KNApSAcK Metabolite C00040142
Metabolite
KNApSAcK Entry
| id | C00040142 |
|---|---|
| Name | Radicicol / (+)-Radicicol |
| CAS RN | 12772-57-5 |
| Standard InChI | InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 981 |
Link
ChEMBL
| By standard InChI | CHEMBL414883 |
|---|---|
| By standard InChI Main Layer | CHEMBL414883 CHEMBL453974 CHEMBL453386 CHEMBL1596863 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | C035359 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Chaetomiaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Chaetomium chiversii | 155873 | Chaetomiaceae | Fungi |
Human Protein / Gene in interaction
44 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q9P1W9 | Serine/threonine-protein kinase pim-2 | Pim | CHEMBL453386 |
CHEMBL1004482
(1)
|
0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | CHEMBL453974 |
CHEMBL2114784
(1)
|
1 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | CHEMBL453386 |
CHEMBL1008495
(1)
|
0 / 3 |
| Q15759 | Mitogen-activated protein kinase 11 | p38 | CHEMBL453386 |
CHEMBL1004486
(1)
|
0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | CHEMBL453974 |
CHEMBL1614076
(1)
|
1 / 1 |
| Q9H2G2 | STE20-like serine/threonine-protein kinase | STE serine/threonine protein kinase SLK subfamily | CHEMBL453386 |
CHEMBL1004491
(1)
|
0 / 0 |
| Q16659 | Mitogen-activated protein kinase 6 | CMGC serine/threonine protein kinase ERK3 subfamily | CHEMBL453386 |
CHEMBL1004485
(1)
|
0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | CHEMBL453974 |
CHEMBL2354282
(1)
|
4 / 2 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | CHEMBL453386 |
CHEMBL1004481
(1)
|
0 / 0 |
| O00444 | Serine/threonine-protein kinase PLK4 | PLK serine/threonine protein kinase subfamily | CHEMBL453386 |
CHEMBL1004495
(1)
|
0 / 0 |
| Q9NQU5 | Serine/threonine-protein kinase PAK 6 | STE serine/threonine protein kinase PAKB subfamily | CHEMBL453386 |
CHEMBL1004496
(1)
|
0 / 0 |
| O75828 | Carbonyl reductase [NADPH] 3 | Enzyme | CHEMBL453386 |
CHEMBL1004501
(1)
CHEMBL1004502
(1)
CHEMBL1004503 (1) |
0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL1596863 |
CHEMBL1794311
(1)
|
2 / 3 |
| Q13188 | Serine/threonine-protein kinase 3 | STE serine/threonine protein kinase MST subfamily | CHEMBL453386 |
CHEMBL1004490
(1)
|
0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL1596863 |
CHEMBL1614458
(1)
|
0 / 0 |
| P07332 | Tyrosine-protein kinase Fes/Fps | Fer | CHEMBL453386 |
CHEMBL1004488
(1)
|
0 / 0 |
| P16152 | Carbonyl reductase [NADPH] 1 | Enzyme | CHEMBL453386 |
CHEMBL1004498
(1)
CHEMBL1004499
(1)
CHEMBL1004500 (1) CHEMBL1004505 (2) |
0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | CHEMBL453974 |
CHEMBL1794584
(1)
|
2 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL453974 |
CHEMBL2114843
(1)
CHEMBL2114780
(1)
|
0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | CHEMBL453974 |
CHEMBL1613838
(1)
|
0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | CHEMBL453974 |
CHEMBL2114788
(1)
|
0 / 0 |
| Q99683 | Mitogen-activated protein kinase kinase kinase 5 | Ste11 | CHEMBL453386 |
CHEMBL1004489
(1)
|
0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | CHEMBL453974 |
CHEMBL1794569
(1)
|
1 / 1 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | CHEMBL453974 |
CHEMBL1963863
(1)
|
0 / 0 |
| P52564 | Dual specificity mitogen-activated protein kinase kinase 6 | Ste7 | CHEMBL453386 |
CHEMBL1004493
(1)
|
0 / 0 |
| O14976 | Cyclin-G-associated kinase | NAK serine/threonine protein kinase subfamily | CHEMBL453386 |
CHEMBL1004484
(1)
|
0 / 0 |
| O94804 | Serine/threonine-protein kinase 10 | STE serine/threonine protein kinase SLK subfamily | CHEMBL453386 |
CHEMBL1004492
(1)
|
1 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL1596863 |
CHEMBL1614038
(1)
|
2 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL453974 |
CHEMBL1738588
(1)
|
0 / 0 |
| P08238 | Heat shock protein HSP 90-beta | Other cytosolic protein | CHEMBL453386 |
CHEMBL636772
(1)
CHEMBL863358
(1)
CHEMBL864232 (1) CHEMBL1020360 (2) CHEMBL1243494 (1) CHEMBL1243495 (1) |
0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | CHEMBL453974 |
CHEMBL1794483
(1)
|
0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | CHEMBL453974 |
CHEMBL1614052
(1)
|
1 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL453974 CHEMBL1596863 |
CHEMBL1614421
(2)
|
4 / 3 |
| Q96P20 | NACHT, LRR and PYD domains-containing protein 3 | Unclassified protein | CHEMBL453974 |
CHEMBL1737963
(1)
CHEMBL1738451
(1)
|
3 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL453974 |
CHEMBL2114908
(1)
|
0 / 0 |
| Q9HCP0 | Casein kinase I isoform gamma-1 | Ck1 | CHEMBL453386 |
CHEMBL1004494
(1)
|
0 / 0 |
| P07900 | Heat shock protein HSP 90-alpha | Other cytosolic protein | CHEMBL453974 CHEMBL453386 |
CHEMBL636772
(1)
CHEMBL693503
(1)
CHEMBL693504 (1) CHEMBL830071 (1) CHEMBL863358 (1) CHEMBL864232 (1) CHEMBL1794333 (1) CHEMBL1806078 (1) CHEMBL1806079 (1) CHEMBL2338980 (1) |
0 / 0 |
| Q86V86 | Serine/threonine-protein kinase pim-3 | Pim | CHEMBL453386 |
CHEMBL1004483
(1)
|
0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | CHEMBL453974 CHEMBL1596863 |
CHEMBL1794536
(2)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL1596863 |
CHEMBL1738442
(1)
|
0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | CHEMBL453974 |
CHEMBL2354311
(1)
|
1 / 0 |
| O00255 | Menin | Unclassified protein | CHEMBL1596863 |
CHEMBL1614257
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL1596863 |
CHEMBL1614257
(1)
|
1 / 3 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | CHEMBL453974 |
CHEMBL2354287
(1)
|
1 / 1 |
CTD interaction (10)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C035359 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [monorden results in decreased expression of AHR protein] |
decreases expression
/ decreases reaction |
protein |
20057149
|
| C035359 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | monorden results in decreased expression of AHR protein |
decreases expression
|
protein |
20057149
|
| C035359 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | monorden inhibits the reaction [Demecolcine results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
12530016
|
| C035359 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | monorden analog results in decreased expression of ESR1 protein |
decreases expression
|
protein |
11448926
|
| C035359 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | monorden results in decreased expression of ESR1 protein |
decreases expression
|
protein |
11448926
|
| C035359 | 3303 |
HSPA1A
HSP70-1 HSP70-1A HSP70I HSP72 HSPA1 |
heat shock 70kDa protein 1A | monorden analog results in increased expression of HSPA1A protein |
increases expression
|
protein |
11448926
|
| C035359 | 3303 |
HSPA1A
HSP70-1 HSP70-1A HSP70I HSP72 HSPA1 |
heat shock 70kDa protein 1A | monorden results in increased expression of HSPA1A protein |
increases expression
|
protein |
11448926
|
| C035359 | 3757 |
KCNH2
ERG1 HERG HERG1 Kv11.1 LQT2 SQT1 |
potassium voltage-gated channel, subfamily H (eag-related), member 2 | monorden results in decreased activity of KCNH2 protein |
decreases activity
|
protein |
12775586
|
| C035359 | 3757 |
KCNH2
ERG1 HERG HERG1 Kv11.1 LQT2 SQT1 |
potassium voltage-gated channel, subfamily H (eag-related), member 2 | monorden results in decreased expression of KCNH2 protein modified form |
decreases expression
|
protein |
12775586
|
| C035359 | 5241 |
PGR
NR3C3 PR |
progesterone receptor | monorden analog results in decreased expression of PGR protein alternative form |
decreases expression
|
protein |
11448926
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (27)
| OMIM | preferred title | UniProt |
|---|---|---|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #607115 | Cinca syndrome; cinca |
Q96P20
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #120100 | Familial cold autoinflammatory syndrome 1; fcas1 |
Q96P20
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #191900 | Muckle-wells syndrome; mws |
Q96P20
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #273300 | Testicular germ cell tumor; tgct |
O94804
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (24)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00282 | Cryopyrin associated periodic syndrome (CAPS) |
Q96P20
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|