KNApSAcK Metabolite C00039732
Metabolite
KNApSAcK Entry
| id | C00039732 |
|---|---|
| Name | Manoalide |
| CAS RN | 75088-80-1 |
| Standard InChI | InChI=1S/C25H36O5/c1-16(10-12-20-17(2)8-6-14-25(20,3)4)7-5-9-18-11-13-21(29-23(18)27)19-15-22(26)30-24(19)28/h7,11,15,21,23-24,27-28H,5-6,8-10,12-14H2,1-4H3/b16-7+/t21-,23-,24-/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C25H36O5/c1-16(10-12-20-17(2)8-6-14-25(20,3)4)7-5-9-18-11-13-21(29-23(18)27)19-15-22(26)30-24(19)28/h7,11,15,21,23-24,27-28H,5-6,8-10,12-14H2,1-4H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 1694 |
Link
ChEMBL
| By standard InChI | CHEMBL463914 |
|---|---|
| By standard InChI Main Layer | CHEMBL463914 CHEMBL497528 |
KEGG
| By LinkDB | C17156 |
|---|
CTD
| By CAS RN | C045673 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Thorectidae | 1 |
List (3)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Luffariaella variabilis | ||||
| Luffariella sp. | ||||
| Luffariella variabilis | 1162756 | Thorectidae | Metazoa |
Human Protein / Gene in interaction
4 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q9UNK4 | Group IID secretory phospholipase A2 | Enzyme | CHEMBL463914 |
CHEMBL818200
(1)
|
0 / 0 |
| P14555 | Phospholipase A2, membrane associated | Enzyme | CHEMBL463914 |
CHEMBL767139
(1)
CHEMBL767149
(1)
CHEMBL877989 (1) CHEMBL1005696 (1) CHEMBL1005697 (1) CHEMBL997269 (1) CHEMBL997270 (1) |
0 / 0 |
| P04054 | Phospholipase A2 | Enzyme | CHEMBL463914 |
CHEMBL761695
(1)
CHEMBL1024192
(1)
|
0 / 0 |
| Q9H2U1 | Probable ATP-dependent RNA helicase DHX36 | Enzyme | CHEMBL463914 |
CHEMBL2043709
(1)
|
0 / 0 |
CTD interaction (4)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C045673 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] |
decreases reaction
/ increases expression |
protein |
7575673
|
| C045673 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] |
decreases reaction
/ increases activity / increases expression |
protein |
7575673
|
| C045673 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | manoalide inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone] |
decreases reaction
/ increases activity / increases chemical synthesis / increases expression |
protein |
7575673
|
| C045673 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] |
decreases reaction
/ increases expression |
protein |
7575673
|