.4) C00000388
5366 PMAIP1, APR, NOXA phorbol-12-myristate-13-acetate-induced protein 1 C00000388
5444 PON1, ESA, MVCD5, PON paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) C00000388
100194835 C00000388
29968 PSAT1, EPIP, PSA, PSAT phosphoserine aminotransferase 1 (EC:2.6.1.52) C00000388
5742 PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000388
7803 PTP4A1, HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1 protein tyrosine phosphatase type IVA, member 1 (EC:3.1.3.48) C00000388
9693 RAPGEF2, CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, Rap-GEP, nRap_GEP Rap guanine nucleotide exchange factor (GEF) 2 C00000388
6319 SCD, FADS5, MSTP008, SCD1, SCDOS stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) C00000388
6403 SELP, CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL selectin P (granule membrane protein 140kDa, antigen CD62) C00000388
5055 SERPINB2, HsT1201, PAI, PAI-2, PAI2, PLANH2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 C00000388
6502 SKP2, FBL1, FBXL1, FLB1, p45 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase C00000388
23657 SLC7A11, CCBR1, xCT solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 C00000388
6591 SNAI2, SLUG, SLUGH1, SNAIL2, WS2D snail family zinc finger 2 C00000388
6648 SOD2, IPOB, MNSOD, MVCD6 superoxide dismutase 2, mitochondrial (EC:1.15.1.1) C00000388
6662 SOX9, CMD1, CMPD1, SRA1 SRY (sex determining region Y)-box 9 C00000388
6678 SPARC, ON secreted protein, acidic, cysteine-rich (osteonectin) C00000388
6683 SPAST, ADPSP, FSP2, SPG4 spastin (EC:3.6.4.3) C00000388
8878 SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B sequestosome 1 C00000388
23380 SRGAP2, ARHGAP34, FNBP2, SRGAP2A, SRGAP3 SLIT-ROBO Rho GTPase activating protein 2 C00000388
8614 STC2, STC-2, STCRP stanniocalcin 2 C00000388
6794 STK11, LKB1, PJS, hLKB1 serine/threonine kinase 11 (EC:2.7.11.1) C00000388
51330 TNFRSF12A, CD266, FN14, TWEAKR tumor necrosis factor receptor superfamily, member 12A C00000388
64759 TNS3, TEM6, TENS1 tensin 3 C00000388
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00000388
7223 TRPC4, HTRP-4, HTRP4, TRP4 transient receptor potential cation channel, subfamily C, member 4 C00000388
59341 TRPV4, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC transient receptor potential cation channel, subfamily V, member 4 C00000388
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00000388
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00000388
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00000388
54657 UGT1A4, HUG-BR2, UDPGT, UDPGT_1-4, UGT-1D, UGT1-04, UGT1.4, UGT1D UDP glucuronosyltransferase 1 family, polypeptide A4 (EC:2.4.1.17) C00000388
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00000388
7364 UGT2B7, UDPGT_2B9, UDPGT2B7, UDPGTH2, UGT2B9 UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) C00000388
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00000388
7534 YWHAZ, 14-3-3-zeta, KCIP-1, YWHAD tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide C00000388
79413 ZBED2 zinc finger, BED-type containing 2 C00000388

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (43)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#119900 Digital clubbing, isolated congenital P15428
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#601665 Obesity P37231
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (70)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

36 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002318 Cardiovascular Diseases C00001215
C00000388
D013927 Thrombosis C00001215
C00000388
D000015 Abnormalities, Multiple C00000388
D000743 Anemia, Hemolytic C00001215
D003327 Coronary Disease C00001215
D003866 Depressive Disorder C00001215
D050171 Dyslipidemias C00001215
D018149 Glucose Intolerance C00001215
D006973 Hypertension C00001215
D015228 Hypertriglyceridemia C00001215
D007333 Insulin Resistance C00001215
D007414 Intestinal Neoplasms C00001215
D048629 Micronuclei, Chromosome-Defective C00001215
D010146 Pain C00001215
D010300 Parkinson Disease C00001215
D012559 Schizophrenia C00001215
D001145 Arrhythmias, Cardiac C00001215
D000014 Abnormalities, Drug-Induced C00000388
D002114 Calcinosis C00001215
D001321 Autistic Disorder C00000388
D001919 Bradycardia C00000388
D019970 Cocaine-Related Disorders C00000388
D019465 Craniofacial Abnormalities C00000388
D004487 Edema C00000388
D005334 Fever C00000388
D005483 Flushing C00000388
D006330 Heart Defects, Congenital C00000388
D006470 Hemorrhage C00000388
D006930 Hyperalgesia C00000388
D007022 Hypotension C00000388
D007249 Inflammation C00000388
D009336 Necrosis C00000388
D009436 Neural Tube Defects C00000388
D010490 Pericardial Effusion C00000388
D013923 Thromboembolism C00000388
D014012 Tinnitus C00000388